{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:03:50Z","timestamp":1792717430719,"version":"4.5.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2013,7,26]],"date-time":"2013-07-26T00:00:00Z","timestamp":1374796800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Saf"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1007\/s40264-013-0089-8","type":"journal-article","created":{"date-parts":[[2013,7,25]],"date-time":"2013-07-25T18:40:48Z","timestamp":1374777648000},"page":"709-721","source":"Crossref","is-referenced-by-count":159,"title":["Tendon Injury and Fluoroquinolone Use: A Systematic Review"],"prefix":"10.1007","volume":"36","author":[{"given":"Anne L.","family":"Stephenson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Cortes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula A.","family":"Rochon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,7,26]]},"reference":[{"issue":"11","key":"89_CR1","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1345\/aph.1K347","volume":"41","author":"AJ Mehlhorn","year":"2007","unstructured":"Mehlhorn AJ, Brown DA. Safety concerns with fluoroquinolones. Ann Pharmacother. 2007;41(11):1859\u201366.","journal-title":"Ann Pharmacother"},{"issue":"5","key":"89_CR2","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/j.1365-2125.2006.02631.x","volume":"61","author":"J Beyer","year":"2006","unstructured":"Beyer J, Schellong S. Bilateral plantar tendinitis during levofloxacin therapy (Review, 8 refs). Br J. Clin Pharm. 2006;61(5):609.","journal-title":"Br J. Clin Pharm"},{"key":"89_CR3","doi-asserted-by":"crossref","unstructured":"Karistinos A, Paulos LE. \u201cCiprofloxacin-induced\u201d bilateral rectus femoris tendon rupture. 17(5):406\u20137.","DOI":"10.1097\/JSM.0b013e31814c3e69"},{"issue":"6","key":"89_CR4","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.jbspin.2003.10.016","volume":"71","author":"D Braun","year":"2004","unstructured":"Braun D, Petitpain N, Cosserat F, Loeuille D, Bitar S, Gillet P, et al. Rupture of multiple tendons after levofloxacin therapy. Revue du Rhumatisme. 2004;71(6):586\u20137.","journal-title":"Revue du Rhumatisme"},{"issue":"4","key":"89_CR5","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/00365540410019390","volume":"36","author":"O Burkhardt","year":"2004","unstructured":"Burkhardt O, Kohnlein T, Pap T, Welte T. Recurrent tendinitis after treatment with two different fluoroquinolones. Scand J Infect Dis. 2004;36(4):315\u20136.","journal-title":"Scand J Infect Dis"},{"issue":"6","key":"89_CR6","first-page":"743","volume":"71","author":"G Mouzopoulos","year":"2005","unstructured":"Mouzopoulos G, Stamatakos M, Vasiliadis G, Skandalakis P. Rupture of adductor longus tendon due to ciprofloxacin. Acta Ortho Belgica. 2005;71(6):743\u20135.","journal-title":"Acta Ortho Belgica"},{"issue":"4","key":"89_CR7","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.cps.2005.05.004","volume":"32","author":"Y Khaliq","year":"2005","unstructured":"Khaliq Y, Zhanel GG. Musculoskeletal injury associated with fluoroquinolone antibiotics (Review, 43 refs). Clinics Plastic Surgery. 2005;32(4):495\u2013502.","journal-title":"Clinics Plastic Surgery"},{"issue":"4","key":"89_CR8","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.bjid.2012.06.015","volume":"16","author":"WA Ever-Silva","year":"2012","unstructured":"Ever-Silva WA, Netto Hde B, Pinto JF, Ferry FR, Neves-Motta R. Severe shoulder tendinopathy associated with levofloxacin. Braz J Infect Dis. 2012;16(4):393\u20135.","journal-title":"Braz J Infect Dis"},{"key":"89_CR9","doi-asserted-by":"crossref","first-page":"a816","DOI":"10.1136\/bmj.a816","volume":"337","author":"JH Tanne","year":"2008","unstructured":"Tanne JH. FDA adds \u201cblack box\u201d warning label to fluoroquinolone antibiotics. BMJ. 2008;337:a816.","journal-title":"BMJ"},{"issue":"1","key":"89_CR10","doi-asserted-by":"crossref","first-page":"13","DOI":"10.2165\/00003495-200262010-00002","volume":"62","author":"GG Zhanel","year":"2002","unstructured":"Zhanel GG, Ennis K, Vercaigne L, Walkty A, Gin AS, Embil J, et al. A critical review of the fluoroquinolones: focus on respiratory infections. Drugs. 2002;62(1):13\u201359.","journal-title":"Drugs"},{"issue":"Suppl 2","key":"89_CR11","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1086\/511159","volume":"44","author":"LA Mandell","year":"2007","unstructured":"Mandell LA, Wunderink RG, Anzueto A, Bartlett JG, Campbell GD, Dean NC, et al. Infectious Diseases Society of America\/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis. 2007;44(Suppl 2):S27\u201372.","journal-title":"Clin Infect Dis"},{"key":"89_CR12","doi-asserted-by":"crossref","unstructured":"O\u2019Donnell DE, Hernandez P, Kaplan A, Aaron S, Bourbeau J, Marciniuk D et al. Canadian Thoracic Society recommendations for management of chronic obstructive pulmonary disease\u20142008 update\u2014highlights for primary care. Can Respir J 2008;15(Suppl A):1A\u20138A.","DOI":"10.1155\/2008\/420268"},{"issue":"11","key":"89_CR13","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1086\/375078","volume":"36","author":"Y Khaliq","year":"2003","unstructured":"Khaliq Y, Zhanel GG. Fluoroquinolone-associated tendinopathy: a critical review of the literature. Clin Infect Dis. 2003;36(11):1404\u201310.","journal-title":"Clin Infect Dis"},{"key":"89_CR14","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.amjmed.2004.09.015","volume":"118","author":"JA Linder","year":"2005","unstructured":"Linder JA, Huang ES, Steinman MA, Gonzales R, Stafford RS. Fluoroquinolone prescribing in the United States: 1995 to 2002. Am J Med. 2005;118:259\u201368.","journal-title":"Am J Med"},{"key":"89_CR15","unstructured":"Wells GA, Shea B, O\u2019Connell D, Peterson J, Welch V, Losos M et al. The Newcastle\u2013Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses."},{"key":"89_CR16","doi-asserted-by":"crossref","first-page":"3540","DOI":"10.3390\/ijerph9103540","volume":"9","author":"SM Costa","year":"2012","unstructured":"Costa SM, Martins CC, Bonfim MC, Zina LG, Paiva SM, Pordeus IA, et al. A systematic review of socioeconomic indicators and dental caries in adults. Int J Environ Res Public Health. 2012;9:3540\u201374.","journal-title":"Int J Environ Res Public Health"},{"key":"89_CR17","doi-asserted-by":"crossref","unstructured":"Wise BL, Peloquin C, Choi H, Lane NE, Zhang Y. Impact of age, sex, obesity, and steroid use on quinolone-associated tendon disorders. Amer J Med. 2012;125(12):1228.e23\u20138.","DOI":"10.1016\/j.amjmed.2012.05.027"},{"issue":"9","key":"89_CR18","doi-asserted-by":"crossref","first-page":"789","DOI":"10.2165\/11536810-000000000-00000","volume":"33","author":"F Lapi","year":"2010","unstructured":"Lapi F, Tuccori M, Motola D, Pugi A, Vietri M, Montanaro N, et al. Safety profile of the fluoroquinolones: analysis of adverse drug reactions in relation to prescription data using four regional pharmacovigilance databases in Italy. Drug Saf. 2010;33(9):789\u201399.","journal-title":"Drug Saf"},{"issue":"11","key":"89_CR19","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1002\/pds.1214","volume":"15","author":"JD Seeger","year":"2006","unstructured":"Seeger JD, West WA, Fife D, Noel GJ, Johnson LN, Walker AM. Achilles tendon rupture and its association with fluoroquinolone antibiotics and other potential risk factors in a managed care population. Pharmacoepidemiol Drug Saf. 2006;15(11):784\u201392.","journal-title":"Pharmacoepidemiol Drug Saf"},{"issue":"10","key":"89_CR20","doi-asserted-by":"crossref","first-page":"889","DOI":"10.2165\/00002018-200629100-00006","volume":"29","author":"G Corrao","year":"2006","unstructured":"Corrao G, Zambon A, Bertu L, Mauri A, Paleari V, Rossi C, et al. Evidence of tendinitis provoked by fluoroquinolone treatment: a case-control study. Drug Saf. 2006;29(10):889\u201396.","journal-title":"Drug Saf"},{"issue":"15","key":"89_CR21","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1001\/archinte.163.15.1801","volume":"163","author":"PD Linden van der","year":"2003","unstructured":"van der Linden PD, Sturkenboom MC, Herings RM, Leufkens HM, Rowlands S, Stricker BH. Increased risk of Achilles tendon rupture with quinolone antibacterial use, especially in elderly patients taking oral corticosteroids. Arch Intern Med. 2003;163(15):1801\u20137.","journal-title":"Arch Intern Med"},{"issue":"2","key":"89_CR22","doi-asserted-by":"crossref","first-page":"109","DOI":"10.2165\/00002018-200326020-00004","volume":"26","author":"R Leone","year":"2003","unstructured":"Leone R, Venegoni M, Motola D, Moretti U, Piazzetta V, Cocci A, et al. Adverse drug reactions related to the use of fluoroquinolone antimicrobials: an analysis of spontaneous reports and fluoroquinolone consumption data from three Italian regions. Drug Saf. 2003;26(2):109\u201320.","journal-title":"Drug Saf"},{"issue":"3","key":"89_CR23","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1183\/09031936.02.00257202","volume":"19","author":"PN Chhajed","year":"2002","unstructured":"Chhajed PN, Plit ML, Hopkins PM, Malouf MA, Glanville AR. Achilles tendon disease in lung transplant recipients: association with ciprofloxacin. Eur Respir J. 2002;19(3):469\u201371.","journal-title":"Eur Respir J"},{"issue":"7349","key":"89_CR24","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1136\/bmj.324.7349.1306","volume":"324","author":"PD Linden van der","year":"2002","unstructured":"van der Linden PD, Sturkenboom MC, Herings RM, Leufkens HG, Stricker BH. Fluoroquinolones and risk of Achilles tendon disorders: case-control study. BMJ. 2002;324(7349):1306\u20137.","journal-title":"BMJ"},{"issue":"3","key":"89_CR25","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/1529-0131(200106)45:3<235::AID-ART254>3.0.CO;2-7","volume":"45","author":"PD Linden van der","year":"2001","unstructured":"van der Linden PD, van Puijenbroek EP, Feenstra J, Veld BA, Sturkenboom MC, Herings RM, et al. Tendon disorders attributed to fluoroquinolones: a study on 42 spontaneous reports in the period 1988 to 1998. Arthritis Rheum. 2001;45(3):235\u20139.","journal-title":"Arthritis Rheum"},{"issue":"3","key":"89_CR26","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1023\/A:1011254030271","volume":"23","author":"PD Linden van der","year":"2001","unstructured":"van der Linden PD, Nab HW, Simonian S, Stricker BH, Leufkens HG, Herings RM. Fluoroquinolone use and the change in incidence of tendon ruptures in the Netherlands (Review, 23 refs). Pharm World Sci. 2001;23(3):89\u201392.","journal-title":"Pharm World Sci"},{"issue":"4","key":"89_CR27","first-page":"419","volume":"51","author":"C Pierfitte","year":"1996","unstructured":"Pierfitte C, Royer RJ. Tendon disorders with fluoroquinolones. Therapie. 1996;51(4):419\u201320.","journal-title":"Therapie"},{"key":"89_CR28","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1002\/pds.3285","volume":"21","author":"K Hori","year":"2012","unstructured":"Hori K, Yamakawa K, Yoshida N, Ohnishi K, Kawakami J. Detection of fluoroquinolone-induced tendon disorders using a hospital database in Japan. Pharmacoepidemiol Drug Saf. 2012;21:886\u20139.","journal-title":"Pharmacoepidemiol Drug Saf"},{"issue":"1","key":"89_CR29","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.healun.2007.09.021","volume":"27","author":"E Barge-Caballero","year":"2008","unstructured":"Barge-Caballero E, Crespo-Leiro MG, Paniagua-Martin MJ, Muniz J, Naya C, Bouzas-Mosquera A, et al. Quinolone-related Achilles tendinopathy in heart transplant patients: incidence and risk factors. J Heart Lung Transpl. 2008;27(1):46\u201351.","journal-title":"J Heart Lung Transpl"},{"issue":"5","key":"89_CR30","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s00228-007-0265-9","volume":"63","author":"J Sode","year":"2007","unstructured":"Sode J, Obel N, Hallas J, Lassen A. Use of fluroquinolone and risk of Achilles tendon rupture: a population-based cohort study. Eur J Clin Pharmacol. 2007;63(5):499\u2013503.","journal-title":"Eur J Clin Pharmacol"},{"issue":"3","key":"89_CR31","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1046\/j.1365-2125.1999.00016.x","volume":"48","author":"PD Linden van der","year":"1999","unstructured":"van der Linden PD, van de Lei J, Nab HW, Knol A, Stricker BH. Achilles tendinitis associated with fluoroquinolones. Br J Clin Pharmacol. 1999;48(3):433\u20137.","journal-title":"Br J Clin Pharmacol"},{"issue":"4","key":"89_CR32","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1046\/j.1365-2125.1996.03013.x","volume":"41","author":"LV Wilton","year":"1996","unstructured":"Wilton LV, Pearce GL, Mann RD. A comparison of ciprofloxacin, norfloxacin, ofloxacin, azithromycin and cefixime examined by observational cohort studies. Br J Clin Pharmacol. 1996;41(4):277\u201384.","journal-title":"Br J Clin Pharmacol"},{"key":"89_CR33","doi-asserted-by":"crossref","unstructured":"Le Huec JC, Schaeverbeke T, Chauveaux, Rivel J, Dehais J, Le Rebeller A. Epicondylitis after treatment with fluoroquinolone antibiotics. J Bone Joint Surg Br. 1995;77(293):295.","DOI":"10.1302\/0301-620X.77B2.7706350"},{"key":"89_CR34","first-page":"419","volume":"66","author":"N Schwald","year":"1999","unstructured":"Schwald N, Debray-Meignan S. Suspected role of ofloxacin in a case of arthralgia, myalgia, and multiple tendinopathy. Revue du Rhumatisme. 1999;66:419\u201321.","journal-title":"Revue du Rhumatisme"},{"issue":"3","key":"89_CR35","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1177\/03635465000280031401","volume":"28","author":"RJ Williams III","year":"2000","unstructured":"Williams RJ III, Attia E, Wickiewicz TL, Hannafin JA. The effect of ciprofloxacin on tendon, paratenon, and capsular fibroblast metabolism. Am J Sports Med. 2000;28(3):364\u20139.","journal-title":"Am J Sports Med"},{"key":"89_CR36","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0092-8674(02)00971-6","volume":"110","author":"RO Hynes","year":"2002","unstructured":"Hynes RO. Integrins: bidirectional, allosteric signaling machines. Cell. 2002;110:673\u201387.","journal-title":"Cell"},{"issue":"1","key":"89_CR37","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1124\/jpet.103.057984","volume":"308","author":"F Pouzaud","year":"2004","unstructured":"Pouzaud F, Bernard-Beaubois K, Thevenin M, Warnet JM, Hayem G, Rat P. In vitro discrimination of fluoroquinolones toxicity on tendon cells: involvement of oxidative stress. J Pharmacol Exp Ther. 2004;308(1):394\u2013402.","journal-title":"J Pharmacol Exp Ther"},{"issue":"10","key":"89_CR38","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1258\/jrsm.97.10.472","volume":"97","author":"N Maffulli","year":"2004","unstructured":"Maffulli N, Sharma P, Luscombe KL. Achilles tendinopathy: aetiology and management. J R Soc Med. 2004;97(10):472\u20136.","journal-title":"J R Soc Med"},{"key":"89_CR39","doi-asserted-by":"crossref","unstructured":"McLauchlan GJ, Handoll HH. Interventions for treating acute and chronic Achilles tendinitis. Cochrane Database Syst Rev 2001;(2):CD000232.","DOI":"10.1002\/14651858.CD000232"},{"issue":"3","key":"89_CR40","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1002\/art.23309","volume":"59","author":"I Marie","year":"2008","unstructured":"Marie I, Delafenetre H, Massy N, Thuillez C, Noblet C, et al. Tendinous disorders attributed to statins: a study on ninety-six spontaneous reports in the period 1990\u20132005 and review of the literature. Arthritis Rheum. 2008;59(3):367\u201372.","journal-title":"Arthritis Rheum"}],"container-title":["Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40264-013-0089-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40264-013-0089-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40264-013-0089-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T12:21:53Z","timestamp":1563538913000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40264-013-0089-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,26]]},"references-count":40,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["89"],"URL":"https:\/\/doi.org\/10.1007\/s40264-013-0089-8","relation":{},"ISSN":["0114-5916","1179-1942"],"issn-type":[{"value":"0114-5916","type":"print"},{"value":"1179-1942","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,26]]}}}