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Dirk Jan Moes was not involved in the selection of peer reviewers for the manuscript nor any of the subsequent editorial decisions. Jasper Kamp, Armin Gelinck, Maryam Lyousoufi, Soufian Meziyerh, Siebe Spijker, Volkert Huurman, Paul van der Boog and Aiko de Vries declare that they have no conflict of interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Data are available from the corresponding author upon reasonable request. All the model codes have been provided in supplementary materials.","order":2,"name":"Ethics","label":"Availability of data and material","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The R code required to run the simulations and analyses is available upon request from the corresponding authors.","order":3,"name":"Ethics","label":"Code availability","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was conducted in accordance with Good Clinical Practice guidelines and the Declaration of Helsinki. The protocol was approved by the Institutional Review Board (IRB), Medical Ethics Review Committee Leiden\/Den Haag\/Delft (date of approval: June 6, 2020, approval number: W2020.031).","order":4,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"A waiver was granted by the IRB for the requirement for informed consent, because obtaining consent was not practically feasible given the large number of patients and the likelihood that some patients were deceased. All data were handled in accordance with institutional policies to protect patient confidentiality and were analyzed in de-identified form.","order":5,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":6,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Conception and design: Dirk Jan Moes , Aiko de Vries. Acquisition of data: Maryam. Lyousoufi, Soufian Meziyerh. Analysis and interpretation of data: Jasper Kamp, Armin Gelinck. Writing, review and\/or revision of the document: All authors. Final approval of manuscript: All authors.","order":7,"name":"Ethics","label":"Author contributions","group":{"name":"EthicsHeading","label":"Declarations"}}]}}