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Additional general development funds for the social listening platform were provided to Epidemico through a public\u2013private partnership but were not used to directly support the specific content of this research. This collaborative effort is provided via the WEB-RADR project (), which is supported by the Innovative Medicines Initiative Joint Undertaking (IMI JU) under Grant Agreement No. 115632, resources of which are composed of financial contributions from the EU\u2019s Seventh Framework Programme (FP7\/2007-2013) and European Federation of Pharmaceutical Industries and Associations (EFPIA) companies\u2019 in-kind contribution (). In addition, general support for the development of the social media listening platform was provided by GlaxoSmithKline (GSK), independent of the research presented herein. GSK, WEB-RADR, and IMI JU had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"Carrie Pierce, Hoa Van Le, Harold Rodriguez, John Brownstein, Clark Freifeld, and Nabarun Dasgupta are employees of or contractors to Epidemico, a technology company intending to commercialize the software platform used in this research. Epidemico is a wholly owned subsidiary of Booz Allen Hamilton. I. Ralph Edwards has no conflicts of interest that are directly relevant to the content of this manuscript. Khaled Bouri, Carol Pamer, Scott Proestel, and Mark Walderhaug are employees of the United States Food and Drug Administration. Development of the social listening platform, research conducted, and manuscript development was funded by the US FDA () under contract with Epidemico, Inc (HHSF223201210217C).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The following authors are employees of the US Government: Khaled Bouri, Carol Pamer, Scott Proestel, and Mark Walderhaug. The opinions expressed in this manuscript are those of the authors and not intended to represent the opinions of the United States Food and Drug Administration.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"US Government employee statement"}},{"value":"All human subject data used in this analysis were publicly available and used in a de-identified format whenever possible.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}}]}}