{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:21:30Z","timestamp":1787876490675,"version":"build-2784847793"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"name":"Epiphare 2023"},{"DOI":"10.13039\/501100004718","name":"Universit\u00e9 de Toulouse","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004718","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drug Saf"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1007\/s40264-025-01556-3","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T14:38:14Z","timestamp":1751294294000},"page":"1047-1061","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Characteristics of Drug-RElated Hospitalizations for Nursing HOme Residents: Cross-Sectional RENHO Study"],"prefix":"10.1007","volume":"48","author":[{"given":"Alice","family":"Lopez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Alfarano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Lepetit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Chebane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nassima","family":"Redjimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana\u00efs","family":"Couret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Fabre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Gardette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Driss","family":"Berda\u00ef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryse","family":"Lapeyre-Mestre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9585-9341","authenticated-orcid":false,"given":"Haleh","family":"Bagheri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,30]]},"reference":[{"key":"1556_CR1","unstructured":"Ageing. https:\/\/www.unfpa.org\/ageing. Accessed 20 May 2025"},{"key":"1556_CR2","unstructured":"Des r\u00e9sidents de plus en plus \u00e2g\u00e9s et d\u00e9pendants dans les \u00e9tablissement d\u2019h\u00e9bergement pour personnes \u00e2g\u00e9es.pdf. https:\/\/drees.solidarites-sante.gouv.fr\/sites\/default\/files\/2022-07\/er1237.pdf. Accessed 16 Feb 2024."},{"key":"1556_CR3","first-page":"92","volume":"113","author":"F Hoffmann","year":"2016","unstructured":"Hoffmann F, Boeschen D, D\u00f6rks M, et al. Renal insufficiency and medication in nursing home residents: a cross-sectional study (IMREN). Dtsch Arztebl Int. 2016;113:92\u20138.","journal-title":"Dtsch Arztebl Int"},{"key":"1556_CR4","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1093\/ageing\/aft077","volume":"43","author":"AL Gordon","year":"2014","unstructured":"Gordon AL, Franklin M, Bradshaw L, et al. Health status of UK care home residents: a cohort study. Age Ageing. 2014;43:97\u2013103.","journal-title":"Age Ageing"},{"key":"1556_CR5","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.amjopharm.2010.01.001","volume":"8","author":"LL Dwyer","year":"2010","unstructured":"Dwyer LL, Han B, Woodwell DA, et al. Polypharmacy in nursing home residents in the United States: results of the 2004 National Nursing Home Survey. Am J Geriatr Pharmacother. 2010;8:63\u201372.","journal-title":"Am J Geriatr Pharmacother"},{"key":"1556_CR6","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1007\/s40520-019-01306-3","volume":"32","author":"AM Fassmer","year":"2019","unstructured":"Fassmer AM, Hoffmann F. Acute health care services use among nursing home residents in Germany: a comparative analysis of out-of-hours medical care, emergency department visits and acute hospital admissions. Aging Clin Exp Res. 2019;32:1359\u201368.","journal-title":"Aging Clin Exp Res"},{"key":"1556_CR7","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.3390\/jcm12041320","volume":"12","author":"A Haerdtlein","year":"2023","unstructured":"Haerdtlein A, Debold E, Rottenkolber M, et al. Which adverse events and which drugs are implicated in drug-related hospital admissions: a systematic review and metaanalysis. J Clin Med. 2023;12:1320.","journal-title":"J Clin Med"},{"key":"1556_CR8","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1111\/j.1532-5415.2010.02768.x","volume":"58","author":"JG Ouslander","year":"2010","unstructured":"Ouslander JG, Lamb G, Perloe M, et al. Potentially avoidable hospitalizations of nursing home residents: frequency, causes, and costs. J Am Geriatr Soc. 2010;58:627\u201335.","journal-title":"J Am Geriatr Soc"},{"key":"1556_CR9","doi-asserted-by":"publisher","first-page":"233372141769667","DOI":"10.1177\/2333721417696671","volume":"3","author":"O Kada","year":"2017","unstructured":"Kada O, Janig H, Likar R, et al. Reducing avoidable hospital transfers from nursing homes in Austria: project outline and baseline results. Gerontol Geriatr Med. 2017;3:2333721417696671.","journal-title":"Gerontol Geriatr Med."},{"key":"1556_CR10","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s12877-019-1028-z","volume":"19","author":"SE Lemoyne","year":"2019","unstructured":"Lemoyne SE, Herbots HH, De Blick D, et al. Appropriateness of transferring nursing home residents to emergency departments: a systematic review. BMC Geriatr. 2019;19:17.","journal-title":"BMC Geriatr"},{"key":"1556_CR11","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/1471-2318-14-80","volume":"14","author":"A Renom-Guiteras","year":"2014","unstructured":"Renom-Guiteras A, Uhrenfeldt L, Meyer G, et al. Assessment tools for determining appropriateness of admission to acute care of persons transferred from long-term care facilities: a systematic review. BMC Geriatr. 2014;14:80.","journal-title":"BMC Geriatr"},{"key":"1556_CR12","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.cger.2012.01.002","volume":"28","author":"BM Shah","year":"2012","unstructured":"Shah BM, Hajjar ER. Polypharmacy, adverse drug reactions, and geriatric syndromes. Clin Geriatr Med. 2012;28:173\u201386.","journal-title":"Clin Geriatr Med"},{"key":"1556_CR13","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.amjopharm.2006.03.002","volume":"4","author":"JK Nguyen","year":"2006","unstructured":"Nguyen JK, Fouts MM, Kotabe SE, et al. Polypharmacy as a risk factor for adverse drug reactions in geriatric nursing home residents. Am J Geriatr Pharmacother. 2006;4:36\u201341.","journal-title":"Am J Geriatr Pharmacother"},{"key":"1556_CR14","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1111\/j.1365-2125.2010.03751.x","volume":"70","author":"EC Davies","year":"2010","unstructured":"Davies EC, Green CF, Mottram DR, et al. Emergency re-ad-missions to hospital due to adverse drug reactions within 1 year of the index admission. Br J Clin Pharmacol. 2010;70:749\u201355.","journal-title":"Br J Clin Pharmacol"},{"key":"1556_CR15","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1007\/s00228-016-2022-4","volume":"72","author":"L Hauviller","year":"2016","unstructured":"Hauviller L, Eyvrard F, Garnault V, et al. Hospital re-admission associated with adverse drug reactions in patients over the age of 65 years. Eur J Clin Pharmacol. 2016;72:631\u20139.","journal-title":"Eur J Clin Pharmacol"},{"key":"1556_CR16","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1007\/s40266-017-0490-6","volume":"34","author":"N Parameswaran Nair","year":"2017","unstructured":"Parameswaran Nair N, Chalmers L, Bereznicki BJ, et al. Repeat adverse drug reaction-related hospital admissions in elderly Australians: a retrospective study at the Royal Hobart Hospital. Drugs Aging. 2017;34:777\u201383.","journal-title":"Drugs Aging"},{"key":"1556_CR17","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1007\/s41999-021-00471-x","volume":"12","author":"F Lombardi","year":"2021","unstructured":"Lombardi F, Paoletti L, Carrieri B, et al. Underprescription of medications in older adults: causes, consequences and solutions: a narrative reveiw. Eur Geriatr Med. 2021;12:453\u201362.","journal-title":"Eur Geriatr Med."},{"key":"1556_CR18","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1111\/bcp.13055","volume":"82","author":"M Wauters","year":"2016","unstructured":"Wauters M, Elseviers M, Vaes B, et al. Too many, too few, or too unsafe? Impact of inappropriate prescribing on mortality, and hospitalization in a cohort of community-dwelling oldest old. Br J Clin Pharmacol. 2016;82:1382\u201392.","journal-title":"Br J Clin Pharmacol"},{"key":"1556_CR19","doi-asserted-by":"publisher","first-page":"429","DOI":"10.2165\/00002018-200932050-00006","volume":"32","author":"AP Jonville-B\u00e9ra","year":"2009","unstructured":"Jonville-B\u00e9ra AP, Saissi H, Bensouda-Grimaldi L, et al. Avoidability of adverse drug eeactions spontaneously reported to French regional drug monitoring. Drug Saf. 2009;32:429\u201340.","journal-title":"Drug Saf"},{"key":"1556_CR20","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1111\/jcpt.13306","volume":"46","author":"LC Abu Esba","year":"2021","unstructured":"Abu Esba LC, Al Mardawi G, Aljasser AI, et al. Adverse drug reactions spontaneously reported at a tertiary care hospital and preventable measures implemented. J Clin Pharm Ther. 2021;46:460\u20139.","journal-title":"J Clin Pharm Ther"},{"key":"1556_CR21","unstructured":"WHO. International statistical classification of diseases and related health problems, 10th revision. http:\/\/apps.who.int\/classifications\/icd10\/browse\/2010\/en. Accessed 14 May 2025."},{"key":"1556_CR22","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1159\/000521288","volume":"91","author":"ME Charlson","year":"2022","unstructured":"Charlson ME, Carrozzino D, Guidi J, et al. Charlson Comorbidity Index: a critical review of clinimetric properties. Psychother Psychosom. 2022;91:8\u201335.","journal-title":"Psychother Psychosom"},{"key":"1556_CR23","first-page":"111","volume":"24","author":"V Coutton","year":"2001","unstructured":"Coutton V. Evaluer la d\u00e9pendance \u00e0 l\u2019aide de groupes iso-ressources (GIR): une tentative en France avec la grille aggir. Gerontol Soc. 2001;24:111\u201329.","journal-title":"Gerontol Soc"},{"key":"1556_CR24","unstructured":"Norwegian Institute of Public Health. Anatomical therapeutic chemical structure and principles. https:\/\/www.whocc.no\/atc\/structure_and_principles. Accessed 10 June 2024."},{"key":"1556_CR25","unstructured":"National Coordinating Council for Medication Error Reporting and Prevention (NCCMERP). What is medication error? https:\/\/www.nccmerp.org\/about-medication-errors. Accessed 10 June 2024."},{"key":"1556_CR26","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1111\/bcp.12657","volume":"80","author":"AD Meid","year":"2015","unstructured":"Meid AD, Lampert A, Burnett A, et al. The impact of pharmaceutical care interventions for medication underuse in older people: a systematic review and meta-analysis. Br J Clin Pharmacol. 2015;80:768\u201376.","journal-title":"Br J Clin Pharmacol"},{"key":"1556_CR28","unstructured":"Medical Dictionary for Regulatory Activities (MedDRA). https:\/\/www.meddra.org\/. Accessed 10 June 2024."},{"key":"1556_CR29","doi-asserted-by":"publisher","first-page":"2752","DOI":"10.1136\/bmj.a2752","volume":"338","author":"M Zhang","year":"2009","unstructured":"Zhang M, Holman CDJ, Price SD, et al. Comorbidity and repeat admission to hospital for adverse drug reactions in older adults: retrospective cohort study. BMJ. 2009;338:2752.","journal-title":"BMJ"},{"key":"1556_CR27","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1097\/00007611-199905000-00007","volume":"92","author":"JW Cooper","year":"1999","unstructured":"Cooper JW. Adverse drug reaction-related hospitalizations of nursing facility patients: a 4-year study. South Med J. 1999;92:485\u201390.","journal-title":"South Med J"},{"key":"1556_CR30","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1136\/bmjqs-2021-014280","volume":"31","author":"N Ayani","year":"2022","unstructured":"Ayani N, Oya N, Kitaoka R, et al. Epidemiology of adverse drug events and medication errors in four nursing homes in Japan: the Japan Adverse Drug Events (JADE) Study. BMJ Qual Saf. 2022;31:878\u201387.","journal-title":"BMJ Qual Saf"},{"key":"1556_CR31","doi-asserted-by":"publisher","first-page":"1044744","DOI":"10.3389\/fphar.2022.1044744","volume":"13","author":"S Zhou","year":"2022","unstructured":"Zhou S, Jia B, Kong J, et al. Drug-induced fall risk in older patients: a pharmacovigilance study in FDA adverse event reporting system database. Front Pharmacol. 2022;13:1044744. https:\/\/doi.org\/10.3389\/fphar.2022.1044744.","journal-title":"Front Pharmacol"},{"key":"1556_CR32","doi-asserted-by":"publisher","first-page":"385","DOI":"10.4140\/TCP.n.2016.385","volume":"31","author":"JH Watanabe","year":"2016","unstructured":"Watanabe JH. Medication use, falls, and fall-related worry in older adults in the United States. Consult Pharm. 2016;31:385\u201393. https:\/\/doi.org\/10.4140\/TCP.n.2016.385.","journal-title":"Consult Pharm"},{"key":"1556_CR33","doi-asserted-by":"publisher","first-page":"3123","DOI":"10.3390\/ijerph19053123","volume":"19","author":"N Oya","year":"2022","unstructured":"Oya N, Ayani N, Kuwahara A, et al. Over half of falls were associated with psychotropic medication use in four nursing homes in Japan: a retrospective cohort study. Int J Environ Res Public Health. 2022;19:3123. https:\/\/doi.org\/10.3390\/ijerph19053123.","journal-title":"Int J Environ Res Public Health"},{"key":"1556_CR34","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1016\/j.jamda.2016.07.004","volume":"17","author":"CA Cox","year":"2016","unstructured":"Cox CA, van Jaarsveld HJ, Houterman S, et al. Psychotropic drug prescription and the risk of falls in nursing home residents. J Am Med Dir Assoc. 2016;17:1089\u201393. https:\/\/doi.org\/10.1016\/j.jamda.2016.07.004.","journal-title":"J Am Med Dir Assoc"},{"key":"1556_CR35","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1111\/j.1447-0594.2011.00703","volume":"11","author":"T Kojima","year":"2011","unstructured":"Kojima T, Akishita M, Nakamura T, et al. Association of polypharmacy with fall risk among geriatric outpatients. Geriatr Gerontol Int. 2011;11:438\u201344. https:\/\/doi.org\/10.1111\/j.1447-0594.2011.00703.","journal-title":"Geriatr Gerontol Int"},{"key":"1556_CR36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0174730","volume":"12","author":"K Donnelly","year":"2017","unstructured":"Donnelly K, Bracchi R, Hewitt J, Routledge PA, Carter B. Benzodiazepines, Z-drugs and the risk of hip fracture: a systematic review and meta-analysis. PLoS ONE. 2017;12: e0174730. https:\/\/doi.org\/10.1371\/journal.pone.0174730.","journal-title":"PLoS ONE"},{"key":"1556_CR37","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1007\/s40266-016-0414-x","volume":"33","author":"M Lapeyre-Mestre","year":"2016","unstructured":"Lapeyre-Mestre M. A review of adverse outcomes associated with psychoactive drug use in nursing home residents with dementia. Drugs Aging. 2016;33:865\u201388. https:\/\/doi.org\/10.1007\/s40266-016-0414-x.","journal-title":"Drugs Aging"},{"key":"1556_CR38","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1016\/j.jamda.2020.02.019","volume":"21","author":"A Couret","year":"2020","unstructured":"Couret A, Gallini A, Poncet M, et al. Benzodiazepine dispensing to persons with dementia in France, 2011\u20132016: a nationwide study. J Am Med Dir Assoc. 2020;21:830\u20136. https:\/\/doi.org\/10.1016\/j.jamda.2020.02.019.","journal-title":"J Am Med Dir Assoc"},{"key":"1556_CR39","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.1093\/pm\/pnw255","volume":"18","author":"S M\u00fcller-Lissner","year":"2017","unstructured":"M\u00fcller-Lissner S, Bassotti G, Coffin B, et al. Opioid-induced constipation and bowel dysfunction: a clinical guideline. Pain Med. 2017;18:1837\u201363. https:\/\/doi.org\/10.1093\/pm\/pnw255.","journal-title":"Pain Med"},{"key":"1556_CR40","first-page":"CD011128","volume":"1","author":"S Every-Palmer","year":"2017","unstructured":"Every-Palmer S, Newtones-Howes G, Clarke MJ. Treatment for antipsychotic-related constipation. Cochrane Database Syst Rev. 2017;1:CD011128.","journal-title":"Cochrane Database Syst Rev"},{"key":"1556_CR41","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/S0002-9343(00)00451-4","volume":"109","author":"JH Gurwitz","year":"2000","unstructured":"Gurwitz JH, Field TS, Avorn J, et al. Incidence and preventability of adverse drug events in nursing homes. Am J Med. 2000;109:87\u201394.","journal-title":"Am J Med"},{"key":"1556_CR42","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1001\/archinte.161.13.1629","volume":"161","author":"TS Field","year":"2001","unstructured":"Field TS, Gurwitz JH, Avorn J, et al. Risk factors for adverse drug events among nursing home residents. Arch Intern Med. 2001;161:1629\u201334. https:\/\/doi.org\/10.1001\/archinte.161.13.1629.","journal-title":"Arch Intern Med"},{"key":"1556_CR43","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1001\/archinte.165.1.68","volume":"165","author":"DT Lau","year":"2005","unstructured":"Lau DT, Kasper JD, Potter DE, Lyles A, Bennett RG. Hospitalization and death associated with potentially inappropriate medication prescriptions among elderly nursing home residents. Arch Intern Med. 2005;165:68\u201374. https:\/\/doi.org\/10.1001\/archinte.165.1.68.","journal-title":"Arch Intern Med"},{"key":"1556_CR44","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1186\/s12877-023-04165-w","volume":"23","author":"HW Chae","year":"2023","unstructured":"Chae HW, Zhao J, Ah YM, et al. Potentially inappropriate medication use as predictors of hospitalization for residents in nursing home. BMC Geriatr. 2023;23:467. https:\/\/doi.org\/10.1186\/s12877-023-04165-w.","journal-title":"BMC Geriatr"},{"key":"1556_CR45","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.jamda.2014.11.017","volume":"16","author":"F Moulis","year":"2015","unstructured":"Moulis F, Moulis G, Balardy L, et al. Exposure to atropinic drugs and frailty status. J Am Med Dir Assoc. 2015;16:253\u20137.","journal-title":"J Am Med Dir Assoc"},{"key":"1556_CR46","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1186\/s12913-015-0950-9","volume":"15","author":"D Picker","year":"2015","unstructured":"Picker D, Heard K, Bailey TC, Martin NR, LaRossa GN, Kollef MH. The number of discharge medications predicts thirty-day hospital readmission: a cohort study. BMC Health Serv Res. 2015;15:282. https:\/\/doi.org\/10.1186\/s12913-015-0950-9.","journal-title":"BMC Health Serv Res"},{"key":"1556_CR47","doi-asserted-by":"publisher","unstructured":"Deschodt M, Devriendt E, Sabbe M, et al. Characteristics of older adults admitted to the emergency department (ED) and their risk factors for ED admission based on comprehensive geriatric assessment: a prospective cohort study. BMC Geriatr. 2015;15:54. https:\/\/doi.org\/10.1186\/s12877-015-0055-7.","DOI":"10.1186\/s12877-015-0055-7"},{"key":"1556_CR48","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1093\/ageing\/afaa139","volume":"50","author":"F Visade","year":"2021","unstructured":"Visade F, Babykina G, Lamer A, et al. Importance of previous hospital stays on the risk of hospital re-admission in older adults: a real life analysis of the PAERPA study population. Age Ageing. 2021;50:141\u20136.","journal-title":"Age Ageing"},{"key":"1556_CR49","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1093\/ageing\/afn093","volume":"37","author":"I Lani\u00e8ce","year":"2008","unstructured":"Lani\u00e8ce I, Couturier P, Dram\u00e9 M, et al. Incidence and main factors associated with early unplanned hospital readmission among French medical inpatients aged 75 and over admitted through emergency units. Age Ageing. 2008;37:416\u201322.","journal-title":"Age Ageing"},{"key":"1556_CR50","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1136\/jech-2015-206978","volume":"70","author":"G Kojima","year":"2016","unstructured":"Kojima G. Frailty as a predictor of hospitalisation among community-dwelling older people: a systematic review and meta-analysis. J Epidemiol Community Health. 2016;70:722\u20139.","journal-title":"J Epidemiol Community Health"},{"key":"1556_CR51","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.archger.2013.03.007","volume":"57","author":"SY Wang","year":"2013","unstructured":"Wang SY, Shamliyan TA, Talley KM, Ramakrishnan R, Kane RL. Not just specific diseases: systematic review of the association of geriatric syndromes with hospitalization or nursing home admission. Arch Gerontol Geriatr. 2013;57:16\u201326.","journal-title":"Arch Gerontol Geriatr"},{"key":"1556_CR52","doi-asserted-by":"publisher","first-page":"1009485","DOI":"10.3389\/fphar.2022.1009485","volume":"13","author":"S Park","year":"2022","unstructured":"Park S, Kim AJ, Ah YM, et al. Prevalence and predictors of medication-related emergency department visit in older adults: a multicenter study linking national claim database and hospital medical records. Front Pharmacol. 2022;13:1009485. https:\/\/doi.org\/10.3389\/fphar.2022.1009485. (eCollection 2022).","journal-title":"Front Pharmacol"},{"key":"1556_CR53","doi-asserted-by":"publisher","first-page":"475","DOI":"10.2165\/00002512-200926060-00004","volume":"26","author":"P Olivier","year":"2009","unstructured":"Olivier P, Bertrand L, Tubery M, Lauque D, Montastruc JL, Lapeyre-Mestre M. Hospitalizations because of adverse drug reactions in elderly patients admitted through the emergency department: a prospective survey. Drugs Aging. 2009;26:475\u201382. https:\/\/doi.org\/10.2165\/00002512-200926060-00004. (PMID: 19591522).","journal-title":"Drugs Aging"},{"key":"1556_CR54","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1186\/1472-6963-13-473","volume":"13","author":"CM Hohl","year":"2013","unstructured":"Hohl CM, Kuramoto L, Yu E, Rogula B, et al. Evaluating adverse drug event reporting in administrative data from emergency departments: a validation study. BMC Health Serv Res. 2013;13:473. https:\/\/doi.org\/10.1186\/1472-6963-13-473.","journal-title":"BMC Health Serv Res"}],"container-title":["Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40264-025-01556-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40264-025-01556-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40264-025-01556-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T00:15:24Z","timestamp":1757204124000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40264-025-01556-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,30]]},"references-count":54,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["1556"],"URL":"https:\/\/doi.org\/10.1007\/s40264-025-01556-3","relation":{},"ISSN":["0114-5916","1179-1942"],"issn-type":[{"value":"0114-5916","type":"print"},{"value":"1179-1942","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,30]]},"assertion":[{"value":"5 May 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was funded by Appel d\u2019Offre Epiphare 2023.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"No commercial organizations had any role in the writing of this paper for publication. Alice Lopez, Chiara Alfarano, Marianne Lepetit, Leila Chebane, Nassima Redjimi, Ana\u00efs Couret, Didier Fabre, Virginie Gardette, Driss Berda\u00ef, Maryse Lapeyre-Mestre, and Haleh Bagheri have no conflicts of interest that are directly relevant to the content of this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest\/competing interests"}},{"value":"Strict confidentiality was ensured at all times during data collection, storage, and analysis. All methods were carried out in accordance with relevant guidelines and regulations. According to the French Ethics and Regulatory law (public health code), retrospective\/prospective studies based on the exploitation of usual care data do not have to be submitted to an ethics committee, but they must be declared or covered by the reference methodology of the French National Commission on Informatics and Liberties\u00a0(CNIL). A collection and computer processing of personal and medical data was implemented to analyze the results of the research. Toulouse University Hospital signed a commitment of compliance to the reference methodology MR-004 of CNIL. After evaluation and validation by the data protection officer and according to the General Data Protection Regulation, this study completing all the criteria, it is registered in the register of data study of the Toulouse University Hospital (RnIPH 2022-192) and covered by the MR-004 (CNIL number: 2206723 v 0). This study was approved by Toulouse University Hospital who confirms that ethics requirements were totally respected in the above report. According to French law on ethics, clinical trials covered by reference methodology MR-004, patients were informed that their codified data will be used for the study; written consent is not required.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Data sharing is not applicable to this article as the datasets used are based on anonymized data that are protected by agreements with the French Data Protection Commission (CNIL).","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data and material"}},{"value":"R version 4.4.1 (2024-06-14 ucrt), \"\"Race for Your Life\" Copyright 2024, The R Foundation for Statistical Computing Platform: x86_64-w64-mingw32\/x64.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}},{"value":"AL and CA contributed to the data collection, analysis of patient records and medications, analysis and interpretation of data, drafting of the manuscript, and critical revision. ML contributed to the data base adjustments, statistical analysis of data, and manuscript revision. LC contributed to database entry and optimization. NR contributed to the acquisition of data (arranging), database entry, and patient record archiving. DF contributed to the acquisition of data (arranging and obtaining) and patient records. VG and DB contributed to critical revision of the manuscript. ML contributed to the conception, design, and methodology, statistical analysis and interpretation of the data, and critical revision of the manuscript. HB contributed to the conception, design and methodology, data collection and analysis supervision, writing manuscript and critical revision, and team coordination. All authors read and approved the final version.","order":9,"name":"Ethics","group":{"name":"EthicsHeading","label":"Authors\u2019 contributions"}}]}}