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P. J. Breur, Nicolaas J.G. Jansen, Joppe Nijman, Kim van Loon, Erik Koomen, Karel Allegaert, Manon J.N.L. Benders, Thomas P.C. Dorlo, and Alwin D.R. Huitema have no conflicts of interest to declare that may be relevant to the contents of this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The raw data are available upon reasonable request by an e-mail to the corresponding author, while blinding for group allocation should be respected until the primary and secondary outcome analyses have been finalized.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data and material"}},{"value":"The codes are available upon reasonable request.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}},{"value":"RS, MN, MB, JB, NJ, JN, KvL, EK, and the CRUCIAL study group were responsible for protocol development, study conduct, study registration, study recruitment, and data collection. Population PK modeling was performed by WC, KA, TD, and AH. The draft of this manuscript was written and reviewed by WC, MN, KA, TD, and AH. All authors and contributors have read and commented on the manuscript and have approved the submitted version.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Authors\u2019 contributions"}},{"value":"The CRUCIAL trial (EudraCT 2017-004596-31; ClinicalTrials.gov NCT04217421) was conducted according to the principles of the Helsinki Declaration (2013). The trial was approved by the Medical Research Ethical Committee of UMC Utrecht (reference number NL62772.041.18) and the Dutch national competent authority Central Committee on Research Involving Human Subjects (reference number NL62772.041.18).","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Written informed consent was collected from all parents or legal guardians before study participation. Parents were informed about the study by the obstetrician or fetal cardiologist between 24 and 36\u2009weeks of gestation and were asked for written consent before the start of delivery.","order":9,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}