{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T06:24:43Z","timestamp":1784615083424,"version":"3.55.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T00:00:00Z","timestamp":1754697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T00:00:00Z","timestamp":1754697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000062","name":"NIDDK","doi-asserted-by":"crossref","award":["U01DK083027"],"award-info":[{"award-number":["U01DK083027"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drug Saf"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s40264-025-01589-8","type":"journal-article","created":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T16:13:44Z","timestamp":1754756024000},"page":"1425-1431","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Meeting Report: Herbal and Dietary Supplement Safety Surveillance Summit"],"prefix":"10.1007","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8298-5381","authenticated-orcid":false,"given":"Dina","family":"Halegoua-DeMarzio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Stolz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharati","family":"Avula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikhlas","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Navarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,9]]},"reference":[{"issue":"3","key":"1589_CR1","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1002\/hep.32689","volume":"77","author":"RJ Fontana","year":"2023","unstructured":"Fontana RJ, Liou I, Reuben A, et al. Aasld practice guidance on drug, herbal, and dietary supplement-induced liver injury. Hepatology. 2023;77(3):1036\u201365.","journal-title":"Hepatology"},{"key":"1589_CR2","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1002\/hep4.1346","volume":"3","author":"V Navarro","year":"2019","unstructured":"Navarro V, Avula B, Khan I, et al. The contents of herbal and dietary supplements implicated in liver injury in the United States are frequently mislabeled. Hepatol Commun. 2019;3:792\u20134.","journal-title":"Hepatol Commun"},{"key":"1589_CR3","unstructured":"Anonymous. Dietary Supplement Health and Education Act of 1994. Available from: https:\/\/ods.od.nih.gov\/About\/DSHEA_Wording.aspx#:~:text=Public%20Law%20103%2D417,103rd%20Congress&text=To%20amend%20the%20Federal%20Food,supplements%2C%20and%20for%20other%20purposes. Accessed 1 Jul 2025."},{"key":"1589_CR4","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1002\/hep.28813","volume":"65","author":"VJ Navarro","year":"2017","unstructured":"Navarro VJ, Khan I, Bj\u00f6rnsson E, et al. Liver injury from herbal and dietary supplements. Hepatology. 2017;65:363\u201373.","journal-title":"Hepatology"},{"key":"1589_CR5","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1002\/hep.27317","volume":"60","author":"VJ Navarro","year":"2014","unstructured":"Navarro VJ, Barnhart H, Bonkovsky HL, Davern T, Fontana RJ, Grant L, et al. Liver injury from herbals and dietary supplements in the U.S. drug-induced liver injury network. Hepatology. 2014;60:1399\u2013408.","journal-title":"Hepatology"},{"issue":"10S","key":"1589_CR6","doi-asserted-by":"publisher","first-page":"S1217","DOI":"10.14309\/01.ajg.0001036048.03722.b9","volume":"119","author":"D Halegoua-DeMarzio","year":"2024","unstructured":"Halegoua-DeMarzio D, Navarro V, Barnhart H, et al. S1670: a recent epidemiologic shift in herbal and dietary supplement-induced liver injury: two decades of experience from the US Drug-Induced Liver Injury Network. Am J Gastroenterol. 2024;119(10S):S1217\u20138.","journal-title":"Am J Gastroenterol"},{"key":"1589_CR7","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1038\/ajg.2016.114","volume":"111","author":"L Hillman","year":"2016","unstructured":"Hillman L, Gottfried M, Whitsett M, et al. Clinical features and outcomes of complementary and alternative medicine induced acute liver failure and injury. Am J Gastroenterol. 2016;111:958\u201365.","journal-title":"Am J Gastroenterol"},{"key":"1589_CR8","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1053\/j.gastro.2015.02.050","volume":"148","author":"DS Goldberg","year":"2015","unstructured":"Goldberg DS, Forde KA, Carbonari DM, et al. Population-representative incidence of drug-induced acute liver failure based on an analysis of an integrated health care system. Gastroenterology. 2015;148:1353\u201361.","journal-title":"Gastroenterology"},{"key":"1589_CR9","doi-asserted-by":"publisher","first-page":"93","DOI":"10.14218\/JCTH.2015.00006","volume":"3","author":"EX Zheng","year":"2015","unstructured":"Zheng EX, Navarro VJ. Liver injury from herbal, dietary, and weight loss supplements: a review. J Clin Transl Hepatol. 2015;3:93\u20138.","journal-title":"J Clin Transl Hepatol"},{"key":"1589_CR10","unstructured":"Herbal and Dietary Supplement Safety Surveillance Summit. 23 September, 2024. Available from: https:\/\/duke.box.com\/s\/osqa1u4l2hf14s4xye4z6hlh2dh8d06t. Accessed 1 Jul 2025."},{"issue":"1","key":"1589_CR11","doi-asserted-by":"publisher","first-page":"55","DOI":"10.2165\/00002018-200932010-00005","volume":"32","author":"RJ Fontana","year":"2009","unstructured":"Fontana RJ, Watkins PB, Bonkovsky HL. Drug-induced liver injury network (DILIN) prospective study: rationale, design and conduct. Drug Saf. 2009;32(1):55\u201368.","journal-title":"Drug Saf"},{"issue":"7","key":"1589_CR12","doi-asserted-by":"publisher","first-page":"735","DOI":"10.2217\/pgs.12.45","volume":"13","author":"TJ Urban","year":"2012","unstructured":"Urban TJ, Goldstein DB, Watkins PB. Genetic basis of susceptibility to drug-induced liver injury: what have we learned and where do we go from here? Pharmacogenomics. 2012;13(7):735\u20138.","journal-title":"Pharmacogenomics"},{"issue":"6","key":"1589_CR13","doi-asserted-by":"publisher","first-page":"2484","DOI":"10.1002\/hep.31538","volume":"73","author":"JH Hoofnagle","year":"2021","unstructured":"Hoofnagle JH, Bonkovsky HL, Phillips EJ, et al. HLA-B*35:01 and green tea-induced liver injury. Hepatology. 2021;73(6):2484\u201393.","journal-title":"Hepatology"},{"issue":"1","key":"1589_CR14","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1002\/hep.30660","volume":"70","author":"C Li","year":"2019","unstructured":"Li C, Rao T, Chen X, et al. HLA-B*35:01 allele is a potential biomarker for predicting Polygonum multiflorum-induced liver injury in humans. Hepatology. 2019;70(1):346\u201357.","journal-title":"Hepatology"},{"issue":"6","key":"1589_CR15","doi-asserted-by":"publisher","first-page":"e1416","DOI":"10.1016\/j.cgh.2021.08.015","volume":"20","author":"R Vuppalanchi","year":"2022","unstructured":"Vuppalanchi R, Bonkovsky HL, Ahmad J, et al. Garcinia cambogia, either alone or in combination with green tea, causes moderate to severe liver injury. Clin Gastroenterol Hepatol. 2022;20(6):e1416\u201325.","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"2","key":"1589_CR16","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.amjmed.2022.09.026","volume":"136","author":"D Halegoua-DeMarzio","year":"2023","unstructured":"Halegoua-DeMarzio D, Navarro V, Ahmad J, et al. Liver injury associated with turmeric\u2014a growing problem: ten cases from the Drug-Induced Liver Injury Network [DILIN]. Am J Med. 2023;136(2):200\u20136.","journal-title":"Am J Med"},{"issue":"9","key":"1589_CR17","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1111\/apt.15211","volume":"49","author":"A Stolz","year":"2019","unstructured":"Stolz A, Navarro V, Hayashi PH, et al. Severe and protracted cholestasis in 44 young men taking bodybuilding supplements: assessment of genetic, clinical and chemical risk factors. Aliment Pharmacol Ther. 2019;49(9):1195\u2013204.","journal-title":"Aliment Pharmacol Ther"},{"issue":"8","key":"1589_CR18","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.26040","volume":"5","author":"C Crawford","year":"2022","unstructured":"Crawford C, Avula B, Lindsey AT, Walter A, Katragunta K, Khan IA, et al. Analysis of select dietary supplement products marketed to support or boost the immune system. JAMA Netw Open. 2022;5(8): e2226040.","journal-title":"JAMA Netw Open"},{"issue":"5","key":"1589_CR19","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.9131","volume":"7","author":"C Crawford","year":"2024","unstructured":"Crawford C, Avula B, Lindsey AT, et al. Label accuracy of weight loss dietary supplements marketed online with military discounts. JAMA Netw Open. 2024;7(5): e249131.","journal-title":"JAMA Netw Open"},{"issue":"2","key":"1589_CR20","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/s40264-024-01484-8","volume":"8","author":"D Halegoua-DeMarzio","year":"2025","unstructured":"Halegoua-DeMarzio D, Navarro VJ, Davis A, et al. Investigation of the role of chemical analysis in causality assessment of herbal and dietary supplement-induced liver injury. Drug Saf. 2025;8(2):143\u201350.","journal-title":"Drug Saf"},{"key":"1589_CR21","unstructured":"US FDA. Human Foods Program. Available from: https:\/\/www.fda.gov\/about-fda\/fda-organization\/human-foods-program. Accessed 5 Nov 2025."},{"issue":"4","key":"1589_CR22","doi-asserted-by":"publisher","first-page":"618","DOI":"10.3390\/livers3040041","volume":"3","author":"JK-S Lin","year":"2023","unstructured":"Lin JK-S, Tujios SR. Hidden dangers: herbal and dietary supplement induced hepatotoxicity. Livers. 2023;3(4):618\u201336.","journal-title":"Livers"},{"key":"1589_CR23","unstructured":"US FDA. About the CORE Network. Available from: https:\/\/www.fda.gov\/food\/outbreaks-foodborne-illness\/about-core-network. Accessed 5 Nov 2025."}],"container-title":["Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40264-025-01589-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40264-025-01589-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40264-025-01589-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T05:19:53Z","timestamp":1762838393000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40264-025-01589-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,9]]},"references-count":23,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["1589"],"URL":"https:\/\/doi.org\/10.1007\/s40264-025-01589-8","relation":{},"ISSN":["0114-5916","1179-1942"],"issn-type":[{"value":"0114-5916","type":"print"},{"value":"1179-1942","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,9]]},"assertion":[{"value":"14 July 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Research reported in this publication was supported by the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health under award numbers U01DK065211 (Indiana University), U01DK065184 (University of Michigan), U01DK065201 (University of North Carolina-Chapel Hill), U01DK083020 (University of Southern California), U01DK083027 (Thomas Jefferson University\/Albert Einstein Medical Center), and U24DK065176 (Duke University). Additional support is provided by the intramural programs of the National Institute of Diabetes and Digestive and Kidney Diseases and National Cancer Institute.\u00a0The content is solely the authors' responsibility and does not necessarily represent the official views of the National Institutes of Health.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"Dina Halegoua-DeMarzio, Andrew Stolz, Bharati Avula, Ikhlas Khan, and Victor Navarro have no conflicts of interest that are directly relevant to the content of this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Not applicable.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data and material"}},{"value":"Not applicable.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}},{"value":"All authors read and approved the final version. DH planned and spoke at the meeting, worked on drafting the report, and provided a critical review and revisions. AS planned and spoke at the meeting and provided a critical review. BA worked on drafting the report and provided a critical review. IK spoke at the meeting, worked on drafting the report, and provided a critical review. VN planned and spoke at the meeting and took the lead in writing the manuscript.","order":9,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author contributions"}}]}}