{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:21:59Z","timestamp":1791267719997,"version":"4.1.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"S1","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Drugs"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1007\/s40263-012-0031-0","type":"journal-article","created":{"date-parts":[[2013,5,24]],"date-time":"2013-05-24T11:11:09Z","timestamp":1369393869000},"page":"29-37","source":"Crossref","is-referenced-by-count":42,"title":["Atypical Antipsychotic Augmentation Strategies in the Context of Guideline-based Care for the Treatment of Major Depressive Disorder"],"prefix":"10.1007","volume":"27","author":[{"given":"Ashwin A.","family":"Patkar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Un","family":"Pae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,5,25]]},"reference":[{"issue":"23","key":"31_CR1","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1001\/jama.289.23.3095","volume":"289","author":"RC Kessler","year":"2003","unstructured":"Kessler RC, Berglund P, Demler O, Jin R, Koretz D, Merikangas KR, et al. The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). JAMA. 2003;289(23):3095\u2013105.","journal-title":"JAMA"},{"issue":"7182","key":"31_CR2","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1136\/bmj.318.7182.527","volume":"318","author":"SH Woolf","year":"1999","unstructured":"Woolf SH, Grol R, Hutchinson A, Eccles M, Grimshaw J. Clinical guidelines: potential benefits, limitations, and harms of clinical guidelines. BMJ. 1999;318(7182):527\u201330.","journal-title":"BMJ"},{"issue":"12","key":"31_CR3","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1001\/archpsyc.55.12.1121","volume":"55","author":"HC Schulberg","year":"1998","unstructured":"Schulberg HC, Katon W, Simon GE, Rush AJ. Treating major depression in primary care practice: an update of the Agency for Health Care Policy and Research Practice Guidelines. Arch Gen Psychiatry. 1998;55(12):1121\u20137.","journal-title":"Arch Gen Psychiatry"},{"issue":"5","key":"31_CR4","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.jclinepi.2009.03.009","volume":"63","author":"DK Owens","year":"2010","unstructured":"Owens DK, Lohr KN, Atkins D, Treadwell JR, Reston JT, Bass EB, et al. AHRQ series paper 5: grading the strength of a body of evidence when comparing medical interventions\u2014agency for healthcare research and quality and the effective health-care program. J Clin Epidemiol. 2010;63(5):513\u201323.","journal-title":"J Clin Epidemiol"},{"issue":"9","key":"31_CR5","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1176\/appi.ajp.2009.09030312","volume":"166","author":"JC Nelson","year":"2009","unstructured":"Nelson JC, Papakostas GI. Atypical antipsychotic augmentation in major depressive disorder: a meta-analysis of placebo-controlled randomized trials. Am J Psychiatry. 2009;166(9):980\u201391.","journal-title":"Am J Psychiatry"},{"issue":"4 Suppl.","key":"31_CR6","first-page":"1","volume":"157","author":"American Psychiatric Association","year":"2000","unstructured":"American Psychiatric Association. Practice guideline for the treatment of patients with major depressive disorder (revision). Am J Psychiatry. 2000;157(4 Suppl.):1\u201345.","journal-title":"Am J Psychiatry"},{"key":"31_CR7","unstructured":"American Psychiatric Association. Practice guideline for the treatment of patients with major depressive disorder (revision 3rd edition), 2010. http:\/\/www.psychiatryonline.com\/pracGuide\/pracGuideChapToc_7 ."},{"issue":"Suppl. 1","key":"31_CR8","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.jad.2009.06.043","volume":"117","author":"SH Kennedy","year":"2009","unstructured":"Kennedy SH, Lam RW, Parikh SV, Patten SB, Ravindran AV. Canadian Network for Mood and Anxiety Treatments (CANMAT) clinical guidelines for the management of major depressive disorder in adults.Introduction. J Affect Disord. 2009;117(Suppl. 1):S1\u20132.","journal-title":"J Affect Disord"},{"key":"31_CR9","unstructured":"National Institute for Health and Clinical Excellence. Depression: the treatment and management of depression in adults. 2009."},{"issue":"4","key":"31_CR10","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1177\/0269881107088441","volume":"22","author":"IM Anderson","year":"2008","unstructured":"Anderson IM, Ferrier IN, Baldwin RC, Cowen PJ, Howard L, Lewis G, et al. Evidence-based guidelines for treating depressive disorders with antidepressants: a revision of the 2000 British Association for Psychopharmacology guidelines. J Psychopharmacol. 2008;22(4):343\u201396.","journal-title":"J Psychopharmacol"},{"key":"31_CR11","unstructured":"Trangle MDB, Gabert T, Haight B, Lindvall B, Mitchell J, Novak H, Rich D, Rossmiller D, Setterlund L, Somers K. Institute for Clinical Systems Improvement. Major Depression in Adults in Primary Care. 2010. Accessed Sep 2012."},{"key":"31_CR12","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1600-0447.2009.01382.x","volume":"439","author":"GS Malhi","year":"2009","unstructured":"Malhi GS, Adams D, Porter R, Wignall A, Lampe L, O\u2019Connor N, et al. Clinical practice recommendations for depression. Acta Psychiatrica Scandinavica Supplementum. 2009;439:8\u201326.","journal-title":"Acta Psychiatrica Scandinavica Supplementum"},{"issue":"Suppl. E1","key":"31_CR13","first-page":"e08","volume":"71","author":"DJ Nutt","year":"2010","unstructured":"Nutt DJ, Davidson JR, Gelenberg AJ, Higuchi T, Kanba S, Karamustafalioglu O, et al. International consensus statement on major depressive disorder. J Clin Psychiatry. 2010;71(Suppl. E1):e08.","journal-title":"J Clin Psychiatry"},{"issue":"40","key":"31_CR14","first-page":"700","volume":"107","author":"M Harter","year":"2010","unstructured":"Harter M, Klesse C, Bermejo I, Schneider F, Berger M. Unipolar depression: diagnostic and therapeutic recommendations from the current S3\/National Clinical Practice Guideline. Dtsch Arzteblatt Int. 2010;107(40):700\u20138.","journal-title":"Dtsch Arzteblatt Int"},{"issue":"2","key":"31_CR15","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1080\/15622970701227829","volume":"8","author":"M Bauer","year":"2007","unstructured":"Bauer M, Bschor T, Pfennig A, Whybrow PC, Angst J, Versiani M, et al. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of unipolar depressive disorders in primary care. World J Biol Psychiatry Off J World Fed Soc Biol Psychiatry. 2007;8(2):67\u2013104.","journal-title":"World J Biol Psychiatry Off J World Fed Soc Biol Psychiatry"},{"key":"31_CR16","volume-title":"Practice guideline for the treatment of patients with major depressive disorder","author":"American Psychiatric Association","year":"2010","unstructured":"American Psychiatric Association. Practice guideline for the treatment of patients with major depressive disorder. 3rd ed. Washington, DC: American Psychiatric Publishing; 2010.","edition":"3"},{"issue":"1","key":"31_CR17","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1136\/ebm.15.1.19","volume":"15","author":"GI Keitner","year":"2010","unstructured":"Keitner GI. Adding atypical antipsychotics to antidepressants increases response in treatment-resistant major depression but increases discontinuation as a result of adverse events. Evid Based Med. 2010;15(1):19\u201320.","journal-title":"Evid Based Med"},{"issue":"2","key":"31_CR18","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0006-3223(01)01262-8","volume":"51","author":"LL Carpenter","year":"2002","unstructured":"Carpenter LL, Yasmin S, Price LH. A double-blind, placebo-controlled study of antidepressant augmentation with mirtazapine. Biol Psychiatry. 2002;51(2):183\u20138.","journal-title":"Biol Psychiatry"},{"issue":"3","key":"31_CR19","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1176\/appi.ajp.2009.09020186","volume":"167","author":"P Blier","year":"2010","unstructured":"Blier P, Ward HE, Tremblay P, Laberge L, Hebert C, Bergeron R. Combination of antidepressant medications from treatment initiation for major depressive disorder: a double-blind randomized study. Am J Psychiatry. 2010;167(3):281\u20138.","journal-title":"Am J Psychiatry"},{"issue":"Suppl. 1","key":"31_CR20","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1016\/j.jad.2009.06.041","volume":"117","author":"RW Lam","year":"2009","unstructured":"Lam RW, Kennedy SH, Grigoriadis S, McIntyre RS, Milev R, Ramasubbu R, et al. Canadian Network for Mood and Anxiety Treatments (CANMAT) clinical guidelines for the management of major depressive disorder in adults. III. Pharmacotherapy. J Affect Disord. 2009;117(Suppl. 1):S26\u201343.","journal-title":"J Affect Disord"},{"issue":"Suppl. 1","key":"31_CR21","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1016\/j.jad.2009.06.042","volume":"117","author":"SV Parikh","year":"2009","unstructured":"Parikh SV, Segal ZV, Grigoriadis S, Ravindran AV, Kennedy SH, Lam RW, et al. Canadian Network for Mood and Anxiety Treatments (CANMAT) clinical guidelines for the management of major depressive disorder in adults. II. Psychotherapy alone or in combination with antidepressant medication. J Affect Disord. 2009;117(Suppl. 1):S15\u201325.","journal-title":"J Affect Disord"},{"issue":"6","key":"31_CR22","doi-asserted-by":"crossref","first-page":"440","DOI":"10.4088\/PCC.v10n0603","volume":"10","author":"ME Thase","year":"2008","unstructured":"Thase ME, Trivedi MH, Nelson JC, Fava M, Swanink R, Tran QV, et al. Examining the efficacy of adjunctive aripiprazole in major depressive disorder: a pooled analysis of 2 studies. Prim Care Companion J Clin Psychiatry. 2008;10(6):440\u20137.","journal-title":"Prim Care Companion J Clin Psychiatry"},{"issue":"7","key":"31_CR23","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1017\/S1461145710000015","volume":"13","author":"N El-Khalili","year":"2010","unstructured":"El-Khalili N, Joyce M, Atkinson S, Buynak RJ, Datto C, Lindgren P, et al. Extended-release quetiapine fumarate (quetiapine XR) as adjunctive therapy in major depressive disorder (MDD) in patients with an inadequate response to ongoing antidepressant treatment: a multicentre, randomized, double-blind, placebo-controlled study. Int J Neuropsychopharmacol. 2010;13(7):917\u201332.","journal-title":"Int J Neuropsychopharmacol"},{"issue":"1\u20133","key":"31_CR24","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jad.2010.08.032","volume":"127","author":"M Bauer","year":"2010","unstructured":"Bauer M, El-Khalili N, Datto C, Szamosi J, Eriksson H. A pooled analysis of two randomised, placebo-controlled studies of extended release quetiapine fumarate adjunctive to antidepressant therapy in patients with major depressive disorder. J Affect Disord. 2010;127(1\u20133):19\u201330.","journal-title":"J Affect Disord"},{"issue":"12 Suppl. 22","key":"31_CR25","first-page":"10","volume":"12","author":"GI Papakostas","year":"2007","unstructured":"Papakostas GI. Augmentation strategies in the treatment of major depressive disorder. Examining the evidence on augmentation with atypical antipsychotics. CNS Spectr. 2007;12(12 Suppl. 22):10\u20132.","journal-title":"CNS Spectr"},{"issue":"6","key":"31_CR26","doi-asserted-by":"crossref","first-page":"826","DOI":"10.4088\/JCP.v68n0602","volume":"68","author":"GI Papakostas","year":"2007","unstructured":"Papakostas GI, Shelton RC, Smith J, Fava M. Augmentation of antidepressants with atypical antipsychotic medications for treatment-resistant major depressive disorder: a meta-analysis. J Clin Psychiatry. 2007;68(6):826\u201331.","journal-title":"J Clin Psychiatry"},{"issue":"Suppl. E1","key":"31_CR27","first-page":"e07","volume":"71","author":"O Karamustafalioglu","year":"2010","unstructured":"Karamustafalioglu O. Major depressive disorder, mental health care, and the use of guidelines in the Middle East. J Clin Psychiatry. 2010;71(Suppl. E1):e07.","journal-title":"J Clin Psychiatry"},{"issue":"Suppl. E1","key":"31_CR28","first-page":"e04","volume":"71","author":"JR Davidson","year":"2010","unstructured":"Davidson JR. Major depressive disorder treatment guidelines in America and Europe. J Clin Psychiatry. 2010;71(Suppl. E1):e04.","journal-title":"J Clin Psychiatry"},{"issue":"Suppl. E1","key":"31_CR29","first-page":"e05","volume":"71","author":"T Higuchi","year":"2010","unstructured":"Higuchi T. Major depressive disorder treatment guidelines in Japan. J Clin Psychiatry. 2010;71(Suppl. E1):e05.","journal-title":"J Clin Psychiatry"},{"issue":"Suppl. E1","key":"31_CR30","first-page":"e06","volume":"71","author":"M Zhang","year":"2010","unstructured":"Zhang M. Major depressive disorder treatment guidelines in China. J Clin Psychiatry. 2010;71(Suppl. E1):e06.","journal-title":"J Clin Psychiatry"},{"issue":"7","key":"31_CR31","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1001\/archpsyc.61.7.669","volume":"61","author":"MH Trivedi","year":"2004","unstructured":"Trivedi MH, Rush AJ, Crismon ML, Kashner TM, Toprac MG, Carmody TJ, et al. Clinical results for patients with major depressive disorder in the Texas Medication Algorithm Project. Arch Gen Psychiatry. 2004;61(7):669\u201380.","journal-title":"Arch Gen Psychiatry"},{"key":"31_CR32","unstructured":"Suehs BTAT, Bendele SD, Crismon ML, Trivedi MH, Kurian B. Texas Medication Algorithm Project procedural manual: Major depressive disorder algorithms. Austin, TX: Texas Department of State Health Services; 2008. http:\/\/www.dshs.state.tx.us\/mhprograms\/disclaimer.shtm . Accessed 20 Aug 2012."},{"issue":"5","key":"31_CR33","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1111\/j.1440-1819.2009.02009.x","volume":"63","author":"A Yoshino","year":"2009","unstructured":"Yoshino A, Sawamura T, Kobayashi N, Kurauchi S, Matsumoto A, Nomura S. Algorithm-guided treatment versus treatment as usual for major depression. Psychiatry Clin Neurosci. 2009;63(5):652\u20137.","journal-title":"Psychiatry Clin Neurosci"},{"issue":"12","key":"31_CR34","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1001\/archpsyc.56.12.1109","volume":"56","author":"W Katon","year":"1999","unstructured":"Katon W, Von Korff M, Lin E, Simon G, Walker E, Unutzer J, et al. Stepped collaborative care for primary care patients with persistent symptoms of depression: a randomized trial. Arch Gen Psychiatry. 1999;56(12):1109\u201315.","journal-title":"Arch Gen Psychiatry"},{"issue":"22","key":"31_CR35","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1001\/jama.288.22.2836","volume":"288","author":"J Unutzer","year":"2002","unstructured":"Unutzer J, Katon W, Callahan CM, Williams JW Jr, Hunkeler E, Harpole L, et al. Collaborative care management of late-life depression in the primary care setting: a randomized controlled trial. JAMA. 2002;288(22):2836\u201345.","journal-title":"JAMA"},{"issue":"1","key":"31_CR36","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1001\/archgenpsychiatry.2009.168","volume":"67","author":"HM Gonzalez","year":"2010","unstructured":"Gonzalez HM, Vega WA, Williams DR, Tarraf W, West BT, Neighbors HW. Depression care in the United States: too little for too few. Arch Gen Psychiatry. 2010;67(1):37\u201346.","journal-title":"Arch Gen Psychiatry"},{"issue":"8 Suppl. 2","key":"31_CR37","first-page":"II46","volume":"39","author":"R Grol","year":"2001","unstructured":"Grol R. Successes and failures in the implementation of evidence-based guidelines for clinical practice. Med Care. 2001;39(8 Suppl. 2):II46\u201354.","journal-title":"Med Care"}],"container-title":["CNS Drugs"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40263-012-0031-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40263-012-0031-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40263-012-0031-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,2]],"date-time":"2019-06-02T19:41:15Z","timestamp":1559504475000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40263-012-0031-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":37,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["31"],"URL":"https:\/\/doi.org\/10.1007\/s40263-012-0031-0","relation":{},"ISSN":["1172-7047","1179-1934"],"issn-type":[{"value":"1172-7047","type":"print"},{"value":"1179-1934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5]]}}}