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These are approved by the East of Scotland Research Ethics Service and the NHS Tayside Caldicott Guardian, with agreement that studies adhering to the standard operating procedures do not require individual ethical review. Non-identifiable data were used for data linkage and analysis, and all data were analysed in an ISO27001 and Scottish Government accredited Data Safe Haven.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The data underlying this article are available in the article and in its online supplementary material. 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