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JR is the recipient of a Doctoral Award from the Canadian Institutes of Health Research (FRN-152254). LA holds a Chercheur-Boursier Senior Award from the Fonds de Recherche du Qu\u00e9bec\u2014Sant\u00e9 and is the recipient of a William Dawson Scholar award from McGill University. Researchers were independent from the funding sources. The funding sources had no influence on the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"JR received consulting fees for work unrelated to this project from Biogen. LA received consulting fees from Janssen and Pfizer for work unrelated to this paper. AP reports participation in research projects funded by Alcon, Almirall Astellas, AstraZeneca, Boehringer-Ingelheim, Novo Nordisk, Servier and LEO Pharma, all with funds paid to the institution where he was employed (no personal fees) and with no relation to the work reported in this paper. KN received research funding from AstraZeneca, Vifor and CSL Behring and personal fees from MSD, Sanofi and Boehringer Ingelheim, all unrelated to this study. HY has no conflicts of interest to disclose.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The study protocol was approved by the Independent Scientific Advisory Committee of the CPRD (protocol number 19_279A) and the Research Ethics Board of the Jewish General Hospital, Montreal, Canada (number 2020-2207).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The data cannot be shared publicly due to patients\u2019 privacy, as per the Clinical Practice Research Datalink policy.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data and materials"}},{"value":"The codes cannot be shared publicly, as per the Lady Davis Institute\u2014Centre for Clinical Epidemiology policy.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}},{"value":"Conception and planning of the work that led to the manuscript (JR, HY, LA). Acquisition, analysis and interpretation of the data (JR, HY, AP, KN, LA). Drafting and\/or critical revision of the manuscript for important intellectual content (JR, HY, AP, KN, LA). Approval of the final submitted version of the manuscript (JR, HY, AP, KN, LA).","order":9,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author contributions"}}]}}