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Dr. Desai reports serving as Principal Investigator on investigator-initiated grants to the Brigham and Women\u2019s Hospital from Novartis, Vertex, and Bayer on unrelated projects. Dr. Schneeweiss is co-principal investigator of an investigator-initiated grant to the Brigham and Women\u2019s Hospital from Boehringer Ingelheim unrelated to the topic of this study. He is a consultant to Aetion Inc., a software manufacturer of which he owns equity. His interests were declared, reviewed, and approved by the Brigham and Women\u2019s Hospital and MGB HealthCare System in accordance with their institutional compliance policies. All other authors have no conflicts of interest to disclose relative to this work.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This Sentinel project was a public health surveillance activity conducted under the authority of the Food and Drug Administration, which did not meet the definition of human subjects research as defined by the Common rule and accordingly was not subject to Institutional Review Board oversight [\n                      \n                      \u2013\n                      \n                      ]. The analysis involved use of data already available with MyHealth Access Network, and the secondary use of the data for this query was reviewed and approved by the HIE\u2019s governance committee comprising local stakeholders and data contributors.","order":2,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":4,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Individual-level data from MyHealth Access Network was used by their authorized users, but only aggregated, de-identified summary statistics were reported. The\u00a0individual-level data remained within the original source environment of MyHealth Access Network at all times. The data that support the findings of this study are not openly available; however, they can be shared by authorized coauthors upon reasonable request.","order":5,"name":"Ethics","label":"Data transparency","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":6,"name":"Ethics","label":"Code availability","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors contributed to study conception, design, manuscript preparation, and commented on previous versions of the manuscript. All authors read and approved the final version of the manuscript. DK and JS were involved in data acquisition and analysis.","order":7,"name":"Ethics","label":"Author contribution","group":{"name":"EthicsHeading","label":"Declarations"}}]}}