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Nguyen discloses: Associate Editor of Stroke; advisory board for Brainomix, Aruna Bio; speaker for Genentech, Kaneka; consulting for Medtronic. M.R. Chen, F. Liu, and H.S. Chen have no potential conflicts of interest that might be relevant to this work.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"H.S. Chen contributed to the conception and design of the study and critically revised the manuscript. M.R. Chen and F. Liu analyzed the data and wrote the original draft of the manuscript. T. Nguyen critically revised the manuscript. All authors read and approved the final manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Authors' Contributions"}},{"value":"The datasets generated during and\/or analyzed during the current study are available from the corresponding author upon reasonable request.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data Availability Statement"}},{"value":"The protocol of the multicenter ARAIS trial (Argatroban plus r-tPA for Acute Ischemic Stroke; NCT03740958) was approved by the ethics committee of the participating hospitals.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"All patients enrolled in the ARAIS trial were required to provide written informed consent.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code Availability"}},{"value":"Not applicable.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}]}}