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JGG received research support from a National Institute of General Medical Sciences funded T32 program (T32GM122741), as well as the American Foundation for Pharmaceutical Education. DG received research support from the National Institute of Child Health and Human Development (K23HD083465, R01HD096435, and HHSN275201000003I). The Best Pharmaceuticals for Children Act Data Coordinating Center was funded under HHSN275201700002C (principal investigator: Ravinder Anand). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"Michael Cohen-Wolkowiez receives support for research from the National Institutes of Health (1U24-MD016258), National Institute of Allergy and Infectious Diseases (HHSN272201500006I, HHSN272201300017I, 1K24-AI143971), National Institute of Child Health and Human Development (HHSN275201000003I), US Food and Drug Administration (5U18-FD006298), and industry for drug development in adults and children. Samit Ganguly, Andrea N. Edginton, Jacqueline G. Gerhart, Rachel G. Greenberg, and Daniel Gonzalez have no conflicts of interest that are directly relevant to the content of this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"For the study protocol that allowed the collection of the PK data from infants with a suspected or confirmed intra-abdominal infection (ClinicalTrials.gov #NCT00621192), institutional review board approval was obtained at each participating site. For the PBPK analyses described in this publication, the Office of Human Research Ethics at the University of North Carolina at Chapel Hill determined that the research did not constitute human subjects research as defined under federal regulations [45 CFR 46.102 (d or f) and 21 CFR 56.102(c)(e)(l)] and did not require institutional review board approval.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"For the original study in infants with a suspected or confirmed intra-abdominal infection (ClinicalTrials.gov #NCT00621192), written permission (informed consent) was obtained from the parent or legal guardian.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Meropenem infant PK data were accessed through the Eunice Kennedy Shriver National Institute of Child Health and Human Development Data and Specimen Hub ().","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data and material"}},{"value":"Not applicable.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}},{"value":"SG and DG designed and performed the research; SG and JGG analyzed the data; SG, ANE, JGG, MC-W, RGG, and DG wrote or contributed to the writing of the manuscript.","order":9,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author contributions"}}]}}