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This study was supported by the National Key Research and Development Program of China (2018YFC1004604), the National Nature Science Foundation of China (U1704281, 31761133015, 81771418), the Department of Science and Technology of Henan Province of China (134200510023, 171100310200), the Swedish Research Council (2018-02267), and Swedish governmental grants to scientists working in healthcare of Gothenburg, Sweden (ALFGBG-717791).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"Juan Song, Yong Wang, Falin Xu, Huiqing Sun, Xiaoli Zhang, Lei Xia, Shan Zhang, Kenan Li, Xirui Peng, Bingbing Li, Yaodong Zhang, Wenqing Kang, Xiaoyang Wang, and Changlian Zhu have no conflicts of interest that are directly relevant to the content of this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The study protocol was approved by the Ethics Committee of Zhengzhou University and Henan Medical Academy and was carried out in accordance with the Helsinki declaration.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent was obtained from all parents included in the study prior to any study-related activities.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"All authors consent to the publication of the manuscript and accept the terms of related agreements.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Not applicable.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}},{"value":"The datasets generated and\/or analyzed during the current trial are available from the corresponding author on reasonable request.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data availability statement"}},{"value":"Study concept and design: CZ. Data acquisition: JS, YW, FX, HS, XZ, LX, SZ, KL, XP, BL, and YZ. Data analysis: JS and YW. Drafting the manuscript: JS and YW. Reviewing the manuscript: WK, XW, and CZ. All authors approved the final version of the manuscript and agreed to be accountable for the work described in the manuscript.","order":9,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author contributions"}}]}}