{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T20:05:09Z","timestamp":1767989109124,"version":"3.49.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T00:00:00Z","timestamp":1731715200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T00:00:00Z","timestamp":1731715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/501100002386","name":"Cairo University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002386","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Drug Investig"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1007\/s40261-024-01404-9","type":"journal-article","created":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T12:30:43Z","timestamp":1731760243000},"page":"897-926","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Network Meta-Analysis of Vasodilator Therapies in Pulmonary Hypertension Patients Undergoing Mitral Valve Replacement Surgery: Insights for Optimizing Hemodynamics"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5592-3908","authenticated-orcid":false,"given":"Amr","family":"Elrosasy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Maher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelraouf","family":"Ramadan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nada G.","family":"Hamam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Soliman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara K.","family":"Kamal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beshoy Emad","family":"Milik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah Ali","family":"Shahat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Menna Nabil","family":"Kamel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed Abdeltawab","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loay Abdelnabi","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Zabady","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8165-9470","authenticated-orcid":false,"given":"Mohamed Abo","family":"Zeid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wael","family":"Abdelmottaleb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameh","family":"Nassar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,11,16]]},"reference":[{"key":"1404_CR1","doi-asserted-by":"crossref","unstructured":"Wijeratne DT, Lajkosz K, Brogly SB, Lougheed MD, Jiang L, Housin A, et al. Increasing incidence and prevalence of World Health Organization groups 1 to 4 pulmonary hypertension. Circ Cardiovasc Qual Outcomes. 2018;11(2).","DOI":"10.1161\/CIRCOUTCOMES.117.003973"},{"key":"1404_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41572-023-00486-7","volume":"10","author":"A Mocumbi","year":"2024","unstructured":"Mocumbi A, Humbert M, Saxena A, Jing Z-C, Sliwa K, Thienemann F, et al. Pulmonary hypertension. Nat Rev Dis Primers. 2024;10:1.","journal-title":"Nat Rev Dis Primers"},{"key":"1404_CR3","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.ijcard.2016.06.242","volume":"221","author":"F Thienemann","year":"2016","unstructured":"Thienemann F, Dzudie A, Mocumbi AO, Blauwet L, Sani MU, Karaye KM, et al. The causes, treatment, and outcome of pulmonary hypertension in Africa: insights from the Pan African Pulmonary Hypertension Cohort (PAPUCO) Registry. Int J Cardiol. 2016;221:205\u201311.","journal-title":"Int J Cardiol"},{"key":"1404_CR4","doi-asserted-by":"publisher","first-page":"2200879","DOI":"10.1183\/13993003.00879-2022","volume":"61","author":"M Humbert","year":"2023","unstructured":"Humbert M, Kovacs G, Hoeper MM, Badagliacca R, Berger RMF, Brida M, et al. 2022 ESC\/ERS guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Respir J. 2023;61:2200879.","journal-title":"Eur Respir J"},{"key":"1404_CR5","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.cjca.2015.01.030","volume":"31","author":"AO Mocumbi","year":"2015","unstructured":"Mocumbi AO, Thienemann F, Sliwa K. A global perspective on the epidemiology of pulmonary hypertension. Can J Cardiol. 2015;31:375\u201381.","journal-title":"Can J Cardiol"},{"key":"1404_CR6","doi-asserted-by":"publisher","first-page":"38","DOI":"10.3390\/diseases6020038","volume":"6","author":"N Lan","year":"2018","unstructured":"Lan N, Massam B, Kulkarni S, Lang C. Pulmonary arterial hypertension: pathophysiology and treatment. Diseases. 2018;6:38.","journal-title":"Diseases"},{"key":"1404_CR7","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1111\/anae.12831","volume":"70","author":"SA Pilkington","year":"2015","unstructured":"Pilkington SA, Taboada D, Martinez G. Pulmonary hypertension and its management in patients undergoing non-cardiac surgery. Anaesthesia. 2015;70:56\u201370.","journal-title":"Anaesthesia"},{"key":"1404_CR8","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1053\/j.jvca.2012.07.017","volume":"27","author":"CA Thunberg","year":"2013","unstructured":"Thunberg CA, Gaitan BD, Grewal A, Ramakrishna H, Stansbury LG, Grigore AM. Pulmonary hypertension in patients undergoing cardiac surgery: pathophysiology, perioperative management, and outcomes. J Cardiothorac Vasc Anesth. 2013;27:551\u201372.","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"1404_CR9","unstructured":"SH O, G M, A S. Pulmonary Hypertension. In: StatPearls [Internet]. Treasure Island (FL). 2024. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK482463\/. Accessed Mar 17 2024."},{"key":"1404_CR10","doi-asserted-by":"publisher","first-page":"D4","DOI":"10.1016\/j.jacc.2013.10.025","volume":"62","author":"RM Tuder","year":"2013","unstructured":"Tuder RM, Archer SL, Dorfm\u00fcller P, Erzurum SC, Guignabert C, Michelakis E, et al. Relevant issues in the pathology and pathobiology of pulmonary hypertension. J Am Coll Cardiol. 2013;62:D4-12.","journal-title":"J Am Coll Cardiol"},{"key":"1404_CR11","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/S1053-0770(97)90054-9","volume":"11","author":"T Hachenberg","year":"1997","unstructured":"Hachenberg T, M\u00f6llhoff T, Holst D, Hammel D, Br\u00fcssel T. Cardiopulmonary effects of enoximone or dobutamine and nitroglycerin on mitral valve regurgitation and pulmonary venous hypertension. J Cardiothorac Vasc Anesth. 1997;11:453\u20137.","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"1404_CR12","doi-asserted-by":"publisher","first-page":"119","DOI":"10.2459\/01.JCM.0000203850.97890.fe","volume":"7","author":"K Fattouch","year":"2006","unstructured":"Fattouch K, Sbraga F, Sampognaro R, Bianco G, Gucciardo M, Lavalle C, et al. Treatment of pulmonary hypertension in patients undergoing cardiac surgery with cardiopulmonary bypass: a randomized, prospective, double-blind study. J Cardiovasc Med (Hagerstown). 2006;7:119\u201323.","journal-title":"J Cardiovasc Med (Hagerstown)"},{"key":"1404_CR13","doi-asserted-by":"publisher","first-page":"328","DOI":"10.4103\/aca.ACA_19_18","volume":"21","author":"T Kundra","year":"2018","unstructured":"Kundra T, Nagaraja P, Bharathi K, Kaur P, Manjunatha N. Inhaled levosimendan versus intravenous levosimendan in patients with pulmonary hypertension undergoing mitral valve replacement. Ann Card Anaesth. 2018;21:328.","journal-title":"Ann Card Anaesth"},{"key":"1404_CR14","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1177\/026765919901400106","volume":"14","author":"JR Beck","year":"1999","unstructured":"Beck JR, Mongero LB, Kroslowitz RM, Choudhri AF, Chen JM, DeRose JJ, et al. Inhaled nitric oxide improves hemodynamics in patients with acute pulmonary hypertension after high-risk cardiac surgery. Perfusion. 1999;14:37\u201342.","journal-title":"Perfusion"},{"key":"1404_CR15","doi-asserted-by":"crossref","unstructured":"Bisserier M, Pradhan N, Hadri L. Current and emerging therapeutic approaches to pulmonary hypertension. Rev Cardiovasc Med. 2020;21:163.","DOI":"10.31083\/j.rcm.2020.02.597"},{"key":"1404_CR16","unstructured":"Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA (editors). Cochrane Handbook for Systematic Reviews of Interventions version 6.5 (updated August 2024). Cochrane, 2024. http:\/\/www.training.cochrane.org\/handbook. Accessed Mar 17 2024."},{"key":"1404_CR17","doi-asserted-by":"publisher","first-page":"777","DOI":"10.7326\/M14-2385","volume":"162","author":"B Hutton","year":"2015","unstructured":"Hutton B, Salanti G, Caldwell DM, Chaimani A, Schmid CH, Cameron C, et al. The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations. Ann Intern Med. 2015;162:777\u201384.","journal-title":"Ann Intern Med"},{"key":"1404_CR18","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1186\/s13643-016-0384-4","volume":"5","author":"M Ouzzani","year":"2016","unstructured":"Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan\u2014a web and mobile app for systematic reviews. Syst Rev. 2016;5:210.","journal-title":"Syst Rev"},{"key":"1404_CR19","doi-asserted-by":"crossref","unstructured":"Sterne JAC, Savovi\u0107 J, Page MJ, Elbers RG, Blencowe NS, Boutron I, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019;366","DOI":"10.1136\/bmj.l4898"},{"key":"1404_CR20","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1007\/s12325-009-0019-4","volume":"26","author":"H Wang","year":"2009","unstructured":"Wang H, Gong M, Zhou B, Dai A. Comparison of inhaled and intravenous milrinone in patients with pulmonary hypertension undergoing mitral valve surgery. Adv Ther. 2009;26:462.","journal-title":"Adv Ther"},{"key":"1404_CR21","unstructured":"Wagner R, \u00c2ern \u0304 J, Piler P, Ne\u00b7Porov\u00e1 J. Effect of nitric oxide on early myocardial function in valvular surgery."},{"key":"1404_CR22","doi-asserted-by":"crossref","unstructured":"\u015eim\u015fek M, Kudsio\u011flu T. Effects of Iloprost and Nitroglycerin in Mitral Valve Patients with Pulmonary Hypertension. J Cardio-Vasc Thorac Anaesth Intensive Care Soc. 2022;28(3).","DOI":"10.14744\/GKDAD.2022.72623"},{"key":"1404_CR23","doi-asserted-by":"publisher","first-page":"E536","DOI":"10.1532\/HSF98.20051161","volume":"9","author":"A Baysal","year":"2006","unstructured":"Baysal A, Bilsel S, Bulbul OG, Kayacioglu I, Idiz M, Yekeler I. Comparison of the usage of intravenous iloprost and nitroglycerin for pulmonary hypertension during valvular heart surgery. Heart Surg Forum. 2006;9:E536\u201342.","journal-title":"Heart Surg Forum"},{"key":"1404_CR24","doi-asserted-by":"publisher","first-page":"281","DOI":"10.4103\/0253-7613.132158","volume":"46","author":"N Shastri","year":"2014","unstructured":"Shastri N, Gandhi H, Kothari J, Shah B, Patel R, Toshani R, et al. Effect of preoperative oral sildenafil on severe pulmonary artery hypertension in patients undergoing mitral valve replacement. Indian J Pharmacol. 2014;46:281.","journal-title":"Indian J Pharmacol."},{"key":"1404_CR25","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1016\/j.jtcvs.2006.08.035","volume":"132","author":"JK Shim","year":"2006","unstructured":"Shim JK, Choi YS, Oh YJ, Kim DH, Hong YW, Kwak YL. Effect of oral sildenafil citrate on intraoperative hemodynamics in patients with pulmonary hypertension undergoing valvular heart surgery. J Thorac Cardiovasc Surg. 2006;132:1420\u20135.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"1404_CR26","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1111\/j.1399-6576.2007.01476.x","volume":"52","author":"S Rex","year":"2008","unstructured":"Rex S, Schaelte G, Metzelder S, Flier S, De Waal E, Autschbach R, et al. Inhaled iloprost to control pulmonary artery hypertension in patients undergoing mitral valve surgery: a prospective, randomized-controlled trial. Acta Anaesthesiol Scand. 2008;52:65\u201372.","journal-title":"Acta Anaesthesiol Scand"},{"key":"1404_CR27","doi-asserted-by":"publisher","first-page":"1648","DOI":"10.1053\/j.jvca.2018.12.023","volume":"33","author":"E Ram","year":"2019","unstructured":"Ram E, Sternik L, Klempfner R, Eldar M, Goldenberg I, Peled Y, et al. Sildenafil for pulmonary hypertension in the early postoperative period after mitral valve surgery. J Cardiothorac Vasc Anesth. 2019;33:1648\u201356.","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"1404_CR28","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1053\/j.jvca.2016.01.015","volume":"30","author":"A Mishra","year":"2016","unstructured":"Mishra A, Kumar B, Dutta V, Arya VK, Mishra AK. Comparative effect of levosimendan and milrinone in cardiac surgery patients with pulmonary hypertension and left ventricular dysfunction. J Cardiothorac Vasc Anesth. 2016;30:639\u201346.","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"1404_CR29","doi-asserted-by":"publisher","first-page":"2123","DOI":"10.1053\/j.jvca.2018.04.022","volume":"32","author":"TS Kundra","year":"2018","unstructured":"Kundra TS, Prabhakar V, Kaur P, Manjunatha N, Gandham R. The effect of inhaled milrinone versus inhaled levosimendan in pulmonary hypertension patients undergoing mitral valve surgery\u2014a pilot randomized double-blind study. J Cardiothorac Vasc Anesth. 2018;32:2123\u20139.","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"1404_CR30","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1111\/j.0886-0440.2005.200383w.x","volume":"20","author":"K Fattouch","year":"2005","unstructured":"Fattouch K, Sbraga F, Bianco G, Speziale G, Gucciardo M, Sampognaro R, et al. Inhaled prostacyclin, nitric oxide, and nitroprusside in pulmonary hypertension after mitral valve replacement. J Card Surg. 2005;20:171\u20136.","journal-title":"J Card Surg"},{"key":"1404_CR31","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1016\/j.hlc.2013.12.014","volume":"23","author":"G Jiang","year":"2014","unstructured":"Jiang G, Li B, Zhang G, Xu E, Liu Y, Xu Z. Effects of sildenafil on prognosis in patients with pulmonary hypertension after left-sided valvular surgery. Heart Lung Circ. 2014;23:680\u20135.","journal-title":"Heart Lung Circ"},{"key":"1404_CR32","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1016\/j.amjcard.2010.11.030","volume":"107","author":"JL Fernandes","year":"2011","unstructured":"Fernandes JL, Sampaio RO, Brand\u00e3o CM, Accorsi TAD, Cardoso LF, Spina GS, et al. Comparison of inhaled nitric oxide versus oxygen on hemodynamics in patients with mitral stenosis and severe pulmonary hypertension after mitral valve surgery. Am J Cardiol. 2011;107:1040\u20135.","journal-title":"Am J Cardiol"},{"key":"1404_CR33","doi-asserted-by":"publisher","first-page":"331","DOI":"10.4103\/jmisr.jmisr_76_22","volume":"5","author":"AKAG Hassan","year":"2022","unstructured":"Hassan AKAG, Sultan SA, Mostafa W-SI, El-Komos Samaan P, Saeed AF. Study of the hemodynamic effect of inhaled milrinone versus inhaled nitroglycerin on mechanically ventilated patients with pulmonary hypertension after mitral valve replacement surgeries. J Med Sci Res. 2022;5:331.","journal-title":"J Med Sci Res"},{"key":"1404_CR34","doi-asserted-by":"publisher","first-page":"2540","DOI":"10.1053\/j.jvca.2018.04.032","volume":"32","author":"AM Eskandr","year":"2018","unstructured":"Eskandr AM, Metwally AA, Abu Elkassem MS, Sadik SA, Elmiligy AE, Mourad M, et al. Dobutamine and nitroglycerin versus milrinone for perioperative management of pulmonary hypertension in mitral valve surgery. A randomized controlled study. J Cardiothorac Vasc Anesth. 2018;32:2540\u20136.","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"1404_CR35","doi-asserted-by":"publisher","first-page":"260","DOI":"10.5830\/CVJA-2013-047","volume":"24","author":"O Ersoy","year":"2013","unstructured":"Ersoy O, Boysan E, Unal EU, Yay K, Yener U, Cicekcioglu F, et al. Effectiveness of prophylactic levosimendan in high-risk valve surgery patients: cardiovascular topics. Cardiovasc J Afr. 2013;24:260\u20134.","journal-title":"Cardiovasc J Afr"},{"key":"1404_CR36","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1016\/j.jtcvs.2011.08.030","volume":"142","author":"M Ghoreishi","year":"2011","unstructured":"Ghoreishi M, Evans CF, DeFilippi CR, Hobbs G, Young CA, Griffith BP, et al. Pulmonary hypertension adversely affects short- and long-term survival after mitral valve operation for mitral regurgitation: implications for timing of surgery. J Thorac Cardiovasc Surg. 2011;142:1439\u201352.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"1404_CR37","doi-asserted-by":"crossref","unstructured":"Patel H, Desai M, Tuzcu EM, Griffin B, Kapadia S. Pulmonary hypertension in mitral regurgitation. J Am Heart Assoc. 2014;3(4).","DOI":"10.1161\/JAHA.113.000748"},{"key":"1404_CR38","doi-asserted-by":"publisher","first-page":"2261","DOI":"10.1053\/j.jvca.2023.07.041","volume":"37","author":"S Sardo","year":"2023","unstructured":"Sardo S, Tripodi VF, Guerzoni F, Musu M, Cortegiani A, Finco G. Pulmonary vasodilator and inodilator drugs in cardiac surgery: a systematic review with Bayesian network meta-analysis. J Cardiothorac Vasc Anesth. 2023;37:2261\u201371.","journal-title":"J Cardiothorac Vasc Anesth"},{"issue":"5","key":"1404_CR39","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/j.athoracsur.2005.11.061","volume":"81","author":"K Fattouch","year":"2006","unstructured":"Fattouch K, Guccione F, Sampognaro R, et al. Inhaled prostacyclin, nitric oxide, or nitroprusside in pulmonary hypertension secondary to mitral valve surgery. Ann Thorac Surg. 2006;81(5):1745\u201352.","journal-title":"Ann Thorac Surg"},{"issue":"5","key":"1404_CR40","first-page":"306","volume":"1","author":"MM Hoeper","year":"2013","unstructured":"Hoeper MM, Humbert M, Souza R, et al. A global view of pulmonary hypertension. Lancet Respir Med. 2013;1(5):306\u201318.","journal-title":"Lancet Respir Med"},{"issue":"1","key":"1404_CR41","doi-asserted-by":"publisher","first-page":"1801913","DOI":"10.1183\/13993003.01913-2018","volume":"53","author":"G Simonneau","year":"2019","unstructured":"Simonneau G, Montani D, Celermajer DS, et al. Haemodynamic definitions and updated clinical classification of pulmonary hypertension. Eur Respir J. 2019;53(1):1801913.","journal-title":"Eur Respir J"},{"issue":"1","key":"1404_CR42","doi-asserted-by":"publisher","first-page":"1801897","DOI":"10.1183\/13993003.01897-2018","volume":"53","author":"JL Vachiery","year":"2019","unstructured":"Vachiery JL, Tedford RJ, Rosenkranz S, et al. Pulmonary hypertension due to left heart disease. Eur Respir J. 2019;53(1):1801897.","journal-title":"Eur Respir J"},{"issue":"1","key":"1404_CR43","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1001\/jamacardio.2019.4428","volume":"5","author":"R Al-Bawardy","year":"2020","unstructured":"Al-Bawardy R, Vemulapalli S, Thourani VH, et al. Association of pulmonary hypertension with clinical outcomes of transcatheter mitral valve repair. JAMA Cardiol. 2020;5(1):47\u201356.","journal-title":"JAMA Cardiol."},{"issue":"10","key":"1404_CR44","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1016\/j.healun.2022.07.005","volume":"41","author":"G Gulati","year":"2022","unstructured":"Gulati G, Grandin EW, DeNofrio D, et al. Association between postoperative hemodynamic metrics of pulmonary hypertension and right ventricular dysfunction and clinical outcomes after left ventricular assist device implantation. J Heart Lung Transplant. 2022;41(10):1459\u201369.","journal-title":"J Heart Lung Transplant"},{"key":"1404_CR45","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1007\/s00392-018-1365-5","volume":"108","author":"MM Kreusser","year":"2019","unstructured":"Kreusser MM, Geis NA, Berlin N, et al. Invasive hemodynamics and cardiac biomarkers to predict outcomes after percutaneous edge-to-edge mitral valve repair in patients with severe heart failure. Clin Res Cardiol. 2019;108:375\u201387.","journal-title":"Clin Res Cardiol"},{"issue":"4","key":"1404_CR46","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.jacc.2016.05.047","volume":"68","author":"C Opitz","year":"2016","unstructured":"Opitz C, Hoeper MM, Gibbs JS, et al. Pre-capillary, combined, and post-capillary pulmonary hypertension: a pathophysiological continuum. J Am Coll Cardiol. 2016;68(4):368\u201378.","journal-title":"J Am Coll Cardiol"},{"key":"1404_CR47","doi-asserted-by":"crossref","unstructured":"Thenappan T, Ormiston ML, Ryan JJ, Archer SL. Pulmonary arterial hypertension: pathogenesis and clinical management. BMJ. 2018;14;360.","DOI":"10.1136\/bmj.j5492"},{"issue":"8","key":"1404_CR48","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/j.recesp.2020.09.009","volume":"74","author":"JF Rodr\u00edguez-Palomares","year":"2021","unstructured":"Rodr\u00edguez-Palomares JF, Lozano-Torres J, Dentamaro I, et al. Predictors of cardiovascular outcomes after surgery in severe tricuspid regurgitation: clinical, imaging and hemodynamic prospective study. Rev Esp Cardiol. 2021;74(8):655\u201363.","journal-title":"Rev Esp Cardiol"}],"container-title":["Clinical Drug Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40261-024-01404-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40261-024-01404-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40261-024-01404-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T15:09:32Z","timestamp":1734016172000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40261-024-01404-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,16]]},"references-count":48,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["1404"],"URL":"https:\/\/doi.org\/10.1007\/s40261-024-01404-9","relation":{},"ISSN":["1173-2563","1179-1918"],"issn-type":[{"value":"1173-2563","type":"print"},{"value":"1179-1918","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,16]]},"assertion":[{"value":"14 October 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 November 2024","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The datasets used and\/or analyzed during the current study are available from the corresponding author upon reasonable request.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data and material"}},{"value":"A.E. conceived and designed the study, interpreted data, drafted the manuscript, and supervised the entire project; A.M. contributed to the study design, data acquisition, statistical modeling and analysis, interpretation of results, and critically revised the manuscript; A.R. was involved in data extraction, interpretation, and critical revision of the manuscript; N.G.H. assisted with data extraction, statistical analysis, and manuscript drafting; M.S. contributed to literature search, screening, and drafting of the results; S.K.K. assisted in methodological design, quality assessment, and manuscript revisions; B.E.M. participated in statistical analysis, data interpretation, and manuscript revision; A.A.S. contributed to literature review and manuscript preparation; M.N.K. assisted with data collection, quality assessment, and manuscript revisions; A.A.A. was involved in data extraction and screening and contributed to manuscript drafting; L.A.H. contributed to data curation, literature search, and manuscript development; A.Z. assisted with literature search, data analysis, and manuscript feedback; M.A.Z. contributed to quality assessment and analysis refinement; W.A. participated in the writing and revision of the manuscript; S.N. provided critical input on study design and wrote and revised the manuscript. All authors approved the final version of the manuscript and agree to be accountable for all aspects of the work.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Authors\u2019 contribution"}}]}}