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General declaration of potential conflict of interests: E.W. was invited to advisory boards from Recordati, Teva, and Boehringer Ingelheim. A.H. was and is a member of advisory boards and received paid speakership by Boehringer-Ingelheim, Lundbeck, Otsuka, Rovi, Teva (no speakership), AbbVie, Recordati, and Advanz. He is editor of the AWMF German guidelines for schizophrenia. W.W.F. has received grants from Otsuka and Lundbeck and speaker\u2019s fees from Sumitomo Pharma. M.D. is an employee of Minerva Neurosciences, a biotech developing central nervous system drugs. In the past 3 years, S.L. has received honoraria as a consultant, adviser, or lecturer from Alkermes, Angelini, Eisai, Gedeon Richter, Janssen, Lundbeck, Lundbeck Institute, Merck Sharpp and Dome, Otsuka, Recordati, Rovi, Sanofi Aventis, TEVA, Medichem, and Mitsubishi. D.S. has no conflicts to declare. All other authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"All study participants provided informed written consent for secondary data analysis.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All study participants provided informed written consent.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Relevant regulatory bodies and ethics committees in each participating country approved the study and its adherence to local regulations and the Declaration of Helsinki. The trial was overseen by the University Medical Center Utrecht in the Netherlands, following the guidelines of Good Clinical Practice and the International Conference on Harmonization.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"A request for receipt of the study data, the data dictionary, study protocol, and informed consent can be submitted for review and approval by the study management group.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data and material"}},{"value":"A request for receipt of the codes (R scripts and SPSS Syntax) can be submitted for review and approval by the study management group.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}},{"value":"M.M., E.W., and A.H. designed the secondary analysis. M.M. and Z.A. conducted the statistical analysis. M.M., A.H., and E.W. interpreted the data and wrote the initial draft of the manuscript. A.H., E.W., and I.W.-v.R. conceptualized the study, provided supervision, and critically revised the manuscript for important intellectual content. I.W.-v.R., R.S.K., W.W.F., M.D., M.W., S.L., and the EULAST Study Group were responsible for the design and conduct of the original EULAST trial and the acquisition of the data. D.S. provided critical intellectual contributions and revisions. All authors reviewed and approved the final manuscript. M.M. and Z.A. share the first authorship; A.H. and E.W. share the last authorship.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author contributions"}}]}}