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Yongchun Zhou is a full-time employee of Wanbang Biopharmaceuticals. Fangfang Wang, Zhiping Liu, Xiaoye Niu, Lin Zhao, Jixiang Zhu, Linjing Qi, Xiaoye Wang, and Haiyan Li have no conflicts of interest that are directly relevant to the content of this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The protocols of two trials (CTR20213292 and CTR20213291) were approved by the Institutional Review Board of Peking University Third Hospital (Beijing, China). The studies were conducted in accordance with the 1964 Declaration of Helsinki and its later amendments and all Chinese regulatory requirements.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent was obtained from all subjects for these two studies before the screening.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All data generated or analyzed during this study are included in this published article and its supplementary information files.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data and material"}},{"value":"Not applicable.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}},{"value":"Conceptualization: LD, JL, YZ, XW, and HL; methodology: LL and ZL; investigation: FW, ZL, XN, LZ, JZ, and LQ; formal analysis: YS; and writing (review and editing): FW, ZL, XN, LZ, JZ, LQ, LL, ZL, YS, LD, JL, YZ, XW, and HL.","order":9,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author contributions"}}]}}