{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:22:01Z","timestamp":1788304921691,"version":"build-2803163510"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2013,10,26]],"date-time":"2013-10-26T00:00:00Z","timestamp":1382745600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Pharmacokinet"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1007\/s40262-013-0110-5","type":"journal-article","created":{"date-parts":[[2013,10,25]],"date-time":"2013-10-25T13:40:15Z","timestamp":1382708415000},"page":"141-153","source":"Crossref","is-referenced-by-count":24,"title":["Clinical Pharmacokinetic Drug Interactions Associated with Artemisinin Derivatives and HIV-Antivirals"],"prefix":"10.1007","volume":"53","author":[{"given":"Tony K. L.","family":"Kiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle J.","family":"Wilby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary H. H.","family":"Ensom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,10,26]]},"reference":[{"key":"110_CR1","unstructured":"World Health Organization. Guidelines for the treatment of malaria. Second edition. March 2010. http:\/\/www.who.int\/malaria\/publications\/atoz\/9789241547925\/en\/index.html . Accessed 14 Jul 2013."},{"key":"110_CR2","unstructured":"Joint United Nations Programme on HIV\/AIDS (UNAIDS). AIDS epidemic update. December 2007. http:\/\/data.unaids.org\/pub\/EPISlides\/2007\/2007_epiupdate_en.pdf . Accessed 14 Jul 2013."},{"key":"110_CR3","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2165\/00003088-200847020-00002","volume":"47","author":"P German","year":"2008","unstructured":"German P, Aweeka FT. Clinical pharmacology of artemisinin-based combination therapies. Clin Pharmacokinet. 2008;47:91\u2013102.","journal-title":"Clin Pharmacokinet"},{"key":"110_CR4","unstructured":"World Health Organization. Malaria and HIV and their implications for public policy, report of a technical consultation, Geneva, Switzerland, 23\u201325 June 2004. http:\/\/www.who.int\/hiv\/pub\/prev_care\/malariahiv.pdf . Accessed 14 Jul 2013."},{"key":"110_CR5","doi-asserted-by":"crossref","first-page":"749","DOI":"10.3201\/eid1505.081009","volume":"15","author":"V Chalwe","year":"2009","unstructured":"Chalwe V, Van Geertruyden JP, Mukwamataba D, et al. Increased risk for severe malaria in HIV-1-infected adults, Zambia. Emerg Infect Dis. 2009;15:749\u201355.","journal-title":"Emerg Infect Dis"},{"key":"110_CR6","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1097\/00002030-200402200-00023","volume":"18","author":"K Grimwade","year":"2004","unstructured":"Grimwade K, French N, Mbatha DD, et al. HIV infection as a cofactor for severe falciparum malaria in adults living in a region of unstable malaria transmission in South Africa. AIDS. 2004;18:547\u201354.","journal-title":"AIDS"},{"key":"110_CR7","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1097\/00002030-200303070-00014","volume":"17","author":"JG Ayisi","year":"2003","unstructured":"Ayisi JG, van Eijk AM, ter Kuile FO, et al. The effect of dual infection with HIV and malaria on pregnancy outcome in western Kenya. AIDS. 2003;17:585\u201394.","journal-title":"AIDS"},{"key":"110_CR8","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1097\/00002030-199507000-00009","volume":"9","author":"PB Bloland","year":"1995","unstructured":"Bloland PB, Wirima JJ, Steketee RW, et al. Maternal HIV infection and infant mortality in Malawi: evidence for increased mortality due to placental malaria infection. AIDS. 1995;9:721\u20136.","journal-title":"AIDS"},{"key":"110_CR9","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1086\/507310","volume":"194","author":"JP Geertruyden Van","year":"2006","unstructured":"Van Geertruyden JP, Mulenga M, Mwananyanda L, et al. HIV-1 immune suppression and antimalarial treatment outcome in Zambian adults with uncomplicated malaria. J Infect Dis. 2006;194:917\u201325.","journal-title":"J Infect Dis"},{"key":"110_CR10","first-page":"233","volume":"365","author":"JG Kublin","year":"2005","unstructured":"Kublin JG, Patnaik P, Jere CS, et al. Effect of Plasmodium falciparum malaria on concentration of HIV-1-RNA in the blood of adults in rural Malawi: a prospective cohort study. Lancet. 2005;365:233\u201340.","journal-title":"Lancet"},{"key":"110_CR11","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1097\/01.aids.0000174445.40379.e0","volume":"19","author":"S Khoo","year":"2005","unstructured":"Khoo S, Back D, Winstanley P. The potential for interactions between antimalarial and antiretroviral drugs. AIDS. 2005;19:995\u20131005.","journal-title":"AIDS"},{"key":"110_CR12","unstructured":"The Department for Health and Human Services [DHHS] guidelines Panel on antiretroviral guidelines for adults and adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents; Feb 2013. http:\/\/aidsinfo.nih.gov\/contentfiles\/lvguidelines\/adultandadolescentgl.pdf . Accessed 14 Jul 2013."},{"key":"110_CR13","first-page":"11","volume":"6","author":"P Byakika-Kibwika","year":"2010","unstructured":"Byakika-Kibwika P, Lamorde M, Mayanja-Kizza H, et al. Update on the efficacy, effectiveness and safety of artemether\u2013lumefantrine combination therapy for treatment of uncomplicated malaria. Ther Clin Risk Manag. 2010;6:11\u201320.","journal-title":"Ther Clin Risk Manag"},{"key":"110_CR14","doi-asserted-by":"crossref","first-page":"343","DOI":"10.2165\/00003088-200140050-00003","volume":"40","author":"PT Giao","year":"2001","unstructured":"Giao PT, de Vries PJ. Pharmacokinetic interactions of antimalarial agents. Clin Pharmacokinet. 2001;40:343\u201373.","journal-title":"Clin Pharmacokinet"},{"key":"110_CR15","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1159\/000252658","volume":"84","author":"B Medhi","year":"2009","unstructured":"Medhi B, Patyar S, Rao RS, et al. Pharmacokinetic and toxicological profile of artemisinin compounds: an update. Pharmacology. 2009;84:323\u201332.","journal-title":"Pharmacology"},{"key":"110_CR16","doi-asserted-by":"crossref","first-page":"5073","DOI":"10.1128\/AAC.05130-11","volume":"55","author":"C Nsanzabana","year":"2011","unstructured":"Nsanzabana C, Rosenthal P. In vitro activity of antiretroviral drugs against Plasmodium falciparum. Antimicrob Agents Chemother. 2011;55:5073\u20137.","journal-title":"Antimicrob Agents Chemother"},{"key":"110_CR17","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1097\/QAI.0b013e3181acb4ff","volume":"51","author":"P German","year":"2009","unstructured":"German P, Parikh S, Lawrence J, et al. Lopinavir\/ritonavir affects pharmacokinetic exposure of artemether\/lumefantrine in HIV-uninfected healthy volunteers. J Acquir Immune Defic Syndr. 2009;51:424\u20139.","journal-title":"J Acquir Immune Defic Syndr"},{"key":"110_CR18","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1093\/jac\/dkr596","volume":"67","author":"P Byakika-Kibwika","year":"2012","unstructured":"Byakika-Kibwika P, Lamorde M, Okaba-Kayom V, et al. Lopinavir\/ritonavir significantly influences pharmacokinetic exposure of artemether\/lumefantrine in HIV-infected Ugandan adults. J Antimicrob Chemother. 2012;67:1217\u201323.","journal-title":"J Antimicrob Chemother"},{"key":"110_CR19","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/hiv.12019","volume":"14","author":"T Kakuda","year":"2013","unstructured":"Kakuda T, Demasi R, van Delft Y, et al. Pharmacokinetic interaction between etravirine or darunavir\/ritonavir and artemether\/lumefantrine in healthy volunteers: a two-panel, two-way, two-period, randomized trial. HIV Med. 2013;14:421\u20139.","journal-title":"HIV Med"},{"key":"110_CR20","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/sj.clpt.6100452","volume":"84","author":"C Wyen","year":"2008","unstructured":"Wyen C, Fuhr U, Frank D, et al. Effect of an antiretroviral regimen containing ritonavir boosted lopinavir on intestinal and hepatic CYP3A, CYP2D6 and P-glycoprotein in HIV-infected patients. Clin Pharmacol Ther. 2008;84:75\u201382.","journal-title":"Clin Pharmacol Ther"},{"key":"110_CR21","doi-asserted-by":"crossref","first-page":"477","DOI":"10.2165\/00003495-200969040-00007","volume":"69","author":"K McKeage","year":"2009","unstructured":"McKeage K, Perry CM, Keam SJ. Darunavir: a review of its use in the management of HIV infection in adults. Drugs. 2009;69:477\u2013503.","journal-title":"Drugs"},{"key":"110_CR22","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1046\/j.1365-2125.2002.01696.x","volume":"54","author":"G Lefevre","year":"2002","unstructured":"Lefevre G, Carpenter P, Souppart C, et al. Pharmacokinetics and electrocardiographic pharmacodynamics of artemether\u2013lumefantrine (Riamet) with concomitant administration of ketoconazole in healthy subjects. Br J Clin Pharmacol. 2002;54:485\u201392.","journal-title":"Br J Clin Pharmacol"},{"key":"110_CR23","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0924-8579(99)00063-1","volume":"12","author":"MA Agtmael van","year":"1999","unstructured":"van Agtmael MA, Cheng-Qi S, Qing JX, et al. Multiple dose pharmacokinetics of artemether in Chinese patients with uncomplicated falciparum malaria. Int J Antimicrob Agents. 1999;12:151\u20138.","journal-title":"Int J Antimicrob Agents"},{"key":"110_CR24","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1097\/01.qai.0000219774.20174.64","volume":"42","author":"RF Yeh","year":"2006","unstructured":"Yeh RF, Gaver VE, Patterson KB, et al. Lopinavir\/ritonavir induces the hepatic activity of cytochrome P450 enzymes CYP2C9, CYP2C19, and CYP1A2 but inhibits the hepatic and intestinal activity of CYP3A as measured by a phenotyping drug cocktail in healthy volunteers. J Acquir Immune Defic Syndr. 2006;42:52\u201360.","journal-title":"J Acquir Immune Defic Syndr"},{"key":"110_CR25","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1345\/aph.1K615","volume":"42","author":"MM Foisy","year":"2008","unstructured":"Foisy MM, Yakiwchuk EM, Hughes CA. Induction effects of ritonavir: implications for drug interactions. Ann Pharmacother. 2008;42:1048\u201359.","journal-title":"Ann Pharmacother"},{"key":"110_CR26","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1124\/dmd.30.9.1005","volume":"30","author":"KF Ilett","year":"2002","unstructured":"Ilett KF, Ethell BT, Maggs JL, et al. Glucuronidation of dihydroartemisinin in vivo and by human liver microsomes and expressed UDP-glucuronosyltransferases. Drug Metab Dispos. 2002;30:1005\u201312.","journal-title":"Drug Metab Dispos"},{"key":"110_CR27","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1124\/dmd.105.005447","volume":"33","author":"D Zhang","year":"2005","unstructured":"Zhang D, Chando TJ, Everett DW, et al. In vitro inhibition of UDP glucuronosyltransferases by atazanavir and other HIV protease inhibitors and the relationship of this property to in vivo bilirubin glucuronidation. Drug Metab Dispos. 2005;33:1729\u201339.","journal-title":"Drug Metab Dispos"},{"key":"110_CR28","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1086\/503423","volume":"42","author":"RN Price","year":"2006","unstructured":"Price RN, Uhlemann AC, van Vugt M, et al. Molecular and pharmacological determinants of the therapeutic response to artemether\u2013lumefantrine in multidrug-resistant Plasmodium falciparum malaria. Clin Infect Dis. 2006;42:1570\u20137.","journal-title":"Clin Infect Dis"},{"key":"110_CR29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2011\/393976","volume":"2011","author":"P Byakika-Kibwika","year":"2011","unstructured":"Byakika-Kibwika P, Lamorde M, Lwabi P, et al. Cardiac conduction safety during coadministration of artemether\u2013lumefantrine and lopinavir\/ritonavir in HIV-infected Ugandan adults. Chemother Res Pract. 2011;2011:1\u20134.","journal-title":"Chemother Res Pract"},{"key":"110_CR30","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1093\/jac\/dks207","volume":"69","author":"P Byakika-Kibwika","year":"2012","unstructured":"Byakika-Kibwika P, Lamorde M, Mayito J, et al. Significant pharmacokinetic interactions between artemether\/lumefantrine and efavirenz or nevirapine in HIV-infected Ugandan adults. J Antimicrob Chemother. 2012;69:2213\u201321.","journal-title":"J Antimicrob Chemother"},{"key":"110_CR31","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1097\/QAI.0b013e31826ebb5c","volume":"61","author":"L Huang","year":"2012","unstructured":"Huang L, Parikh S, Rosenthal PJ, et al. Concomitant efavirenz reduces pharmacokinetic exposure to the antimalarial drug artemether\u2013lumefantrine in healthy volunteers. J Acquir Immune Defic Syndr. 2012;61:310\u20136.","journal-title":"J Acquir Immune Defic Syndr"},{"key":"110_CR32","doi-asserted-by":"crossref","first-page":"5616","DOI":"10.1128\/AAC.05265-11","volume":"55","author":"T Kredo","year":"2011","unstructured":"Kredo T, Mauff K, Van der Walt JS, et al. Interaction between artemether\u2013lumefantrine and nevirapine-based antiretroviral therapy in HIV-1-infected patients. Antimicrob Agents Chemother. 2011;55:5616\u201323.","journal-title":"Antimicrob Agents Chemother"},{"key":"110_CR33","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1177\/0091270004269142","volume":"44","author":"N Hariparsad","year":"2004","unstructured":"Hariparsad N, Nallani SC, Sane RS, et al. Induction of CYP3A4 by efavirenz in primary human hepatocytes: comparison with rifampin and phenobarbital. J Clin Pharmacol. 2004;44:1273\u201381.","journal-title":"J Clin Pharmacol"},{"key":"110_CR34","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1124\/jpet.106.112136","volume":"320","author":"SR Faucette","year":"2007","unstructured":"Faucette SR, Zhang TC, Moore R, et al. Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers. J Pharmacol Exp Ther. 2007;320:72\u201380.","journal-title":"J Pharmacol Exp Ther"},{"key":"110_CR35","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1124\/dmd.111.044404","volume":"40","author":"LJ Yanakakis","year":"2012","unstructured":"Yanakakis LJ, Bumpus NN. Biotransformation of the antiretroviral drug etravirine: metabolite identification, reaction phenotyping, and characterization of autoinduction of cytochrome P450-dependent metabolism. Drug Metab Dispos. 2012;40:803\u201314.","journal-title":"Drug Metab Dispos"},{"key":"110_CR36","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1097\/QAD.0b013e32835cae3b","volume":"27","author":"M Lamorde","year":"2013","unstructured":"Lamorde M, Byakika-Kibwika P, Mayito J, et al. Lower artemether, dihydroartemisinin and lumefantrine concentrations during rifampicin-based tuberculosis treatment. AIDS. 2013;27:961\u20135.","journal-title":"AIDS"},{"key":"110_CR37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/703604","volume":"2012","author":"FA Fehintola","year":"2012","unstructured":"Fehintola FA, Scarsi KK, Ma Q, et al. Nevirapine-based antiretroviral therapy impacts artesunate and dihydroartemisinin disposition in HIV-infected Nigerian adults. AIDS Res Treat. 2012;2012:1\u20136.","journal-title":"AIDS Res Treat"},{"key":"110_CR38","doi-asserted-by":"crossref","first-page":"489","DOI":"10.4269\/ajtmh.2012.11-0558","volume":"86","author":"CA Morris","year":"2012","unstructured":"Morris CA, Lopez-Lazaro L, Jung D, et al. Drug\u2013drug interaction analysis of pyronaridine\/artesunate and ritonavir in healthy volunteers. Am J Trop Med Hyg. 2012;86:489\u201395.","journal-title":"Am J Trop Med Hyg"},{"key":"110_CR39","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s00228-003-0636-9","volume":"59","author":"XQ Li","year":"2003","unstructured":"Li XQ, Bjorkman A, Andersson TB, et al. Identification of human cytochrome P(450)s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data. Eur J Clin Pharmacol. 2003;59:429\u201342.","journal-title":"Eur J Clin Pharmacol"},{"key":"110_CR40","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0009-9236(99)80079-4","volume":"65","author":"M Lamson","year":"1999","unstructured":"Lamson M, MacGregor T, Riska P, et al. Nevirapine induces both CYP3A4 and CYP2B6 metabolic pathways. Clin Pharmacol Ther. 1999;65:137.","journal-title":"Clin Pharmacol Ther"},{"key":"110_CR41","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.clpt.2005.09.001","volume":"78","author":"RE Aarnoutse","year":"2005","unstructured":"Aarnoutse RE, Kleinnijenhuis J, Koopmans PP, et al. Effect of low-dose ritonavir (100\u00a0mg twice daily) on the activity of cytochrome P450 2D6 in healthy volunteers. Clin Pharmacol Ther. 2005;78:664\u201374.","journal-title":"Clin Pharmacol Ther"},{"key":"110_CR42","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1186\/1475-2875-11-270","volume":"11","author":"SL Croft","year":"2012","unstructured":"Croft SL, Duparc S, Arbe-Barnes SJ, et al. Review of pyronaridine anti-malarial properties and product characteristics. Malar J. 2012;11:270\u201398.","journal-title":"Malar J"},{"key":"110_CR43","doi-asserted-by":"crossref","first-page":"717","DOI":"10.4269\/ajtmh.2001.65.717","volume":"65","author":"P Teja-Isavadharm","year":"2001","unstructured":"Teja-Isavadharm P, Watt G, Eamsila C, et al. Comparative pharmacokinetics and effect kinetics of orally administered artesunate in healthy volunteers and patients with uncomplicated falciparum malaria. Am J Trop Med Hyg. 2001;65:717\u201321.","journal-title":"Am J Trop Med Hyg"},{"key":"110_CR44","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1097\/COH.0b013e3282f82bf1","volume":"3","author":"L Dickinson","year":"2008","unstructured":"Dickinson L, Khoo S, Back D, et al. Differences in the pharmacokinetics of protease inhibitors between healthy volunteers and HIV-infected persons. Curr Opin HIV AIDS. 2008;3:296\u2013305.","journal-title":"Curr Opin HIV AIDS"}],"container-title":["Clinical Pharmacokinetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40262-013-0110-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40262-013-0110-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40262-013-0110-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T15:20:02Z","timestamp":1646925602000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40262-013-0110-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,26]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["110"],"URL":"https:\/\/doi.org\/10.1007\/s40262-013-0110-5","relation":{},"ISSN":["0312-5963","1179-1926"],"issn-type":[{"value":"0312-5963","type":"print"},{"value":"1179-1926","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,26]]}}}