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Int Arch Otorhinolaryngol. 2016;20:145\u201350.","journal-title":"Int Arch Otorhinolaryngol"}],"container-title":["CNS Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40263-025-01232-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40263-025-01232-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40263-025-01232-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T21:02:50Z","timestamp":1767646970000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40263-025-01232-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,23]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["1232"],"URL":"https:\/\/doi.org\/10.1007\/s40263-025-01232-1","relation":{},"ISSN":["1172-7047","1179-1934"],"issn-type":[{"value":"1172-7047","type":"print"},{"value":"1179-1934","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,23]]},"assertion":[{"value":"3 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All the authors are investigators of the phase 3 trial and report research funding and study drugs from Ignis Therapeutics as the trial sponsor. The authors declare no other\u00a0conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}},{"value":"The protocol and subsequent amendments were approved before the start of the study by the institutional review board or independent ethics committee at each site that participated. The study was performed in accordance with the Declaration of Helsinki and Good Clinical Practice (2020) guidelines published by the China National Medical Products Administration.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All study participants provided written informed consent at screening, before any study-related procedures or assessments were performed.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The data underlying this article are not publicly available but may be shared on reasonable request to the corresponding author.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data availability statement"}},{"value":"L.L., M.W.F., C.H.R., C.R., Z.S.Q., Z.N.F., P.J.Y., and W.X.Y. conceived and designed the study. All the authors conducted the study. M.W.F., M.Z.L., Z.W., C.T., T.S.Y., and Z.W.H. analyzed and interpreted the data. L.Y.H., Z.X.Q., Y.H., T.M.Q., W.Z., and W.C.X. verified the data. C.H.R., D.L.Y., and M.W.F. drafted the manuscript with the assistance provided by Indegene Limited. All the authors reviewed and revised the manuscript, approved the final submitted version, and agreed to be accountable for the work.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author contributions"}}]}}