{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T21:01:57Z","timestamp":1791666117350,"version":"4.3.4"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Institutional Research Grants from Chongqing Health Center for Women and Children","award":["2019YJMS07"],"award-info":[{"award-number":["2019YJMS07"]}]},{"name":"Chongqing Traditional Chinese Medicine Research Project (Joint project of Chongqing Health Commission and Science and Technology Bureau","award":["2023MSXM153"],"award-info":[{"award-number":["2023MSXM153"]}]},{"DOI":"10.13039\/501100012232","name":"National Key Clinical Specialty Discipline Construction Program of China","doi-asserted-by":"publisher","award":["Obstetrics"],"award-info":[{"award-number":["Obstetrics"]}],"id":[{"id":"10.13039\/501100012232","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012232","name":"National Key Clinical Specialty Discipline Construction Program of China","doi-asserted-by":"publisher","award":["Gynecology"],"award-info":[{"award-number":["Gynecology"]}],"id":[{"id":"10.13039\/501100012232","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Drug Investig"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1007\/s40261-026-01547-x","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T11:01:04Z","timestamp":1774868464000},"page":"551-559","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effectiveness of Dexmedetomidine and Sufentanil in Preventing Adverse Reactions to Carboprost Tromethamine During Cesarean Section with Noninvasive Cardiac System Monitoring"],"prefix":"10.1007","volume":"46","clinical-trial-number":[{"clinical-trial-number":"chictr2000038350","registry":"10.18810\/chictr"}],"author":[{"given":"Jing","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8568-9166","authenticated-orcid":false,"given":"Jin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"key":"1547_CR1","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1111\/hdi.12589","volume":"22","author":"MJ Germain","year":"2018","unstructured":"Germain MJ, Joubert J, O\u2019Grady D, Nathanson BH, Chait Y, Levin NW. Comparison of stroke volume measurements during hemodialysis using bioimpedance cardiography and echocardiography. Hemodial Int. 2018;22:201\u20138.","journal-title":"Hemodial Int"},{"key":"1547_CR2","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.advms.2024.02.005","volume":"69","author":"M Anshory","year":"2024","unstructured":"Anshory M, Kuan WS, Rohman MS, Waranugraha Y, Kamila PA, Iskandar A, et al. Can non-invasive cardiac hemodynamics and fluid content system (NICaS) parameters predict acute heart failure outcomes in Caucasian and Asian patients in the emergency department? Adv Med Sci. 2024;69:81\u20139.","journal-title":"Adv Med Sci"},{"key":"1547_CR3","first-page":"2257","volume":"31","author":"Z Ling","year":"2018","unstructured":"Ling Z, Yao L, Cui Z, Lifan C. Effect of carboprost tromethamine in prevention of postpartum hemorrhage in cesarean section. Pak J Pharm Sci. 2018;31:2257\u201362.","journal-title":"Pak J Pharm Sci"},{"key":"1547_CR4","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1111\/anae.14757","volume":"74","author":"M Heesen","year":"2019","unstructured":"Heesen M, Carvalho B, Carvalho JCA, Duvekot JJ, Dyer RA, Lucas DN, et al. International consensus statement on the use of uterotonic agents during caesarean section. Anaesthesia. 2019;74:1305\u201319.","journal-title":"Anaesthesia"},{"key":"1547_CR5","doi-asserted-by":"publisher","first-page":"2233138","DOI":"10.1155\/2022\/2233138","volume":"2022","author":"X Gong","year":"2022","unstructured":"Gong X, Wu X. Cohort study summary of the effects of carboprost tromethamine combined with oxytocin on infant outcome, postpartum hemorrhage and uterine involution of parturients undergoing cesarean section. Comput Math Methods Med. 2022;2022:2233138.","journal-title":"Comput Math Methods Med"},{"key":"1547_CR6","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.2147\/DDDT.S251525","volume":"14","author":"B Hu","year":"2020","unstructured":"Hu B, Zhou H, Zou X, Shi J, Li X, Tan L. A comparison of dexmedetomidine and midazolam for the prevention of postoperative nausea and vomiting caused by hemabate in cesarean delivery: a randomized controlled trial. Drug Des Dev Ther. 2020;14:2127\u201333.","journal-title":"Drug Des Dev Ther"},{"key":"1547_CR7","first-page":"13776","volume":"8","author":"Y Liu","year":"2015","unstructured":"Liu Y, Chen HX, Kang DL, Kuang XH, Liu WX, Ni J. Influence of dexmedetomidine on incidence of adverse reactions introduced by hemabate in postpartum hemorrhage during cesarean section. Int J Clin Exp Med. 2015;8:13776\u201382.","journal-title":"Int J Clin Exp Med"},{"key":"1547_CR8","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1159\/000514946","volume":"28","author":"L Yu","year":"2021","unstructured":"Yu L, Yao Z, Wei Q, Qu M, Yang Q, Chang Y. Efficacy of electroacupuncture combined with tropisetron in treating carboprost tromethamine-induced nausea and vomiting during cesarean section under lumbar anesthesia. Complement Med Res. 2021;28:516\u201322.","journal-title":"Complement Med Res."},{"key":"1547_CR9","doi-asserted-by":"publisher","first-page":"980","DOI":"10.3389\/fphar.2020.00980","volume":"11","author":"CN Wei","year":"2020","unstructured":"Wei CN, Chang XY, Dong JH, Zhou QH. Remifentanil for carboprost-induced adverse reactions during cesarean delivery under combined spinal-epidural anesthesia. Front Pharmacol. 2020;11:980.","journal-title":"Front Pharmacol"},{"key":"1547_CR10","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1002\/ijgo.13742","volume":"157","author":"Y Bi","year":"2022","unstructured":"Bi Y, Zhong R, Huang J, Huang H. Effect of continuous infusion of a subhypnotic dose of propofol on nausea and vomiting after carboprost administration at cesarean delivery: a randomized, double-blind, placebo-controlled trial. Int J Gynaecol Obstet. 2022;157:283\u20138.","journal-title":"Int J Gynaecol Obstet"},{"issue":"5","key":"1547_CR11","first-page":"379","volume":"94","author":"Q Hu","year":"2023","unstructured":"Hu Q, Guo J, Bai P, Xiao X, He T, Yang P, et al. Sufentanil for carboprost-induced adverse reactions during cesarean delivery under combined spinal-epidural anesthesia. Ginekol Pol. 2023;94(5):379\u201388.","journal-title":"Ginekol Pol"},{"key":"1547_CR12","first-page":"E997","volume":"24","author":"M Rekatsina","year":"2021","unstructured":"Rekatsina M, Theodosopoulou P, Staikou C. Effects of intravenous dexmedetomidine versus lidocaine on postoperative pain, analgesic consumption and functional recovery after abdominal gynecological surgery: a randomized placebo-controlled double blind study. Pain Physician. 2021;24:E997-1006.","journal-title":"Pain Physician"},{"key":"1547_CR13","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1186\/s12884-018-1861-7","volume":"18","author":"A Lavie","year":"2018","unstructured":"Lavie A, Ram M, Lev S, Blecher Y, Amikam U, Shulman Y, et al. Maternal cardiovascular hemodynamics in normotensive versus preeclamptic pregnancies: a prospective longitudinal study using a noninvasive cardiac system (NICaS). BMC Pregnancy Childbirth. 2018;18:229.","journal-title":"BMC Pregnancy Childbirth"},{"key":"1547_CR14","doi-asserted-by":"publisher","DOI":"10.1080\/19932820.2018.1436845","volume":"13","author":"E Tarikci Kilic","year":"2018","unstructured":"Tarikci Kilic E, Aydin G. Effects of dexmedetomidine infusion during spinal anesthesia on hemodynamics and sedation. Libyan J Med. 2018;13:1436845.","journal-title":"Libyan J Med"},{"key":"1547_CR15","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.934611","volume":"28","author":"W Xia","year":"2022","unstructured":"Xia W, Yang C. Safety and efficacy of sufentanil and fentanyl analgesia in patients with traumatic brain injury: a retrospective study. Med Sci Monit. 2022;28:e934611.","journal-title":"Med Sci Monit"},{"key":"1547_CR16","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1097\/00000542-200402000-00026","volume":"100","author":"H Groeben","year":"2004","unstructured":"Groeben H, Mitzner W, Brown RH. Effects of the alpha2-adrenoceptor agonist dexmedetomidine on bronchoconstriction in dogs. Anesthesiology. 2004;100:359\u201363.","journal-title":"Anesthesiology"},{"key":"1547_CR17","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.resp.2012.10.001","volume":"185","author":"M Baroffio","year":"2013","unstructured":"Baroffio M, Crimi E, Rehder K, Brusasco V. Effects of kappa- and mu-opioid agonists on cholinergic neurotransmission and contraction in isolated bovine trachealis. Respir Physiol Neurobiol. 2013;185:281\u20136.","journal-title":"Respir Physiol Neurobiol"},{"key":"1547_CR18","doi-asserted-by":"publisher","first-page":"46","DOI":"10.3892\/etm.2013.1379","volume":"7","author":"J Bai","year":"2014","unstructured":"Bai J, Sun Q, Zhai H. A comparison of oxytocin and carboprost tromethamine in the prevention of postpartum hemorrhage in high-risk patients undergoing cesarean delivery. Exp Ther Med. 2014;7:46\u201350.","journal-title":"Exp Ther Med"},{"key":"1547_CR19","doi-asserted-by":"publisher","first-page":"2036","DOI":"10.3892\/etm.2017.4759","volume":"14","author":"Y Mo","year":"2017","unstructured":"Mo Y, Qiu S. Effects of dexmedetomidine in reducing post-cesarean adverse reactions. Exp Ther Med. 2017;14:2036\u20139.","journal-title":"Exp Ther Med"},{"key":"1547_CR20","doi-asserted-by":"publisher","first-page":"207","DOI":"10.7150\/ijms.39374","volume":"17","author":"HM Lee","year":"2020","unstructured":"Lee HM, Kil HK, Koo BN, Song MS, Park JH. Comparison of sufentanil- and fentanyl-based intravenous patient-controlled analgesia on postoperative nausea and vomiting after laparoscopic nephrectomy: a prospective, double-blind, randomized-controlled trial. Int J Med Sci. 2020;17:207\u201313.","journal-title":"Int J Med Sci"},{"key":"1547_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2021.110437","volume":"75","author":"C Massoth","year":"2021","unstructured":"Massoth C, Schwellenbach J, Saadat-Gilani K, Weiss R, Popping D, Kullmar M, et al. Impact of opioid-free anaesthesia on postoperative nausea, vomiting and pain after gynaecological laparoscopy: a randomised controlled trial. J Clin Anesth. 2021;75:110437.","journal-title":"J Clin Anesth"}],"container-title":["Clinical Drug Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40261-026-01547-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40261-026-01547-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40261-026-01547-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T13:39:46Z","timestamp":1776865186000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40261-026-01547-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,30]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["1547"],"URL":"https:\/\/doi.org\/10.1007\/s40261-026-01547-x","relation":{},"ISSN":["1173-2563","1179-1918"],"issn-type":[{"value":"1173-2563","type":"print"},{"value":"1179-1918","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,30]]},"assertion":[{"value":"28 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Jing Li, Bo Xiang, Xiaofeng Lei, and Yu Jin have no conflicts of interest that are directly relevant to the content of this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This trial was approved by the Medical Ethics Committee of Chongqing Health Center for Women and Children (No. 2020-11). The protocol was registered at\n                      \n                      (registration number: ChiCTR2000038350).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The trial was performed in accordance with International Conference on Harmonization-Guidelines for Good Clinical Practice (ICH-GCP) and the Declaration of Helsinki. Written informed consent was obtained from all participants.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The data presented in this study are available upon request from the corresponding author. The data are not publicly available because this was a clinical trial containing information that could compromise the privacy of research participants.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data and material"}},{"value":"Not applicable.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}},{"value":"JY and JL designed the study. JL, BX, and JY coordinated the clinical procedures and anesthesia management. XL supervised the research and anesthesia procedures. JY performed the statistical analysis and prepared the manuscript. All authors have read and approved the final version and agree to be accountable for the work.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Authors\u2019 contributions"}}]}}