{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T17:18:01Z","timestamp":1723483081264},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T00:00:00Z","timestamp":1560124800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T00:00:00Z","timestamp":1560124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Drug Investig"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1007\/s40261-019-00809-1","type":"journal-article","created":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T18:10:49Z","timestamp":1560190249000},"page":"891-898","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Determinants of Antithrombotic Treatment for Atrial Fibrillation in Octogenarians: Results of the OCTOFA Study"],"prefix":"10.1007","volume":"39","author":[{"given":"Jacques","family":"Blacher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Sorbets","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Guedj Meynier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Pierre","family":"Huberman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Gauthier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serge","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Hoffman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,6,10]]},"reference":[{"issue":"37","key":"809_CR1","first-page":"2893","volume":"2016","author":"Kirchhof P, Benussi S, Kotecha D, Ahlsson A, Atar D, Casadei B, Castella M, Diener HC, Heidbuchel H, Hendriks J, Hindricks G, Manolis AS, Oldgren J, Popescu BA, Schotten U, Van Putte B, Vardas P; ESC Scientific Document Group","year":"2016","unstructured":"Kirchhof P, Benussi S, Kotecha D, Ahlsson A, Atar D, Casadei B, Castella M, Diener HC, Heidbuchel H, Hendriks J, Hindricks G, Manolis AS, Oldgren J, Popescu BA, Schotten U, Van Putte B, Vardas P; ESC Scientific Document Group. ESC\u00a0guidelines\u00a0for the management of\u00a0atrial fibrillation\u00a0developed in collaboration with EACTS. Eur Heart J. 2016;2016(37):2893\u2013962.","journal-title":"Eur Heart J"},{"key":"809_CR2","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1161\/CIRCULATIONAHA.113.005119","volume":"129","author":"SS Chugh","year":"2014","unstructured":"Chugh SS, Havmoeller R, Narayanan K, Singh D, Rienstra M, Benjamin EJ, Gillum RF, Kim YH, McAnulty JH Jr, Zheng ZJ, Forouzanfar MH, Naghavi M, Mensah GA, Ezzati M, Murray CJ. Worldwide epidemiology of atrial fibrillation: a Global Burden of Disease 2010 Study. Circulation. 2014;129:837\u201347.","journal-title":"Circulation"},{"key":"809_CR3","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1161\/01.STR.22.8.983","volume":"22","author":"PA Wolf","year":"1991","unstructured":"Wolf PA, Abbott RD, Kannel WB. Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. Stroke. 1991;22:983\u20138.","journal-title":"Stroke"},{"key":"809_CR4","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/S0002-9343(02)01236-6","volume":"113","author":"S Stewart","year":"2002","unstructured":"Stewart S, Hart CL, Hole DJ, McMurray JJ. A population-based study of the longterm risks associated with atrial fibrillation: 20-year follow-up of the Renfrew\/ Paisley study. Am J Med. 2002;113:359\u201364.","journal-title":"Am J Med"},{"key":"809_CR5","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1378\/chest.09-1584","volume":"137","author":"GY Lip","year":"2010","unstructured":"Lip GY, Nieuwlaat R, Pisters R, Lane DA, Crijns HJ. Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: the euro heart survey on atrial fibrillation. Chest. 2010;137:263\u201372.","journal-title":"Chest"},{"key":"809_CR6","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1378\/chest.10-0134","volume":"138","author":"R Pisters","year":"2010","unstructured":"Pisters R, Lane DA, Nieuwlaat R, de Vos CB, Crijns HJ, Lip GY. A novel userfriendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: the Euro Heart Survey. Chest. 2010;138:1093\u2013100.","journal-title":"Chest"},{"key":"809_CR7","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1161\/CIRCULATIONAHA.114.012061","volume":"131","author":"DJ Graham","year":"2015","unstructured":"Graham DJ, Reichman ME, Wernecke M, Zhang R, Southworth MR, Levenson M, Sheu TC, Mott K, Goulding MR, Houstoun M, MaCurdy TE, Worrall C, Kelman JA. Cardiovascular, bleeding, and mortality risks in elderly Medicare patients treated with dabigatran or warfarin for nonvalvular atrial fibrillation. Circulation. 2015;131:157\u201364.","journal-title":"Circulation"},{"key":"809_CR8","doi-asserted-by":"publisher","first-page":"3365","DOI":"10.1093\/eurheartj\/ehu374","volume":"35","author":"GY Lip","year":"2014","unstructured":"Lip GY, Laroche C, Ioachim PM, Rasmussen LH, Vitali-Serdoz L, Petrescu L, Darabantiu D, Crijns HJ, Kirchhof P, Vardas P, Tavazzi L, Maggioni AP, Boriani G. Prognosis and treatment of atrial fibrillation patients by European cardiologists: one year follow-up of the EURObservational Research Programme-Atrial Fibrillation General Registry Pilot Phase (EORP-AF Pilot registry). Eur Heart J. 2014;35:3365\u201376.","journal-title":"Eur Heart J"},{"key":"809_CR9","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1016\/S0140-6736(13)62343-0","volume":"383","author":"CT Ruff","year":"2014","unstructured":"Ruff CT, Giugliano RP, Braunwald E, Hoffman EB, Deenadayalu N, Ezekowitz MD, Camm AJ, Weitz JI, Lewis BS, Parkhomenko A, Yamashita T, Antman EM. Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials. Lancet. 2014;383:955\u201362.","journal-title":"Lancet"},{"key":"809_CR10","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/j.jacc.2010.05.028","volume":"56","author":"R Marinigh","year":"2010","unstructured":"Marinigh R, Lip GY, Fiotti N, Giansante C, Lane DA. Age as a risk factor for stroke in atrial fibrillation patients: implications for thromboprophylaxis. J Am Coll Cardiol. 2010;56:827\u201337.","journal-title":"J Am Coll Cardiol"},{"key":"809_CR11","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1161\/01.STR.31.4.822","volume":"31","author":"BF Gage","year":"2000","unstructured":"Gage BF, Boechler M, Doggette AL, Fortune G, Flaker GC, Rich MW, Radford MJ. Adverse outcomes and predictors of underuse of antithrombotic therapy in medicare beneficiaries with chronic atrial fibrillation. Stroke. 2000;31:822\u20137.","journal-title":"Stroke"},{"key":"809_CR12","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1161\/01.STR.31.6.1217","volume":"31","author":"N Cohen","year":"2000","unstructured":"Cohen N, Almoznino-Sarafian D, Alon I, Gorelik O, Koopfer M, Chachashvily S, Shteinshnaider M, Litvinjuk V, Modai D. Warfarin for stroke prevention still underused in atrial fibrillation: patterns of omission. Stroke. 2000;31:1217\u201322.","journal-title":"Stroke"},{"key":"809_CR13","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1001\/archinte.163.13.1580","volume":"163","author":"M Man-Son-Hing","year":"2003","unstructured":"Man-Son-Hing M, Laupacis A. Anticoagulant-related bleeding in older persons with atrial fibrillation: physicians\u2019 fears often unfounded. Arch Intern Med. 2003;163:1580\u20136.","journal-title":"Arch Intern Med"},{"key":"809_CR14","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.amjopharm.2009.06.002","volume":"7","author":"LG Jacobs","year":"2009","unstructured":"Jacobs LG, Billett HH, Freeman K, Dinglas C, Jumaquio L. Anticoagulation for stroke prevention in elderly patients with atrial fibrillation, including those with falls and\/or early-stage dementia: a single-center, retrospective, observational study. Am J Geriatr Pharmacother. 2009;7:159\u201366.","journal-title":"Am J Geriatr Pharmacother"},{"key":"809_CR15","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1159\/000155654","volume":"55","author":"F Formiga","year":"2009","unstructured":"Formiga F, Fort I, Reig L, Robles MJ, Espinosa MC, Rodriguez D. Atrial fibrillation in elderly patients with dementia. Gerontology. 2009;55:202\u20134.","journal-title":"Gerontology"},{"key":"809_CR16","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1093\/europace\/euu225","volume":"17","author":"JB Olesen","year":"2015","unstructured":"Olesen JB, Sorensen R, Hansen ML, Lamberts M, Weeke P, Mikkelsen AP, K\u00f8ber L, Gislason GH, Torp-Pedersen C, Fosb\u00f8l EL. Non-vitamin K antagonist oral anticoagulation agents in anticoagulant naive atrial fibrillation patients: Danish nationwide descriptive data 2011\u20132013. Europace. 2015;17:187\u201393.","journal-title":"Europace"},{"issue":"5","key":"809_CR17","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1097\/TA.0000000000001245","volume":"81","author":"JM Feeney","year":"2016","unstructured":"Feeney JM, Santone E, DiFiori M, Kis L, Jayaraman V, Montgomery SC. Compared to warfarin, direct oral anticoagulants are associated with lower mortality in patients with blunt traumatic intracranial hemorrhage: a TQIP study. J Trauma Acute Care Surg. 2016;81(5):843\u20138.","journal-title":"J Trauma Acute Care Surg."},{"key":"809_CR18","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1016\/S0140-6736(06)68845-4","volume":"367","author":"S Connolly","year":"2006","unstructured":"Connolly S, Pogue J, Hart R, Pfeffer M, Hohnloser S, Chrolavicius S, Pfeffer M, Hohnloser S, Yusuf S, ACTIVE Writing Group of the ACTIVE Investigators. Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial fibrillation Clopidogrel Trial with Irbesartan for prevention of Vascular Events (ACTIVE W): a randomised controlled trial. Lancet. 2006;367:1903\u201312.","journal-title":"Lancet."},{"key":"809_CR19","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1016\/S0140-6736(13)62343-0","volume":"383","author":"CT Ruff","year":"2014","unstructured":"Ruff CT, Giugliano RP, Braunwald E, Hoffman EB, Deenadayalu N, Ezekowitz MD, Camm AJ, Weitz JI, Lewis BS, Parkhomenko A, Yamashita T, Antman EM. Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials. Lancet. 2014;383:955\u201362.","journal-title":"Lancet"},{"key":"809_CR20","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1093\/ije\/dyt271","volume":"43","author":"L Richiardi","year":"2014","unstructured":"Richiardi L, Pizzi C, Pearce N. Representativeness. Int J Epidemiol. 2014;43:632\u20133.","journal-title":"Int J Epidemiol"},{"key":"809_CR21","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1097\/EDE.0b013e31816326e9","volume":"19","author":"A Fourrier-R\u00e9glat","year":"2008","unstructured":"Fourrier-R\u00e9glat A, Droz-Perroteau C, B\u00e9nichou J, Depont F, Amouretti M, B\u00e9gaud B, Moride Y, Blin P, CADEUS Team. Moore N (2008) Impact of prescriber nonresponse on patient representativeness. Epidemiology. 2008;19:186\u201390.","journal-title":"Epidemiology."}],"container-title":["Clinical Drug Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40261-019-00809-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40261-019-00809-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40261-019-00809-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T23:30:21Z","timestamp":1591659021000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40261-019-00809-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,10]]},"references-count":21,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["809"],"URL":"https:\/\/doi.org\/10.1007\/s40261-019-00809-1","relation":{},"ISSN":["1173-2563","1179-1918"],"issn-type":[{"value":"1173-2563","type":"print"},{"value":"1179-1918","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,10]]},"assertion":[{"value":"10 June 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"All authors have no conflict of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. The CNCF (<i>Coll\u00e8ge National des Cardiologues Fran\u00e7ais<\/i>) supported all expenses of the OCTOFA study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"Both the program and the study received approval from the appropriate ethics and administrative committees.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All participants provided written informed consent.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}