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The ConcePTION project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement no. 821520. This joint undertaking receives support from the European Union\u2019s Horizon 2020 Research and Innovation Program and EFPIA. The research leading to these results was conducted as part of the ConcePTION Consortium. This paper only reflects personal views of the stated authors.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"GF, JLR, AO, SS, YRJvRW, DB, AP, CC, EvP, ODC, MB, TDH, FG and UW declare no conflicts of interest, no other financial relationships with any organisations that might have an interest in the submitted work in the previous 3 years, and no previous or ongoing relationships or activities that could appear to have influenced the submitted work. A. Moore was a Novartis associate whilst working on this manuscript and other aspects of the ConcePTION project and holds shares in Novartis Pharma AG. YG and VJ are employees of Novartis Pharma AG. M. Stellfeld is an employee of Novo Nordisk A\/S. M. Sabid\u00f3 and SdS are employees of Merck Healthcare KGaA. LMY received honoraria from Sanofi Genzyme South Africa on two occasions in 2021 for (1) an advisory board presentation on genetic testing in Gaucher\u2019s disease (April 2021) and (2) a conference lecture on genetic testing in the cardiac clinic\u2019 (September 2021). A. Mor is an employee of Sanofi and holds shares in Sanofi.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of Interest\/Competing Interests"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"Data will be available\u00a0from the corresponding author to third parties interested in reusing them upon reasonable request.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of Data and Material"}},{"value":"Not applicable.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code Availability"}},{"value":"GF, JLR, A. Moore, YG, AO, SS, ODC, MB, A. Mor, M. Sabid\u00f3, YRJvRW, EvP, LMY, M. Stellfeld and UW contributed to the study conception and design. GF, JLR, A. Moore, YG, AO, SS, ODC, MB, TDH, A. Mor, M. Sabid\u00f3, SdS, CC, YRJvRW, EvP, LMY, FG, M. Stellfeld and UW contributed to the acquisition of data. GF, JLR, M, Stellfeld and UW contributed to the data analysis. GF, JLR, A. Moore, YG, VJ, AO, SS, ODC, MB, TDH, DB, AP, A. Mor, M Sabid\u00f3, SdS, CC, YRJvRW, EvP, LMY, FG, M. Stellfeld and UW contributed to interpretation of the data, and drafting and revising of the manuscript for intellectual content.\u00a0All authors read and approved the final version.","order":9,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author Contributions"}}]}}