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Laura Canafoglia has received consultancy fee from Eisai. Maria Paola Canevini has received speaker\u2019s or consultancy fees from Bial, Eisai, Italfarmaco, Sanofi, and UCB Pharma. Sara Casciato has participated in pharmaceutical industry-sponsored symposia for Eisai, UCB Pharma and Lusofarmaco. Valentina Chiesa has received speaker\u2019s or consultancy fees from Eisai and UCB Pharma. Anna Teresa Giallonardo has received consulting fees or speaker honoraria from Eisai. Angela La Neve has received speaker\u2019s or consultancy fees from Eisai, Mylan, Bial, Sanofi, and UCB Pharma. Patrizia Pulitano has received consulting fees or speaker honoraria from UCB Pharma and Eisai. Pier Paolo Quarato has participated in pharmaceutical industry-sponsored clinical trials and symposia for UCB Pharma. Federica Ranzato has received speaker\u2019s fees from Eisai, UCB, and Livanova. Eleonora Rosati has received fees for participation in advisory board\u00a0or scientific consultation from Eisai, GW Pharmaceuticals, Bial, and UCB Pharma. Laura Tassi has received speaker\u2019s or consultancy fees from Arvelle Therapeutics, Eisai and UCB Pharma. Carlo Di Bonaventura has received consulting fees or speaker honoraria from UCB Pharma, Eisai, GW Pharmaceuticals, Bial, and Lusopharma., Filippo Dainese, Giovanni De Maria, Giuseppe Didato, Giovanni Falcicchio, Martina Fanella, Edoardo Ferlazzo, Giacomo Fisco, Massimo Gangitano, Filippo Sean Giorgi, Oriano Mecarelli, Elisa Montalenti and Federico Piazza have no conflicts of interest to declare.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the Ethical Committee at all participating sites and was conducted in accordance with the Declaration of Helsinki.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Informed consent was obtained from every patient and\/or their parent or legal representative.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"Anonymized data will be shared at the request of any qualified investigator.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of Data and Material"}},{"value":"Not applicable.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code Availability"}},{"value":"SL designed and conceptualized the study, coordinated and supervised the data collection, carried out the data analyses, and drafted the manuscript. VC, EF, ALN, and EM designed and conceptualized the study, and coordinated and supervised the data collection. LC, MPC, SC, FD, GDM, GD, GF, MF, GF, MG, ATG, FSG, OM, FP, PP, PPQ, FR, ER and LT were involved in the acquisition of data. CDB designed and conceptualized the study, coordinated and supervised the data collection, and drafted the manuscript. All authors critically revised the manuscript for important intellectual content. All authors approved the final manuscript for submission and agree to be accountable for all aspects of the work.","order":9,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author Contributions"}}]}}