{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T17:03:23Z","timestamp":1786554203316,"version":"build-2736575974"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2014,2,15]],"date-time":"2014-02-15T00:00:00Z","timestamp":1392422400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.5"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CNS Drugs"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1007\/s40263-014-0141-y","type":"journal-article","created":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T11:39:14Z","timestamp":1392637154000},"page":"217-228","source":"Crossref","is-referenced-by-count":25,"title":["Transdermal Therapy for Attention-Deficit Hyperactivity Disorder with the Methylphenidate Patch (MTS)"],"prefix":"10.1007","volume":"28","author":[{"given":"Robert L.","family":"Findling","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Dinh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,2,15]]},"reference":[{"issue":"2","key":"141_CR1","doi-asserted-by":"crossref","first-page":"116","DOI":"10.2146\/ajhp110158","volume":"69","author":"C Durand","year":"2012","unstructured":"Durand C, Alhammad A, Willett KC. Practical considerations for transdermal drug delivery. Am J Health Syst Pharm. 2012;69(2):116\u201324.","journal-title":"Am J Health Syst Pharm"},{"key":"141_CR2","unstructured":"Neupro [package insert]. Smyrna (GA): UCB, Inc; 2012."},{"key":"141_CR3","unstructured":"Catapres-TTS [package insert]. Ridgefield (CT): Boehringer Ingelheim International GmBH; 2012."},{"key":"141_CR4","unstructured":"Daytrana [package insert]. Miami (FL): Noven Pharmaceuticals, Inc; 2010."},{"issue":"5","key":"141_CR5","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1097\/JCP.0b013e3181f0c2f6","volume":"30","author":"D Pierce","year":"2010","unstructured":"Pierce D, Katic A, Buckwalter M, et al. Single- and multiple-dose pharmacokinetics of methylphenidate administered as methylphenidate transdermal system or osmotic-release oral system methylphenidate to children and adolescents with attention deficit hyperactivity disorder. J Clin Psychopharmacol. 2010;30(5):554\u201364.","journal-title":"J Clin Psychopharmacol"},{"issue":"10","key":"141_CR6","doi-asserted-by":"crossref","first-page":"849","DOI":"10.3109\/09513590.2010.538095","volume":"27","author":"AJ Jakimiuk","year":"2011","unstructured":"Jakimiuk AJ, Crosignani PG, Chernev T, et al. High levels of women\u2019s satisfaction and compliance with transdermal contraception: results from a European multinational, 6-month study. Gynecol Endocrinol. 2011;27(10):849\u201356.","journal-title":"Gynecol Endocrinol"},{"issue":"1","key":"141_CR7","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1586\/ern.11.178","volume":"12","author":"JL Molinuevo","year":"2012","unstructured":"Molinuevo JL, Arranz FJ. Impact of transdermal drug delivery on treatment adherence in patients with Alzheimer\u2019s disease. Expert Rev Neurother. 2012;12(1):31\u20137.","journal-title":"Expert Rev Neurother"},{"key":"141_CR8","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1100\/tsw.2004.107","volume":"4","author":"S Logsdon","year":"2004","unstructured":"Logsdon S, Richards J, Omar HA. Long-term evaluation of the use of the transdermal contraceptive patch in adolescents. Sci World J. 2004;4:512\u20136.","journal-title":"Sci World J"},{"issue":"2","key":"141_CR9","doi-asserted-by":"crossref","first-page":"219","DOI":"10.2332\/allergolint.11-RA-0358","volume":"61","author":"G Tamura","year":"2012","unstructured":"Tamura G, Ichinose M, Fukuchi Y, et al. Transdermal tulobuterol patch, a long-acting \u03b2(2)-agonist. Allergol Int. 2012;61(2):219\u201329.","journal-title":"Allergol Int"},{"issue":"5","key":"141_CR10","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/gps.1806","volume":"22","author":"B Winblad","year":"2007","unstructured":"Winblad B, Kawata AK, Beusterien KM, et al. Caregiver preference for rivastigmine patch relative to capsules for treatment of probable Alzheimer\u2019s disease. Int J Geriatr Psychiatry. 2007;22(5):485\u201391.","journal-title":"Int J Geriatr Psychiatry"},{"issue":"10","key":"141_CR11","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1007\/s12325-009-0075-9","volume":"26","author":"I Ale","year":"2009","unstructured":"Ale I, Lachapelle JM, Maibach HI. Skin tolerability associated with transdermal drug delivery systems: an overview. Adv Ther. 2009;26(10):920\u201335.","journal-title":"Adv Ther"},{"issue":"11","key":"141_CR12","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1038\/nbt.1504","volume":"26","author":"MR Prausnitz","year":"2008","unstructured":"Prausnitz MR, Langer R. Transdermal drug delivery. Nat Biotechnol. 2008;26(11):1261\u20138.","journal-title":"Nat Biotechnol"},{"issue":"5","key":"141_CR13","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/bjaceaccp\/mkm033","volume":"7","author":"L Margetts","year":"2007","unstructured":"Margetts L, Sawyer R. Transdermal drug delivery: principles and opioid therapy. Contin Educ Anaesth Crit Care Pain. 2007;7(5):171\u20136.","journal-title":"Contin Educ Anaesth Crit Care Pain."},{"issue":"1","key":"141_CR14","doi-asserted-by":"crossref","first-page":"88","DOI":"10.18433\/J3C30D","volume":"12","author":"JJ Escobar-Ch\u00e1vez","year":"2009","unstructured":"Escobar-Ch\u00e1vez JJ, Bonilla-Mart\u00ednez D, Villegas-Gonz\u00e1lez MA, et al. The use of sonophoresis in the administration of drugs throughout the skin. J Pharm Pharm Sci. 2009;12(1):88\u2013115.","journal-title":"J Pharm Pharm Sci"},{"issue":"4","key":"141_CR15","first-page":"1439","volume":"59","author":"Centers for Disease Control and Prevention","year":"2010","unstructured":"Centers for Disease Control and Prevention. Increasing prevalence of parent-reported attention-deficit\/hyperactivity disorder among children\u2014United States, 2003 and 2007. Morb Mortal Wkly Rep. 2010;59(4):1439\u201343.","journal-title":"Morb Mortal Wkly Rep"},{"key":"141_CR16","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/1741-7015-9-72","volume":"9","author":"KM Antshel","year":"2011","unstructured":"Antshel KM, Hargrave TM, Simonescu M, et al. Advances in understanding and treating ADHD. BMC Med. 2011;9:72\u201384.","journal-title":"BMC Med"},{"issue":"2","key":"141_CR17","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nrd3628","volume":"11","author":"MJ Millan","year":"2012","unstructured":"Millan MJ, Agid Y, Br\u00fcne M, et al. Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy. Nat Rev Drug Discov. 2012;11(2):141\u201368.","journal-title":"Nat Rev Drug Discov"},{"key":"141_CR18","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/1471-244X-10-67","volume":"10","author":"SJ Kooij","year":"2010","unstructured":"Kooij SJ, Bejerot S, Blackwell A, et al. European consensus statement on diagnosis and treatment of adult ADHD: The European Network Adult ADHD. BMC Psychiatry. 2010;10:67\u201391.","journal-title":"BMC Psychiatry"},{"issue":"7","key":"141_CR19","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1097\/chi.0b013e318054e724","volume":"46","author":"S Pliszka","year":"2007","unstructured":"Pliszka S, AACAP Work Group on Quality Issues. Practice parameter for the assessment and treatment of children and adolescents with attention-deficit\/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2007;46(7):894\u2013921.","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"1","key":"141_CR20","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/1824-7288-36-79","volume":"36","author":"P Curatolo","year":"2010","unstructured":"Curatolo P, D\u2019Agati E, Moavero R. The neurobiological basis of ADHD. Ital J Pediatr. 2010;36(1):79\u201383.","journal-title":"Ital J Pediatr"},{"key":"141_CR21","doi-asserted-by":"crossref","unstructured":"Elia J, Wilson Z, La Porta LS, et al. Methylphenidate transdermal system: clinical applications for attention deficit\/hyperactivity disorder. Expert Rev Clin Pharmacol. 2011;4(3):311\u201328.","DOI":"10.1586\/ecp.11.11"},{"issue":"4","key":"141_CR22","first-page":"4","volume":"8","author":"SV Faraone","year":"2006","unstructured":"Faraone SV, Biederman J, Spencer TJ, et al. Comparing the efficacy of medications for ADHD using meta-analysis. Med Gen Med. 2006;8(4):4.","journal-title":"Med Gen Med"},{"issue":"1","key":"141_CR23","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3810\/pgm.2010.01.2112","volume":"122","author":"LD Adler","year":"2010","unstructured":"Adler LD, Nierenberg AA. Review of medication adherence in children and adults with ADHD. Postgrad Med. 2010;122(1):184\u201391.","journal-title":"Postgrad Med"},{"issue":"6","key":"141_CR24","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1097\/CHI.0b013e31816bffdf","volume":"47","author":"TE Wilens","year":"2008","unstructured":"Wilens TE, Boellner SW, L\u00f3pez FA, et al. Varying the wear time of the methylphenidate transdermal system in children with attention-deficit\/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2008;47(6):700\u20138.","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"4","key":"141_CR25","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1089\/cap.2007.0148","volume":"18","author":"D Pierce","year":"2008","unstructured":"Pierce D, Dixon CM, Wigal SB, et al. Pharmacokinetics of methylphenidate transdermal system (MTS): results from a laboratory classroom study. J Child Adolesc Psychopharmacol. 2008;18(4):355\u201364.","journal-title":"J Child Adolesc Psychopharmacol"},{"issue":"3","key":"141_CR26","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1089\/cap.2008.0081","volume":"19","author":"MA Gonz\u00e1lez","year":"2009","unstructured":"Gonz\u00e1lez MA, Campbell D, Rubin J. Effects of application to two different skin sites on the pharmacokinetics of transdermal methylphenidate in pediatric patients with attention-deficit\/hyperactivity disorder. J Child Adolesc Psychopharmacol. 2009;19(3):227\u201332.","journal-title":"J Child Adolesc Psychopharmacol"},{"issue":"3","key":"141_CR27","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1177\/1087054705284089","volume":"9","author":"JJ McGough","year":"2006","unstructured":"McGough JJ, Wigal SB, Abikoff H, et al. A randomized, double-blind, placebo-controlled, laboratory classroom assessment of methylphenidate transdermal system in children with ADHD. J Atten Disord. 2006;9(3):476\u201385.","journal-title":"J Atten Disord"},{"issue":"6","key":"141_CR28","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1097\/01.chi.0000157548.48960.95","volume":"44","author":"WE Pelham Jr","year":"2005","unstructured":"Pelham WE Jr, Manos MJ, Ezzell CE, et al. A dose-ranging study of a methylphenidate transdermal system in children with ADHD. J Am Acad Child Adolesc Psychiatry. 2005;44(6):522\u20139.","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"2","key":"141_CR29","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1037\/1064-1297.13.2.111","volume":"13","author":"WE Pelham","year":"2005","unstructured":"Pelham WE, Burrows-Maclean L, Gnagy EM, et al. Transdermal methylphenidate, behavioral, and combined treatment for children with ADHD. Exp Clin Psychopharmacol. 2005;13(2):111\u201326.","journal-title":"Exp Clin Psychopharmacol"},{"issue":"5","key":"141_CR30","doi-asserted-by":"crossref","first-page":"548","DOI":"10.4088\/JCP.09m05779pur","volume":"71","author":"TE Wilens","year":"2010","unstructured":"Wilens TE, Hammerness P, Martelon M, et al. A controlled trial of the methylphenidate transdermal system on before-school functioning in children with attention-deficit\/hyperactivity disorder. J Clin Psychiatry. 2010;71(5):548\u201356.","journal-title":"J Clin Psychiatry"},{"issue":"1","key":"141_CR31","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1185\/03007990903437412","volume":"26","author":"LE Arnold","year":"2010","unstructured":"Arnold LE, Bozzolo DR, Hodgkins P, et al. Switching from oral extended-release methylphenidate to the methylphenidate transdermal system: continued attention-deficit\/hyperactivity disorder symptom control and tolerability after abrupt conversion. Curr Med Res Opin. 2010;26(1):129\u201337.","journal-title":"Curr Med Res Opin"},{"issue":"1","key":"141_CR32","doi-asserted-by":"crossref","first-page":"149","DOI":"10.4088\/JCP.v69n0120","volume":"69","author":"RL Findling","year":"2008","unstructured":"Findling RL, Bukstein OG, Melmed RD, et al. A randomized, double-blind, placebo-controlled, parallel-group study of methylphenidate transdermal system in pediatric patients with attention-deficit\/hyperactivity disorder. J Clin Psychiatry. 2008;69(1):149\u201359.","journal-title":"J Clin Psychiatry"},{"issue":"8","key":"141_CR33","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1016\/j.clinthera.2009.08.002","volume":"31","author":"RL Findling","year":"2009","unstructured":"Findling RL, Wigal SB, Bukstein OG, et al. Long-term tolerability of the methylphenidate transdermal system in pediatric attention-deficit\/hyperactivity disorder: a multicenter, prospective, 12-month, open-label, uncontrolled, phase III extension of four clinical trials. Clin Ther. 2009;31(8):1844\u201355.","journal-title":"Clin Ther"},{"issue":"4","key":"141_CR34","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1177\/1087054708314844","volume":"12","author":"SV Faraone","year":"2009","unstructured":"Faraone SV, Glatt SJ, Bukstein OG, et al. Effects of once-daily oral and transdermal methylphenidate on sleep behavior of children with ADHD. J Atten Disord. 2009;12(4):308\u201315.","journal-title":"J Atten Disord"},{"issue":"9","key":"141_CR35","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1097\/chi.0b013e31806ad1d7","volume":"46","author":"SV Faraone","year":"2007","unstructured":"Faraone SV, Giefer EE. Long-term effects of methylphenidate transdermal delivery system treatment of ADHD on growth. J Am Acad Child Adolesc Psychiatry. 2007;46(9):1138\u201347.","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"141_CR36","doi-asserted-by":"crossref","unstructured":"Warshaw EM, Squires L, Li Y, Civil R, et al. Methylphenidate transdermal system: a multisite, open-label study of dermal reactions in pediatric patients diagnosed with ADHD. Prim Care Companion J Clin Psychiatry. 2010;12(6). pii: PCC.10m00996.","DOI":"10.4088\/PCC.10m00996pur"},{"issue":"6","key":"141_CR37","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.pediatrneurol.2011.09.003","volume":"45","author":"A Ashkenasi","year":"2011","unstructured":"Ashkenasi A. Effect of transdermal methylphenidate wear times on sleep in children with attention deficit hyperactivity disorder. Pediatr Neurol. 2011;45(6):381\u20136.","journal-title":"Pediatr Neurol"},{"issue":"7","key":"141_CR38","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1017\/S1092852900000353","volume":"15","author":"RL Findling","year":"2010","unstructured":"Findling RL, Turnbow J, Burnside J, et al. A randomized, double-blind, multicenter, parallel-group, placebo-controlled, dose-optimization study of the methylphenidate transdermal system for the treatment of ADHD in adolescents. CNS Spectr. 2010;15(7):419\u201330.","journal-title":"CNS Spectr"},{"issue":"5","key":"141_CR39","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1089\/cap.2009.0122","volume":"20","author":"RL Findling","year":"2010","unstructured":"Findling RL, Katic A, Rubin R, et al. A 6-month, open-label, extension study of the tolerability and effectiveness of the methylphenidate transdermal system in adolescents diagnosed with attention-deficit\/hyperactivity disorder. J Child Adolesc Psychopharmacol. 2010;20(5):365\u201375.","journal-title":"J Child Adolesc Psychopharmacol"},{"issue":"12","key":"141_CR40","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1185\/03007990903388797","volume":"25","author":"M Manos","year":"2009","unstructured":"Manos M, Frazier TW, Landgraf JM, Weiss M, Hodgkins P. HRQL and medication satisfaction in children with ADHD treated with the methylphenidate transdermal system. Curr Med Res Opin. 2009;25(12):3001\u201310.","journal-title":"Curr Med Res Opin."},{"issue":"5","key":"141_CR41","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1089\/cap.2009.0092","volume":"20","author":"TW Frazier","year":"2010","unstructured":"Frazier TW, Weiss M, Hodgkins P, et al. Time course and predictors of health-related quality of life improvement and medication satisfaction in children diagnosed with attention-deficit\/hyperactivity disorder treated with the methylphenidate transdermal system. J Child Adolesc Psychopharmacol. 2010;20(5):355\u201364.","journal-title":"J Child Adolesc Psychopharmacol"},{"issue":"1","key":"141_CR42","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1753-2000-3-39","volume":"3","author":"OG Bukstein","year":"2009","unstructured":"Bukstein OG, Arnold LE, Landgraf JM, et al. Does switching from oral extended-release methylphenidate to the methylphenidate transdermal system affect health-related quality-of-life and medication satisfaction for children with attention-deficit\/hyperactivity disorder? Child Adolesc Psychiatry Ment Health. 2009;3(1):39\u201341.","journal-title":"Child Adolesc Psychiatry Ment Health"}],"container-title":["CNS Drugs"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40263-014-0141-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40263-014-0141-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40263-014-0141-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T14:06:23Z","timestamp":1565186783000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40263-014-0141-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,15]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["141"],"URL":"https:\/\/doi.org\/10.1007\/s40263-014-0141-y","relation":{},"ISSN":["1172-7047","1179-1934"],"issn-type":[{"value":"1172-7047","type":"print"},{"value":"1179-1934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,15]]}}}