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Gargiulo has been a consultant for Almirall. M.\u00a0Valenti\u00a0has been a consultant and\/or speaker for Sanofi, Leo Pharma, Eli Lilly,\u00a0and Boehringer. A. Costanzo has served as an advisory board member and consultant and has received fees and speaker\u2019s honoraria or has participated in clinical trials for Abbvie, Almirall, Biogen, LEO Pharma, Lilly, Janssen, Novartis, Pfizer, Sanofi Genzyme, and UCB-Pharma. A. Narcisi has served on advisory boards and received honoraria for lectures and research grants from Almirall, Abbvie, Leo Pharma, Celgene, Eli Lilly, Janssen, Novartis, Sanofi\u2010Genzyme, Amgen, and Boehringer Ingelheim. The other authors have nothing to disclose.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Institutional review board approval was exempted as the study protocol did not deviate from standard clinical practice. All patients received biological drugs as in good clinical practice, in accordance with Italian guidelines. The study was performed in accordance with the Helsinki Declaration of 1964 and its later amendments. Data collection and handling complied with applicable laws, regulations, and guidance regarding patient protection, including patient privacy.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethics guidelines"}},{"value":"All included patients had provided written consent for retrospective study of data collected during routine clinical practice (demographics, clinical scores).","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All included patients had provided written consent for publication of their data.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The datasets generated during and\/or analyzed during the current study are available from the corresponding author on reasonable request.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data availability"}},{"value":"Not applicable.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}},{"value":"All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Luigi Gargiulo, Luciano Ibba, Andrea Cortese, Angela Alfano, Mario Valenti, Antonio Costanzo, and Alessandra Narcisi. The first draft of the manuscript was written by Luigi Gargiulo and Luciano Ibba, and all authors commented on previous versions of the manuscript. Supervision: Alessandra Narcisi. All authors read and approved the final manuscript.","order":9,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author contribution"}}]}}