{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T01:41:32Z","timestamp":1785462092349,"version":"3.56.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2018,5,11]],"date-time":"2018-05-11T00:00:00Z","timestamp":1525996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["CNS Drugs"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1007\/s40263-018-0522-8","type":"journal-article","created":{"date-parts":[[2018,5,11]],"date-time":"2018-05-11T06:28:54Z","timestamp":1526020134000},"page":"567-578","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Polypharmacy Among Headache Patients: A Cross-Sectional Study"],"prefix":"10.1007","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9536-3995","authenticated-orcid":false,"given":"Anna","family":"Ferrari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8432-1888","authenticated-orcid":false,"given":"Carlo","family":"Baraldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4309-9309","authenticated-orcid":false,"given":"Manuela","family":"Licata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8917-9980","authenticated-orcid":false,"given":"Cecilia","family":"Rustichelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,5,11]]},"reference":[{"issue":"39","key":"522_CR1","doi-asserted-by":"publisher","first-page":"52","DOI":"10.7748\/ns.30.39.52.s45","volume":"30","author":"G Kaufman","year":"2016","unstructured":"Kaufman G. Polypharmacy: the challenge for nurses. Nurs Stand. 2016;30(39):52\u201360.","journal-title":"Nurs Stand"},{"issue":"12","key":"522_CR2","doi-asserted-by":"publisher","first-page":"e84967","DOI":"10.1371\/journal.pone.0084967","volume":"8","author":"A Calder\u00f3n-Larra\u00f1aga","year":"2013","unstructured":"Calder\u00f3n-Larra\u00f1aga A, Gimeno-Feliu LA, Gonz\u00e1lez-Rubio F, Poblador-Plou B, Lairla-San Jos\u00e9 M, Abad-D\u00edez JM, Poncel-Falc\u00f3 A, Prados-Torres A. Polypharmacy patterns: unravelling systematic associations between prescribed medications. PLoS ONE. 2013;8(12):e84967.","journal-title":"PLoS ONE"},{"issue":"1","key":"522_CR3","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.amjopharm.2010.01.001","volume":"8","author":"LL Dwyer","year":"2010","unstructured":"Dwyer LL, Han B, Woodwell DA, Rechtsteiner EA. Polypharmacy in nursing home residents in the United States: results of the 2004 National Nursing Home Survey. Am J Geriatr Pharmacother. 2010;8(1):63\u201372.","journal-title":"Am J Geriatr Pharmacother"},{"issue":"7","key":"522_CR4","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1007\/s002280050669","volume":"55","author":"LJ Veehof","year":"1999","unstructured":"Veehof LJ, Stewart RE, Meyboom-de Jong B, Haaijer-Ruskamp FM. Adverse drug reactions and polypharmacy in the elderly in general practice. Eur J Clin Pharmacol. 1999;55(7):533\u20136.","journal-title":"Eur J Clin Pharmacol"},{"issue":"3","key":"522_CR5","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/0304-3959(93)90167-N","volume":"52","author":"S Berndt","year":"1993","unstructured":"Berndt S, Maier C, Sch\u00fctz HW. Polymedication and medication compliance in patients with chronic non-malignant pain. Pain. 1993;52(3):331\u20139.","journal-title":"Pain"},{"issue":"3","key":"522_CR6","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1080\/17843286.2016.1148298","volume":"71","author":"M Wauters","year":"2016","unstructured":"Wauters M, Elseviers M, Vaes B, Degryse J, Dalleur O, Vander Stichele R, Van Bortel L, Azermai M. Polypharmacy in a Belgian cohort of community-dwelling oldest old (80\u2009+). Acta Clin Belg. 2016;71(3):158\u201366.","journal-title":"Acta Clin Belg"},{"issue":"3","key":"522_CR7","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.sapharm.2005.06.004","volume":"1","author":"RR Aparasu","year":"2005","unstructured":"Aparasu RR, Mort JR, Brandt H. Polypharmacy trends in office visits by the elderly in the United States, 1990 and 2000. Res Soc Adm Pharm. 2005;1(3):446\u201359.","journal-title":"Res Soc Adm Pharm"},{"issue":"5","key":"522_CR8","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1111\/jep.12514","volume":"22","author":"N Jokanovic","year":"2016","unstructured":"Jokanovic N, Tan EC, Dooley MJ, Kirkpatrick CM, Elliott RA, Bell JS. Why is polypharmacy increasing in aged care facilities? The views of Australian health care professionals. J Eval Clin Pract. 2016;22(5):677\u201382.","journal-title":"J Eval Clin Pract"},{"issue":"1","key":"522_CR9","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1177\/1099800416657636","volume":"19","author":"V Menzies","year":"2017","unstructured":"Menzies V, Thacker LR 2nd, Mayer SD, Young AM, Evans S, Barstow L. Polypharmacy, opioid use, and fibromyalgia: a secondary analysis of clinical trial data. Biol Res Nurs. 2017;19(1):97\u2013105.","journal-title":"Biol Res Nurs"},{"issue":"3","key":"522_CR10","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1111\/pme.12586","volume":"16","author":"MJ Giummarra","year":"2015","unstructured":"Giummarra MJ, Gibson SJ, Allen AR, Pichler AS, Arnold CA. Polypharmacy and chronic pain: harm exposure is not all about the opioids. Pain Med. 2015;16(3):472\u20139.","journal-title":"Pain Med"},{"issue":"8","key":"522_CR11","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1111\/j.1526-4610.1993.hed3308436.x","volume":"33","author":"LN Oates","year":"1993","unstructured":"Oates LN, Scholz MJ, Hoffert MJ. Polypharmacy in a headache centre population. Headache. 1993;33(8):436\u20138.","journal-title":"Headache"},{"issue":"7","key":"522_CR12","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1046\/j.1468-2982.1999.019007668.x","volume":"19","author":"GP Putnam","year":"1999","unstructured":"Putnam GP, O\u2019Quinn S, Bolden-Watson CP, Davis RL, Gutterman DL, Fox AW. Migraine polypharmacy and the tolerability of sumatriptan: a large-scale, prospective study. Cephalalgia. 1999;19(7):668\u201375.","journal-title":"Cephalalgia"},{"issue":"4","key":"522_CR13","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/s10194-010-0217-0","volume":"11","author":"LJ Stovner","year":"2010","unstructured":"Stovner LJ, Andree C. Prevalence of headache in Europe: a review for the Eurolight project. J Headache Pain. 2010;11(4):289\u201399.","journal-title":"J Headache Pain"},{"key":"522_CR14","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1111\/j.1468-1331.2011.03612.x","volume":"19","author":"M Linde","year":"2012","unstructured":"Linde M, Gustavsson A, Stovner LJ, Steiner TJ, Barr\u00e9 J, Katsarava Z, Lainez JM, Lampl C, Lant\u00e9ri-Minet M, Rastenyte D, Ruiz de la Torre E, Tassorelli C, Andr\u00e9e C. The cost of headache disorders in Europe: the Eurolight project. Eur J Neurol. 2012;19:703\u201311.","journal-title":"Eur J Neurol"},{"key":"522_CR15","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1136\/jnnp.2009.192492","volume":"81","author":"DC Buse","year":"2010","unstructured":"Buse DC, Manack A, Serrano D, Turkel C, Lipton RB. Sociodemographic and comorbidity profiles of chronic migraine and episodic migraine sufferers. J Neurol Neurosurg Psychiatry. 2010;81:428\u201332.","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"2","key":"522_CR16","doi-asserted-by":"publisher","first-page":"S31","DOI":"10.1007\/s10194-012-0437-6","volume":"13","author":"P Sarchielli","year":"2012","unstructured":"Sarchielli P, Granella F, Prudenzano MP, Pini LA, Guidetti V, Bono G, Pinessi L, Alessandri M, Antonaci F, Fanciullacci M, Ferrari A, Guazzelli M, Nappi G, Sances G, Sandrini G, Savi L, Tassorelli C, Zanchin G. Italian guidelines for primary headaches: 2012 revised version. J Headache Pain. 2012;13(2):S31\u201370.","journal-title":"J Headache Pain"},{"issue":"5","key":"522_CR17","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1007\/s40265-018-0894-6","volume":"78","author":"JE Frampton","year":"2018","unstructured":"Frampton JE, Silberstein S. OnabotulinumtoxinA: a review in the prevention of chronic migraine. Drugs. 2018;78(5):589\u2013600.","journal-title":"Drugs"},{"issue":"9","key":"522_CR18","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1007\/s00228-016-2074-5","volume":"72","author":"A Ferrari","year":"2016","unstructured":"Ferrari A, Baraldi C, Licata M, Vandelli D, Marchesi F, Palazzoli F, Verri P, Rustichelli C, Giuliani E, Silingardi E. Hair analysis for detection of triptans occasionally used or overused by migraine patients-a pilot study. Eur J Clin Pharmacol. 2016;72(9):1075\u201381.","journal-title":"Eur J Clin Pharmacol"},{"key":"522_CR19","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.jpba.2016.04.015","volume":"126","author":"M Licata","year":"2016","unstructured":"Licata M, Rustichelli C, Palazzoli F, Ferrari A, Baraldi C, Vandelli D, Verri P, Marchesi F, Silingardi E. Hair testing in clinical setting: simultaneous determination of 50 psychoactive drugs and metabolites in headache patients by LC tandem MS. J Pharm Biomed Anal. 2016;126:14\u201325.","journal-title":"J Pharm Biomed Anal"},{"key":"522_CR20","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.jchromb.2016.02.031","volume":"1017\u20131018","author":"D Vandelli","year":"2016","unstructured":"Vandelli D, Palazzoli F, Verri P, Rustichelli C, Marchesi F, Ferrari A, Baraldi C, Giuliani E, Licata M, Silingardi E. Development and validation of a liquid chromatography-tandem mass spectrometric assay for quantitative analyses of triptans in hair. J Chromatogr B Analyt Technol Biomed Life Sci. 2016;1017\u20131018:136\u201344.","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"issue":"2","key":"522_CR21","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/s00228-016-2163-5","volume":"73","author":"A Ferrari","year":"2017","unstructured":"Ferrari A, Licata M, Rustichelli C, Baraldi C, Vandelli D, Marchesi F, Palazzoli F, Verri P, Silingardi E. Monitoring of adherence to headache treatments by means of hair analysis. Eur J Clin Pharmacol. 2017;73(2):197\u2013203.","journal-title":"Eur J Clin Pharmacol"},{"key":"522_CR22","doi-asserted-by":"crossref","unstructured":"Headache Classification Committee of the International Headache Society (IHS). The international classification of headache disorders, 3rd edition (beta version). Cephalalgia. 2013;33(9):629\u2013808.","DOI":"10.1177\/0333102413485658"},{"issue":"3","key":"522_CR23","doi-asserted-by":"publisher","first-page":"e006681","DOI":"10.1136\/bmjopen-2014-006681","volume":"5","author":"A Vincent","year":"2015","unstructured":"Vincent A, Whipple MO, McAllister SJ, Aleman KM, St Sauver JL. A cross-sectional assessment of the prevalence of multiple chronic conditions and medication use in a sample of community-dwelling adults with fibromyalgia in Olmsted County, Minnesota. BMJ Open. 2015;5(3):e006681.","journal-title":"BMJ Open"},{"issue":"6","key":"522_CR24","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1016\/j.jpainsymman.2014.03.008","volume":"48","author":"A Kotlinska-Lemieszek","year":"2014","unstructured":"Kotlinska-Lemieszek A, Paulsen O, Kaasa S, Klepstad P. Polypharmacy in patients with advanced cancer and pain: a European cross-sectional study of 2282 patients. J Pain Symptom Manage. 2014;48(6):1145\u201359.","journal-title":"J Pain Symptom Manage"},{"issue":"5","key":"522_CR25","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s00228-007-0443-9","volume":"64","author":"A Ferrari","year":"2008","unstructured":"Ferrari A, Pinetti D, Bertolini A, Coccia C, Sternieri E. Interindividual variability of oral sumatriptan pharmacokinetics and of clinical response in migraine patients. Eur J Clin Pharmacol. 2008;64(5):489\u201395.","journal-title":"Eur J Clin Pharmacol"},{"issue":"4","key":"522_CR26","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1517\/14656566.4.4.433","volume":"4","author":"ME Bigal","year":"2003","unstructured":"Bigal ME, Krymchantowski AV, Rapoport AM. New developments in migraine prophylaxis. Expert Opin Pharmacother. 2003;4(4):433\u201343.","journal-title":"Expert Opin Pharmacother"},{"issue":"79","key":"522_CR27","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1097\/j.pain.0000000000000541","volume":"157","author":"E Mehuys","year":"2016","unstructured":"Mehuys E, Paemeleire K, Crombez G, Adriaens E, Van Hees T, Demarche S, Christiaens T, Van Bortel L, Van Tongelen I, Remon JP, Boussery K. The heterogeneity of headache patients who self-medicate: a cluster analysis approach. Pain. 2016;157(79):1464\u201371.","journal-title":"Pain"},{"issue":"1","key":"522_CR28","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s10194-018-0839-1","volume":"19","author":"Z Katsarava","year":"2018","unstructured":"Katsarava Z, Mania M, Lampl C, Herberhold J, Steiner TJ. Poor medical care for people with migraine in Europe\u2014evidence from the Eurolight study. J Headache Pain. 2018;19(1):10.","journal-title":"J Headache Pain"},{"issue":"1","key":"522_CR29","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s10194-018-0846-2","volume":"19","author":"TJ Steiner","year":"2018","unstructured":"Steiner TJ, Stovner LJ, Vos T, Jensen R, Katsarava Z. Migraine is first cause of disability in under 50\u00a0s: will health politicians now take notice? J Headache Pain. 2018;19(1):17.","journal-title":"J Headache Pain"},{"issue":"5","key":"522_CR30","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.ejpain.2004.01.005","volume":"8","author":"K Bingefors","year":"2004","unstructured":"Bingefors K, Isacson D. Epidemiology, co-morbidity, and impact on health-related quality of life of self-reported headache and musculoskeletal pain\u2014a gender perspective. Eur J Pain. 2004;8(5):435\u201350.","journal-title":"Eur J Pain"},{"issue":"3 Suppl","key":"522_CR31","doi-asserted-by":"crossref","first-page":"S56","DOI":"10.1097\/01.PHM.0000154904.83278.32","volume":"84","author":"DA Fishbain","year":"2005","unstructured":"Fishbain DA. Polypharmacy treatment approaches to the psychiatric and somatic comorbidities found in patients with chronic pain. Am J Phys Med Rehabil. 2005;84(3 Suppl):S56\u201363.","journal-title":"Am J Phys Med Rehabil"},{"issue":"2","key":"522_CR32","doi-asserted-by":"crossref","first-page":"159","DOI":"10.23736\/S0026-4806.17.04877-7","volume":"108","author":"A Olivieri","year":"2017","unstructured":"Olivieri A, Di Cosmo C, De Angelis S, Da Cas R, Stacchini P, Pastorelli A, Vitti P. Regional observatories for goiter prevention. The way forward in Italy for iodine. Minerva Med. 2017;108(2):159\u201368.","journal-title":"Minerva Med"},{"issue":"10","key":"522_CR33","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1177\/0333102414540058","volume":"34","author":"BL Uhlig","year":"2014","unstructured":"Uhlig BL, Engstr\u00f8m M, \u00d8deg\u00e5rd SS, Hagen KK, Sand T. Headache and insomnia in population-based epidemiological studies. Cephalalgia. 2014;34(10):745\u201351.","journal-title":"Cephalalgia"},{"issue":"1","key":"522_CR34","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1186\/s10194-016-0681-2","volume":"17","author":"J Kim","year":"2016","unstructured":"Kim J, Cho SJ, Kim WJ, Yang KI, Yun CH, Chu MK. Insomnia in probable migraine: a population-based study. J Headache Pain. 2016;17(1):92.","journal-title":"J Headache Pain"},{"key":"522_CR35","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.eplepsyres.2017.11.001","volume":"139","author":"A Baftiu","year":"2018","unstructured":"Baftiu A, Feet SA, Larsson PG, Burns ML, Henning O, S\u00e6tre E, Molden E, Granas AG, Johannessen SI, Landmark CJ. Utilisation and polypharmacy aspects of antiepileptic drugs in elderly versus younger patients with epilepsy: a pharmacoepidemiological study of CNS-active drugs in Norway, 2004-2015. Epilepsy Res. 2018;139:35\u201342.","journal-title":"Epilepsy Res"},{"issue":"7472","key":"522_CR36","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1136\/bmj.38232.680567.EB","volume":"329","author":"L Hooper","year":"2004","unstructured":"Hooper L, Brown TJ, Elliott R, Payne K, Roberts C, Symmons D. The effectiveness of five strategies for the prevention of gastrointestinal toxicity induced by non-steroidal anti-inflammatory drugs: systematic review. BMJ. 2004;329(7472):948.","journal-title":"BMJ"},{"issue":"4","key":"522_CR37","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/s10194-009-0127-1","volume":"10","author":"A Ferrari","year":"2009","unstructured":"Ferrari A, Spaccapelo L, Gallesi D, Sternieri E. Focus on headache as an adverse reaction to drugs. J Headache Pain. 2009;10(4):235\u20139.","journal-title":"J Headache Pain"},{"issue":"1","key":"522_CR38","doi-asserted-by":"publisher","first-page":"43","DOI":"10.2174\/157488606775252610","volume":"1","author":"A Ferrari","year":"2006","unstructured":"Ferrari A. Headache: one of the most common and troublesome adverse reactions to drugs. Curr Drug Saf. 2006;1(1):43\u201358.","journal-title":"Curr Drug Saf"},{"issue":"6","key":"522_CR39","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1517\/17425255.2.6.961","volume":"2","author":"E Sternieri","year":"2006","unstructured":"Sternieri E, Coccia CP, Pinetti D, Ferrari A. Pharmacokinetics and interactions of headache medications, part I: introduction, pharmacokinetics, metabolism and acute treatments. Expert Opin Drug Metab Toxicol. 2006;2(6):961\u201379.","journal-title":"Expert Opin Drug Metab Toxicol"},{"issue":"4","key":"522_CR40","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1517\/17425255.2016.1154042","volume":"12","author":"L Lionetto","year":"2016","unstructured":"Lionetto L, Borro M, Curto M, Capi M, Negro A, Cipolla F, Gentile G, Martelletti P. Choosing the safest acute therapy during chronic migraine prophylactic treatment: pharmacokinetic and pharmacodynamic considerations. Expert Opin Drug Metab Toxicol. 2016;12(4):399\u2013406.","journal-title":"Expert Opin Drug Metab Toxicol"},{"issue":"9","key":"522_CR41","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1080\/17425255.2016.1201067","volume":"12","author":"F Andr\u00e9s De","year":"2016","unstructured":"De Andr\u00e9s F, Lionetto L, Curto M, Capi M, Cipolla F, Negro A, Martelletti P. Acute, transitional and long-term cluster headache treatment: pharmacokinetic issues. Expert Opin Drug Metab Toxicol. 2016;12(9):1011\u201320.","journal-title":"Expert Opin Drug Metab Toxicol"},{"issue":"7573","key":"522_CR42","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1038\/nature15816","volume":"526","author":"SJ Aronson","year":"2015","unstructured":"Aronson SJ, Rehm HL. Building the foundation for genomics in precision medicine. Nature. 2015;526(7573):336\u201342.","journal-title":"Nature"},{"issue":"1","key":"522_CR43","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s10194-017-0830-2","volume":"19","author":"P Martelletti","year":"2018","unstructured":"Martelletti P. The journey from genetic predisposition to medication overuse headache to its acquisition as sequela of chronic migraine. J Headache Pain. 2018;19(1):2.","journal-title":"J Headache Pain"},{"key":"522_CR44","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-018-0617-4","author":"PR Holland","year":"2018","unstructured":"Holland PR, Goadsby PJ. Targeted CGRP small molecule antagonists for acute migraine therapy. Neurotherapeutics. 2018. https:\/\/doi.org\/10.1007\/s13311-018-0617-4 .","journal-title":"Neurotherapeutics"},{"issue":"2","key":"522_CR45","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1111\/head.12757","volume":"56","author":"ER Lebedeva","year":"2016","unstructured":"Lebedeva ER, Kobzeva NR, Gilev DV, Olesen J. Factors associated with primary headache according to diagnosis, sex, and social group. Headache. 2016;56(2):341\u201356.","journal-title":"Headache"},{"issue":"9","key":"522_CR46","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1016\/j.jclinepi.2012.02.018","volume":"65","author":"D Gnjidic","year":"2012","unstructured":"Gnjidic D, Hilmer SN, Blyth FM, Naganathan V, Waite L, Seibel MJ, McLachlan AJ, Cumming RG, Handelsman DJ, Le Couteur DG. Polypharmacy cutoff and outcomes: five or more medicines were used to identify community-dwelling older men at risk of different adverse outcomes. J Clin Epidemiol. 2012;65(9):989\u201395.","journal-title":"J Clin Epidemiol"},{"issue":"4","key":"522_CR47","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1007\/s00520-015-2970-8","volume":"24","author":"JP Turner","year":"2016","unstructured":"Turner JP, Jamsen KM, Shakib S, Singhal N, Prowse R, Bell JS. Polypharmacy cut-points in older people with cancer: how many medications are too many? Support Care Cancer. 2016;24(4):1831\u201340.","journal-title":"Support Care Cancer"},{"issue":"4","key":"522_CR48","doi-asserted-by":"publisher","first-page":"e0151066","DOI":"10.1371\/journal.pone.0151066","volume":"11","author":"NJ Ailabouni","year":"2016","unstructured":"Ailabouni NJ, Nishtala PS, Mangin D, Tordoff JM. Challenges and enablers of deprescribing: a general practitioner perspective. PLoS ONE. 2016;11(4):e0151066.","journal-title":"PLoS ONE"},{"issue":"11","key":"522_CR49","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1007\/s40263-013-0081-y","volume":"27","author":"JR Saper","year":"2013","unstructured":"Saper JR, Da Silva AN. Medication overuse headache: history, features, prevention and management strategies. CNS Drugs. 2013;27(11):867\u201377.","journal-title":"CNS Drugs"},{"issue":"4","key":"522_CR50","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1111\/head.12047","volume":"53","author":"E Schulman","year":"2013","unstructured":"Schulman E. Refractory migraine - a review. Headache. 2013;53(4):599\u2013613.","journal-title":"Headache"},{"issue":"4","key":"522_CR51","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.amjopharm.2007.12.002","volume":"5","author":"ER Hajjar","year":"2007","unstructured":"Hajjar ER, Cafiero AC, Hanlon JT. Polypharmacy in elderly patients. Am J Geriatr Pharmacother. 2007;5(4):345\u201351.","journal-title":"Am J Geriatr Pharmacother"},{"issue":"4","key":"522_CR52","doi-asserted-by":"publisher","first-page":"e010505","DOI":"10.1136\/bmjopen-2015-010505","volume":"6","author":"M O\u2019Dwyer","year":"2016","unstructured":"O\u2019Dwyer M, Peklar J, McCallion P, McCarron M, Henman MC. Factors associated with polypharmacy and excessive polypharmacy in older people with intellectual disability differ from the general population: a cross-sectional observational nationwide study. BMJ Open. 2016;6(4):e010505.","journal-title":"BMJ Open"}],"container-title":["CNS Drugs"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40263-018-0522-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40263-018-0522-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40263-018-0522-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T11:20:18Z","timestamp":1661253618000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40263-018-0522-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,11]]},"references-count":52,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["522"],"URL":"https:\/\/doi.org\/10.1007\/s40263-018-0522-8","relation":{},"ISSN":["1172-7047","1179-1934"],"issn-type":[{"value":"1172-7047","type":"print"},{"value":"1179-1934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,11]]},"assertion":[{"value":"11 May 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors. The open access fee was paid by a research grant attributed to Dr Anna Ferrari from the Ministry of Education, University and Research (MIUR) (Italy).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"The authors, Anna Ferrari, Carlo Baraldi, Manuela Licata and Cecilia Rustichelli, declare that they have no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the Ethical Provincial Committee of Modena (Prot. n. 3610\/C.E., file 126\/13) and conducted in compliance with the latest version of the Declaration of Helsinki.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"All the patients gave their written consent for their participation in the study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}}]}}