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SS is the recipient of the Distinguished James McGill Professor Award.","order":1,"name":"Ethics","label":"Funding","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"In the last three years, SS attended scientific advisory meetings for Novartis and Panalgo and received speaking fees from Covis Pharma and CSL Behring. PE has received speaker fees from Astra Zeneca. JL has no conflict of interest to disclose.","order":2,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study is based in part on data from the Clinical Practice Research Datalink obtained under license from the UK Medicines and Healthcare products Regulatory Agency. The data are provided by patients and collected by the UK National Health Service as part of their care and support. The interpretation and conclusions contained in this study are those of the authors alone. Because electronic health records are classified as \u201csensitive data\u201d by the UK Data Protection Act, information governance restrictions (to protect patient confidentiality) prevent data sharing via public deposition. Data are available with approval through the individual constituent entities controlling access to the data. Specifically, the primary-care data can be requested via application to the Clinical Practice Research Datalink (\n                      \n                      ).","order":3,"name":"Ethics","label":"Data availability","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocol was approved by the Independent Scientific Advisory Committee of the CRPD (No. 20_004080) and the Ethics Committee of the Jewish General Hospital, Montreal, QC, Canada (No. 2025-4280).","order":4,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":5,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":6,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Codes may be made privately available upon reasonable request to the corresponding author.","order":7,"name":"Ethics","label":"Code availability","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors conceived and designed the study and were involved in the interpretation of the results. Analyses were performed by JL. The first draft of the manuscript was written by JL, with editing by SS and PE. All authors commented on previous versions of the manuscript. All authors read and approved the final version. SS and PE obtained funding and SS supervised the study.","order":8,"name":"Ethics","label":"Author contributions","group":{"name":"EthicsHeading","label":"Declarations"}}]}}