{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T22:51:42Z","timestamp":1794091902065,"version":"4.8.0"},"reference-count":296,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T00:00:00Z","timestamp":1736553600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T00:00:00Z","timestamp":1736553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/501100004695","name":"University of KwaZulu-Natal","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004695","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Pharmacokinet"],"DOI":"10.1007\/s40262-024-01466-0","type":"journal-article","created":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T05:07:13Z","timestamp":1736572033000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Influence of Ageing on the Pharmacodynamics and Pharmacokinetics of Chronically Administered Medicines in Geriatric Patients: A Review"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0513-991X","authenticated-orcid":false,"given":"Nokwanda N.","family":"Ngcobo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,11]]},"reference":[{"issue":"1","key":"1466_CR1","doi-asserted-by":"publisher","first-page":"15","DOI":"10.4103\/0976-500X.124411","volume":"5","author":"BN Jhaveri","year":"2014","unstructured":"Jhaveri BN, Patel TK, Barvaliya MJ, Tripathi CB. Drug utilization pattern and pharmacoeconomic analysis in geriatric medical in-patients of a tertiary care hospital of India. J Pharmacol Pharmacother. 2014;5(1):15\u201320. https:\/\/doi.org\/10.4103\/0976-500X.124411.","journal-title":"J Pharmacol Pharmacother"},{"issue":"4","key":"1466_CR2","doi-asserted-by":"publisher","first-page":"FC04","DOI":"10.7860\/JCDR\/2017\/21080.9731","volume":"11","author":"RS Narvekar","year":"2017","unstructured":"Narvekar RS, Bhandare NN, Gouveia JJ, Bhandare PN. Utilization pattern of potentially inappropriate medications in geriatric patients in a tertiary care hospital: a retrospective observational study. J Clin Diagn Res. 2017;11(4):FC04\u20138. https:\/\/doi.org\/10.7860\/JCDR\/2017\/21080.9731.","journal-title":"J Clin Diagn Res"},{"issue":"9","key":"1466_CR3","doi-asserted-by":"publisher","first-page":"2885","DOI":"10.3390\/jcm9092885","volume":"9","author":"D Trapani","year":"2020","unstructured":"Trapani D, Zagami P, Nicol\u00f2 E, Pravettoni G, Curigliano G. Management of cardiac toxicity induced by chemotherapy. J Clin Med. 2020;9(9):2885. https:\/\/doi.org\/10.3390\/jcm9092885.","journal-title":"J Clin Med"},{"issue":"10","key":"1466_CR4","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1111\/bcp.14094","volume":"86","author":"AC Drenth-van Maanen","year":"2020","unstructured":"Drenth-van Maanen AC, Wilting I, Jansen PAF. Prescribing medicines to older people-How to consider the impact of ageing on human organ and body functions. Br J Clin Pharmacol. 2020;86(10):1921\u201330. https:\/\/doi.org\/10.1111\/bcp.14094.","journal-title":"Br J Clin Pharmacol"},{"issue":"11","key":"1466_CR5","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.1016\/j.mayocp.2016.07.024","volume":"91","author":"M Markota","year":"2016","unstructured":"Markota M, Rummans TA, Bostwick JM, Lapid MI. Benzodiazepine use in older adults: dangers, management, and alternative therapies. Mayo Clin Proc. 2016;91(11):1632\u20139. https:\/\/doi.org\/10.1016\/j.mayocp.2016.07.024.","journal-title":"Mayo Clin Proc"},{"key":"1466_CR6","unstructured":"Bounds CG, Patel P. Benzodiazepines. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK470159\/"},{"key":"1466_CR7","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.arr.2014.01.003","volume":"14","author":"RS Petralia","year":"2014","unstructured":"Petralia RS, Mattson MP, Yao PJ. Communication breakdown: the impact of ageing on synapse structure. Ageing Res Rev. 2014;14:31\u201342. https:\/\/doi.org\/10.1016\/j.arr.2014.01.003.","journal-title":"Ageing Res Rev"},{"issue":"7","key":"1466_CR8","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1161\/CIRCRESAHA.118.312806","volume":"123","author":"CW Chia","year":"2018","unstructured":"Chia CW, Egan JM, Ferrucci L. Age-related changes in glucose metabolism, hyperglycemia, and cardiovascular risk. Circ Res. 2018;123(7):886\u2013904. https:\/\/doi.org\/10.1161\/CIRCRESAHA.118.312806.","journal-title":"Circ Res"},{"key":"1466_CR9","doi-asserted-by":"publisher","unstructured":"By the 2023 American Geriatrics Society Beers Criteria\u00ae Update Expert Panel. American Geriatrics Society 2023 updated AGS Beers Criteria\u00ae for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2023;71(7):2052\u20132081. https:\/\/doi.org\/10.1111\/jgs.18372","DOI":"10.1111\/jgs.18372"},{"key":"1466_CR10","unstructured":"Marino M, Jamal Z, Zito PM. Pharmacodynamics. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK507791\/"},{"issue":"4","key":"1466_CR11","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1517\/17425255.2015.1004310","volume":"11","author":"E Reeve","year":"2015","unstructured":"Reeve E, Wiese MD, Mangoni AA. Alterations in drug disposition in older adults. Expert Opin Drug Metab Toxicol. 2015;11(4):491\u2013508. https:\/\/doi.org\/10.1517\/17425255.2015.1004310.","journal-title":"Expert Opin Drug Metab Toxicol"},{"issue":"1","key":"1466_CR12","doi-asserted-by":"publisher","first-page":"47","DOI":"10.7861\/clinmedicine.15-1-47","volume":"15","author":"O Mukhtar","year":"2015","unstructured":"Mukhtar O, Jackson SH. Drug therapies in older adults (part 1). Clin Med (Lond). 2015;15(1):47\u201353. https:\/\/doi.org\/10.7861\/clinmedicine.15-1-47.","journal-title":"Clin Med (Lond)"},{"issue":"11","key":"1466_CR13","doi-asserted-by":"publisher","first-page":"5954","DOI":"10.3390\/ijms23115954","volume":"23","author":"RI Teleanu","year":"2022","unstructured":"Teleanu RI, Niculescu AG, Roza E, Vlad\u00e2cenco O, Grumezescu AM, Teleanu DM. Neurotransmitters-key factors in neurological and neurodegenerative disorders of the central nervous system. Int J Mol Sci. 2022;23(11):5954. https:\/\/doi.org\/10.3390\/ijms23115954.","journal-title":"Int J Mol Sci"},{"issue":"7","key":"1466_CR14","doi-asserted-by":"publisher","first-page":"320","DOI":"10.3390\/medicina56070320","volume":"56","author":"E B\u0142eszy\u0144ska","year":"2020","unstructured":"B\u0142eszy\u0144ska E, Wierucki \u0141, Zdrojewski T, Renke M. Pharmacological interactions in the elderly. Medicina (Kaunas). 2020;56(7):320. https:\/\/doi.org\/10.3390\/medicina56070320.","journal-title":"Medicina (Kaunas)"},{"issue":"7","key":"1466_CR15","doi-asserted-by":"publisher","first-page":"672","DOI":"10.3390\/pharmaceutics12070672","volume":"12","author":"L Cheng","year":"2020","unstructured":"Cheng L, Wong H. Food effects on oral drug absorption: application of physiologically-based pharmacokinetic modeling as a predictive tool. Pharmaceutics. 2020;12(7):672. https:\/\/doi.org\/10.3390\/pharmaceutics12070672. (Published 2020 Jul 17).","journal-title":"Pharmaceutics"},{"key":"1466_CR16","unstructured":"Alagga AA, Pellegrini MV, Gupta V. Drug absorption.. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK557405\/"},{"issue":"3","key":"1466_CR17","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.cger.2015.04.003","volume":"31","author":"S Soenen","year":"2015","unstructured":"Soenen S, Rayner CK, Horowitz M, Jones KL. Gastric emptying in the elderly. Clin Geriatr Med. 2015;31(3):339\u201353. https:\/\/doi.org\/10.1016\/j.cger.2015.04.003.","journal-title":"Clin Geriatr Med"},{"key":"1466_CR18","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1111\/ene.15734","volume":"30","author":"V Leta","year":"2023","unstructured":"Leta V, Klingelhoefer L, Longardner K, Campagnolo M, Levent H\u00c7, Aureli F, et al. Gastrointestinal barriers to levodopa transport and absorption in Parkinson\u2019s disease. Eur J Neurol. 2023;30:1465\u201380. https:\/\/doi.org\/10.1111\/ene.15734.","journal-title":"Eur J Neurol"},{"issue":"7","key":"1466_CR19","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.3390\/cancers16071310","volume":"16","author":"C Castellana","year":"2024","unstructured":"Castellana C, Eusebi LH, Dajti E, et al. Autoimmune atrophic gastritis: a clinical review. Cancers (Basel). 2024;16(7):1310. https:\/\/doi.org\/10.3390\/cancers16071310. (Published 2024 Mar 28).","journal-title":"Cancers (Basel)"},{"key":"1466_CR20","doi-asserted-by":"publisher","first-page":"6757524","DOI":"10.1155\/2019\/6757524","volume":"2019","author":"I Dumic","year":"2019","unstructured":"Dumic I, Nordin T, Jecmenica M, Stojkovic Lalosevic M, Milosavljevic T, Milovanovic T. Gastrointestinal tract disorders in older age. Can J Gastroenterol Hepatol. 2019;2019:6757524. https:\/\/doi.org\/10.1155\/2019\/6757524. (Published 2019 Jan 17).","journal-title":"Can J Gastroenterol Hepatol"},{"issue":"1","key":"1466_CR21","doi-asserted-by":"publisher","first-page":"6","DOI":"10.3390\/cancers8010006","volume":"8","author":"MR Crombag","year":"2016","unstructured":"Crombag MR, Joerger M, Th\u00fcrlimann B, Schellens JH, Beijnen JH, Huitema AD. Pharmacokinetics of selected anticancer drugs in elderly cancer patients: focus on breast cancer. Cancers (Basel). 2016;8(1):6. https:\/\/doi.org\/10.3390\/cancers8010006. (Published 2016 Jan 2).","journal-title":"Cancers (Basel)"},{"issue":"2","key":"1466_CR22","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/s11682-022-00750-6","volume":"17","author":"CG Swinford","year":"2023","unstructured":"Swinford CG, Risacher SL, Wu YC, et al. Altered cerebral blood flow in older adults with Alzheimer\u2019s disease: a systematic review. Brain Imaging Behav. 2023;17(2):223\u201356. https:\/\/doi.org\/10.1007\/s11682-022-00750-6.","journal-title":"Brain Imaging Behav"},{"issue":"5","key":"1466_CR23","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1111\/joim.12745","volume":"283","author":"JM L\u00f6hr","year":"2018","unstructured":"L\u00f6hr JM, Panic N, Vujasinovic M, Verbeke CS. The ageing pancreas: a systematic review of the evidence and analysis of the consequences. J Intern Med. 2018;283(5):446\u201360. https:\/\/doi.org\/10.1111\/joim.12745.","journal-title":"J Intern Med"},{"issue":"Suppl 2","key":"1466_CR24","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/s12055-020-01042-8","volume":"37","author":"S Manickavel","year":"2021","unstructured":"Manickavel S. Pathophysiology of respiratory failure and physiology of gas exchange during ECMO. Indian J Thorac Cardiovasc Surg. 2021;37(Suppl 2):203\u20139. https:\/\/doi.org\/10.1007\/s12055-020-01042-8.","journal-title":"Indian J Thorac Cardiovasc Surg."},{"key":"1466_CR25","unstructured":"Farzam K, Sabir S, O'Rourke MC. Antihistamines. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024.\u00a0Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK538188\/"},{"key":"1466_CR26","unstructured":"Onetto AJ, Sharif S. Drug distribution. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024.\u00a0Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK567736\/"},{"key":"1466_CR27","unstructured":"Mansoor A, Mahabadi N. Volume of distribution. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024.\u00a0Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK545280\/"},{"issue":"6","key":"1466_CR28","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.7150\/thno.21254","volume":"8","author":"X Dong","year":"2018","unstructured":"Dong X. Current strategies for brain drug delivery. Theranostics. 2018;8(6):1481\u201393. https:\/\/doi.org\/10.7150\/thno.21254. (Published 2018 Feb 5).","journal-title":"Theranostics"},{"issue":"11","key":"1466_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2019.e02879","volume":"5","author":"M Bteich","year":"2019","unstructured":"Bteich M. An overview of albumin and alpha-1-acid glycoprotein main characteristics: highlighting the roles of amino acids in binding kinetics and molecular interactions. Heliyon. 2019;5(11): e02879. https:\/\/doi.org\/10.1016\/j.heliyon.2019.e02879. (Published 2019 Nov 21).","journal-title":"Heliyon"},{"issue":"2","key":"1466_CR30","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1007\/s11095-018-2551-x","volume":"36","author":"SA Smith","year":"2018","unstructured":"Smith SA, Waters NJ. Pharmacokinetic and pharmacodynamic considerations for drugs binding to \u03b1-1-acid glycoprotein. Pharm Res. 2018;36(2):30. https:\/\/doi.org\/10.1007\/s11095-018-2551-x. (Published 2018 Dec 28).","journal-title":"Pharm Res"},{"issue":"4","key":"1466_CR31","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1093\/gastro\/gow013","volume":"4","author":"S Bharadwaj","year":"2016","unstructured":"Bharadwaj S, Ginoya S, Tandon P, et al. Malnutrition: laboratory markers vs nutritional assessment. Gastroenterol Rep (Oxf). 2016;4(4):272\u201380. https:\/\/doi.org\/10.1093\/gastro\/gow013.","journal-title":"Gastroenterol Rep (Oxf)."},{"issue":"1","key":"1466_CR32","doi-asserted-by":"publisher","first-page":"7953","DOI":"10.1038\/s41598-021-87217-8","volume":"11","author":"H Watanabe","year":"2021","unstructured":"Watanabe H, Fujimura R, Hiramoto Y, et al. An acute phase protein \u03b11-acid glycoprotein mitigates AKI and its progression to CKD through its anti-inflammatory action. Sci Rep. 2021;11(1):7953. https:\/\/doi.org\/10.1038\/s41598-021-87217-8. (Published 2021 Apr 12).","journal-title":"Sci Rep"},{"key":"1466_CR33","doi-asserted-by":"publisher","first-page":"657","DOI":"10.2147\/CIA.S133640","volume":"13","author":"A Giarratano","year":"2018","unstructured":"Giarratano A, Green SE, Nicolau DP. Review of antimicrobial use and considerations in the elderly population. Clin Interv Aging. 2018;13:657\u201367. https:\/\/doi.org\/10.2147\/CIA.S133640. (Published 2018 Apr 17).","journal-title":"Clin Interv Aging"},{"issue":"5","key":"1466_CR34","doi-asserted-by":"publisher","first-page":"525","DOI":"10.2217\/cpr.14.46","volume":"11","author":"M Mallappallil","year":"2014","unstructured":"Mallappallil M, Friedman EA, Delano BG, McFarlane SI, Salifu MO. Chronic kidney disease in the elderly: evaluation and management. Clin Pract (Lond). 2014;11(5):525\u201335. https:\/\/doi.org\/10.2217\/cpr.14.46.","journal-title":"Clin Pract (Lond)."},{"issue":"2","key":"1466_CR35","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1177\/1751143714564816","volume":"16","author":"S Shah","year":"2015","unstructured":"Shah S, Barton G, Fischer A. Pharmacokinetic considerations and dosing strategies of antibiotics in the critically ill patient. J Intensive Care Soc. 2015;16(2):147\u201353. https:\/\/doi.org\/10.1177\/1751143714564816.","journal-title":"J Intensive Care Soc."},{"key":"1466_CR36","doi-asserted-by":"publisher","unstructured":"Bell R, Mandalia R. Diuretics and the kidney [published correction appears in BJA Educ. 2022 Nov;22(11):449. https:\/\/doi.org\/10.1016\/j.bjae.2022.06.001].\u00a0BJA Educ. 2022;22(6):216\u201323. https:\/\/doi.org\/10.1016\/j.bjae.2022.02.003","DOI":"10.1016\/j.bjae.2022.06.001 10.1016\/j.bjae.2022.02.003"},{"key":"1466_CR37","unstructured":"David MNV, Shetty M. Digoxin. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024.\u00a0Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK556025\/"},{"issue":"1","key":"1466_CR38","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1186\/s12882-018-1101-4","volume":"19","author":"J Davis","year":"2018","unstructured":"Davis J, Desmond M, Berk M. Lithium and nephrotoxicity: a literature review of approaches to clinical management and risk stratification. BMC Nephrol. 2018;19(1):305. https:\/\/doi.org\/10.1186\/s12882-018-1101-4. (Published 2018 Nov 3).","journal-title":"BMC Nephrol"},{"key":"1466_CR39","unstructured":"Chokhawala K, Lee S, Saadabadi A. Lithium. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK519062\/"},{"issue":"4","key":"1466_CR40","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.817","volume":"9","author":"S Dro\u017cd\u017cal","year":"2021","unstructured":"Dro\u017cd\u017cal S, Lechowicz K, Szostak B, et al. Kidney damage from nonsteroidal anti-inflammatory drugs-Myth or truth? Review of selected literature. Pharmacol Res Perspect. 2021;9(4): e00817. https:\/\/doi.org\/10.1002\/prp2.817.","journal-title":"Pharmacol Res Perspect"},{"key":"1466_CR41","unstructured":"Herman TF, Santos C. First-pass effect. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK551679\/"},{"issue":"5","key":"1466_CR42","first-page":"S29","volume":"7","author":"EJ Begg","year":"1989","unstructured":"Begg EJ, Bailey RR, Lynn KL, Robson RA, Frank GJ, Olson SC. The pharmacokinetics of angiotensin converting enzyme inhibitors in patients with renal impairment. J Hypertens Suppl. 1989;7(5):S29\u201332.","journal-title":"J Hypertens Suppl"},{"issue":"2","key":"1466_CR43","doi-asserted-by":"publisher","first-page":"89","DOI":"10.2174\/1389200221666200414094644","volume":"21","author":"MN Kalam","year":"2020","unstructured":"Kalam MN, Rasool MF, Rehman AU, Ahmed N. Clinical pharmacokinetics of propranolol hydrochloride: a review. Curr Drug Metab. 2020;21(2):89\u2013105. https:\/\/doi.org\/10.2174\/1389200221666200414094644.","journal-title":"Curr Drug Metab"},{"issue":"3","key":"1466_CR44","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.3748\/wjg.v22.i3.1260","volume":"22","author":"P Palatini","year":"2016","unstructured":"Palatini P, De Martin S. Pharmacokinetic drug interactions in liver disease: an update. World J Gastroenterol. 2016;22(3):1260\u201378. https:\/\/doi.org\/10.3748\/wjg.v22.i3.1260.","journal-title":"World J Gastroenterol"},{"issue":"10","key":"1466_CR45","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.mpaic.2020.07.001","volume":"21","author":"R Vaja","year":"2020","unstructured":"Vaja R, Rana M. Drugs and the liver. Anaesthesia Intensive Care Med. 2020;21(10):517\u201323. https:\/\/doi.org\/10.1016\/j.mpaic.2020.07.001.","journal-title":"Anaesthesia Intensive Care Med."},{"issue":"12","key":"1466_CR46","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1007\/s40266-015-0318-1","volume":"32","author":"JL Tan","year":"2015","unstructured":"Tan JL, Eastment JG, Poudel A, Hubbard RE. Age-related changes in hepatic function: an update on implications for drug therapy. Drugs Aging. 2015;32(12):999\u20131008. https:\/\/doi.org\/10.1007\/s40266-015-0318-1.","journal-title":"Drugs Aging"},{"issue":"11","key":"1466_CR47","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.19924","volume":"13","author":"RY Alhassani","year":"2021","unstructured":"Alhassani RY, Bagadood RM, Balubaid RN, Barno HI, Alahmadi MO, Ayoub NA. Drug therapies affecting renal function: an overview. Cureus. 2021;13(11): e19924. https:\/\/doi.org\/10.7759\/cureus.19924. (Published 2021 Nov 26).","journal-title":"Cureus."},{"key":"1466_CR48","unstructured":"Kyriakopoulos C, Gupta V. Renal failure drug dose adjustments. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK560512\/"},{"issue":"3","key":"1466_CR49","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1002\/cpt.757","volume":"102","author":"JO Miners","year":"2017","unstructured":"Miners JO, Yang X, Knights KM, Zhang L. The role of the kidney in drug elimination: transport, metabolism, and the impact of kidney disease on drug clearance. Clin Pharmacol Ther. 2017;102(3):436\u201349. https:\/\/doi.org\/10.1002\/cpt.757.","journal-title":"Clin Pharmacol Ther"},{"key":"1466_CR50","unstructured":"Phang-Lyn S, Llerena VA. Biochemistry, biotransformation. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024.\u00a0Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK544353\/"},{"key":"1466_CR51","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.646554","volume":"9","author":"YQ Yu","year":"2021","unstructured":"Yu YQ, Yang X, Wu XF, Fan YB. Enhancing permeation of drug molecules across the skin via delivery in nanocarriers: novel strategies for effective transdermal applications. Front Bioeng Biotechnol. 2021;9: 646554. https:\/\/doi.org\/10.3389\/fbioe.2021.646554. (Published 2021 Mar 29).","journal-title":"Front Bioeng Biotechnol"},{"key":"1466_CR52","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2020.101151","volume":"63","author":"Y Fang","year":"2020","unstructured":"Fang Y, Gong AY, Haller ST, Dworkin LD, Liu Z, Gong R. The ageing kidney: molecular mechanisms and clinical implications. Ageing Res Rev. 2020;63: 101151. https:\/\/doi.org\/10.1016\/j.arr.2020.101151.","journal-title":"Ageing Res Rev"},{"issue":"11","key":"1466_CR53","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e21866","volume":"9","author":"J Yim","year":"2023","unstructured":"Yim J, Son NH, Kyong T, Park Y, Kim JH. Muscle mass has a greater impact on serum creatinine levels in older males than in females. Heliyon. 2023;9(11): e21866. https:\/\/doi.org\/10.1016\/j.heliyon.2023.e21866. (Published 2023 Nov 4).","journal-title":"Heliyon"},{"key":"1466_CR54","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1016\/j.csbj.2019.07.021","volume":"17","author":"NJ Hunt","year":"2019","unstructured":"Hunt NJ, Kang SWS, Lockwood GP, Le Couteur DG, Cogger VC. Hallmarks of aging in the liver. Comput Struct Biotechnol J. 2019;17:1151\u201361. https:\/\/doi.org\/10.1016\/j.csbj.2019.07.021. (Published 2019 Aug 7).","journal-title":"Comput Struct Biotechnol J"},{"issue":"2","key":"1466_CR55","doi-asserted-by":"publisher","first-page":"646","DOI":"10.14336\/AD.2020.0909","volume":"12","author":"SS Adav","year":"2021","unstructured":"Adav SS, Wang Y. Metabolomics signatures of aging: recent advances. Aging Dis. 2021;12(2):646\u201361. https:\/\/doi.org\/10.14336\/AD.2020.0909. (Published 2021 Apr 1).","journal-title":"Aging Dis"},{"issue":"12","key":"1466_CR56","doi-asserted-by":"publisher","first-page":"301","DOI":"10.3390\/metabo9120301","volume":"9","author":"S Srivastava","year":"2019","unstructured":"Srivastava S. Emerging insights into the metabolic alterations in aging using metabolomics. Metabolites. 2019;9(12):301. https:\/\/doi.org\/10.3390\/metabo9120301. (Published 2019 Dec 13).","journal-title":"Metabolites"},{"issue":"4","key":"1466_CR57","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1016\/j.cell.2016.07.031","volume":"166","author":"C L\u00f3pez-Ot\u00edn","year":"2016","unstructured":"L\u00f3pez-Ot\u00edn C, Galluzzi L, Freije JMP, Madeo F, Kroemer G. Metabolic control of longevity. Cell. 2016;166(4):802\u201321. https:\/\/doi.org\/10.1016\/j.cell.2016.07.031.","journal-title":"Cell"},{"key":"1466_CR58","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.mce.2016.12.021","volume":"455","author":"B Victoria","year":"2017","unstructured":"Victoria B, Nunez Lopez YO, Masternak MM. MicroRNAs and the metabolic hallmarks of aging. Mol Cell Endocrinol. 2017;455:131\u201347. https:\/\/doi.org\/10.1016\/j.mce.2016.12.021.","journal-title":"Mol Cell Endocrinol"},{"issue":"10","key":"1466_CR59","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1038\/s41574-018-0059-4","volume":"14","author":"C Franceschi","year":"2018","unstructured":"Franceschi C, Garagnani P, Parini P, Giuliani C, Santoro A. Inflammaging: a new immune-metabolic viewpoint for age-related diseases. Nat Rev Endocrinol. 2018;14(10):576\u201390. https:\/\/doi.org\/10.1038\/s41574-018-0059-4.","journal-title":"Nat Rev Endocrinol"},{"issue":"7","key":"1466_CR60","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/s41580-019-0101-y","volume":"20","author":"MS Hipp","year":"2019","unstructured":"Hipp MS, Kasturi P, Hartl FU. The proteostasis network and its decline in ageing. Nat Rev Mol Cell Biol. 2019;20(7):421\u201335. https:\/\/doi.org\/10.1038\/s41580-019-0101-y.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"24","key":"1466_CR61","doi-asserted-by":"publisher","first-page":"8656","DOI":"10.3390\/molecules27248656","volume":"27","author":"A Castro","year":"2022","unstructured":"Castro A, Signini \u00c9F, De Oliveira JM, et al. The aging process: a metabolomics perspective. Molecules. 2022;27(24):8656. https:\/\/doi.org\/10.3390\/molecules27248656. (Published 2022 Dec 7).","journal-title":"Molecules"},{"issue":"42","key":"1466_CR62","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.add6155","volume":"8","author":"DJ Panyard","year":"2022","unstructured":"Panyard DJ, Yu B, Snyder MP. The metabolomics of human aging: advances, challenges, and opportunities. Sci Adv. 2022;8(42): eadd6155. https:\/\/doi.org\/10.1126\/sciadv.add6155.","journal-title":"Sci Adv"},{"issue":"37","key":"1466_CR63","doi-asserted-by":"publisher","first-page":"3866","DOI":"10.1093\/eurheartj\/ehab481","volume":"42","author":"AR Orkaby","year":"2021","unstructured":"Orkaby AR. Moving beyond chronological age: frailty as an important risk factor for cardiovascular disease. Eur Heart J. 2021;42(37):3866\u20138. https:\/\/doi.org\/10.1093\/eurheartj\/ehab481.","journal-title":"Eur Heart J"},{"issue":"6","key":"1466_CR64","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.14336\/AD.2018.1026","volume":"9","author":"AK Shetty","year":"2018","unstructured":"Shetty AK, Kodali M, Upadhya R, Madhu LN. Emerging anti-aging strategies\u2014scientific basis and efficacy. Aging Dis. 2018;9(6):1165\u201384. https:\/\/doi.org\/10.14336\/AD.2018.1026. (Published 2018 Dec 4).","journal-title":"Aging Dis"},{"key":"1466_CR65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fnagi.2020.572090","volume":"12","author":"K Mayne","year":"2020","unstructured":"Mayne K, White JA, McMurran CE, Rivera FJ, de la Feunte AG. Aging and neurodegenerative disease: Is the adaptive immune system a friend or foe? Front Aging Neurosci. 2020;12:1\u201324 (Published 2020 Sept 23).","journal-title":"Front Aging Neurosci"},{"issue":"21","key":"1466_CR66","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.3969\/j.issn.1673-5374.2013.21.009","volume":"8","author":"C Guo","year":"2013","unstructured":"Guo C, Sun L, Chen X, Zhang D. Oxidative stress, mitochondrial damage and neurodegenerative diseases. Neural Regen Res. 2013;8(21):2003\u201314. https:\/\/doi.org\/10.3969\/j.issn.1673-5374.2013.21.009.","journal-title":"Neural Regen Res"},{"issue":"2","key":"1466_CR67","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1038\/s41380-021-01361-1","volume":"27","author":"CE Finger","year":"2022","unstructured":"Finger CE, Moreno-Gonzalez I, Gutierrez A, Moruno-Manchon JF, McCullough LD. Age-related immune alterations and cerebrovascular inflammation. Mol Psychiatry. 2022;27(2):803\u201318. https:\/\/doi.org\/10.1038\/s41380-021-01361-1.","journal-title":"Mol Psychiatry"},{"key":"1466_CR68","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.3389\/fnins.2019.01309","volume":"13","author":"J L\u00f3pez-\u00c1lvarez","year":"2019","unstructured":"L\u00f3pez-\u00c1lvarez J, Sevilla-Llewellyn-Jones J, Ag\u00fcera-Ortiz L. Anticholinergic drugs in geriatric psychopharmacology. Front Neurosci. 2019;13:1309. https:\/\/doi.org\/10.3389\/fnins.2019.01309. (Published 2019 Dec 6).","journal-title":"Front Neurosci"},{"issue":"29\u201330","key":"1466_CR69","doi-asserted-by":"publisher","first-page":"508","DOI":"10.3238\/arztebl.2019.0508","volume":"116","author":"T Kratz","year":"2019","unstructured":"Kratz T, Diefenbacher A. Psychopharmacological treatment in older people: avoiding drug interactions and polypharmacy. Dtsch Arztebl Int. 2019;116(29\u201330):508\u201318. https:\/\/doi.org\/10.3238\/arztebl.2019.0508.","journal-title":"Dtsch Arztebl Int"},{"issue":"8","key":"1466_CR70","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1177\/1756285617712979","volume":"10","author":"OP Tible","year":"2017","unstructured":"Tible OP, Riese F, Savaskan E, von Gunten A. Best practice in the management of behavioural and psychological symptoms of dementia. Ther Adv Neurol Disord. 2017;10(8):297\u2013309. https:\/\/doi.org\/10.1177\/1756285617712979.","journal-title":"Ther Adv Neurol Disord"},{"issue":"3","key":"1466_CR71","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1111\/bcp.14527","volume":"87","author":"J Brett","year":"2021","unstructured":"Brett J, Pearson SA, Daniels B, Wylie CE, Buckley NA. A cross sectional study of psychotropic medicine use in Australia in 2018: a focus on polypharmacy. Br J Clin Pharmacol. 2021;87(3):1369\u201377. https:\/\/doi.org\/10.1111\/bcp.14527.","journal-title":"Br J Clin Pharmacol"},{"issue":"1","key":"1466_CR72","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1093\/ageing\/afaa122","volume":"50","author":"P Grill","year":"2021","unstructured":"Grill P, Marwick C, De Souza N, Burton JK, Hughes C, Guthrie B. The burden of psychotropic and anticholinergic medicines use in care homes: population-based analysis in 147 care homes. Age Ageing. 2021;50(1):183\u20139. https:\/\/doi.org\/10.1093\/ageing\/afaa122.","journal-title":"Age Ageing"},{"issue":"9","key":"1466_CR73","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1080\/13607863.2017.1348469","volume":"22","author":"CHW Smeets","year":"2018","unstructured":"Smeets CHW, Gerritsen DL, Zuidema SU, et al. Psychotropic drug prescription for nursing home residents with dementia: prevalence and associations with non-resident-related factors. Aging Ment Health. 2018;22(9):1239\u201346. https:\/\/doi.org\/10.1080\/13607863.2017.1348469.","journal-title":"Aging Ment Health"},{"key":"1466_CR74","doi-asserted-by":"publisher","first-page":"31","DOI":"10.14235\/bs.2017.1383","volume":"6","author":"Z Ozturk","year":"2018","unstructured":"Ozturk Z, Cuhadar S. Effects of age, gender, and comorbid diseases on serum digoxin levels during digoxin treatment. Bezmialem Sci. 2018;6:31\u20136.","journal-title":"Bezmialem Sci"},{"issue":"11","key":"1466_CR75","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1017\/S1041610216001150","volume":"28","author":"SI Janus","year":"2016","unstructured":"Janus SI, van Manen JG, IJzerman MJ, Zuidema SU. Psychotropic drug prescriptions in Western European nursing homes. Int Psychogeriatr. 2016;28(11):1775\u201390. https:\/\/doi.org\/10.1017\/S1041610216001150.","journal-title":"Int Psychogeriatr"},{"issue":"1\u20132","key":"1466_CR76","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1177\/0898264320959293","volume":"33","author":"R Bajracharya","year":"2021","unstructured":"Bajracharya R, Qato DM. Patterns of psychoactive medication use in community-dwelling older adults in the US in 2016: a descriptive cross-sectional study. J Aging Health. 2021;33(1\u20132):86\u2013100. https:\/\/doi.org\/10.1177\/0898264320959293.","journal-title":"J Aging Health"},{"issue":"3","key":"1466_CR77","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afac060","volume":"51","author":"E Bednarczyk","year":"2022","unstructured":"Bednarczyk E, Cook S, Brauer R, Garfield S. Stakeholders\u2019 views on the use of psychotropic medication in older people: a systematic review. Age Ageing. 2022;51(3): afac060. https:\/\/doi.org\/10.1093\/ageing\/afac060.","journal-title":"Age Ageing"},{"issue":"6","key":"1466_CR78","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1007\/s41999-020-00376-1","volume":"11","author":"MAD Izza","year":"2020","unstructured":"Izza MAD, Lunt E, Gordon AL, Gladman JRF, Armstrong S, Logan P. Polypharmacy, benzodiazepines, and antidepressants, but not antipsychotics, are associated with increased falls risk in UK care home residents: a prospective multi-centre study. Eur Geriatr Med. 2020;11(6):1043\u201350. https:\/\/doi.org\/10.1007\/s41999-020-00376-1.","journal-title":"Eur Geriatr Med."},{"issue":"2","key":"1466_CR79","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/s40268-017-0181-0","volume":"17","author":"SIM Janus","year":"2017","unstructured":"Janus SIM, Reinders GH, van Manen JG, Zuidema SU, IJzerman MJ. Psychotropic drug-related fall incidents in nursing home residents living in the eastern part of the Netherlands. Drugs R D. 2017;17(2):321\u20138. https:\/\/doi.org\/10.1007\/s40268-017-0181-0.","journal-title":"Drugs R D"},{"issue":"1","key":"1466_CR80","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1186\/s12916-020-01821-5","volume":"18","author":"K Richardson","year":"2020","unstructured":"Richardson K, Loke YK, Fox C, et al. Adverse effects of Z-drugs for sleep disturbance in people living with dementia: a population-based cohort study. BMC Med. 2020;18(1):351. https:\/\/doi.org\/10.1186\/s12916-020-01821-5. (Published 2020 Nov 24).","journal-title":"BMC Med"},{"issue":"1","key":"1466_CR81","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1186\/s12888-019-2177-5","volume":"19","author":"S Zivkovic","year":"2019","unstructured":"Zivkovic S, Koh CH, Kaza N, Jackson CA. Antipsychotic drug use and risk of stroke and myocardial infarction: a systematic review and meta-analysis. BMC Psychiatry. 2019;19(1):189. https:\/\/doi.org\/10.1186\/s12888-019-2177-5. (Published 2019 Jun 20).","journal-title":"BMC Psychiatry"},{"issue":"5","key":"1466_CR82","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1001\/jamapsychiatry.2014.3018","volume":"72","author":"DT Maust","year":"2015","unstructured":"Maust DT, Kim HM, Seyfried LS, et al. Antipsychotics, other psychotropics, and the risk of death in patients with dementia: number needed to harm. JAMA Psychiat. 2015;72(5):438\u201345. https:\/\/doi.org\/10.1001\/jamapsychiatry.2014.3018.","journal-title":"JAMA Psychiat"},{"issue":"1","key":"1466_CR83","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s40266-022-00992-5","volume":"40","author":"M Rogowska","year":"2023","unstructured":"Rogowska M, Thornton M, Creese B, et al. Implications of adverse outcomes associated with antipsychotics in older patients with dementia: a 2011\u20132022 update. Drugs Aging. 2023;40(1):21\u201332. https:\/\/doi.org\/10.1007\/s40266-022-00992-5.","journal-title":"Drugs Aging"},{"issue":"3","key":"1466_CR84","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1002\/wps.20567","volume":"17","author":"TS Stroup","year":"2018","unstructured":"Stroup TS, Gray N. Management of common adverse effects of antipsychotic medications. World Psychiatry. 2018;17(3):341\u201356. https:\/\/doi.org\/10.1002\/wps.20567.","journal-title":"World Psychiatry"},{"issue":"11","key":"1466_CR85","doi-asserted-by":"publisher","first-page":"2144","DOI":"10.1111\/bcp.14304","volume":"86","author":"KS Just","year":"2020","unstructured":"Just KS, Dormann H, Schurig M, et al. The phenotype of adverse drug effects: Do emergency visits due to adverse drug reactions look different in older people? Results from the ADRED study. Br J Clin Pharmacol. 2020;86(11):2144\u201354. https:\/\/doi.org\/10.1111\/bcp.14304.","journal-title":"Br J Clin Pharmacol"},{"issue":"5","key":"1466_CR86","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1159\/000524400","volume":"91","author":"SL Dubovsky","year":"2022","unstructured":"Dubovsky SL, Marshall D. Benzodiazepines remain important therapeutic options in psychiatric practice. Psychother Psychosom. 2022;91(5):307\u201334. https:\/\/doi.org\/10.1159\/000524400.","journal-title":"Psychother Psychosom"},{"key":"1466_CR87","doi-asserted-by":"publisher","unstructured":"By the 2019 American Geriatrics Society Beers Criteria\u00ae Update Expert Panel. American Geriatrics Society 2019 updated AGS Beers Criteria\u00ae for potentially inappropriate medication use in older adults.\u00a0J Am Geriatr Soc. 2019;67(4):674\u2013694. https:\/\/doi.org\/10.1111\/jgs.15767","DOI":"10.1111\/jgs.15767"},{"issue":"11","key":"1466_CR88","doi-asserted-by":"publisher","first-page":"1560","DOI":"10.1001\/jamainternmed.2018.2413","volume":"178","author":"LB Gerlach","year":"2018","unstructured":"Gerlach LB, Maust DT, Leong SH, Mavandadi S, Oslin DW. Factors associated with long-term benzodiazepine use among older adults. JAMA Intern Med. 2018;178(11):1560\u20132. https:\/\/doi.org\/10.1001\/jamainternmed.2018.2413.","journal-title":"JAMA Intern Med"},{"issue":"6","key":"1466_CR89","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1007\/s40266-024-01117-w","volume":"41","author":"N Gronich","year":"2024","unstructured":"Gronich N. Central nervous system medications: pharmacokinetic and pharmacodynamic considerations for older adults. Drugs Aging. 2024;41(6):507\u201319. https:\/\/doi.org\/10.1007\/s40266-024-01117-w.","journal-title":"Drugs Aging"},{"issue":"4","key":"1466_CR90","doi-asserted-by":"publisher","first-page":"594","DOI":"10.3390\/neurolint13040059","volume":"13","author":"AN Edinoff","year":"2021","unstructured":"Edinoff AN, Nix CA, Hollier J, et al. Benzodiazepines: uses, dangers, and clinical considerations. Neurol Int. 2021;13(4):594\u2013607. https:\/\/doi.org\/10.3390\/neurolint13040059. (Published 2021 Nov 10).","journal-title":"Neurol Int"},{"issue":"2","key":"1466_CR91","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3390\/toxics9020025","volume":"9","author":"E Sanabria","year":"2021","unstructured":"Sanabria E, Cuenca RE, Esteso M\u00c1, Maldonado M. Benzodiazepines: their use either as essential medicines or as toxics substances. Toxics. 2021;9(2):25. https:\/\/doi.org\/10.3390\/toxics9020025. (Published 2021 Feb 1).","journal-title":"Toxics."},{"issue":"14","key":"1466_CR92","doi-asserted-by":"publisher","first-page":"8564","DOI":"10.3390\/ijerph19148564","volume":"19","author":"I Na","year":"2022","unstructured":"Na I, Seo J, Park E, Lee J. Risk of falls associated with long-acting benzodiazepines or tricyclic antidepressants use in community-dwelling older adults: a nationwide population-based case-crossover study. Int J Environ Res Public Health. 2022;19(14):8564. https:\/\/doi.org\/10.3390\/ijerph19148564. (Published 2022 Jul 13).","journal-title":"Int J Environ Res Public Health"},{"issue":"1","key":"1466_CR93","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1186\/s12877-022-03497-3","volume":"22","author":"DT Maust","year":"2022","unstructured":"Maust DT, Bohnert ASB, Strominger J, et al. Prescription characteristics associated with fall-related injury risk among older adults prescribed benzodiazepines: a cohort study. BMC Geriatr. 2022;22(1):824. https:\/\/doi.org\/10.1186\/s12877-022-03497-3. (Published 2022 Oct 26).","journal-title":"BMC Geriatr"},{"issue":"4","key":"1466_CR94","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0174730","volume":"12","author":"K Donnelly","year":"2017","unstructured":"Donnelly K, Bracchi R, Hewitt J, Routledge PA, Carter B. Benzodiazepines, Z-drugs and the risk of hip fracture: a systematic review and meta-analysis. PLoS ONE. 2017;12(4): e0174730. https:\/\/doi.org\/10.1371\/journal.pone.0174730. (Published 2017 Apr 27).","journal-title":"PLoS ONE"},{"issue":"11","key":"1466_CR95","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3928\/02793695-20151022-01","volume":"53","author":"RH Howland","year":"2015","unstructured":"Howland RH. Buspirone: back to the future. J Psychosoc Nurs Ment Health Serv. 2015;53(11):21\u20134. https:\/\/doi.org\/10.3928\/02793695-20151022-01.","journal-title":"J Psychosoc Nurs Ment Health Serv"},{"issue":"1","key":"1466_CR96","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s40501-017-0102-4","volume":"4","author":"EA Crocco","year":"2017","unstructured":"Crocco EA, Jaramillo S, Cruz-Ortiz C, Camfield K. Pharmacological management of anxiety disorders in the elderly. Curr Treat Options Psychiatry. 2017;4(1):33\u201346. https:\/\/doi.org\/10.1007\/s40501-017-0102-4.","journal-title":"Curr Treat Options Psychiatry."},{"issue":"2","key":"1466_CR97","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1176\/appi.ps.201800321","volume":"70","author":"DT Maust","year":"2019","unstructured":"Maust DT, Lin LA, Blow FC. Benzodiazepine use and misuse among adults in the United States. Psychiatr Serv. 2019;70(2):97\u2013106. https:\/\/doi.org\/10.1176\/appi.ps.201800321.","journal-title":"Psychiatr Serv"},{"issue":"1","key":"1466_CR98","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1186\/s12877-024-04742-7","volume":"24","author":"A Luka\u010di\u0161inov\u00e1","year":"2024","unstructured":"Luka\u010di\u0161inov\u00e1 A, Reissigov\u00e1 J, Ortner-Had\u017eiabdi\u0107 M, et al. Prevalence, country-specific prescribing patterns and determinants of benzodiazepine use in community-residing older adults in 7 European countries. BMC Geriatr. 2024;24(1):240. https:\/\/doi.org\/10.1186\/s12877-024-04742-7. (Published 2024 Mar 7).","journal-title":"BMC Geriatr"},{"key":"1466_CR99","doi-asserted-by":"publisher","unstructured":"Agarwal SD, Landon BE. Patterns in outpatient benzodiazepine prescribing in the United States [published correction appears in JAMA Netw Open. 2019 Mar 1;2(3):e191203. https:\/\/doi.org\/10.1001\/jamanetworkopen.2019.1203]. JAMA Netw Open. 2019;2(1):e187399. https:\/\/doi.org\/10.1001\/jamanetworkopen.2018.7399 (Published 2019 Jan 4)","DOI":"10.1001\/jamanetworkopen.2019.1203 10.1001\/jamanetworkopen.2018.7399"},{"issue":"12","key":"1466_CR100","doi-asserted-by":"publisher","first-page":"2546","DOI":"10.1111\/jgs.14379","volume":"64","author":"DT Maust","year":"2016","unstructured":"Maust DT, Kales HC, Wiechers IR, Blow FC, Olfson M. No end in sight: benzodiazepine use in older adults in the United States. J Am Geriatr Soc. 2016;64(12):2546\u201353. https:\/\/doi.org\/10.1111\/jgs.14379.","journal-title":"J Am Geriatr Soc"},{"issue":"10","key":"1466_CR101","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.11042","volume":"12","author":"T Gress","year":"2020","unstructured":"Gress T, Miller M, Meadows C 3rd, Neitch SM. Benzodiazepine overuse in elders: defining the problem and potential solutions. Cureus. 2020;12(10): e11042. https:\/\/doi.org\/10.7759\/cureus.11042. (Published 2020 Oct 19).","journal-title":"Cureus."},{"issue":"5","key":"1466_CR102","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1159\/000525988","volume":"28","author":"SPG Zetsen","year":"2022","unstructured":"Zetsen SPG, Schellekens AFA, Paling EP, Kan CC, Kessels RPC. Cognitive functioning in long-term benzodiazepine users. Eur Addict Res. 2022;28(5):377\u201381. https:\/\/doi.org\/10.1159\/000525988.","journal-title":"Eur Addict Res"},{"key":"1466_CR103","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.595623","volume":"11","author":"L Liu","year":"2020","unstructured":"Liu L, Jian P, Zhou Y, et al. Is the long-term use of benzodiazepines associated with worse cognition performance in highly educated older adults? Front Psychiatry. 2020;11: 595623. https:\/\/doi.org\/10.3389\/fpsyt.2020.595623. (Published 2020 Oct 26).","journal-title":"Front Psychiatry."},{"key":"1466_CR104","doi-asserted-by":"publisher","first-page":"344","DOI":"10.3389\/fnagi.2019.00344","volume":"11","author":"M Ettcheto","year":"2020","unstructured":"Ettcheto M, Olloquequi J, S\u00e1nchez-L\u00f3pez E, et al. Benzodiazepines and related drugs as a risk factor in Alzheimer\u2019s disease dementia. Front Aging Neurosci. 2020;11:344. https:\/\/doi.org\/10.3389\/fnagi.2019.00344. (Published 2020 Jan 8).","journal-title":"Front Aging Neurosci"},{"issue":"3\u20134","key":"1466_CR105","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1159\/000454881","volume":"47","author":"MM Islam","year":"2016","unstructured":"Islam MM, Iqbal U, Walther B, et al. Benzodiazepine use and risk of dementia in the elderly population: a systematic review and meta-analysis. Neuroepidemiology. 2016;47(3\u20134):181\u201391. https:\/\/doi.org\/10.1159\/000454881.","journal-title":"Neuroepidemiology"},{"issue":"1","key":"1466_CR106","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/s40360-017-0183-0","volume":"18","author":"I Arnold","year":"2017","unstructured":"Arnold I, Straube K, Himmel W, et al. High prevalence of prescription of psychotropic drugs for older patients in a general hospital. BMC Pharmacol Toxicol. 2017;18(1):76. https:\/\/doi.org\/10.1186\/s40360-017-0183-0. (Published 2017 Dec 4).","journal-title":"BMC Pharmacol Toxicol"},{"key":"1466_CR107","doi-asserted-by":"publisher","unstructured":"GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017 [published correction appears in Lancet. 2019 Jun 22;393(10190):e44. https:\/\/doi.org\/10.1016\/S0140-6736(19)31047-5].\u00a0Lancet. 2018;392(10159):1789\u2013858. https:\/\/doi.org\/10.1016\/S0140-6736(18)32279-7","DOI":"10.1016\/S0140-6736(19)31047-5 10.1016\/S0140-6736(18)32279-7"},{"issue":"1","key":"1466_CR108","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/s12991-021-00375-x","volume":"20","author":"Y Zenebe","year":"2021","unstructured":"Zenebe Y, Akele B, W\/Selassie M, Necho M. Prevalence and determinants of depression among old age: a systematic review and meta-analysis. Ann Gen Psychiatry. 2021;20(1):55. https:\/\/doi.org\/10.1186\/s12991-021-00375-x. (Published 2021 Dec 18).","journal-title":"Ann Gen Psychiatry"},{"issue":"2","key":"1466_CR109","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1093\/ije\/dyu038","volume":"43","author":"Z Steel","year":"2014","unstructured":"Steel Z, Marnane C, Iranpour C, et al. The global prevalence of common mental disorders: a systematic review and meta-analysis 1980\u20132013. Int J Epidemiol. 2014;43(2):476\u201393. https:\/\/doi.org\/10.1093\/ije\/dyu038.","journal-title":"Int J Epidemiol"},{"issue":"6","key":"1466_CR110","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1056\/NEJMp1315214","volume":"370","author":"V Patel","year":"2014","unstructured":"Patel V, Saxena S. Transforming lives, enhancing communities\u2013innovations in global mental health. N Engl J Med. 2014;370(6):498\u2013501. https:\/\/doi.org\/10.1056\/NEJMp1315214.","journal-title":"N Engl J Med"},{"key":"1466_CR111","doi-asserted-by":"publisher","first-page":"204512532312123","DOI":"10.1177\/20451253231212327","volume":"13","author":"M Srifuengfung","year":"2023","unstructured":"Srifuengfung M, Pennington BRT, Lenze EJ. Optimizing treatment for older adults with depression. Ther Adv Psychopharmacol. 2023;13:20451253231212330. https:\/\/doi.org\/10.1177\/20451253231212327. (Published 2023 Nov 18).","journal-title":"Ther Adv Psychopharmacol"},{"issue":"Suppl 3","key":"1466_CR112","doi-asserted-by":"publisher","first-page":"S341","DOI":"10.4103\/0019-5545.224474","volume":"60","author":"A Avasthi","year":"2018","unstructured":"Avasthi A, Grover S. Clinical practice guidelines for management of depression in elderly. Indian J Psychiatry. 2018;60(Suppl 3):S341\u201362. https:\/\/doi.org\/10.4103\/0019-5545.224474.","journal-title":"Indian J Psychiatry."},{"issue":"9","key":"1466_CR113","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1586\/14737175.2015.1070671","volume":"15","author":"WD Taylor","year":"2015","unstructured":"Taylor WD. Should antidepressant medication be used in the elderly? Expert Rev Neurother. 2015;15(9):961\u20133. https:\/\/doi.org\/10.1586\/14737175.2015.1070671.","journal-title":"Expert Rev Neurother"},{"issue":"4","key":"1466_CR114","doi-asserted-by":"publisher","first-page":"184","DOI":"10.4103\/2229-3485.167099","volume":"6","author":"P Shenoy","year":"2015","unstructured":"Shenoy P, Harugeri A. Elderly patients\u2019 participation in clinical trials. Perspect Clin Res. 2015;6(4):184\u20139. https:\/\/doi.org\/10.4103\/2229-3485.167099.","journal-title":"Perspect Clin Res"},{"issue":"1","key":"1466_CR115","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1186\/s12888-018-1911-8","volume":"18","author":"Y Mirkena","year":"2018","unstructured":"Mirkena Y, Reta MM, Haile K, Nassir Z, Sisay MM. Prevalence of depression and associated factors among older adults at ambo town, Oromia region, Ethiopia. BMC Psychiatry. 2018;18(1):338. https:\/\/doi.org\/10.1186\/s12888-018-1911-8. (Published 2018 Oct 18).","journal-title":"BMC Psychiatry"},{"issue":"2","key":"1466_CR116","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/20786190.2016.1272250","volume":"59","author":"U Padayachey","year":"2017","unstructured":"Padayachey U, Ramlall S, Chipps JA. Depression in older adults: prevalence and risk factors in a primary health care sample. S Afr Fam Pract. 2017;59(2):1\u20136. https:\/\/doi.org\/10.1080\/20786190.2016.1272250.","journal-title":"S Afr Fam Pract."},{"issue":"1","key":"1466_CR117","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1093\/eurpub\/ckt014","volume":"24","author":"P Andreasen","year":"2014","unstructured":"Andreasen P, L\u00f6nnroos E, von Euler-Chelpin MC. Prevalence of depression among older adults with dementia living in low- and middle-income countries: a cross-sectional study. Eur J Public Health. 2014;24(1):40\u20134. https:\/\/doi.org\/10.1093\/eurpub\/ckt014.","journal-title":"Eur J Public Health"},{"key":"1466_CR118","unstructured":"Sekhon S, Patel J, Sapra A. Late-life depression. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024.\u00a0Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK551507\/"},{"key":"1466_CR119","unstructured":"Moraczewski J, Awosika AO, Aedma KK. Tricyclic antidepressants. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024.\u00a0Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK557791\/"},{"issue":"6","key":"1466_CR120","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/j.encep.2016.05.006","volume":"42","author":"DJ David","year":"2016","unstructured":"David DJ, Gourion D. Antid\u00e9presseurs et tol\u00e9rance: d\u00e9terminants et prise en charge des principaux effets ind\u00e9sirables [Antidepressant and tolerance: determinants and management of major side effects]. Encephale. 2016;42(6):553\u201361. https:\/\/doi.org\/10.1016\/j.encep.2016.05.006.","journal-title":"Encephale."},{"key":"1466_CR121","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.704281","volume":"8","author":"A Calvi","year":"2021","unstructured":"Calvi A, Fischetti I, Verzicco I, et al. Antidepressant drugs effects on blood pressure. Front Cardiovasc Med. 2021;8: 704281. https:\/\/doi.org\/10.3389\/fcvm.2021.704281.","journal-title":"Front Cardiovasc Med."},{"issue":"8","key":"1466_CR122","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/j.jash.2018.06.002","volume":"12","author":"R Briggs","year":"2018","unstructured":"Briggs R, Carey D, McNicholas T, et al. The association between antidepressant use and orthostatic hypotension in older people: a matched cohort study. J Am Soc Hypertens. 2018;12(8):597\u2013604. https:\/\/doi.org\/10.1016\/j.jash.2018.06.002. (e1).","journal-title":"J Am Soc Hypertens"},{"issue":"8","key":"1466_CR123","doi-asserted-by":"publisher","first-page":"2584","DOI":"10.3390\/jcm9082584","volume":"9","author":"Q Wu","year":"2020","unstructured":"Wu Q, Xu Y, Bao Y, Alvarez J, Gonzales ML. Tricyclic antidepressant use and risk of fractures: a meta-analysis of cohort studies through the use of both frequentist and bayesian approaches. J Clin Med. 2020;9(8):2584. https:\/\/doi.org\/10.3390\/jcm9082584. (Published 2020 Aug 10).","journal-title":"J Clin Med"},{"key":"1466_CR124","unstructured":"Khalid MM, Waseem M. Tricyclic antidepressant toxicity. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024.\u00a0Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK430931\/"},{"issue":"12","key":"1466_CR125","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1002\/gps.4974","volume":"33","author":"V Khanassov","year":"2018","unstructured":"Khanassov V, Hu J, Reeves D, van Marwijk H. Selective serotonin reuptake inhibitor and selective serotonin and norepinephrine reuptake inhibitor use and risk of fractures in adults: a systematic review and meta-analysis. Int J Geriatr Psychiatry. 2018;33(12):1688\u2013708. https:\/\/doi.org\/10.1002\/gps.4974.","journal-title":"Int J Geriatr Psychiatry"},{"key":"1466_CR126","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2020.115306","volume":"135","author":"JH Park","year":"2020","unstructured":"Park JH, Song YM, Jung JH, Han K. Comparative analysis of the risk of osteoporotic fractures with proton pump inhibitor use and histamine-2 receptor antagonist therapy in elderly women: a nationwide population-based nested case-control study. Bone. 2020;135: 115306. https:\/\/doi.org\/10.1016\/j.bone.2020.115306.","journal-title":"Bone"},{"issue":"1","key":"1466_CR127","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s12916-018-1022-x","volume":"16","author":"C Coupland","year":"2018","unstructured":"Coupland C, Hill T, Morriss R, Moore M, Arthur A, Hippisley-Cox J. Antidepressant use and risk of adverse outcomes in people aged 20\u201364 years: cohort study using a primary care database. BMC Med. 2018;16(1):36. https:\/\/doi.org\/10.1186\/s12916-018-1022-x. (Published 2018 Mar 8).","journal-title":"BMC Med"},{"issue":"7","key":"1466_CR128","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1111\/jgs.16404","volume":"68","author":"R Tamblyn","year":"2020","unstructured":"Tamblyn R, Bates DW, Buckeridge DL, et al. Multinational investigation of fracture risk with antidepressant use by class, drug, and indication. J Am Geriatr Soc. 2020;68(7):1494\u2013503. https:\/\/doi.org\/10.1111\/jgs.16404.","journal-title":"J Am Geriatr Soc"},{"issue":"20","key":"1466_CR129","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1093\/eurheartj\/ehu100","volume":"35","author":"S Fanoe","year":"2014","unstructured":"Fanoe S, Kristensen D, Fink-Jensen A, et al. Risk of arrhythmia induced by psychotropic medications: a proposal for clinical management. Eur Heart J. 2014;35(20):1306\u201315. https:\/\/doi.org\/10.1093\/eurheartj\/ehu100.","journal-title":"Eur Heart J"},{"issue":"2","key":"1466_CR130","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1111\/bcp.15533","volume":"89","author":"AL Leutritz","year":"2023","unstructured":"Leutritz AL, van Braam L, Preis K, et al. Psychotropic medication in pregnancy and lactation and early development of exposed children. Br J Clin Pharmacol. 2023;89(2):737\u201350. https:\/\/doi.org\/10.1111\/bcp.15533.","journal-title":"Br J Clin Pharmacol"},{"key":"1466_CR131","unstructured":"Thour A, Marwaha R. Amitriptyline. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024.\u00a0Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK537225\/"},{"key":"1466_CR132","unstructured":"Fayez R, Gupta V. Imipramine. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024.\u00a0Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK557656\/"},{"issue":"6","key":"1466_CR133","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1177\/02692163221085855","volume":"36","author":"A Hussein","year":"2022","unstructured":"Hussein A, Digges M, Chang S, et al. Pharmacovigilance in hospice\/palliative care: net effect of amitriptyline or nortriptyline on neuropathic pain: UTS\/IMPACCT Rapid programme international consecutive cohort. Palliat Med. 2022;36(6):938\u201344. https:\/\/doi.org\/10.1177\/02692163221085855.","journal-title":"Palliat Med"},{"key":"1466_CR134","unstructured":"Merwar G, Gibbons JR, Hosseini SA, et al. Nortriptyline. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024.\u00a0Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK482214\/"},{"issue":"20","key":"1466_CR135","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1001\/jama.2017.5706","volume":"317","author":"RM Kok","year":"2017","unstructured":"Kok RM, Reynolds CF 3rd. Management of depression in older adults: a review. JAMA. 2017;317(20):2114\u201322. https:\/\/doi.org\/10.1001\/jama.2017.5706.","journal-title":"JAMA"},{"issue":"1","key":"1466_CR136","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s40800-017-0069-5","volume":"5","author":"M King","year":"2018","unstructured":"King M, Ashraf N. Tricyclic antidepressant-induced anticholinergic delirium in a young healthy male individual. Drug Saf Case Rep. 2018;5(1):1. https:\/\/doi.org\/10.1007\/s40800-017-0069-5. (Published 2018 Jan 2).","journal-title":"Drug Saf Case Rep."},{"key":"1466_CR137","unstructured":"Sheffler ZM, Patel P, Abdijadid S. Antidepressants. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK538182\/"},{"key":"1466_CR138","unstructured":"Huecker MR, Smiley A, Saadabadi A. Bupropion. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK470212\/"},{"issue":"2","key":"1466_CR139","doi-asserted-by":"publisher","first-page":"101","DOI":"10.4068\/cmj.2018.54.2.101","volume":"54","author":"SM Wang","year":"2018","unstructured":"Wang SM, Han C, Bahk WM, et al. Addressing the side effects of contemporary antidepressant drugs: a comprehensive review. Chonnam Med J. 2018;54(2):101\u201312. https:\/\/doi.org\/10.4068\/cmj.2018.54.2.101.","journal-title":"Chonnam Med J"},{"issue":"3","key":"1466_CR140","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1001\/jamapsychiatry.2019.3655","volume":"77","author":"PO Coffin","year":"2020","unstructured":"Coffin PO, Santos GM, Hern J, et al. Effects of mirtazapine for methamphetamine use disorder among cisgender men and transgender women who have sex with men: a placebo-controlled randomized clinical trial. JAMA Psychiat. 2020;77(3):246\u201355. https:\/\/doi.org\/10.1001\/jamapsychiatry.2019.3655.","journal-title":"JAMA Psychiat"},{"key":"1466_CR141","first-page":"1","volume":"377","author":"DJ Brody","year":"2020","unstructured":"Brody DJ, Gu Q. Antidepressant use among adults: United States, 2015\u20132018. NCHS Data Brief. 2020;377:1\u20138.","journal-title":"NCHS Data Brief"},{"issue":"4","key":"1466_CR142","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1002\/gps.5047","volume":"34","author":"FH Boehlen","year":"2019","unstructured":"Boehlen FH, Freigofas J, Herzog W, et al. Evidence for underuse and overuse of antidepressants in older adults: results of a large population-based study. Int J Geriatr Psychiatry. 2019;34(4):539\u201347. https:\/\/doi.org\/10.1002\/gps.5047.","journal-title":"Int J Geriatr Psychiatry"},{"key":"1466_CR143","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.genhosppsych.2023.03.009","volume":"82","author":"K Ishtiak-Ahmed","year":"2023","unstructured":"Ishtiak-Ahmed K, K\u00f6hler-Forsberg O, Mortensen EL, Nierenberg AA, Gasse C. Concurrent use of polypharmacy and potentially inappropriate medications with antidepressants in older adults: a nationwide descriptive study in Denmark during 2015\u20132019. Gen Hosp Psychiatry. 2023;82:66\u201374. https:\/\/doi.org\/10.1016\/j.genhosppsych.2023.03.009.","journal-title":"Gen Hosp Psychiatry"},{"key":"1466_CR144","doi-asserted-by":"publisher","unstructured":"O'Mahony D, O'Sullivan D, Byrne S, O'Connor MN, Ryan C, Gallagher P. STOPP\/START criteria for potentially inappropriate prescribing in older people: version 2 [published correction appears in Age Ageing. 2018 May 1;47(3):489. https:\/\/doi.org\/10.1093\/ageing\/afx178].\u00a0Age Ageing. 2015;44(2):213\u20138. https:\/\/doi.org\/10.1093\/ageing\/afu145","DOI":"10.1093\/ageing\/afx178 10.1093\/ageing\/afu145"},{"issue":"1","key":"1466_CR145","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1186\/s12888-020-02514-2","volume":"20","author":"K Gutsmiedl","year":"2020","unstructured":"Gutsmiedl K, Krause M, Bighelli I, Schneider-Thoma J, Leucht S. How well do elderly patients with major depressive disorder respond to antidepressants: a systematic review and single-group meta-analysis. BMC Psychiatry. 2020;20(1):102. https:\/\/doi.org\/10.1186\/s12888-020-02514-2. (Published 2020 Mar 4).","journal-title":"BMC Psychiatry"},{"key":"1466_CR146","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.clinbiochem.2017.10.002","volume":"52","author":"ACC da Silva","year":"2018","unstructured":"da Silva ACC, Raasch JR, Vargas TG, et al. Simultaneous determination of fluoxetine and norfluoxetine in dried blood spots using high-performance liquid chromatography-tandem mass spectrometry. Clin Biochem. 2018;52:85\u201393. https:\/\/doi.org\/10.1016\/j.clinbiochem.2017.10.002.","journal-title":"Clin Biochem"},{"issue":"1","key":"1466_CR147","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1002\/cpt.597","volume":"102","author":"JK Hicks","year":"2017","unstructured":"Hicks JK, Sangkuhl K, Swen JJ, et al. Clinical pharmacogenetics implementation consortium guideline (CPIC) for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants: 2016 update. Clin Pharmacol Ther. 2017;102(1):37\u201344. https:\/\/doi.org\/10.1002\/cpt.597.","journal-title":"Clin Pharmacol Ther"},{"key":"1466_CR148","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.jad.2019.02.063","volume":"250","author":"A Holck","year":"2019","unstructured":"Holck A, Wolkowitz OM, Mellon SH, et al. Plasma serotonin levels are associated with antidepressant response to SSRIs. J Affect Disord. 2019;250:65\u201370. https:\/\/doi.org\/10.1016\/j.jad.2019.02.063.","journal-title":"J Affect Disord"},{"key":"1466_CR149","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1186\/s12875-014-0210-9","volume":"15","author":"CF Johnson","year":"2014","unstructured":"Johnson CF, Dougall NJ, Williams B, MacGillivray SA, Buchanan AI, Hassett RD. Patient factors associated with SSRI dose for depression treatment in general practice: a primary care cross sectional study. BMC Fam Pract. 2014;15:210. https:\/\/doi.org\/10.1186\/s12875-014-0210-9. (Published 2014 Dec 24).","journal-title":"BMC Fam Pract"},{"key":"1466_CR150","unstructured":"Sohel AJ, Shutter MC, Patel P, et al. Fluoxetine. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024.\u00a0Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459223\/"},{"key":"1466_CR151","doi-asserted-by":"publisher","unstructured":"Cavanah LR, Goldhirsh JL, Huey LY, Piper BJ. Specialty-type and state-level variation in paroxetine use among older adult patients. Preprint. medRxiv. 2023;2023.02.15.23285973. https:\/\/doi.org\/10.1101\/2023.02.15.23285973 (Published 2023 Feb 16)","DOI":"10.1101\/2023.02.15.23285973"},{"key":"1466_CR152","unstructured":"Nath M, Gupta V. Mood stabilizers. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024.\u00a0Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK556141\/"},{"issue":"9","key":"1466_CR153","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1002\/2327-6924.12275","volume":"27","author":"U McCormick","year":"2015","unstructured":"McCormick U, Murray B, McNew B. Diagnosis and treatment of patients with bipolar disorder: a review for advanced practice nurses. J Am Assoc Nurse Pract. 2015;27(9):530\u201342. https:\/\/doi.org\/10.1002\/2327-6924.12275.","journal-title":"J Am Assoc Nurse Pract"},{"issue":"12","key":"1466_CR154","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1016\/j.jagp.2015.07.001","volume":"23","author":"A Vasudev","year":"2015","unstructured":"Vasudev A, Shariff SZ, Liu K, et al. Trends in psychotropic dispensing among older adults with dementia living in long-term care facilities: 2004\u20132013. Am J Geriatr Psychiatry. 2015;23(12):1259\u201369. https:\/\/doi.org\/10.1016\/j.jagp.2015.07.001.","journal-title":"Am J Geriatr Psychiatry"},{"issue":"2","key":"1466_CR155","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1136\/bmjqs-2018-007840","volume":"28","author":"NM Ivers","year":"2019","unstructured":"Ivers NM, Taljaard M, Giannakeas V, Reis C, Williams E, Bronskill S. Public reporting of antipsychotic prescribing in nursing homes: population-based interrupted time series analyses. BMJ Qual Saf. 2019;28(2):121\u201331. https:\/\/doi.org\/10.1136\/bmjqs-2018-007840.","journal-title":"BMJ Qual Saf"},{"issue":"2","key":"1466_CR156","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1177\/0004867418758919","volume":"53","author":"J Westbury","year":"2019","unstructured":"Westbury J, Gee P, Ling T, Kitsos A, Peterson G. More action needed: psychotropic prescribing in Australian residential aged care. Aust N Z J Psychiatry. 2019;53(2):136\u201347. https:\/\/doi.org\/10.1177\/0004867418758919.","journal-title":"Aust N Z J Psychiatry"},{"key":"1466_CR157","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.euroneuro.2021.10.003","volume":"54","author":"KN Fountoulakis","year":"2022","unstructured":"Fountoulakis KN, Tohen M, Zarate CA Jr. Lithium treatment of Bipolar disorder in adults: a systematic review of randomized trials and meta-analyses. Eur Neuropsychopharmacol. 2022;54:100\u201315. https:\/\/doi.org\/10.1016\/j.euroneuro.2021.10.003.","journal-title":"Eur Neuropsychopharmacol"},{"key":"1466_CR158","doi-asserted-by":"publisher","unstructured":"Christl J, M\u00fcller-Oerlinghausen B, Bauer M, et al. Lithium Therapy in old age: recommendations from a Delphi Survey [published correction appears in Pharmacopsychiatry. 2023 Sep;56(5):e1. https:\/\/doi.org\/10.1055\/a-2158-9744].\u00a0Pharmacopsychiatry. 2023;56(5):188\u201396. https:\/\/doi.org\/10.1055\/a-2117-5200","DOI":"10.1055\/a-2158-9744 10.1055\/a-2117-5200"},{"key":"1466_CR159","doi-asserted-by":"publisher","first-page":"407","DOI":"10.2147\/IMCRJ.S316943","volume":"14","author":"S Niida","year":"2021","unstructured":"Niida S, Ogawa F, Nakajima K, et al. A case of central pontine Myelinolysis occurred during treatment of hyperosmolar hyperglycemic syndrome. Int Med Case Rep J. 2021;14:407\u201312. https:\/\/doi.org\/10.2147\/IMCRJ.S316943. (Published 2021 Jun 18).","journal-title":"Int Med Case Rep J"},{"issue":"9","key":"1466_CR160","doi-asserted-by":"publisher","first-page":"609","DOI":"10.4103\/0972-5229.140153","volume":"18","author":"AA Jha","year":"2014","unstructured":"Jha AA, Behera V, Jairam A, Baliga KV. Osmotic demyelination syndrome in a normonatremic patient of chronic kidney disease. Indian J Crit Care Med. 2014;18(9):609\u201311. https:\/\/doi.org\/10.4103\/0972-5229.140153.","journal-title":"Indian J Crit Care Med."},{"issue":"4","key":"1466_CR161","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1111\/anec.12118","volume":"19","author":"MD Gupta","year":"2014","unstructured":"Gupta MD, Girish, Goyal M, Subhendu M, Tyagi S. Unusual cause of syncope in a patient with ischemic heart disease. Ann Noninvasive Electrocardiol. 2014;19(4):395\u20137. https:\/\/doi.org\/10.1111\/anec.12118.","journal-title":"Ann Noninvasive Electrocardiol"},{"issue":"16","key":"1466_CR162","doi-asserted-by":"publisher","first-page":"10044","DOI":"10.3390\/ijerph191610044","volume":"19","author":"YH Liu","year":"2022","unstructured":"Liu YH, Tsai KF, Hsu PC, et al. Hemodialysis treatment for patients with lithium poisoning. Int J Environ Res Public Health. 2022;19(16):10044. https:\/\/doi.org\/10.3390\/ijerph191610044. (Published 2022 Aug 15).","journal-title":"Int J Environ Res Public Health"},{"issue":"2","key":"1466_CR163","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1111\/bdi.12714","volume":"21","author":"KI Shulman","year":"2019","unstructured":"Shulman KI, Almeida OP, Herrmann N, et al. Delphi survey of maintenance lithium treatment in older adults with bipolar disorder: an ISBD task force report. Bipolar Disord. 2019;21(2):117\u201323. https:\/\/doi.org\/10.1111\/bdi.12714.","journal-title":"Bipolar Disord"},{"issue":"4","key":"1466_CR164","doi-asserted-by":"publisher","first-page":"556","DOI":"10.3988\/jcn.2020.16.4.556","volume":"16","author":"JG Seo","year":"2020","unstructured":"Seo JG, Cho YW, Kim KT, et al. Pharmacological treatment of epilepsy in elderly patients. J Clin Neurol. 2020;16(4):556\u201361. https:\/\/doi.org\/10.3988\/jcn.2020.16.4.556.","journal-title":"J Clin Neurol"},{"issue":"2","key":"1466_CR165","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1212\/WNL.0000000000005755","volume":"91","author":"AM Kanner","year":"2018","unstructured":"Kanner AM, Ashman E, Gloss D, et al. Practice guideline update summary: efficacy and tolerability of the new antiepileptic drugs I: treatment of new-onset epilepsy: report of the guideline development, dissemination, and implementation subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurology. 2018;91(2):74\u201381. https:\/\/doi.org\/10.1212\/WNL.0000000000005755.","journal-title":"Neurology"},{"issue":"2","key":"1466_CR166","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s13760-019-01132-4","volume":"119","author":"U Kaur","year":"2019","unstructured":"Kaur U, Chauhan I, Gambhir IS, Chakrabarti SS. Antiepileptic drug therapy in the elderly: a clinical pharmacological review. Acta Neurol Belg. 2019;119(2):163\u201373. https:\/\/doi.org\/10.1007\/s13760-019-01132-4.","journal-title":"Acta Neurol Belg"},{"issue":"5","key":"1466_CR167","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1111\/bcp.13510","volume":"84","author":"J Methaneethorn","year":"2018","unstructured":"Methaneethorn J. A systematic review of population pharmacokinetics of valproic acid. Br J Clin Pharmacol. 2018;84(5):816\u201334. https:\/\/doi.org\/10.1111\/bcp.13510.","journal-title":"Br J Clin Pharmacol"},{"key":"1466_CR168","unstructured":"Rahman M, Awosika AO, Nguyen H. Valproic acid. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK559112\/"},{"key":"1466_CR169","unstructured":"Gupta M, Tripp J. Phenytoin. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024.\u00a0Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK551520\/"},{"key":"1466_CR170","unstructured":"Preuss CV, Randhawa G, Wy TJP, et al. Oxcarbazepine. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024.\u00a0Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK482313\/"},{"key":"1466_CR171","doi-asserted-by":"publisher","unstructured":"Pan C, Zhao Z, Liu Z, et al. Valproate encephalopathy: case series and literature review. SAGE Open Med Case Rep. 2024;12:2050313X241260152. https:\/\/doi.org\/10.1177\/2050313X241260152 (Published 2024 Jun 20)","DOI":"10.1177\/2050313X241260152"},{"key":"1466_CR172","doi-asserted-by":"publisher","first-page":"147","DOI":"10.2174\/1875692116666180830124924","volume":"16","author":"U Kaur","year":"2018","unstructured":"Kaur U, Chakrabarti S, Singh B, Gambhir I. A prospective observational pilot study of adverse drug reactions in patients admitted in the geriatric ward of a tertiary hospital in North India. Curr Pharmacogenomics Person Med. 2018;16:147\u201355. https:\/\/doi.org\/10.2174\/1875692116666180830124924.","journal-title":"Curr Pharmacogenomics Person Med."},{"issue":"4","key":"1466_CR173","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1684\/epd.2014.0714","volume":"16","author":"G Zaccara","year":"2014","unstructured":"Zaccara G, Perucca E. Interactions between antiepileptic drugs, and between antiepileptic drugs and other drugs. Epileptic Disord. 2014;16(4):409\u201331. https:\/\/doi.org\/10.1684\/epd.2014.0714.","journal-title":"Epileptic Disord"},{"key":"1466_CR174","unstructured":"Verghese C, Abdijadid S. Methylphenidate. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024.\u00a0Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK482451\/"},{"issue":"Suppl 3","key":"1466_CR175","first-page":"30S","volume":"32","author":"R Pary","year":"2015","unstructured":"Pary R, Scarff JR, Jijakli A, Tobias C, Lippmann S. A review of psychostimulants for adults with depression. Fed Pract. 2015;32(Suppl 3):30S-37S.","journal-title":"Fed Pract"},{"issue":"1","key":"1466_CR176","volume":"2015","author":"HY Tong","year":"2015","unstructured":"Tong HY, D\u00edaz C, Collantes E, Medrano N, Borobia AM, Jara P, Ram\u00edrez E. Liver transplant in a patient under methylphenidate therapy: a case report and review of the literature. Case Reports Paeds. 2015;2015(1): 437298.","journal-title":"Case Reports Paeds."},{"issue":"6","key":"1466_CR177","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1176\/appi.ajp.2014.14070889","volume":"172","author":"H Lavretsky","year":"2015","unstructured":"Lavretsky H, Reinlieb M, St Cyr N, Siddarth P, Ercoli LM, Senturk D. Citalopram, methylphenidate, or their combination in geriatric depression: a randomized, double-blind, placebo-controlled trial. Am J Psychiatry. 2015;172(6):561\u20139. https:\/\/doi.org\/10.1176\/appi.ajp.2014.14070889.","journal-title":"Am J Psychiatry"},{"issue":"9","key":"1466_CR178","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008165.pub4","volume":"9","author":"A Rankin","year":"2018","unstructured":"Rankin A, Cadogan CA, Patterson SM, et al. Interventions to improve the appropriate use of polypharmacy for older people. Cochrane Database Syst Rev. 2018;9(9): CD008165. https:\/\/doi.org\/10.1002\/14651858.CD008165.pub4. (Published 2018 Sep 3).","journal-title":"Cochrane Database Syst Rev"},{"issue":"12","key":"1466_CR179","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.50323","volume":"15","author":"AA Alzeer","year":"2023","unstructured":"Alzeer AA, Suliman I, Altamimi M, Alshudukhi AM, Alzeer AA, Alwasidi EO. Acute myocardial infarction associated with amphetamine use and smoking in a young healthy individual. Cureus. 2023;15(12): e50323. https:\/\/doi.org\/10.7759\/cureus.50323. (Published 2023 Dec 11).","journal-title":"Cureus"},{"issue":"2","key":"1466_CR180","doi-asserted-by":"publisher","first-page":"126","DOI":"10.2174\/1570159X17666191010093021","volume":"18","author":"KLM Sassi","year":"2020","unstructured":"Sassi KLM, Rocha NP, Colpo GD, John V, Teixeira AL. Amphetamine use in the elderly: a systematic review of the literature. Curr Neuropharmacol. 2020;18(2):126\u201335. https:\/\/doi.org\/10.2174\/1570159X17666191010093021.","journal-title":"Curr Neuropharmacol"},{"issue":"12","key":"1466_CR181","doi-asserted-by":"publisher","first-page":"2459","DOI":"10.1093\/gerona\/glac033","volume":"77","author":"JR Latronica","year":"2022","unstructured":"Latronica JR, Tuan WJ, Clegg TJ, Silvis ML, Bone C. Cardiovascular outcomes among older individuals with depression prescribed amphetamines: a retrospective cohort study. J Gerontol A Biol Sci Med Sci. 2022;77(12):2459\u201363. https:\/\/doi.org\/10.1093\/gerona\/glac033.","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"12","key":"1466_CR182","doi-asserted-by":"publisher","first-page":"1712","DOI":"10.1177\/1087054720925884","volume":"25","author":"M Michielsen","year":"2021","unstructured":"Michielsen M, Kleef D, Bijlenga D, et al. Response and side effects using stimulant medication in older adults with ADHD: an observational archive study. J Atten Disord. 2021;25(12):1712\u20139. https:\/\/doi.org\/10.1177\/1087054720925884.","journal-title":"J Atten Disord"},{"issue":"12","key":"1466_CR183","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD013304.pub2","volume":"12","author":"V M\u00fchlbauer","year":"2021","unstructured":"M\u00fchlbauer V, M\u00f6hler R, Dichter MN, Zuidema SU, K\u00f6pke S, Luijendijk HJ. Antipsychotics for agitation and psychosis in people with Alzheimer\u2019s disease and vascular dementia. Cochrane Database Syst Rev. 2021;12(12): CD013304. https:\/\/doi.org\/10.1002\/14651858.CD013304.pub2. (Published 2021 Dec 17).","journal-title":"Cochrane Database Syst Rev"},{"issue":"7","key":"1466_CR184","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/j.jalz.2016.03.006","volume":"12","author":"H Arai","year":"2016","unstructured":"Arai H, Nakamura Y, Taguchi M, et al. Mortality risk in current and new antipsychotic Alzheimer\u2019s disease users: large scale Japanese study. Alzheimers Dement. 2016;12(7):823\u201330. https:\/\/doi.org\/10.1016\/j.jalz.2016.03.006.","journal-title":"Alzheimers Dement"},{"issue":"2","key":"1466_CR185","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1002\/pds.3912","volume":"25","author":"HJ Luijendijk","year":"2016","unstructured":"Luijendijk HJ, de Bruin NC, Hulshof TA, Koolman X. Terminal illness and the increased mortality risk of conventional antipsychotics in observational studies: a systematic review. Pharmacoepidemiol Drug Saf. 2016;25(2):113\u201322. https:\/\/doi.org\/10.1002\/pds.3912.","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"1466_CR186","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.2147\/CIA.S63942","volume":"9","author":"P Gareri","year":"2014","unstructured":"Gareri P, Segura-Garc\u00eda C, Manfredi VG, et al. Use of atypical antipsychotics in the elderly: a clinical review. Clin Interv Aging. 2014;9:1363\u201373. https:\/\/doi.org\/10.2147\/CIA.S63942. (Published 2014 Aug 16).","journal-title":"Clin Interv Aging"},{"key":"1466_CR187","unstructured":"Tackling G, Borhade MB. Hypertensive heart disease. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024.\u00a0Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK539800\/"},{"issue":"2","key":"1466_CR188","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1002\/clc.23303","volume":"43","author":"E Oliveros","year":"2020","unstructured":"Oliveros E, Patel H, Kyung S, et al. Hypertension in older adults: assessment, management, and challenges. Clin Cardiol. 2020;43(2):99\u2013107. https:\/\/doi.org\/10.1002\/clc.23303.","journal-title":"Clin Cardiol"},{"key":"1466_CR189","doi-asserted-by":"publisher","unstructured":"SPRINT Research Group, Wright JT Jr, Williamson JD, et al. A Randomized trial of intensive versus standard blood-pressure control [published correction appears in N Engl J Med. 2017 Dec 21;377(25):2506. https:\/\/doi.org\/10.1056\/NEJMx170008].\u00a0N Engl J Med. 2015;373(22):2103\u201316. https:\/\/doi.org\/10.1056\/NEJMoa1511939","DOI":"10.1056\/NEJMx170008 10.1056\/NEJMoa1511939"},{"issue":"26","key":"1466_CR190","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1093\/eurheartj\/eht565","volume":"35","author":"CM McEniery","year":"2014","unstructured":"McEniery CM, Cockcroft JR, Roman MJ, Franklin SS, Wilkinson IB. Central blood pressure: current evidence and clinical importance. Eur Heart J. 2014;35(26):1719\u201325. https:\/\/doi.org\/10.1093\/eurheartj\/eht565.","journal-title":"Eur Heart J"},{"issue":"2","key":"1466_CR191","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1002\/clc.23313","volume":"43","author":"NSV Singam","year":"2020","unstructured":"Singam NSV, Fine C, Fleg JL. Cardiac changes associated with vascular aging. Clin Cardiol. 2020;43(2):92\u20138. https:\/\/doi.org\/10.1002\/clc.23313.","journal-title":"Clin Cardiol"},{"issue":"13","key":"1466_CR192","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1042\/CS20171156","volume":"132","author":"V Obas","year":"2018","unstructured":"Obas V, Vasan RS. The aging heart. Clin Sci (Lond). 2018;132(13):1367\u201382. https:\/\/doi.org\/10.1042\/CS20171156. (Published 2018 Jul 9).","journal-title":"Clin Sci (Lond)"},{"key":"1466_CR193","doi-asserted-by":"publisher","first-page":"6731093","DOI":"10.1155\/2016\/6731093","volume":"2016","author":"HE Yoon","year":"2016","unstructured":"Yoon HE, Kim EN, Kim MY, et al. Age-associated changes in the vascular renin-angiotensin system in mice. Oxid Med Cell Longev. 2016;2016:6731093. https:\/\/doi.org\/10.1155\/2016\/6731093.","journal-title":"Oxid Med Cell Longev"},{"issue":"1","key":"1466_CR194","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1002\/prca.201500038","volume":"10","author":"R Padmanabhan Iyer","year":"2016","unstructured":"Padmanabhan Iyer R, Chiao YA, Flynn ER, et al. Matrix metalloproteinase-9-dependent mechanisms of reduced contractility and increased stiffness in the aging heart. Proteomics Clin Appl. 2016;10(1):92\u2013107. https:\/\/doi.org\/10.1002\/prca.201500038.","journal-title":"Proteomics Clin Appl"},{"issue":"7","key":"1466_CR195","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1161\/CIRCRESAHA.118.313236","volume":"124","author":"A Benetos","year":"2019","unstructured":"Benetos A, Petrovic M, Strandberg T. Hypertension management in older and frail older patients. Circ Res. 2019;124(7):1045\u201360. https:\/\/doi.org\/10.1161\/CIRCRESAHA.118.313236.","journal-title":"Circ Res"},{"key":"1466_CR196","doi-asserted-by":"publisher","DOI":"10.1268\/f1000research.20323.1","volume":"9","author":"O Bilen","year":"2020","unstructured":"Bilen O, Wenger NK. Hypertension management in older adults. F1000Res. 2020;9: F1000 Faculty Rev-1003. https:\/\/doi.org\/10.1268\/f1000research.20323.1. (Published 2020 Aug 19).","journal-title":"F1000Res"},{"issue":"10","key":"1466_CR197","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1007\/s40266-020-00796-5","volume":"37","author":"G Rivasi","year":"2020","unstructured":"Rivasi G, Rafanelli M, Mossello E, Brignole M, Ungar A. Drug-related orthostatic hypotension: beyond anti-hypertensive medications. Drugs Aging. 2020;37(10):725\u201338. https:\/\/doi.org\/10.1007\/s40266-020-00796-5.","journal-title":"Drugs Aging"},{"issue":"4","key":"1466_CR198","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1161\/HYPERTENSIONAHA.119.13445","volume":"74","author":"SP Juraschek","year":"2019","unstructured":"Juraschek SP, Simpson LM, Davis BR, Beach JL, Ishak A, Mukamal KJ. Effects of antihypertensive class on falls, syncope, and orthostatic hypotension in older adults: the ALLHAT trial. Hypertension. 2019;74(4):1033\u201340. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.119.13445.","journal-title":"Hypertension"},{"issue":"2","key":"1466_CR199","doi-asserted-by":"publisher","first-page":"155","DOI":"10.3390\/medicina57020155","volume":"57","author":"SA Cojocariu","year":"2021","unstructured":"Cojocariu SA, Ma\u0219taleru A, Sasc\u0103u RA, St\u0103tescu C, Mitu F, Leon-Constantin MM. Neuropsychiatric consequences of lipophilic \u03b2-blockers. Medicina (Kaunas). 2021;57(2):155. https:\/\/doi.org\/10.3390\/medicina57020155. (Published 2021 Feb 9).","journal-title":"Medicina (Kaunas)"},{"key":"1466_CR200","unstructured":"Khan KM, Patel JB, Schaefer TJ. Nifedipine. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024.\u00a0Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK537052\/"},{"key":"1466_CR201","unstructured":"Fahie S, Cassagnol M. Verapamil. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024.\u00a0Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK538495\/"},{"key":"1466_CR202","unstructured":"Sidhu G, Puckett Y. Bumetanide. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024.\u00a0Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK559181\/"},{"key":"1466_CR203","unstructured":"Arumugham VB, Shahin MH. Therapeutic Uses of Diuretic Agents. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024.\u00a0Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK557838\/"},{"issue":"10","key":"1466_CR204","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1002\/pds.5292","volume":"30","author":"TY Chyou","year":"2021","unstructured":"Chyou TY, Nishtala PS. Identifying frequent drug combinations associated with delirium in older adults: application of association rules method to a case-time-control design. Pharmacoepidemiol Drug Saf. 2021;30(10):1402\u201310. https:\/\/doi.org\/10.1002\/pds.5292.","journal-title":"Pharmacoepidemiol Drug Saf"},{"issue":"4","key":"1466_CR205","doi-asserted-by":"publisher","first-page":"201","DOI":"10.9740\/mhc.2016.07.201","volume":"6","author":"M Marvanova","year":"2016","unstructured":"Marvanova M. Drug-induced cognitive impairment: effect of cardiovascular agents. Ment Health Clin. 2016;6(4):201\u20136. https:\/\/doi.org\/10.9740\/mhc.2016.07.201. (Published 2016 Jun 29).","journal-title":"Ment Health Clin"},{"key":"1466_CR206","unstructured":"Khan TM, Patel R, Siddiqui AH. Furosemide. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024.\u00a0Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK499921\/"},{"issue":"11","key":"1466_CR207","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1007\/s40266-023-01061-1","volume":"40","author":"C Okoye","year":"2023","unstructured":"Okoye C, Mazzarone T, Cargiolli C, Guarino D. Discontinuation of loop diuretics in older patients with chronic stable heart failure: a narrative review. Drugs Aging. 2023;40(11):981\u201390. https:\/\/doi.org\/10.1007\/s40266-023-01061-1.","journal-title":"Drugs Aging"},{"issue":"44","key":"1466_CR208","doi-asserted-by":"publisher","first-page":"3605","DOI":"10.1093\/eurheartj\/ehz554","volume":"40","author":"LE Rohde","year":"2019","unstructured":"Rohde LE, Rover MM, Figueiredo Neto JA, et al. Short-term diuretic withdrawal in stable outpatients with mild heart failure and no fluid retention receiving optimal therapy: a double-blind, multicentre, randomized trial. Eur Heart J. 2019;40(44):3605\u201312. https:\/\/doi.org\/10.1093\/eurheartj\/ehz554.","journal-title":"Eur Heart J"},{"key":"1466_CR209","doi-asserted-by":"publisher","first-page":"e11","DOI":"10.1016\/j.ejim.2017.03.025","volume":"42","author":"G Romano","year":"2017","unstructured":"Romano G, Vitale G, Bellavia D, Agnese V, Clemenza F. Is diuretic withdrawal safe in patients with heart failure and reduced ejection fraction? A retrospective analysis of our outpatient cohort. Eur J Intern Med. 2017;42:e11\u20133. https:\/\/doi.org\/10.1016\/j.ejim.2017.03.025.","journal-title":"Eur J Intern Med"},{"issue":"6","key":"1466_CR210","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1097\/MEJ.0000000000001065","volume":"30","author":"P Andrews","year":"2023","unstructured":"Andrews P, Anseeuw K, Kotecha D, Lapostolle F, Thanacoody R. Diagnosis and practical management of digoxin toxicity: a narrative review and consensus. Eur J Emerg Med. 2023;30(6):395\u2013401. https:\/\/doi.org\/10.1097\/MEJ.0000000000001065.","journal-title":"Eur J Emerg Med"},{"issue":"11","key":"1466_CR211","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1016\/j.amjmed.2019.05.012","volume":"132","author":"SZ Qamer","year":"2019","unstructured":"Qamer SZ, Malik A, Bayoumi E, et al. Digoxin use and outcomes in patients with heart failure with reduced ejection fraction. Am J Med. 2019;132(11):1311\u20139. https:\/\/doi.org\/10.1016\/j.amjmed.2019.05.012.","journal-title":"Am J Med"},{"issue":"1","key":"1466_CR212","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.amjmed.2013.08.027","volume":"127","author":"A Ahmed","year":"2014","unstructured":"Ahmed A, Bourge RC, Fonarow GC, et al. Digoxin use and lower 30-day all-cause readmission for Medicare beneficiaries hospitalized for heart failure. Am J Med. 2014;127(1):61\u201370. https:\/\/doi.org\/10.1016\/j.amjmed.2013.08.027.","journal-title":"Am J Med"},{"issue":"3","key":"1466_CR213","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1002\/clc.22889","volume":"41","author":"PH Lam","year":"2018","unstructured":"Lam PH, Bhyan P, Arundel C, et al. Digoxin use and lower risk of 30-day all-cause readmission in older patients with heart failure and reduced ejection fraction receiving \u03b2-blockers. Clin Cardiol. 2018;41(3):406\u201312. https:\/\/doi.org\/10.1002\/clc.22889.","journal-title":"Clin Cardiol"},{"key":"1466_CR214","unstructured":"Sizar O, Khare S, Patel P, et al. Statin medications. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024.\u00a0Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK430940\/"},{"key":"1466_CR215","unstructured":"McIver LA, Siddique MS. Atorvastatin. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024.\u00a0Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK430779\/"},{"key":"1466_CR216","unstructured":"Talreja O, Kerndt CC, Cassagnol M. Simvastatin. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024.\u00a0Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK532919\/"},{"issue":"3","key":"1466_CR217","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.jacl.2015.03.080","volume":"9","author":"A Khan","year":"2015","unstructured":"Khan A, Make CK, Ito MK, Cohen JD, Sponseller CA, Brinton EA, Jacobson TA. Statin associated muscle symptoms: characteristics of patients and recommendations by providers. J Clin Lipidol. 2015;9(3):460.","journal-title":"J Clin Lipidol"},{"issue":"2","key":"1466_CR218","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1002\/hep.27157","volume":"60","author":"MW Russo","year":"2014","unstructured":"Russo MW, Hoofnagle JH, Gu J, et al. Spectrum of statin hepatotoxicity: experience of the drug-induced liver injury network. Hepatology. 2014;60(2):679\u201386. https:\/\/doi.org\/10.1002\/hep.27157.","journal-title":"Hepatology"},{"key":"1466_CR219","doi-asserted-by":"publisher","unstructured":"Newman CB, Preiss D, Tobert JA, et al. Statin safety and associated adverse events: a scientific statement from the American Heart Association [published correction appears in Arterioscler Thromb Vasc Biol. 2019 May;39(5):e158. https:\/\/doi.org\/10.1161\/ATV.0000000000000081].\u00a0Arterioscler Thromb Vasc Biol. 2019;39(2):e38\u201381. https:\/\/doi.org\/10.1161\/ATV.0000000000000073.","DOI":"10.1161\/ATV.0000000000000081 10.1161\/ATV.0000000000000073"},{"issue":"11","key":"1466_CR220","doi-asserted-by":"publisher","first-page":"721","DOI":"10.3390\/medicina55110721","volume":"55","author":"RN Horodinschi","year":"2019","unstructured":"Horodinschi RN, Stanescu AMA, Bratu OG, Pantea Stoian A, Radavoi DG, Diaconu CC. Treatment with statins in elderly patients. Medicina (Kaunas). 2019;55(11):721. https:\/\/doi.org\/10.3390\/medicina55110721. (Published 2019 Oct 30).","journal-title":"Medicina (Kaunas)"},{"issue":"39","key":"1466_CR221","doi-asserted-by":"publisher","first-page":"2999","DOI":"10.1093\/eurheartj\/ehw272","volume":"37","author":"AL Catapano","year":"2016","unstructured":"Catapano AL, Graham I, De Backer G, et al. 2016 ESC\/EAS guidelines for the management of dyslipidaemias. Eur Heart J. 2016;37(39):2999\u20133058. https:\/\/doi.org\/10.1093\/eurheartj\/ehw272.","journal-title":"Eur Heart J"},{"key":"1466_CR222","unstructured":"Iqbal AM, Lopez RA, Hai O. Antiplatelet Medications. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024.\u00a0Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK537062\/"},{"issue":"6","key":"1466_CR223","doi-asserted-by":"publisher","first-page":"2686","DOI":"10.1111\/bcp.15221","volume":"88","author":"G Passacquale","year":"2022","unstructured":"Passacquale G, Sharma P, Perera D, Ferro A. Antiplatelet therapy in cardiovascular disease: current status and future directions. Br J Clin Pharmacol. 2022;88(6):2686\u201399. https:\/\/doi.org\/10.1111\/bcp.15221.","journal-title":"Br J Clin Pharmacol"},{"issue":"7","key":"1466_CR224","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1212\/WNL.0000000000001844","volume":"85","author":"X Wang","year":"2015","unstructured":"Wang X, Zhao X, Johnston SC, et al. Effect of clopidogrel with aspirin on functional outcome in TIA or minor stroke: CHANCE substudy. Neurology. 2015;85(7):573\u20139. https:\/\/doi.org\/10.1212\/WNL.0000000000001844.","journal-title":"Neurology"},{"issue":"12","key":"1466_CR225","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0242466","volume":"15","author":"YS Wong","year":"2020","unstructured":"Wong YS, Tsai CF, Hsu YH, Ong CT. Efficacy of aspirin, clopidogrel, and ticlopidine in stroke prevention: a population-based case-cohort study in Taiwan. PLoS ONE. 2020;15(12): e0242466. https:\/\/doi.org\/10.1371\/journal.pone.0242466. (Published 2020 Dec 28).","journal-title":"PLoS ONE"},{"issue":"11","key":"1466_CR226","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1212\/WNL.0000000000000779","volume":"83","author":"AL Berkowitz","year":"2014","unstructured":"Berkowitz AL, Westover MB, Bianchi MT, Chou SH. Aspirin for secondary prevention after stroke of unknown etiology in resource-limited settings. Neurology. 2014;83(11):1004\u201311. https:\/\/doi.org\/10.1212\/WNL.0000000000000779.","journal-title":"Neurology"},{"key":"1466_CR227","doi-asserted-by":"publisher","unstructured":"Arnett DK, Blumenthal RS, Albert MA, et al. 2019 ACC\/AHA Guideline on the Primary Prevention of Cardiovascular Disease: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines [published correction appears in Circulation. 2019 Sep 10;140(11):e649-e650. https:\/\/doi.org\/10.1161\/CIR.0000000000000725] [published correction appears in Circulation. 2020 Jan 28;141(4):e60. https:\/\/doi.org\/10.1161\/CIR.0000000000000755] [published correction appears in Circulation. 2020 Apr 21;141(16):e774. https:\/\/doi.org\/10.1161\/CIR.0000000000000771].\u00a0Circulation. 2019;140(11):e596\u2013646. https:\/\/doi.org\/10.1161\/CIR.0000000000000678.","DOI":"10.1161\/CIR.0000000000000725 10.1161\/CIR.0000000000000755 10.1161\/CIR.0000000000000771 10.1161\/CIR.0000000000000678"},{"issue":"23","key":"1466_CR228","doi-asserted-by":"publisher","first-page":"2915","DOI":"10.1016\/j.jacc.2019.03.501","volume":"73","author":"HK Abdelaziz","year":"2019","unstructured":"Abdelaziz HK, Saad M, Pothineni NVK, et al. Aspirin for primary prevention of cardiovascular events. J Am Coll Cardiol. 2019;73(23):2915\u201329. https:\/\/doi.org\/10.1016\/j.jacc.2019.03.501.","journal-title":"J Am Coll Cardiol"},{"issue":"17","key":"1466_CR229","doi-asserted-by":"publisher","first-page":"6618","DOI":"10.18632\/aging.102255","volume":"11","author":"M Saad","year":"2019","unstructured":"Saad M, Abdelaziz HK, Mehta JL. Aspirin for primary prevention in the elderly. Aging (Albany NY). 2019;11(17):6618\u20139. https:\/\/doi.org\/10.18632\/aging.102255.","journal-title":"Aging (Albany NY)."},{"issue":"1","key":"1466_CR230","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1111\/jth.13177","volume":"14","author":"M Verdoia","year":"2016","unstructured":"Verdoia M, Pergolini P, Rolla R, et al. Advanced age and high-residual platelet reactivity in patients receiving dual antiplatelet therapy with clopidogrel or ticagrelor. J Thromb Haemost. 2016;14(1):57\u201364. https:\/\/doi.org\/10.1111\/jth.13177.","journal-title":"J Thromb Haemost"},{"issue":"4","key":"1466_CR231","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1016\/j.ahj.2014.06.026","volume":"168","author":"D Alexopoulos","year":"2014","unstructured":"Alexopoulos D, Xanthopoulou I, Storey RF, et al. Platelet reactivity during ticagrelor maintenance therapy: a patient-level data meta-analysis. Am Heart J. 2014;168(4):530\u20136. https:\/\/doi.org\/10.1016\/j.ahj.2014.06.026.","journal-title":"Am Heart J"},{"issue":"5","key":"1466_CR232","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1097\/MOH.0000000000000526","volume":"26","author":"E Montenont","year":"2019","unstructured":"Montenont E, Rondina MT, Campbell RA. Altered functions of platelets during aging. Curr Opin Hematol. 2019;26(5):336\u201342. https:\/\/doi.org\/10.1097\/MOH.0000000000000526.","journal-title":"Curr Opin Hematol"},{"issue":"31","key":"1466_CR233","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000016560","volume":"98","author":"A Ga\u017eov\u00e1","year":"2019","unstructured":"Ga\u017eov\u00e1 A, Leddy JJ, Rexov\u00e1 M, Hliv\u00e1k P, Hatala R, Kyselovi\u010d J. Predictive value of CHA2DS2-VASc scores regarding the risk of stroke and all-cause mortality in patients with atrial fibrillation (CONSORT compliant). Medicine (Baltimore). 2019;98(31): e16560. https:\/\/doi.org\/10.1097\/MD.0000000000016560.","journal-title":"Medicine (Baltimore)"},{"issue":"16","key":"1466_CR234","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.008764","volume":"7","author":"LR Jackson 2nd","year":"2018","unstructured":"Jackson LR 2nd, Kim S, Fonarow GC, et al. Stroke risk and treatment in patients with atrial fibrillation and low CHA2DS2-VASc scores: findings from the ORBIT-AF I and II registries. J Am Heart Assoc. 2018;7(16): e008764. https:\/\/doi.org\/10.1161\/JAHA.118.008764.","journal-title":"J Am Heart Assoc"},{"issue":"3","key":"1466_CR235","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002197","volume":"5","author":"SD Pokorney","year":"2016","unstructured":"Pokorney SD, Piccini JP, Stevens SR, et al. Cause of death and predictors of all-cause mortality in anticoagulated patients with nonvalvular atrial fibrillation: data from ROCKET AF. J Am Heart Assoc. 2016;5(3): e002197. https:\/\/doi.org\/10.1161\/JAHA.115.002197. (Published 2016 Mar 8).","journal-title":"J Am Heart Assoc"},{"key":"1466_CR236","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.ejim.2019.10.026","volume":"71","author":"M Bo","year":"2020","unstructured":"Bo M, Marchionni N. Practical use of Direct Oral Anti Coagulants (DOACs) in the older persons with atrial fibrillation. Eur J Intern Med. 2020;71:32\u20138. https:\/\/doi.org\/10.1016\/j.ejim.2019.10.026.","journal-title":"Eur J Intern Med"},{"key":"1466_CR237","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.684638","volume":"12","author":"R Roberti","year":"2021","unstructured":"Roberti R, Iannone LF, Palleria C, et al. Direct oral anticoagulants: from randomized clinical trials to real-world clinical practice. Front Pharmacol. 2021;12: 684638. https:\/\/doi.org\/10.3389\/fphar.2021.684638. (Published 2021 May 26).","journal-title":"Front Pharmacol"},{"issue":"5","key":"1466_CR238","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.003432","volume":"5","author":"ET Kato","year":"2016","unstructured":"Kato ET, Giugliano RP, Ruff CT, et al. Efficacy and safety of edoxaban in elderly patients with atrial fibrillation in the ENGAGE AF-TIMI 48 trial. J Am Heart Assoc. 2016;5(5): e003432. https:\/\/doi.org\/10.1161\/JAHA.116.003432. (Published 2016 May 20).","journal-title":"J Am Heart Assoc"},{"issue":"18","key":"1466_CR239","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1056\/NEJMoa2012883","volume":"383","author":"K Okumura","year":"2020","unstructured":"Okumura K, Akao M, Yoshida T, et al. Low-dose edoxaban in very elderly patients with atrial fibrillation. N Engl J Med. 2020;383(18):1735\u201345. https:\/\/doi.org\/10.1056\/NEJMoa2012883.","journal-title":"N Engl J Med"},{"issue":"3","key":"1466_CR240","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1161\/CIRCULATIONAHA.114.013267","volume":"132","author":"M Sharma","year":"2015","unstructured":"Sharma M, Cornelius VR, Patel JP, Davies JG, Molokhia M. Efficacy and harms of direct oral anticoagulants in the elderly for stroke prevention in atrial fibrillation and secondary prevention of venous thromboembolism: systematic review and meta-analysis. Circulation. 2015;132(3):194\u2013204. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.114.013267.","journal-title":"Circulation"},{"issue":"1","key":"1466_CR241","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1093\/ageing\/afx103","volume":"47","author":"Y Bai","year":"2018","unstructured":"Bai Y, Guo SD, Deng H, et al. Effectiveness and safety of oral anticoagulants in older patients with atrial fibrillation: a systematic review and meta-regression analysis. Age Ageing. 2018;47(1):9\u201317. https:\/\/doi.org\/10.1093\/ageing\/afx103.","journal-title":"Age Ageing"},{"key":"1466_CR242","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.thromres.2019.08.024","volume":"183","author":"D Poli","year":"2019","unstructured":"Poli D, Antonucci E, Bert\u00f9 L, et al. Very elderly patients with venous thromboembolism on oral anticoagulation with VKAs or DOACs: results from the prospective multicenter START2-Register Study. Thromb Res. 2019;183:28\u201332. https:\/\/doi.org\/10.1016\/j.thromres.2019.08.024.","journal-title":"Thromb Res"},{"key":"1466_CR243","doi-asserted-by":"publisher","first-page":"247","DOI":"10.2147\/CIA.S453527","volume":"19","author":"J Ding","year":"2024","unstructured":"Ding J, Sun Y, Zhang K, et al. Effects of anticoagulant therapy and frailty in the elderly patients with atrial fibrillation. Clin Interv Aging. 2024;19:247\u201354. https:\/\/doi.org\/10.2147\/CIA.S453527. (Published 2024 Feb 14).","journal-title":"Clin Interv Aging"},{"issue":"8","key":"1466_CR244","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afac192","volume":"51","author":"M Proietti","year":"2022","unstructured":"Proietti M, Romiti GF, Vitolo M, et al. Epidemiology and impact of frailty in patients with atrial fibrillation in Europe. Age Ageing. 2022;51(8): afac192. https:\/\/doi.org\/10.1093\/ageing\/afac192.","journal-title":"Age Ageing"},{"key":"1466_CR245","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.583311","volume":"11","author":"M Grymonprez","year":"2020","unstructured":"Grymonprez M, Steurbaut S, De Backer TL, Petrovic M, Lahousse L. Effectiveness and safety of oral anticoagulants in older patients with atrial fibrillation: a systematic review and meta-analysis. Front Pharmacol. 2020;11: 583311. https:\/\/doi.org\/10.3389\/fphar.2020.583311. (Published 2020 Sep 9).","journal-title":"Front Pharmacol"},{"key":"1466_CR246","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.archger.2017.05.014","volume":"72","author":"G Viscogliosi","year":"2017","unstructured":"Viscogliosi G, Ettorre E, Chiriac IM. Dementia correlates with anticoagulation underuse in older patients with atrial fibrillation. Arch Gerontol Geriatr. 2017;72:108\u201312. https:\/\/doi.org\/10.1016\/j.archger.2017.05.014.","journal-title":"Arch Gerontol Geriatr"},{"issue":"6","key":"1466_CR247","doi-asserted-by":"publisher","first-page":"1870","DOI":"10.4022\/jafib.1870","volume":"10","author":"Z Oqab","year":"2018","unstructured":"Oqab Z, Pournazari P, Sheldon RS. What is the impact of frailty on prescription of anticoagulation in elderly patients with atrial fibrillation? A systematic review and meta-analysis. J Atr Fibrill. 2018;10(6):1870. https:\/\/doi.org\/10.4022\/jafib.1870. (Published 2018 Apr 30).","journal-title":"J Atr Fibrill"},{"issue":"6","key":"1466_CR248","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.014108","volume":"9","author":"S Sanghai","year":"2020","unstructured":"Sanghai S, Wong C, Wang Z, et al. Rates of potentially inappropriate dosing of direct-acting oral anticoagulants and associations with geriatric conditions among older patients with atrial fibrillation: the SAGE-AF study. J Am Heart Assoc. 2020;9(6): e014108. https:\/\/doi.org\/10.1161\/JAHA.119.014108.","journal-title":"J Am Heart Assoc"},{"key":"1466_CR249","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.ahj.2019.01.005","volume":"211","author":"M Madhavan","year":"2019","unstructured":"Madhavan M, Holmes DN, Piccini JP, et al. Association of frailty and cognitive impairment with benefits of oral anticoagulation in patients with atrial fibrillation. Am Heart J. 2019;211:77\u201389. https:\/\/doi.org\/10.1016\/j.ahj.2019.01.005.","journal-title":"Am Heart J"},{"issue":"12","key":"1466_CR250","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.1016\/j.amjcard.2019.02.060","volume":"123","author":"AH Malik","year":"2019","unstructured":"Malik AH, Yandrapalli S, Aronow WS, Panza JA, Cooper HA. Meta-analysis of direct-acting oral anticoagulants compared with warfarin in patients >75 years of age. Am J Cardiol. 2019;123(12):2051\u20137. https:\/\/doi.org\/10.1016\/j.amjcard.2019.02.060.","journal-title":"Am J Cardiol"},{"key":"1466_CR251","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.470016","volume":"7","author":"PL Gross","year":"2021","unstructured":"Gross PL, Chan NC. Thromboembolism in older adults. Front Med (Lausanne). 2021;7: 470016. https:\/\/doi.org\/10.3389\/fmed.2020.470016. (Published 2021 Jan 27).","journal-title":"Front Med (Lausanne)"},{"issue":"10","key":"1466_CR252","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1177\/000313481408001014","volume":"80","author":"S Reddy","year":"2014","unstructured":"Reddy S, Sharma R, Grotts J, Ferrigno L, Kaminski S. Incidence of intracranial hemorrhage and outcomes after ground-level falls in geriatric trauma patients taking preinjury anticoagulants and antiplatelet agents. Am Surg. 2014;80(10):975\u20138.","journal-title":"Am Surg"},{"issue":"4","key":"1466_CR253","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1378\/chest.15-1719","volume":"149","author":"K Dahal","year":"2016","unstructured":"Dahal K, Kunwar S, Rijal J, Schulman P, Lee J. Stroke, major bleeding, and mortality outcomes in warfarin users with atrial fibrillation and chronic kidney disease: a meta-analysis of observational studies. Chest. 2016;149(4):951\u20139. https:\/\/doi.org\/10.1378\/chest.15-1719.","journal-title":"Chest"},{"issue":"3","key":"1466_CR254","doi-asserted-by":"publisher","first-page":"245","DOI":"10.2337\/ds18-0033","volume":"31","author":"E Leung","year":"2018","unstructured":"Leung E, Wongrakpanich S, Munshi MN. Diabetes management in the elderly. Diabetes Spectr. 2018;31(3):245\u201353. https:\/\/doi.org\/10.2337\/ds18-0033.","journal-title":"Diabetes Spectr"},{"issue":"5","key":"1466_CR255","first-page":"1","volume":"21","author":"N Ngcobo","year":"2024","unstructured":"Ngcobo N, Sibiya N. The role of high mobility group box-1 on the development of diabetes complications: a plausible pharmacological target. Diabetes Vasc Res. 2024;21(5):1\u201314.","journal-title":"Diabetes Vasc Res."},{"issue":"12","key":"1466_CR256","doi-asserted-by":"publisher","first-page":"1808","DOI":"10.1001\/jamainternmed.2017.6040","volume":"177","author":"JS Haw","year":"2017","unstructured":"Haw JS, Galaviz KI, Straus AN, et al. Long-term sustainability of diabetes prevention approaches: a systematic review and meta-analysis of randomized clinical trials. JAMA Intern Med. 2017;177(12):1808\u201317. https:\/\/doi.org\/10.1001\/jamainternmed.2017.6040.","journal-title":"JAMA Intern Med"},{"issue":"3","key":"1466_CR257","doi-asserted-by":"publisher","first-page":"236","DOI":"10.2337\/ds20-0018","volume":"33","author":"N Pandya","year":"2020","unstructured":"Pandya N, Hames E, Sandhu S. Challenges and strategies for managing diabetes in the elderly in long-term care settings. Diabetes Spectr. 2020;33(3):236\u201345. https:\/\/doi.org\/10.2337\/ds20-0018.","journal-title":"Diabetes Spectr"},{"key":"1466_CR258","doi-asserted-by":"publisher","first-page":"391","DOI":"10.2147\/DMSO.S48898","volume":"7","author":"L Kezerle","year":"2014","unstructured":"Kezerle L, Shalev L, Barski L. Treating the elderly diabetic patient: special considerations. Diabetes Metab Syndr Obes. 2014;7:391\u2013400. https:\/\/doi.org\/10.2147\/DMSO.S48898. (Published 2014 Aug 28).","journal-title":"Diabetes Metab Syndr Obes"},{"key":"1466_CR259","unstructured":"Hardin MD, Jacobs TF. Glyburide. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024 Jan-.\u00a0Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK545313\/"},{"key":"1466_CR260","unstructured":"Singh G, Can AS, Correa R. Pioglitazone. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024 Jan-.\u00a0Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK544287\/"},{"key":"1466_CR261","unstructured":"Quintanilla Rodriguez BS, Correa R. Rosiglitazone. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024.\u00a0Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK544230\/"},{"issue":"6","key":"1466_CR262","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.15648","volume":"13","author":"F Sahil","year":"2021","unstructured":"Sahil F, Kumar J, Raiz G, et al. Association between long-term use of non-steroidal anti-inflammatory drugs and hyperkalemia in diabetic patients. Cureus. 2021;13(6): e15648. https:\/\/doi.org\/10.7759\/cureus.15648. (Published 2021 Jun 14).","journal-title":"Cureus."},{"issue":"2","key":"1466_CR263","doi-asserted-by":"publisher","first-page":"131","DOI":"10.7861\/clinmed.2021-0039","volume":"21","author":"FWD Tai","year":"2021","unstructured":"Tai FWD, McAlindon ME. Non-steroidal anti-inflammatory drugs and the gastrointestinal tract. Clin Med (Lond). 2021;21(2):131\u20134. https:\/\/doi.org\/10.7861\/clinmed.2021-0039.","journal-title":"Clin Med (Lond)"},{"issue":"4","key":"1466_CR264","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1002\/cpt.794","volume":"102","author":"T Grosser","year":"2017","unstructured":"Grosser T, Theken KN, FitzGerald GA. Cyclooxygenase inhibition: pain, inflammation, and the cardiovascular system. Clin Pharmacol Ther. 2017;102(4):611\u201322. https:\/\/doi.org\/10.1002\/cpt.794.","journal-title":"Clin Pharmacol Ther"},{"issue":"17","key":"1466_CR265","doi-asserted-by":"publisher","first-page":"4262","DOI":"10.3390\/ijms20174262","volume":"20","author":"S Khan","year":"2019","unstructured":"Khan S, Andrews KL, Chin-Dusting JPF. Cyclo-oxygenase (COX) inhibitors and cardiovascular risk: Are non-steroidal anti-inflammatory drugs really anti-inflammatory? Int J Mol Sci. 2019;20(17):4262. https:\/\/doi.org\/10.3390\/ijms20174262. (Published 2019 Aug 30).","journal-title":"Int J Mol Sci"},{"issue":"1","key":"1466_CR266","doi-asserted-by":"publisher","first-page":"143","DOI":"10.14336\/AD.2017.0306","volume":"9","author":"S Wongrakpanich","year":"2018","unstructured":"Wongrakpanich S, Wongrakpanich A, Melhado K, Rangaswami J. A comprehensive review of non-steroidal anti-inflammatory drug use in the elderly. Aging Dis. 2018;9(1):143\u201350. https:\/\/doi.org\/10.14336\/AD.2017.0306.","journal-title":"Aging Dis"},{"key":"1466_CR267","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s12911-016-0277-4","volume":"16","author":"RJ Kate","year":"2016","unstructured":"Kate RJ, Perez RM, Mazumdar D, Pasupathy KS, Nilakantan V. Prediction and detection models for acute kidney injury in hospitalized older adults. BMC Med Inform Decis Mak. 2016;16:39. https:\/\/doi.org\/10.1186\/s12911-016-0277-4. (Published 2016 Mar 29).","journal-title":"BMC Med Inform Decis Mak"},{"key":"1466_CR268","unstructured":"Runde TJ, Nappe TM. Salicylates toxicity. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024.\u00a0Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK499879\/"},{"key":"1466_CR269","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bonr.2014.10.003","volume":"1","author":"CM Jankowski","year":"2015","unstructured":"Jankowski CM, Shea K, Barry DW, et al. Timing of ibuprofen use and musculoskeletal adaptations to exercise training in older adults. Bone Rep. 2015;1:1\u20138. https:\/\/doi.org\/10.1016\/j.bonr.2014.10.003.","journal-title":"Bone Rep."},{"issue":"1","key":"1466_CR270","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1093\/ageing\/afu141","volume":"44","author":"K Richardson","year":"2015","unstructured":"Richardson K, Bennett K, Kenny RA. Polypharmacy including falls risk-increasing medications and subsequent falls in community-dwelling middle-aged and older adults. Age Ageing. 2015;44(1):90\u20136. https:\/\/doi.org\/10.1093\/ageing\/afu141.","journal-title":"Age Ageing"},{"issue":"3","key":"1466_CR271","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1111\/ggi.12741","volume":"17","author":"A Zia","year":"2017","unstructured":"Zia A, Kamaruzzaman SB, Tan MP. The consumption of two or more fall risk-increasing drugs rather than polypharmacy is associated with falls. Geriatr Gerontol Int. 2017;17(3):463\u201370. https:\/\/doi.org\/10.1111\/ggi.12741.","journal-title":"Geriatr Gerontol Int"},{"issue":"2","key":"1466_CR272","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-041543","volume":"11","author":"K Ikuta","year":"2021","unstructured":"Ikuta K, Nakagawa S, Momo K, et al. Association of proton pump inhibitors and concomitant drugs with risk of acute kidney injury: a nested case-control study. BMJ Open. 2021;11(2): e041543. https:\/\/doi.org\/10.1136\/bmjopen-2020-041543. (Published 2021 Feb 15).","journal-title":"BMJ Open"},{"issue":"9","key":"1466_CR273","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1177\/2042098617715381","volume":"8","author":"ML Maes","year":"2017","unstructured":"Maes ML, Fixen DR, Linnebur SA. Adverse effects of proton-pump inhibitor use in older adults: a review of the evidence. Ther Adv Drug Saf. 2017;8(9):273\u201397. https:\/\/doi.org\/10.1177\/2042098617715381.","journal-title":"Ther Adv Drug Saf."},{"key":"1466_CR274","unstructured":"Pino MA, Azer SA. Cimetidine. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024.\u00a0Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK544255\/"},{"issue":"4","key":"1466_CR275","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1038\/ki.2014.74","volume":"86","author":"ML Blank","year":"2014","unstructured":"Blank ML, Parkin L, Paul C, Herbison P. A nationwide nested case-control study indicates an increased risk of acute interstitial nephritis with proton pump inhibitor use. Kidney Int. 2014;86(4):837\u201344. https:\/\/doi.org\/10.1038\/ki.2014.74.","journal-title":"Kidney Int"},{"issue":"2","key":"1466_CR276","doi-asserted-by":"publisher","first-page":"115","DOI":"10.4068\/cmj.2023.59.2.115","volume":"59","author":"NMP Maideen","year":"2023","unstructured":"Maideen NMP. Adverse effects associated with long-term use of proton pump inhibitors. Chonnam Med J. 2023;59(2):115\u201327. https:\/\/doi.org\/10.4068\/cmj.2023.59.2.115.","journal-title":"Chonnam Med J"},{"issue":"2","key":"1466_CR277","doi-asserted-by":"publisher","first-page":"E166","DOI":"10.9778\/cmajo.20140074","volume":"3","author":"T Antoniou","year":"2015","unstructured":"Antoniou T, Macdonald EM, Hollands S, et al. Proton pump inhibitors and the risk of acute kidney injury in older patients: a population-based cohort study. CMAJ Open. 2015;3(2):E166\u201371. https:\/\/doi.org\/10.9778\/cmajo.20140074. (Published 2015 Apr 2).","journal-title":"CMAJ Open"},{"issue":"8","key":"1466_CR278","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1007\/s40264-018-0663-1","volume":"41","author":"H Svanstr\u00f6m","year":"2018","unstructured":"Svanstr\u00f6m H, Lund M, Melbye M, Pasternak B. Use of proton pump inhibitors and the risk of acute kidney injury among patients with rheumatoid arthritis: cohort study. Drug Saf. 2018;41(8):817\u201326. https:\/\/doi.org\/10.1007\/s40264-018-0663-1.","journal-title":"Drug Saf"},{"issue":"10","key":"1466_CR279","doi-asserted-by":"publisher","first-page":"781","DOI":"10.2217\/cer-2019-0017","volume":"8","author":"SS Sutton","year":"2019","unstructured":"Sutton SS, Magagnoli J, Cummings TH, Hardin JW. Risk of acute kidney injury in patients with HIV receiving proton pump inhibitors. J Comp Eff Res. 2019;8(10):781\u201390. https:\/\/doi.org\/10.2217\/cer-2019-0017.","journal-title":"J Comp Eff Res."},{"key":"1466_CR280","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.2147\/DDDT.S130568","volume":"11","author":"Y Yang","year":"2017","unstructured":"Yang Y, George KC, Shang WF, Zeng R, Ge SW, Xu G. Proton-pump inhibitors use, and risk of acute kidney injury: a meta-analysis of observational studies. Drug Des Devel Ther. 2017;11:1291\u20139. https:\/\/doi.org\/10.2147\/DDDT.S130568. (Published 2017 Apr 24).","journal-title":"Drug Des Devel Ther."},{"issue":"1","key":"1466_CR281","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1007\/s00198-015-3365-x","volume":"27","author":"B Zhou","year":"2016","unstructured":"Zhou B, Huang Y, Li H, Sun W, Liu J. Proton-pump inhibitors and risk of fractures: an update meta-analysis. Osteoporos Int. 2016;27(1):339\u201347. https:\/\/doi.org\/10.1007\/s00198-015-3365-x.","journal-title":"Osteoporos Int"},{"issue":"6","key":"1466_CR282","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1007\/s00223-014-9855-6","volume":"94","author":"J Ding","year":"2014","unstructured":"Ding J, Heller DA, Ahern FM, Brown TV. The relationship between proton pump inhibitor adherence and fracture risk in the elderly. Calcif Tissue Int. 2014;94(6):597\u2013607. https:\/\/doi.org\/10.1007\/s00223-014-9855-6.","journal-title":"Calcif Tissue Int"},{"issue":"11","key":"1466_CR283","doi-asserted-by":"publisher","first-page":"2489","DOI":"10.1002\/jbmr.2279","volume":"29","author":"JR Lewis","year":"2014","unstructured":"Lewis JR, Barre D, Zhu K, et al. Long-term proton pump inhibitor therapy and falls and fractures in elderly women: a prospective cohort study. J Bone Miner Res. 2014;29(11):2489\u201397. https:\/\/doi.org\/10.1002\/jbmr.2279.","journal-title":"J Bone Miner Res"},{"issue":"5","key":"1466_CR284","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1001\/jamainternmed.2015.42","volume":"175","author":"EG McDonald","year":"2015","unstructured":"McDonald EG, Milligan J, Frenette C, Lee TC. Continuous proton pump inhibitor therapy and the associated risk of recurrent clostridium difficile infection. JAMA Intern Med. 2015;175(5):784\u201391. https:\/\/doi.org\/10.1001\/jamainternmed.2015.42.","journal-title":"JAMA Intern Med"},{"key":"1466_CR285","doi-asserted-by":"publisher","unstructured":"Lee HJ, Lee H, Oh SH, et al. Chronic kidney disease (CKD) patients are exposed to more proton pump inhibitor (PPI)s compared to non-CKD patients [published correction appears in PLoS One. 2018 Nov 12;13(11):e0207561. https:\/\/doi.org\/10.1371\/journal.pone.0207561]. PLoS One. 2018;13(9):e0203878. https:\/\/doi.org\/10.1371\/journal.pone.0203878 (Published 2018 Sep 13).","DOI":"10.1371\/journal.pone.0207561 10.1371\/journal.pone.0203878"},{"issue":"11","key":"1466_CR286","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.1016\/j.ekir.2023.08.031","volume":"8","author":"RE Campbell","year":"2023","unstructured":"Campbell RE, Chen CH, Edelstein CL. Overview of antibiotic-induced nephrotoxicity. Kidney Int Rep. 2023;8(11):2211\u201325. https:\/\/doi.org\/10.1016\/j.ekir.2023.08.031. (Published 2023 Aug 25).","journal-title":"Kidney Int Rep."},{"issue":"9","key":"1466_CR287","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1503\/cmaj.150067","volume":"187","author":"N Singh","year":"2015","unstructured":"Singh N, Gandhi S, McArthur E, et al. Kidney function and the use of nitrofurantoin to treat urinary tract infections in older women. CMAJ. 2015;187(9):648\u201356. https:\/\/doi.org\/10.1503\/cmaj.150067.","journal-title":"CMAJ"},{"key":"1466_CR288","doi-asserted-by":"publisher","first-page":"1148603","DOI":"10.3389\/fcimb.2023.1148603","volume":"13","author":"M Mahdizade Ari","year":"2023","unstructured":"Mahdizade Ari M, Dashtbin S, Ghasemi F, et al. Nitrofurantoin: properties and potential in treatment of urinary tract infection: a narrative review. Front Cell Infect Microbiol. 2023;13:1148603. https:\/\/doi.org\/10.3389\/fcimb.2023.1148603. (Published 2023 Jul 27).","journal-title":"Front Cell Infect Microbiol"},{"key":"1466_CR289","unstructured":"Squadrito FJ, del Portal D. Nitrofurantoin. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024.\u00a0Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK470526\/"},{"issue":"7","key":"1466_CR290","doi-asserted-by":"publisher","first-page":"381","DOI":"10.4140\/TCP.n.2016.381","volume":"31","author":"P Hoang","year":"2016","unstructured":"Hoang P, Salbu RL. Updated nitrofurantoin recommendations in the elderly: a closer look at the evidence. Consult Pharm. 2016;31(7):381\u20134. https:\/\/doi.org\/10.4140\/TCP.n.2016.381.","journal-title":"Consult Pharm"},{"key":"1466_CR291","doi-asserted-by":"publisher","unstructured":"By the American Geriatrics Society 2015 Beers Criteria Update Expert Panel. American Geriatrics Society 2015 Updated Beers Criteria for Potentially Inappropriate Medication Use in Older Adults. J Am Geriatr Soc. 2015;63(11):2227\u201346. https:\/\/doi.org\/10.1111\/jgs.13702","DOI":"10.1111\/jgs.13702"},{"key":"1466_CR292","unstructured":"Chao YS, Farrah K. Fluoroquinolones for the treatment of urinary tract infection: a review of clinical effectiveness, cost-effectiveness, and guidelines. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2019.\u00a0Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK543513\/"},{"issue":"sup1","key":"1466_CR293","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1080\/1120009X.2017.1380357","volume":"29","author":"A Novelli","year":"2017","unstructured":"Novelli A, Rosi E. Pharmacological properties of oral antibiotics for the treatment of uncomplicated urinary tract infections. J Chemother. 2017;29(sup1):10\u20138. https:\/\/doi.org\/10.1080\/1120009X.2017.1380357.","journal-title":"J Chemother"},{"issue":"13","key":"1466_CR294","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1001\/jama.2017.13883","volume":"318","author":"SH Chang","year":"2017","unstructured":"Chang SH, Chou IJ, Yeh YH, et al. Association between use of non-vitamin K oral anticoagulants with and without concurrent medications and risk of major bleeding in nonvalvular atrial fibrillation. JAMA. 2017;318(13):1250\u20139. https:\/\/doi.org\/10.1001\/jama.2017.13883.","journal-title":"JAMA"},{"key":"1466_CR295","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1007\/s40266-023-01019-3","volume":"40","author":"L Soraci","year":"2023","unstructured":"Soraci L, Cherubini A, Paoletti L, et al. Safety and tolerability of antimicrobial agents in the older patient. Drugs Aging. 2023;40:499\u2013526. https:\/\/doi.org\/10.1007\/s40266-023-01019-3.","journal-title":"Drugs Aging"},{"issue":"7","key":"1466_CR296","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1055\/s-0034-1381233","volume":"40","author":"G Lippi","year":"2014","unstructured":"Lippi G, Favaloro EJ, Mattiuzzi C. Combined administration of antibiotics and direct oral anticoagulants: a renewed indication for laboratory monitoring? Semin Thromb Hemost. 2014;40(7):756\u201365. https:\/\/doi.org\/10.1055\/s-0034-1381233.","journal-title":"Semin Thromb Hemost"}],"updated-by":[{"DOI":"10.1007\/s40262-025-01494-4","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T00:00:00Z","timestamp":1741996800000}}],"container-title":["Clinical Pharmacokinetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40262-024-01466-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40262-024-01466-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40262-024-01466-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T11:40:22Z","timestamp":1742038822000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40262-024-01466-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,11]]},"references-count":296,"alternative-id":["1466"],"URL":"https:\/\/doi.org\/10.1007\/s40262-024-01466-0","relation":{},"ISSN":["0312-5963","1179-1926"],"issn-type":[{"value":"0312-5963","type":"print"},{"value":"1179-1926","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,11]]},"assertion":[{"value":"23 November 2024","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 March 2025","order":3,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":4,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original online version of this article was revised to correct a cross reference in a sentence.","order":5,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 March 2025","order":6,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":7,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s40262-025-01494-4","URL":"https:\/\/doi.org\/10.1007\/s40262-025-01494-4","order":9,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Open access funding provided by University of KwaZulu-Natal.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"The authors declare no conflicts of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"NN contributed to the design, data collection, analysis of the results and to the writing of the manuscript. The author(s) approved final version to be reviewed and possibly published.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Authors' Contributions"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data Availability Statement"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code Availability"}},{"value":"Not applicable.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":9,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}]}}