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All authors read and approved the final version. Wen, Lawal and Meador conceptualized and designed this study, and drafted the initial version of the manuscript. Wen, Meador, Lawal and Belviso contributed to data preparation, statistical analyses, and interpretation. Wang contributed to statistical analyses and interpretation. Matson and Quilliam provided clinical and technical support, and contribution to interpretation of study findings.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author contributions"}},{"value":"Research reported in this publication was supported by the Eunice Kennedy Shriver National Institute Of Child Health & Human Development of the National Institutes of Health under Award Number R15HD097588. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Principal Investigator: Wen X. The funding source had no role in the design or conduct of the study; collection, management, analysis, or the interpretation of the data preparation, review, or approval of the manuscript; or the decision to submit the manuscript for publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding\/support"}},{"value":"Dr Meador has received research support from the National Institutes of Health and Sunovion Pharmaceuticals, and travel support from Eisai. The Epilepsy Study Consortium pays Dr Meador\u2019s university for his research consultant time related to Eisai, GW\u00a0Pharmaceuticals, NeuroPace, Novartis, Supernus, Upsher-Smith Laboratories, and UCB\u00a0Pharma. The other authors have no conflicts of interests to declare.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest and financial disclosures"}},{"value":"This study uses deidentified data, hence was considered exempt by the University of Rhode Island Institutional Review Board.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"A data use agreement exists between The University of Rhode Island College of Pharmacy and Optum. The Optum Clinformatics Data Mart database cannot be shared by authors with parties external to this agreement.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data and material"}},{"value":"Not applicable.","order":9,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}}]}}