{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T18:10:28Z","timestamp":1788977428369,"version":"build-2803163510"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T00:00:00Z","timestamp":1693353600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T00:00:00Z","timestamp":1693353600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["U24 OD024957"],"award-info":[{"award-number":["U24 OD024957"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["UG1 OD024942"],"award-info":[{"award-number":["UG1 OD024942"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["UG1 OD024945"],"award-info":[{"award-number":["UG1 OD024945"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["UG1 OD024946"],"award-info":[{"award-number":["UG1 OD024946"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["UG1 OD024954"],"award-info":[{"award-number":["UG1 OD024954"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["UG1 OD024943"],"award-info":[{"award-number":["UG1 OD024943"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["UG1 OD024944"],"award-info":[{"award-number":["UG1 OD024944"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["UG1 OD024947"],"award-info":[{"award-number":["UG1 OD024947"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["UG1 OD024948"],"award-info":[{"award-number":["UG1 OD024948"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["UG1 OD030016"],"award-info":[{"award-number":["UG1 OD030016"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["UG1 OD024950"],"award-info":[{"award-number":["UG1 OD024950"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["UG1 OD024951"],"award-info":[{"award-number":["UG1 OD024951"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["UG1 OD024952"],"award-info":[{"award-number":["UG1 OD024952"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["UG1 OD024953"],"award-info":[{"award-number":["UG1 OD024953"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["UG1 OD024955"],"award-info":[{"award-number":["UG1 OD024955"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["UG1 OD024956"],"award-info":[{"award-number":["UG1 OD024956"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["UG1 OD024958"],"award-info":[{"award-number":["UG1 OD024958"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["UG1 OD024959"],"award-info":[{"award-number":["UG1 OD024959"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["UG1 OD030019"],"award-info":[{"award-number":["UG1 OD030019"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008519","name":"University of Arkansas for Medical Sciences","doi-asserted-by":"publisher","award":["5110575"],"award-info":[{"award-number":["5110575"]}],"id":[{"id":"10.13039\/100008519","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Pharmacokinet"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1007\/s40262-023-01285-9","type":"journal-article","created":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T13:03:14Z","timestamp":1693400594000},"page":"1567-1579","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Pharmacokinetics of Oral Vitamin D in Children with Obesity and Asthma"],"prefix":"10.1007","volume":"62","clinical-trial-number":[{"clinical-trial-number":"nct03686150","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9115-5312","authenticated-orcid":false,"given":"Jason E.","family":"Lang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Gonzalez","family":"Ramirez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Balevic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Bickel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph P.","family":"Hornik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Marc","family":"Majure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saranya","family":"Venkatachalam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Snowden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"O\u2019Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,8,30]]},"reference":[{"issue":"1","key":"1285_CR1","doi-asserted-by":"publisher","first-page":"e152","DOI":"10.1542\/peds.2012-1711","volume":"131","author":"CB Turer","year":"2013","unstructured":"Turer CB, Lin H, Flores G. Prevalence of vitamin D deficiency among overweight and obese US children. Pediatrics. 2013;131(1):e152\u201361.","journal-title":"Pediatrics"},{"issue":"1","key":"1285_CR2","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.jaci.2010.03.043","volume":"126","author":"JM Brehm","year":"2010","unstructured":"Brehm JM, Schuemann B, Fuhlbrigge AL, Hollis BW, Strunk RC, Zeiger RS, Childhood Asthma Management Program Research Group, et al. Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study. J Allergy Clin Immunol. 2010;126(1):52-58.e55.","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"1285_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1542\/peds.2015-2354","volume":"137","author":"LJ Akinbami","year":"2016","unstructured":"Akinbami LJ, Simon AE, Rossen LM. Changing trends in asthma prevalence among children. Pediatrics. 2016;137(1):1\u20137.","journal-title":"Pediatrics"},{"issue":"12","key":"1285_CR4","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1111\/all.12508","volume":"69","author":"R Confino-Cohen","year":"2014","unstructured":"Confino-Cohen R, Brufman I, Goldberg A, Feldman BS. Vitamin D, asthma prevalence and asthma exacerbations: a large adult population-based study. Allergy. 2014;69(12):1673\u201380.","journal-title":"Allergy"},{"issue":"1","key":"1285_CR5","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1186\/s12931-019-1072-4","volume":"20","author":"J Liu","year":"2019","unstructured":"Liu J, Dong YQ, Yin J, Yao J, Shen J, Sheng GJ, et al. Meta-analysis of vitamin D and lung function in patients with asthma. Respir Res. 2019;20(1):161.","journal-title":"Respir Res"},{"issue":"8","key":"1285_CR6","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1001\/jama.2014.732","volume":"311","author":"CL Ogden","year":"2014","unstructured":"Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of childhood and adult obesity in the United States, 2011\u20132012. JAMA. 2014;311(8):806\u201314.","journal-title":"JAMA"},{"issue":"4","key":"1285_CR7","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1016\/j.jaci.2018.02.004","volume":"141","author":"U Peters","year":"2018","unstructured":"Peters U, Dixon AE, Forno E. Obesity and asthma. J Allergy Clin Immunol. 2018;141(4):1169\u201379.","journal-title":"J Allergy Clin Immunol"},{"key":"1285_CR8","first-page":"22","volume":"37","author":"JE Lang","year":"2021","unstructured":"Lang JE. Contribution of comorbidities to obesity-related asthma in children. Paediatr Respir Rev. 2021;37:22\u20139.","journal-title":"Paediatr Respir Rev"},{"issue":"10","key":"1285_CR9","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/S2352-4642(22)00185-7","volume":"6","author":"J Reyes-Angel","year":"2022","unstructured":"Reyes-Angel J, Kaviany P, Rastogi D, Forno E. Obesity-related asthma in children and adolescents. Lancet Child Adolesc Health. 2022;6(10):713\u201324.","journal-title":"Lancet Child Adolesc Health."},{"issue":"10","key":"1285_CR10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0186657","volume":"12","author":"HM Wolsk","year":"2017","unstructured":"Wolsk HM, Chawes BL, Litonjua AA, Hollis BW, Waage J, Stokholm J, et al. Prenatal vitamin D supplementation reduces risk of asthma\/recurrent wheeze in early childhood: a combined analysis of two randomized controlled trials. PLoS ONE. 2017;12(10): e0186657.","journal-title":"PLoS ONE"},{"issue":"2","key":"1285_CR11","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1097\/ACI.0000000000000509","volume":"19","author":"AA Litonjua","year":"2019","unstructured":"Litonjua AA. Vitamin D and childhood asthma: causation and contribution to disease activity. Curr Opin Allergy Clin Immunol. 2019;19(2):126\u201331.","journal-title":"Curr Opin Allergy Clin Immunol"},{"issue":"10","key":"1285_CR12","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1136\/thoraxjnl-2015-207334","volume":"70","author":"ST Weiss","year":"2015","unstructured":"Weiss ST, Litonjua AA. Vitamin D dosing for infectious and immune disorders. Thorax. 2015;70(10):919\u201320.","journal-title":"Thorax"},{"issue":"2","key":"1285_CR13","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.jaci.2016.11.019","volume":"139","author":"AA Litonjua","year":"2017","unstructured":"Litonjua AA, Weiss ST. Vitamin D status through the first 10 years of life: a vital piece of the puzzle in asthma inception. J Allergy Clin Immunol. 2017;139(2):459\u201361.","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"1285_CR14","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1093\/ajcn\/72.3.690","volume":"72","author":"J Wortsman","year":"2000","unstructured":"Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr. 2000;72(3):690\u20133.","journal-title":"Am J Clin Nutr"},{"issue":"12","key":"1285_CR15","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.1017\/S1368980014002845","volume":"18","author":"JC Zhou","year":"2015","unstructured":"Zhou JC, Zhu YM, Chen Z, Mo JL, Xie FZ, Wen YH, et al. Oral vitamin D supplementation has a lower bioavailability and reduces hypersecretion of parathyroid hormone and insulin resistance in obese Chinese males. Public Health Nutr. 2015;18(12):2211\u20139.","journal-title":"Public Health Nutr"},{"issue":"2","key":"1285_CR16","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1002\/ppul.25053","volume":"56","author":"BP O'Sullivan","year":"2021","unstructured":"O\u2019Sullivan BP, James L, Majure JM, Bickel S, Phan LT, Serrano Gonzalez M, et al. Obesity-related asthma in children: a role for vitamin D. Pediatr Pulmonol. 2021;56(2):354\u201361.","journal-title":"Pediatr Pulmonol"},{"key":"1285_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2022.106861","volume":"120","author":"L James","year":"2022","unstructured":"James L, O\u2019Sullivan BP, Majure M, Lang J, Ounpraseuth S, Hornik C, et al. Protocol for the Vitamin D Oral Replacement in Asthma (VDORA) study. Contemp Clin Trials. 2022;120: 106861.","journal-title":"Contemp Clin Trials"},{"issue":"7","key":"1285_CR18","doi-asserted-by":"publisher","first-page":"5111","DOI":"10.3390\/nu7075111","volume":"7","author":"H Mazahery","year":"2015","unstructured":"Mazahery H, von Hurst PR. Factors affecting 25-hydroxyvitamin D concentration in response to vitamin D supplementation. Nutrients. 2015;7(7):5111\u201342.","journal-title":"Nutrients"},{"issue":"2","key":"1285_CR19","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/j.jaci.2016.07.032","volume":"139","author":"EM Hollams","year":"2017","unstructured":"Hollams EM, Teo SM, Kusel M, Holt BJ, Holt KE, Inouye M, et al. Vitamin D over the first decade and susceptibility to childhood allergy and asthma. J Allergy Clin Immunol. 2017;139(2):472-81.e479.","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"1285_CR20","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.jaci.2010.03.043","volume":"126","author":"JM Brehm","year":"2010","unstructured":"Brehm JM, Schuemann B, Fuhlbrigge AL, Hollis BW, Strunk RC, Zeiger RS, et al. Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study. J Allergy Clin Immunol. 2010;126(1):52-58.e55.","journal-title":"J Allergy Clin Immunol"},{"issue":"5","key":"1285_CR21","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.mayocp.2015.03.015","volume":"90","author":"MF Holick","year":"2015","unstructured":"Holick MF. Vitamin D is not as toxic as was once thought: a historical and an up-to-date perspective. Mayo Clin Proc. 2015;90(5):561\u20134.","journal-title":"Mayo Clin Proc"},{"issue":"7","key":"1285_CR22","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1210\/jc.2011-0385","volume":"96","author":"MF Holick","year":"2011","unstructured":"Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911\u201330.","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"1285_CR23","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s10928-016-9465-1","volume":"43","author":"AS Ocampo-Pelland","year":"2016","unstructured":"Ocampo-Pelland AS, Gastonguay MR, French JF, Riggs MM. Model-based meta-analysis for development of a population-pharmacokinetic (PPK) model for vitamin D3 and its 25OHD3 metabolite using both individual and arm-level data. J Pharmacokinet Pharmacodyn. 2016;43(2):191\u2013206.","journal-title":"J Pharmacokinet Pharmacodyn"},{"issue":"11","key":"1285_CR24","first-page":"1654","volume":"12","author":"K Madden","year":"2015","unstructured":"Madden K, Feldman HA, Chun RF, Smith EM, Sullivan RM, Agan AA, et al. Critically ill children have low vitamin D-binding protein, influencing bioavailability of vitamin D. Ann Am Thorac Soc. 2015;12(11):1654\u201361.","journal-title":"Ann Am Thorac Soc"},{"issue":"9","key":"1285_CR25","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.1007\/s00467-013-2493-9","volume":"28","author":"MR Denburg","year":"2013","unstructured":"Denburg MR, Kalkwarf HJ, de Boer IH, Hewison M, Shults J, Zemel BS, et al. Vitamin D bioavailability and catabolism in pediatric chronic kidney disease. Pediatr Nephrol. 2013;28(9):1843\u201353.","journal-title":"Pediatr Nephrol"},{"issue":"12","key":"1285_CR26","doi-asserted-by":"publisher","first-page":"4816","DOI":"10.1210\/jc.2013-2728","volume":"98","author":"RD Lewis","year":"2013","unstructured":"Lewis RD, Laing EM, Hill Gallant KM, Hall DB, McCabe GP, Hausman DB, et al. A randomized trial of vitamin D(3) supplementation in children: dose-response effects on vitamin D metabolites and calcium absorption. J Clin Endocrinol Metab. 2013;98(12):4816\u201325.","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"1285_CR27","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1001\/jama.2020.12384","volume":"324","author":"E Forno","year":"2020","unstructured":"Forno E, Bacharier LB, Phipatanakul W, Guilbert TW, Cabana MD, Ross K, et al. Effect of vitamin D3 supplementation on severe asthma exacerbations in children with asthma and low vitamin D levels: the VDKA randomized clinical trial. JAMA. 2020;324(8):752\u201360.","journal-title":"JAMA"},{"key":"1285_CR28","unstructured":"EMA. ICH guideline E8 (R1): general considerations for clinical studies. Amsterdam, The Netherlands: European Medicines Agency; 2021."},{"issue":"1","key":"1285_CR29","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/BF01061410","volume":"34","author":"R Schmidt","year":"1988","unstructured":"Schmidt R. Dose-finding studies in clinical drug development. Eur J Clin Pharmacol. 1988;34(1):15\u20139.","journal-title":"Eur J Clin Pharmacol"},{"key":"1285_CR30","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/981581","volume":"2014","author":"P Yousefzadeh","year":"2014","unstructured":"Yousefzadeh P, Shapses SA, Wang X. Vitamin D binding protein impact on 25-hydroxyvitamin D levels under different physiologic and pathologic conditions. Int J Endocrinol. 2014;2014: 981581.","journal-title":"Int J Endocrinol."}],"container-title":["Clinical Pharmacokinetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40262-023-01285-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40262-023-01285-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40262-023-01285-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T14:24:40Z","timestamp":1697552680000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40262-023-01285-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,30]]},"references-count":30,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["1285"],"URL":"https:\/\/doi.org\/10.1007\/s40262-023-01285-9","relation":{},"ISSN":["0312-5963","1179-1926"],"issn-type":[{"value":"0312-5963","type":"print"},{"value":"1179-1926","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,30]]},"assertion":[{"value":"26 June 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 August 2023","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"U24 OD024957 (University of Arkansas Data Coordinating and Operations Center), UG1 OD024942 (University of Mississippi Medical Center), UG1 OD024943 (University of Kansas Medical Center), UG1 OD024944 (Alaska Native Tribal Health Consortium), UG1 OD024945 (Arkansas Children\u2019s Research Institute), UG1 OD024946 (Dartmouth College), UG1 OD024947 (University of New Mexico Health Sciences Center), UG1 OD024948 (University of Hawaii at Manoa), UG1 OD030016 (West Virginia University), UG1 OD024950 (University of Oklahoma Health Sciences Center), UG1 OD024951 (Rhode Island Hospital), UG1 OD024952 (University of Montana), UG1 OD024953 (University of Nebraska Medical Center), UG1 OD024954 (University of Louisville), UG1 OD024955 (University of Vermont and State Agricultural College), UG1 OD024956 (University of South Carolina at Columbia), UG1 OD024958 (Nemours Alfred I. duPont Hospital for Children), UG1 OD024959 (Louisiana State University Pennington Biomedical Research Center), UG1 OD030019 (Avera Research Institute Center for Pediatric and Community Research), 5110575 (Duke University).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"Jason E. Lang reports consulting fees from AbbVie, Inc. unrelated to the current project. Saranya Venkatachalam, Jessica Snowden, Laura James, Scott Bickel, J. Marc Majure, Rodrigo Gonzalez Ramirez, Brian O\u2019Sullivan, and Christoph P. Hornik have no conflicts of interest that are directly relevant to the content of this article. Stephen Balevic is a consultant for UCB and has received research funding from Purdu Pharma.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of Interest\/Competing Interests"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"Not applicable.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of Data and Material"}},{"value":"Not applicable.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code Availability"}},{"value":"Not applicable.","order":9,"name":"Ethics","group":{"name":"EthicsHeading","label":"Authors\u2019 Contributions"}}]}}