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Gilead Sciences donated the study drug and covered costs related to drug concentration assessment, but had no role in study design, collection, analysis, and interpretation of data, writing of the manuscript, or the decision to submit the manuscript for publication.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"Peter Anderson has received consulting fees from Gilead, Merck, and ViiV, and research funding paid to his institution from Gilead. All other authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. It was approved by the Evandro Chagas National Institute of Infectious Diseases-FIOCRUZ Institutional Review Board. The PrEParadas study is registered with clinicaltrials.gov (NCT03220152). Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Data are available from the corresponding author upon request.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data and material"}},{"value":"Not applicable.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}},{"value":"EMJ, VGV, BG and RE conceived the study and interpreted the findings. EMJ, BG, RE and VBC drafted the manuscript. VBC did the statistical analyses with aid from EMJ and RE. TT, SWC, LE, CRVC and LM helped with data acquisition, interpretation of the findings, and drafting the manuscript. VGV, PA, LB and EW were involved in revising the manuscript for important intellectual content. All authors read and approved the final manuscript.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author contributions"}}]}}