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The research work is based on the data of the project Labeling of Enalapril from Neonates up to Adolescents (LENA), which was funded by a European Union Seventh Framework Program (FP7\/2007-2013) under the grant agreement no. 602295. The open access fee was funded by the Heinrich Heine University D\u00fcsseldorf.","order":1,"name":"Ethics","label":"Funding","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflicts of interest.","order":2,"name":"Ethics","label":"Conflicts of Interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The analysed datasets from the LENA project are not publicly available due to the data protection contract of the product owner.","order":3,"name":"Ethics","label":"Availability of Data and Material:","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocols responding to specific national requirements were submitted to the responsible Independent Ethics Committees (IECs) in the participating countries for review and received approval. The address from the Ethics Committee of the coordinating principal investigator\u2019s IEC of Study EudraCT 2015-002335-17 (DCM patients) was: Secretariaat Medisch Ethische Toetsings Commissie Erasmus MC, Postbus 2040, 3000 CA Rotterdam, the Netherlands, NL, dossiers: 4 December 2015, nos. NL54914.078.15, NL54738.078.15, MEC-2015-634 and MEC-2015-635; Ethics Committee UMC Utrecht, NL: 17 February 2016 nos. Mvd\/vb\/16\/004864, Mvd\/vb\/16\/004964; Medical Research Council, Ethics Committee for Clinical Pharmacology, National Institute of Pharmacy and Nutrition, Budapest, 30 November 2015, nos. OGYI\/36681-7\/2015 and OGYI\/36999-9\/2015; Ethikkommission Medizinische Universit\u00e4t Wien: 21 December 2015 no.1803\/2015. The address of the coordinating principal investigator\u2019s IEC of study EudraCT 2015-002396-18 (CHD patients) was: Ethics Committee of the University Children\u2019s Hospital in Belgrade and the Institute of Mother and Child Health \u2018Dr Vukan \u010cupi\u0107\u2019 Univerzitetska De\u010dja Klinika, Tirsova 10, 11129 Belgrade, Serbia. 29 February 2016 and 5 April 2017, nos. 26\/307 and 8\/9; Ethikkommisison der \u00c4rztekammer Hamburg, Germany, 22 May 2017, PVN9495 and PVN5496. The studies were conducted in accordance with the Declaration of Helsinki.","order":4,"name":"Ethics","label":"Ethics Approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Informed parental consent was obtained for each subject included in the studies. Assent of participating children was obtained in accordance with national requirements.","order":5,"name":"Ethics","label":"Consent to Participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":6,"name":"Ethics","label":"Consent for Publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":7,"name":"Ethics","label":"Code Availability","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Conception and design of the work were developed by M.S., C.W. and S.L. Data preparation was performed by M.S. M.S. performed the population pharmacokinetic analysis and simulations. W.C. and S.L. critically reviewed and discussed the analysis and simulations. M.S. drafted the manuscript. W.C. and S.L. critically reviewed and revised the manuscript. All authors read and approved the final manuscript.","order":8,"name":"Ethics","label":"Author Contributions","group":{"name":"EthicsHeading","label":"Declarations"}}]}}