{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:21:34Z","timestamp":1791174094131,"version":"4.1.0"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"S1","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Saf"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1007\/s40264-013-0112-0","type":"journal-article","created":{"date-parts":[[2013,10,28]],"date-time":"2013-10-28T12:31:54Z","timestamp":1382963514000},"page":"195-204","source":"Crossref","is-referenced-by-count":7,"title":["The Impact of Drug and Outcome Prevalence on the Feasibility and Performance of Analytical Methods for a Risk Identification and Analysis System"],"prefix":"10.1007","volume":"36","author":[{"given":"Christian G.","family":"Reich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick B.","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc A.","family":"Suchard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,10,29]]},"reference":[{"issue":"2","key":"112_CR1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00228-011-1088-2","volume":"68","author":"Y Takahashi","year":"2012","unstructured":"Takahashi Y, Nishida Y, Asai S. Utilization of health care databases for pharmacoepidemiology. Eur J Clin Pharmacol. 2012;68(2):123\u20139.","journal-title":"Eur J Clin Pharmacol"},{"issue":"2","key":"112_CR2","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.amjmed.2008.09.030","volume":"122","author":"SL Silverman","year":"2009","unstructured":"Silverman SL. From randomized controlled trials to observational studies. Am J Med. 2009;122(2):114\u201320.","journal-title":"Am J Med"},{"issue":"9422","key":"112_CR3","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/S0140-6736(04)16261-2","volume":"363","author":"JP Vandenbroucke","year":"2004","unstructured":"Vandenbroucke JP. When are observational studies as credible as randomised trials? Lancet. 2004;363(9422):1728\u201331.","journal-title":"Lancet"},{"issue":"9","key":"112_CR4","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1001\/jama.281.9.841","volume":"281","author":"R Temple","year":"1999","unstructured":"Temple R. Meta-analysis and epidemiologic studies in drug development and postmarketing surveillance. JAMA. 1999;281(9):841\u20134.","journal-title":"JAMA"},{"issue":"5221","key":"112_CR5","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1126\/science.7618077","volume":"269","author":"G Taubes","year":"1995","unstructured":"Taubes G. Epidemiology faces its limits. Science. 1995;269(5221):164\u20139.","journal-title":"Science"},{"issue":"6","key":"112_CR6","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1002\/pds.3197","volume":"21","author":"PM Coloma","year":"2012","unstructured":"Coloma PM, Trifir\u00f2 G, Schuemie MJ, Gini R, Herings R, Hippisley-Cox J, et al. Electronic healthcare databases for active drug safety surveillance: is there enough leverage? Pharmacoepidemiol Drug Saf. 2012;21(6):611\u201321.","journal-title":"Pharmacoepidemiol Drug Saf"},{"issue":"30","key":"112_CR7","doi-asserted-by":"crossref","first-page":"4401","DOI":"10.1002\/sim.5620","volume":"31","author":"PB Ryan","year":"2012","unstructured":"Ryan PB, Madigan D, Stang PE, Marc Overhage J, Racoosin JA, Hartzema AG. Empirical assessment of methods for risk identification in healthcare data: results from the experiments of the Observational Medical Outcomes Partnership. Stat Med. 2012;31(30):4401\u201315.","journal-title":"Stat Med"},{"key":"112_CR8","doi-asserted-by":"crossref","unstructured":"Ryan PB, Stang PE, Overhage JM, Suchard MA, Hartzema AG, DuMouchel W, et al. A comparison of the empirical performance of methods for a risk identification system. Drug Saf (in this supplement issue). doi: 10.1007\/s40264-013-0108-9 .","DOI":"10.1007\/s40264-013-0108-9"},{"issue":"2","key":"112_CR9","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1093\/aje\/126.2.356","volume":"126","author":"B Armstrong","year":"1987","unstructured":"Armstrong B. A simple estimator of minimum detectable relative risk, sample size, or power in cohort studies. Am J Epidemiol. 1987;126(2):356\u20138.","journal-title":"Am J Epidemiol"},{"issue":"5","key":"112_CR10","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1093\/oxfordjournals.aje.a113244","volume":"114","author":"JJ Beaumont","year":"1981","unstructured":"Beaumont JJ, Breslow NE. Power considerations in epidemiologic studies of vinyl chloride workers. Am J Epidemiol. 1981;114(5):725\u201334.","journal-title":"Am J Epidemiol"},{"key":"112_CR11","doi-asserted-by":"crossref","unstructured":"Overhage JM, Ryan PB, Schuemie MJ, Stang PE. Desideratum for Evidence Based Epidemiology. Drug Saf (in this supplement issue). doi: 10.1007\/s40264-013-0102-2 .","DOI":"10.1007\/s40264-013-0102-2"},{"key":"112_CR12","doi-asserted-by":"crossref","unstructured":"Ryan PB, Schuemie MJ, Welebob E, Duke J, Valentine S, Hartzema AG. Defining a reference set to support methodological research in drug safety. Drug Saf (in this supplement issue). doi: 10.1007\/s40264-013-0097-8 .","DOI":"10.1007\/s40264-013-0097-8"},{"issue":"4","key":"112_CR13","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1177\/0272989X0002000410","volume":"20","author":"SB Cantor","year":"2000","unstructured":"Cantor SB, Kattan MW. Determining the area under the ROC curve for a binary diagnostic test. Med Decis Making. 2000;20(4):468\u201370.","journal-title":"Med Decis Making"},{"key":"112_CR14","unstructured":"FDA Drug Safety Communication: risk of progressive multifocal leukoencephalopathy (PML) with the use of Tysabri (natalizumab). 02-05-2010 [cited 2013 January 28]. http:\/\/www.fda.gov\/drugs\/drugsafety\/postmarketdrugsafetyinformationforpatientsandproviders\/ucm199872.htm ."},{"key":"112_CR15","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1002\/sim.2477","volume":"25","author":"P Musonda","year":"2006","unstructured":"Musonda P, Farrington CP, Whitaker HJ. Sample sizes for self-controlled case series studies. Stat Med. 2006;25:2618\u201331.","journal-title":"Stat Med"},{"issue":"2","key":"112_CR16","doi-asserted-by":"crossref","first-page":"499","DOI":"10.2307\/2531021","volume":"39","author":"DA Schoenfeld","year":"1983","unstructured":"Schoenfeld DA. Sample-size formula for the proportional-hazards regression model. Biometrics. 1983;39(2):499\u2013503.","journal-title":"Biometrics"},{"key":"112_CR17","doi-asserted-by":"crossref","unstructured":"Reich CG, Ryan PB, Schuemie MJ. Alternative outcome definitions and their effect on the performance of methods for observational outcome studies. Drug Saf (in this supplement issue). doi: 10.1007\/s40264-013-0111-1 .","DOI":"10.1007\/s40264-013-0111-1"}],"container-title":["Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40264-013-0112-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40264-013-0112-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40264-013-0112-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T11:23:07Z","timestamp":1564572187000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40264-013-0112-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":17,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["112"],"URL":"https:\/\/doi.org\/10.1007\/s40264-013-0112-0","relation":{},"ISSN":["0114-5916","1179-1942"],"issn-type":[{"value":"0114-5916","type":"print"},{"value":"1179-1942","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10]]}}}