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Claudia Testa also served as a consultant for Lundbeck, with honoraria donated to the Medical College of Virginia Foundation. Mary C. Edmondson reports serving on a Wave Life Sciences Clinical Advisory Committee, funding from uniQure, and ENROLL-HD DSMB involvement. Blair R. Leavitt is currently employed as a Professor in the Department of Medical Genetics,\u00a0and Division of Neurology, Department of Medicine and as a senior scientist at the Centre for Molecular Medicine and Therapeutics,\u00a0The\u00a0University of British Columbia, and BC Children\u2019s Hospital. In the last 5 years, he has held or applied for research grants in\u00a0the area of neurodegenerative disease from the Canadian Institutes of Health\u00a0Research, The\u00a0Huntington Society of Canada, Weston Brain Foundation, Brain\u00a0Canada, uniQure, Triplet, and the Nanomedicines Innovations Network. He has\u00a0served on scientific advisory boards for sRNAlytics, the\u00a0Huntington\u2019s Disease\u00a0Society of America, and the Huntington Society of Canada. In addition, he has\u00a0acted as a paid consultant to Roche, uniQure, Novartis, PTC Therapeutics,\u00a0Triplet Therapeutics, Genentech,\u00a0Takeda, and Ionis.\u00a0He is also a shareholder,\u00a0co-founder, and CEO of Incisive Genetics Inc., a biotech start-up company\u00a0developing therapies for genetic brain diseases. David Oakes received research support from Auspex (for the First-HD and related studies), Vaccinex Inc., Prana Pharmaceuticals, Biogen, Inc., and the National Institutes of Health; and received honoraria from Raptor Pharmaceuticals and Voyager Inc. Christina Vaughan received an emergency fast-track COVID-19 response grant from the Adira Foundation. Nicholas Gross and Mark Forrest Gordon are employees of Teva Pharmaceuticals, and Juha-Matti Savola is a former employee of Teva Pharmaceuticals. Jody Goldstein, Elise Kayson, Christine O\u2019Neill, and Jacquelyn Whaley report no disclosures.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study (ClinicalTrials.gov identifier: NCT01897896) was approved by the ethics boards at all involved centers prior to subject enrollment and conducted in accordance with the Helsinki Declaration and the International Council for Harmonisation Good Clinical Practice Guidelines.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"At enrollment, an independent qualified healthcare provider assessed all subjects for capacity to provide informed consent, and study personnel subsequently assessed subjects for capacity to continue in the study. Subjects or legally authorized representatives provided written informed consent, and subjects without capacity provided assent, if required by local regulations.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Qualified researchers may request access to patient-level data and related study documents, including the study protocol and the statistical analysis plan. Requests will be reviewed for scientific merit, product approval status, and conflicts of interest. Patient-level data will be de-identified and study documents will be redacted to protect the privacy of trial participants and to protect commercially confidential information. Please e-mail USMedInfo@tevapharm.com to make your request.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data and material"}},{"value":"Not applicable.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}},{"value":"SF and MFG contributed to the drafting\/revision of the manuscript for content, including medical writing for content, and had a major role in the acquisition of data, study concept or design, and the analysis or interpretation of data. CT, JG, EK, CV, and JW contributed to the drafting\/revision of the manuscript for content, including medical writing for content, and had a major role in the acquisition of data and the analysis or interpretation of data. MCE, BRL, CO, and J-MS had a major role in the acquisition of data. DO and NG contributed to the drafting\/revision of the manuscript for content, including medical writing for content, and the analysis or interpretation of data. All authors read and approved the final manuscript.","order":9,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author contributions"}}]}}