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WTH has received funds related to consulting or advisory work for the Task Force for Global Health, Vaccine Monitoring Collaboration for Europe, and ImmunAdd Inc., outside of this study. ECCL has received research funding from Amgen, Sanofi, Takeda, Pfizer, and Novartis for other research projects, but these funding sources played no role in the current study. Other authors have no conflicts of interest to declare.","order":1,"name":"Ethics","label":"Conflicts of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study protocol was reviewed and approved by the Research Ethics Committee at National Taiwan University Hospital (202111097RINC) and Human Research Ethics Committee at National Cheng Kung University (112-609).","order":2,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":4,"name":"Ethics","label":"Consent to publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors applied for and remotely accessed the data from the data center of the Ministry of Health and Welfare in Taiwan. Researchers who are citizens of Taiwan and interested in accessing the datasets could submit a formal application to the Ministry of Health and Welfare to request access (\n                      \n                      ). Data dictionary can be accessed at:\n                      \n                      .","order":5,"name":"Ethics","label":"Availability of data and material (data transparency)","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The algorithm has been implemented as a SAS analytical module and is publicly available on GitHub:\n                      \n                      .","order":6,"name":"Ethics","label":"Code availability","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"WTH, CWL, and ECCL conceptualized and developed the research question. CWL designed the study protocol. MHCH and WTH drafted the manuscript. ZCJC and MHCH are the guarantors. WTH, ZCJC, CWL and MHCH edited the study protocol, and interpreted the results. CWL wrote the statistical analysis plan. ZCJC, MHCH and BMHL conducted the statistical analysis. All authors read and approved the final version. The corresponding author attests that all listed authors meet authorship criteria and that no others meeting the criteria have been omitted. During manuscript preparation, we used ChatGPT (GPT- 4o; OpenAI) to assist with language editing and grammar checks. The authors reviewed and revised all AI-assisted text and accept full responsibility for the manuscript\u2019s content.","order":7,"name":"Ethics","label":"Authors' contribution","group":{"name":"EthicsHeading","label":"Declarations"}}]}}