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Susan Jick and Christoph Meier were not involved in the selection of peer reviewers for the manuscript nor in any of the subsequent editorial decisions. SG, MR, JG, and JS do not report any conflicts of interest.","order":1,"name":"Ethics","label":"Conflicts of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Independent Scientific Advisory Committee for MHRA database research (protocol no: 21_000359). The protocol was made available to the journal reviewers upon request.","order":2,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":4,"name":"Ethics","label":"Consent to publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study is based on data from the Clinical Practice Research Datalink obtained under license from the UK Medicines and Healthcare products Regulatory Agency. The data are provided by patients and collected by the National Health Service as part of their care and support. The interpretation and conclusions contained in this study are those of the authors alone. Due to the terms of our license, we cannot make data available to others; however, researchers can request data directly from the CPRD.","order":5,"name":"Ethics","label":"Availability of data and material","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Codes of outcomes are provided in the Electronic Supplementary Material. Other codes (including statistical codes) can be provided upon request.","order":6,"name":"Ethics","label":"Code availability","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"SG: conceptualization, data curation, formal analysis, investigation, methodology, project administration, visualization, writing\u2014original draft preparation, writing\u2014review and editing. MR: conceptualization, methodology, supervision, writing\u2014review and editing. JG: conceptualization, methodology, writing\u2014review and editing. CM: conceptualization, project administration, supervision, writing\u2014review and editing. JS: conceptualization, data curation, formal analysis, methodology, project administration, supervision, writing\u2014original draft preparation, writing\u2014review and editing. All authors read and approved the final version of the manuscript.","order":7,"name":"Ethics","label":"Authors\u2019 contributions","group":{"name":"EthicsHeading","label":"Declarations"}}]}}