{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T05:27:00Z","timestamp":1772774820953,"version":"3.50.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T00:00:00Z","timestamp":1683158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T00:00:00Z","timestamp":1683158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/501100005774","name":"Universitat de Barcelona","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005774","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Pharmacokinet"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1007\/s40262-023-01237-3","type":"journal-article","created":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T07:02:07Z","timestamp":1683183727000},"page":"861-880","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Comparison of Three Renal Function Formulas for Ganciclovir\/Valganciclovir Dose Individualization in CMV-Infected Solid Organ Transplantation Patients Using a Population Approach"],"prefix":"10.1007","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8245-1758","authenticated-orcid":false,"given":"Panagiotis Nikolaos","family":"Lalagkas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Iliou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raul","family":"Rigo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Miarons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Fern\u00e1ndez-Alarcon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oriol","family":"Bestard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep M.","family":"Cruzado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edoardo","family":"Melilli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Torras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep M.","family":"Griny\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuria","family":"Lloberas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Colom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,5,4]]},"reference":[{"issue":"6","key":"1237_CR1","doi-asserted-by":"publisher","first-page":"2242","DOI":"10.3390\/v6062242","volume":"6","author":"P Hanley","year":"2014","unstructured":"Hanley P, Bollard C. Controlling cytomegalovirus: helping the immune system take the lead. Viruses. 2014;6(6):2242\u201358. https:\/\/doi.org\/10.3390\/v6062242.","journal-title":"Viruses"},{"issue":"3","key":"1237_CR2","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/s00430-015-0415-0","volume":"204","author":"JGP Sissons","year":"2015","unstructured":"Sissons JGP, Wills MR. How understanding immunology contributes to managing CMV disease in immunosuppressed patients: now and in future. Med Microbiol Immunol. 2015;204(3):307\u201316. https:\/\/doi.org\/10.1007\/s00430-015-0415-0.","journal-title":"Med Microbiol Immunol"},{"issue":"11","key":"1237_CR3","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1086\/652438","volume":"50","author":"SL Bate","year":"2010","unstructured":"Bate SL, Dollard SC, Cannon MJ. Cytomegalovirus seroprevalence in the United States: the National Health and Nutrition Examination Surveys, 1988\u20132004. Clin Infect Dis. 2010;50(11):1439\u201347. https:\/\/doi.org\/10.1086\/652438.","journal-title":"Clin Infect Dis"},{"issue":"4","key":"1237_CR4","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1002\/rmv.655","volume":"20","author":"MJ Cannon","year":"2010","unstructured":"Cannon MJ, Schmid DS, Hyde TB. Review of cytomegalovirus seroprevalence and demographic characteristics associated with infection: CMV seroprevalence. Rev Med Virol. 2010;20(4):202\u201313. https:\/\/doi.org\/10.1002\/rmv.655.","journal-title":"Rev Med Virol"},{"issue":"3","key":"1237_CR5","doi-asserted-by":"publisher","first-page":"260","DOI":"10.3947\/ic.2013.45.3.260","volume":"45","author":"P Ramanan","year":"2013","unstructured":"Ramanan P, Razonable RR. Cytomegalovirus infections in solid organ transplantation: a review. Infect Chemother. 2013;45(3):260. https:\/\/doi.org\/10.3947\/ic.2013.45.3.260.","journal-title":"Infect Chemother"},{"issue":"9","key":"1237_CR6","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1086\/508173","volume":"43","author":"SAS Staras","year":"2006","unstructured":"Staras SAS, Dollard SC, Radford KW, Flanders WD, Pass RF, Cannon MJ. Seroprevalence of cytomegalovirus infection in the United States, 1988\u20131994. Clin Infect Dis. 2006;43(9):1143\u201351. https:\/\/doi.org\/10.1086\/508173.","journal-title":"Clin Infect Dis"},{"issue":"6","key":"1237_CR7","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1007\/s11908-012-0292-2","volume":"14","author":"E Beam","year":"2012","unstructured":"Beam E, Razonable RR. Cytomegalovirus in solid organ transplantation: epidemiology, prevention, and treatment. Curr Infect Dis Rep. 2012;14(6):633\u201341. https:\/\/doi.org\/10.1007\/s11908-012-0292-2.","journal-title":"Curr Infect Dis Rep."},{"issue":"31","key":"1237_CR8","doi-asserted-by":"publisher","first-page":"4849","DOI":"10.3748\/wjg.14.4849","volume":"14","author":"R-R Razonable","year":"2008","unstructured":"Razonable R-R. Cytomegalovirus infection after liver transplantation: current concepts and challenges. World J Gastroenterol. 2008;14(31):4849. https:\/\/doi.org\/10.3748\/wjg.14.4849.","journal-title":"World J Gastroenterol"},{"issue":"20","key":"1237_CR9","doi-asserted-by":"publisher","first-page":"2427","DOI":"10.1182\/blood-2015-11-679639","volume":"127","author":"P Teira","year":"2016","unstructured":"Teira P, Battiwalla M, Ramanathan M et al. Early cytomegalovirus reactivation remains associated with increased transplant-related mortality in the current era: a CIBMTR analysis. Blood. 2016;127(20):2427\u201338. https:\/\/doi.org\/10.1182\/blood-2015-11-679639.","journal-title":"Blood"},{"issue":"5","key":"1237_CR10","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1002\/bdra.23601","volume":"109","author":"NL Davis","year":"2017","unstructured":"Davis NL, King CC. Kourtis AP Cytomegalovirus infection in pregnancy: cytomegalovirus infection in pregnancy. Birth Defects Res. 2017;109(5):336\u201346. https:\/\/doi.org\/10.1002\/bdra.23601.","journal-title":"Birth Defects Res"},{"issue":"9","key":"1237_CR11","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1093\/cid\/cit494","volume":"57","author":"N Ford","year":"2013","unstructured":"Ford N, Shubber Z, Saranchuk P et al. Burden of HIV-related cytomegalovirus retinitis in resource-limited settings: a systematic review. Clin Infect Dis. 2013;57(9):1351\u201361. https:\/\/doi.org\/10.1093\/cid\/cit494.","journal-title":"Clin Infect Dis"},{"issue":"2","key":"1237_CR12","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1002\/hon.2453","volume":"36","author":"F Marchesi","year":"2018","unstructured":"Marchesi F, Pimpinelli F, Ensoli F, Mengarelli A. Cytomegalovirus infection in hematologic malignancy settings other than the allogeneic transplant. Hematol Oncol. 2018;36(2):381\u201391. https:\/\/doi.org\/10.1002\/hon.2453.","journal-title":"Hematol Oncol"},{"key":"1237_CR13","doi-asserted-by":"publisher","first-page":"S78","DOI":"10.1111\/j.1600-6143.2009.02897.x","volume":"9","author":"A Humar","year":"2009","unstructured":"Humar A, Snydman D, AST Infectious Diseases Community of Practice. Cytomegalovirus in solid organ transplant recipients. Am J Transplant. 2009;9:S78-86. https:\/\/doi.org\/10.1111\/j.1600-6143.2009.02897.x.","journal-title":"Am J Transplant"},{"issue":"12","key":"1237_CR14","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.1097\/TP.0b013e3182000042","volume":"90","author":"H Welker","year":"2010","unstructured":"Welker H, Farhan M, Humar A, Washington C. Ganciclovir pharmacokinetic parameters do not change when extending valganciclovir cytomegalovirus prophylaxis from 100 to 200 days. Transplantation. 2010;90(12):1414\u20139. https:\/\/doi.org\/10.1097\/TP.0b013e3182000042.","journal-title":"Transplantation"},{"key":"1237_CR15","unstructured":"Enna SJ, Bylund DB, Elsevier Science (Firm), XPharm: the comprehensive pharmacology reference. Amsterdam, Boston: Elsevier; 2008. Available: from: https:\/\/www.sciencedirect.com\/science\/referenceworks\/9780080552323. Accessed 10 Apr 2022."},{"issue":"10","key":"1237_CR16","doi-asserted-by":"publisher","first-page":"2811","DOI":"10.1128\/AAC.44.10.2811-2815.2000","volume":"44","author":"MD Pescovitz","year":"2000","unstructured":"Pescovitz MD, Rabkin J, Merion RM et al. Valganciclovir results in improved oral absorption of ganciclovir in liver transplant recipients. Antimicrob Agents Chemother. 2000;44(10):2811\u20135. https:\/\/doi.org\/10.1128\/AAC.44.10.2811-2815.2000.","journal-title":"Antimicrob Agents Chemother"},{"issue":"3","key":"1237_CR17","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/clpt.1986.177","volume":"40","author":"C Fletcher","year":"1986","unstructured":"Fletcher C, Sawchuk R, Chinnock B, de Miranda P, Balfour HH. Human pharmacokinetics of the antiviral drug DHPG. Clin Pharmacol Ther. 1986;40(3):281\u20136. https:\/\/doi.org\/10.1038\/clpt.1986.177.","journal-title":"Clin Pharmacol Ther"},{"issue":"2","key":"1237_CR18","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/0002-9343(87)90685-1","volume":"83","author":"OL Laskin","year":"1987","unstructured":"Laskin OL, Cederberg DM, Mills J, Eron LJ, Mildvan D, Spector SA. Ganciclovir for the treatment and suppression of serious infections caused by cytomegalovirus. Am J Med. 1987;83(2):201\u20137. https:\/\/doi.org\/10.1016\/0002-9343(87)90685-1.","journal-title":"Am J Med"},{"issue":"Suppl E","key":"1237_CR19","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1093\/jac\/23.suppl_E.37","volume":"23","author":"HJ Metselaar","year":"1989","unstructured":"Metselaar HJ, Weimar W. Cytomegalovirus infection and renal transplantation. J Antimicrob Chemother. 1989;23(Suppl E):37\u201347. https:\/\/doi.org\/10.1093\/jac\/23.suppl_E.37.","journal-title":"J Antimicrob Chemother"},{"key":"1237_CR20","unstructured":"DrugBank. Ganciclovir. Available from: https:\/\/go.drugbank.com\/drugs\/DB01004. Accessed 14 Mar 2023."},{"issue":"6","key":"1237_CR21","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1007\/s11255-012-0293-y","volume":"45","author":"G Bedino","year":"2013","unstructured":"Bedino G, Esposito P, Bosio F et al. The role of therapeutic drug monitoring in the treatment of cytomegalovirus disease in kidney transplantation. Int Urol Nephrol. 2013;45(6):1809\u201313. https:\/\/doi.org\/10.1007\/s11255-012-0293-y.","journal-title":"Int Urol Nephrol"},{"issue":"7","key":"1237_CR22","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1097\/TP.0b013e3181cee42f","volume":"89","author":"CN Kotton","year":"2010","unstructured":"Kotton CN, Kumar D, Caliendo AM et al. The thirdInternational consensus guidelines on the management of cytomegalovirus in solid organ transplantation. Transplantation. 2010;89(7):779\u201395. https:\/\/doi.org\/10.1097\/TP.0b013e3181cee42f.","journal-title":"Transplantation"},{"issue":"1","key":"1237_CR23","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1053\/j.ajkd.2009.03.008","volume":"54","author":"LA Stevens","year":"2009","unstructured":"Stevens AL, Nolin TD, Richardson MM et al. Comparison of drug dosing recommendations based on measured GFR and kidney function estimating equations. Am J Kidney Dis. 2009;54(1):33\u201342. https:\/\/doi.org\/10.1053\/j.ajkd.2009.03.008.","journal-title":"Am J Kidney Dis"},{"issue":"6","key":"1237_CR24","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.2215\/CJN.06870909","volume":"5","author":"WM Michels","year":"2010","unstructured":"Michels WM, Grootendorst DC, Verduijn M, Elliott EG, Dekker FW, Krediet RT. Performance of the Cockcroft\u2013Gault, MDRD, and new CKD-EPI formulas in relation to GFR, age, and body size. Clin J Am Soc Nephrol. 2010;5(6):1003\u20139. https:\/\/doi.org\/10.2215\/CJN.06870909.","journal-title":"Clin J Am Soc Nephrol"},{"issue":"9","key":"1237_CR25","doi-asserted-by":"publisher","first-page":"2120","DOI":"10.1111\/bcp.13647","volume":"84","author":"M-E Palacio-Lacambra","year":"2018","unstructured":"Palacio-Lacambra M-E, Comas-Reixach I, Blanco-Grau A, Su\u00f1\u00e9-Negre J-M, Segarra-Medrano A, Montoro-Ronsano J-B. Comparison of the Cockcroft\u2013Gault, MDRD and CKD-EPI equations for estimating ganciclovir clearance: ganciclovir clearance and renal function estimation. Br J Clin Pharmacol. 2018;84(9):2120\u20138. https:\/\/doi.org\/10.1111\/bcp.13647.","journal-title":"Br J Clin Pharmacol"},{"issue":"11","key":"1237_CR26","doi-asserted-by":"publisher","first-page":"4816","DOI":"10.1128\/AAC.00085-09","volume":"53","author":"A Cald\u00e9s","year":"2009","unstructured":"Cald\u00e9s A, colom H, Armendariz Y et al. Population pharmacokinetics of ganciclovir after intravenous ganciclovir and oral valganciclovir administration in solid organ transplant patients infected with cytomegalovirus. Antimicrob Agents Chemother. 2009;53(11):4816\u201324. https:\/\/doi.org\/10.1128\/AAC.00085-09.","journal-title":"Antimicrob Agents Chemother"},{"issue":"7","key":"1237_CR27","doi-asserted-by":"publisher","first-page":"3017","DOI":"10.1128\/AAC.00836-08","volume":"53","author":"N Perrottet","year":"2009","unstructured":"Perrottet N, Csajka C, Pascual M et al. Population pharmacokinetics of ganciclovir in solid-organ transplant recipients receiving oral valganciclovir. Antimicrob Agents Chemother. 2009;53(7):3017\u201323. https:\/\/doi.org\/10.1128\/AAC.00836-08.","journal-title":"Antimicrob Agents Chemother"},{"issue":"4","key":"1237_CR28","doi-asserted-by":"publisher","first-page":"1992","DOI":"10.1128\/AAC.02130-15","volume":"60","author":"A Padull\u00e9s","year":"2016","unstructured":"Padull\u00e9s A, Colom H, Bestard O et al. Contribution of Population pharmacokinetics to dose optimization of ganciclovir-valganciclovir in solid-organ transplant patients. Antimicrob Agents Chemother. 2016;60(4):1992\u20132002. https:\/\/doi.org\/10.1128\/AAC.02130-15.","journal-title":"Antimicrob Agents Chemother"},{"issue":"3","key":"1237_CR29","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1111\/j.1467-3010.1977.tb00966.x","volume":"4","author":"WPT James","year":"1977","unstructured":"James WPT. Research on obesity. Nutr Bull. 1977;4(3):187\u201390. https:\/\/doi.org\/10.1111\/j.1467-3010.1977.tb00966.x.","journal-title":"Nutr Bull"},{"key":"1237_CR30","doi-asserted-by":"publisher","unstructured":"Mosteller RD. Simplified calculation of body-surface area. N Engl J Med. 1987;317(17):1098. https:\/\/doi.org\/10.1056\/NEJM198710223171717.","DOI":"10.1056\/NEJM198710223171717"},{"issue":"1","key":"1237_CR31","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/ajcn\/33.1.27","volume":"33","author":"PE Watson","year":"1980","unstructured":"Watson PE, Watson ID, Batt RD. Total body water volumes for adult males and females estimated from simple anthropometric measurements. Am J Clin Nutr. 1980;33(1):27\u201339. https:\/\/doi.org\/10.1093\/ajcn\/33.1.27.","journal-title":"Am J Clin Nutr"},{"issue":"1","key":"1237_CR32","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1159\/000180580","volume":"16","author":"DW Cockcroft","year":"1976","unstructured":"Cockcroft DW, Gault H. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16(1):31\u201341. https:\/\/doi.org\/10.1159\/000180580.","journal-title":"Nephron"},{"issue":"6","key":"1237_CR33","doi-asserted-by":"publisher","first-page":"461","DOI":"10.7326\/0003-4819-130-6-199903160-00002","volume":"130","author":"AS Levey","year":"1999","unstructured":"Levey AS, Bosch JP, Lewis JB et al. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Ann Intern Med. 1999;130(6):461. https:\/\/doi.org\/10.7326\/0003-4819-130-6-199903160-00002.","journal-title":"Ann Intern Med"},{"issue":"9","key":"1237_CR34","doi-asserted-by":"publisher","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","volume":"150","author":"AS Levey","year":"2009","unstructured":"Levey AS, Stevens LA, Schmid CH et al. A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009;150(9):604. https:\/\/doi.org\/10.7326\/0003-4819-150-9-200905050-00006.","journal-title":"Ann Intern Med"},{"issue":"3","key":"1237_CR35","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1111\/j.1399-3062.2009.00481.x","volume":"12","author":"A Cald\u00e9s","year":"2009","unstructured":"Cald\u00e9s a, Gil-Vernet S, Armendariz Y et al. Sequential treatment of cytomegalovirus infection or disease with a short course of intravenous ganciclovir followed by oral valganciclovir: efficacy, safety, and pharmacokinetics: IV ganciclovir followed by valganciclovir for CMV infection in SOT. Transpl Infect Dis. 2009;12(3):204\u201312. https:\/\/doi.org\/10.1111\/j.1399-3062.2009.00481.x.","journal-title":"Transpl Infect Dis"},{"key":"1237_CR36","unstructured":"Pou L, Campos F, Almirante B, Pascual C. A rapid liquid chromatographic (HPLC) method for determination of ganciclovir in serum, 1993, p. 183\u2013186. In: Galteau MM, Siest G, Henny J (ed.), Biologie prospective. Comptes rendus du 8\u00b0 Colloque de Pont-a\u0300-Mousson. John Libbey Eurotext, Paris, France."},{"issue":"4\u20135","key":"1237_CR37","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.clinbiochem.2011.12.014","volume":"45","author":"A Padull\u00e9s","year":"2012","unstructured":"Padull\u00e9s A, Colom H, Armendariz Y et al. Determination of ganciclovir in human plasma by ultra performance liquid chromatography-UV detection. Clin Biochem. 2012;45(4\u20135):309\u201314. https:\/\/doi.org\/10.1016\/j.clinbiochem.2011.12.014.","journal-title":"Clin Biochem"},{"issue":"1","key":"1237_CR38","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1146\/annurev.pharmtox.48.113006.094708","volume":"48","author":"BJ Anderson","year":"2008","unstructured":"Anderson BJ, Holford NHG. Mechanism-based concepts of size and maturity in pharmacokinetics. Annu Rev Pharmacol Toxicol. 2008;48(1):303\u201332. https:\/\/doi.org\/10.1146\/annurev.pharmtox.48.113006.094708.","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"1","key":"1237_CR39","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S0169-2607(98)00067-4","volume":"58","author":"EN Jonsson","year":"1998","unstructured":"Jonsson EN, Karlsson MO. Xpose: an S-PLUS based population pharmacokinetic\/pharmacodynamic model building aid for NONMEM. Comput Methods Programs Biomed. 1998;58(1):51\u201364. https:\/\/doi.org\/10.1016\/S0169-2607(98)00067-4.","journal-title":"Comput Methods Programs Biomed"},{"issue":"2","key":"1237_CR40","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1208\/s12248-011-9255-z","volume":"13","author":"M Bergstrand","year":"2011","unstructured":"Bergstrand M, Hooker AC, Wallin JE, Karlsson MO. Prediction-corrected visual predictive checks for diagnosing nonlinear mixed-effects models. AAPS J. 2011;13(2):143\u201351. https:\/\/doi.org\/10.1208\/s12248-011-9255-z.","journal-title":"AAPS J"},{"issue":"2","key":"1237_CR41","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.cmpb.2007.12.002","volume":"90","author":"E Comets","year":"2008","unstructured":"Comets E, Brendel K, Mentr\u00e9 F. Computing normalised prediction distribution errors to evaluate nonlinear mixed-effect models: the npde add-on package for R. Comput Methods Programs Biomed. 2008;90(2):154\u201366. https:\/\/doi.org\/10.1016\/j.cmpb.2007.12.002.","journal-title":"Comput Methods Programs Biomed"},{"issue":"4","key":"1237_CR42","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1007\/BF01060893","volume":"9","author":"LB Sheiner","year":"1981","unstructured":"Sheiner LB, Beal SL. Some suggestions for measuring predictive performance. J Pharmacokinet Biopharm. 1981;9(4):503\u201312. https:\/\/doi.org\/10.1007\/BF01060893.","journal-title":"J Pharmacokinet Biopharm"}],"container-title":["Clinical Pharmacokinetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40262-023-01237-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40262-023-01237-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40262-023-01237-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T15:12:28Z","timestamp":1686323548000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40262-023-01237-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,4]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["1237"],"URL":"https:\/\/doi.org\/10.1007\/s40262-023-01237-3","relation":{},"ISSN":["0312-5963","1179-1926"],"issn-type":[{"value":"0312-5963","type":"print"},{"value":"1179-1926","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,4]]},"assertion":[{"value":"2 March 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 May 2023","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"PNL: data analysis, writing, original draft preparation; JI: data analysis; RR: analytical methods; MM: patient data source; BF-A: revision; OB: patient care and patient data source; JMC: patient care and patient data source; JT: patient care and patient data source; EM: patient care and patient data source; JMG: writing, review, supervision; NL: data analysis, writing original draft preparation, supervision, conceptualization; HC: data analysis, writing original draft preparation, supervision, conceptualization.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Authors\u2019 Contributions"}},{"value":"Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"The authors have no conflicts of interest that are directly relevant to the content of this article.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of Interest\/Competing Interests"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"Data that support the findings of this study are available on request from the corresponding authors.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of Data and Material"}},{"value":"The code is available upon request.","order":9,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code Availability"}}]}}