{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:01:29Z","timestamp":1790726489957,"version":"4.1.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drugs"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1007\/s40265-021-01551-9","type":"journal-article","created":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T15:04:29Z","timestamp":1625583869000},"page":"1203-1211","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Bupivacaine\/Meloxicam Prolonged Release: A Review in Postoperative Pain"],"prefix":"10.1007","volume":"81","author":[{"given":"Hannah A.","family":"Blair","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,6]]},"reference":[{"issue":"4","key":"1551_CR1","doi-asserted-by":"publisher","first-page":"347","DOI":"10.2217\/pmt-2020-0097","volume":"11","author":"EM Cornett","year":"2021","unstructured":"Cornett EM, Turpin MAC, Busby M, et al. HTX-011 (bupivacaine and meloxicam) for the prevention of postoperative pain - clinical considerations. Pain Manag. 2021;11(4):347\u201356.","journal-title":"Pain Manag"},{"issue":"3","key":"1551_CR2","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1007\/s11916-020-0837-2","volume":"24","author":"AD Kaye","year":"2020","unstructured":"Kaye AD, Novitch MB, Carlson SF, et al. The role of Exparel plus meloxicam for postoperative pain management. Curr Pain Headache Rep. 2020;24(3):6.","journal-title":"Curr Pain Headache Rep"},{"key":"1551_CR3","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.2147\/JPR.S144066","volume":"10","author":"TJ Gan","year":"2017","unstructured":"Gan TJ. Poorly controlled postoperative pain: prevalence, consequences, and prevention. J Pain Res. 2017;10:2287\u201398.","journal-title":"J Pain Res"},{"issue":"5","key":"1551_CR4","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1213\/ANE.0000000000002458","volume":"125","author":"JM Hah","year":"2017","unstructured":"Hah JM, Bateman BT, Ratliff J, et al. Chronic opioid use after surgery: implications for perioperative management in the face of the opioid epidemic. Anesth Analg. 2017;125(5):1733\u201340.","journal-title":"Anesth Analg"},{"issue":"2","key":"1551_CR5","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1136\/rapm-2019-100714","volume":"45","author":"T Ottoboni","year":"2019","unstructured":"Ottoboni T, Quart B, Pawasauskas J, et al. Mechanism of action of HTX-011: a novel, extended-release, dual-acting local anesthetic formulation for postoperative pain. Reg Anesth Pain Med. 2019;45(2):117\u201323.","journal-title":"Reg Anesth Pain Med"},{"issue":"3","key":"1551_CR6","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/S0885-3924(00)00174-3","volume":"20","author":"I Svensson","year":"2000","unstructured":"Svensson I, Sjostrom B, Haljamae H. Assessment of pain experiences after elective surgery. J Pain Symptom Manage. 2000;20(3):193\u2013201.","journal-title":"J Pain Symptom Manage"},{"key":"1551_CR7","unstructured":"Heron Therapeutics. ZYNRELEFTM (bupivacaine and meloxicam) extended-release solution: US prescribing information. 2021. https:\/\/www.zynrelef.com\/prescribing-information.pdf. Accessed 9 Jun 2021."},{"key":"1551_CR8","unstructured":"European Medicines Agency. Zynrelef (bupivacaine\/meloxicam) prolonged-release wound solution: EU summary of product characteristics. 2020. https:\/\/www.ema.europa.eu\/. Accessed 9 Jun 2021."},{"key":"1551_CR9","unstructured":"Luke C, Saleh J, Hardman D, et al. HTX-011: predictable release rates of bupivacaine and meloxicam for 72 hours [abstract no. A4283 plus poster]. In: American Society of Anesthesiology (ASA) Annual Meeting. 2020."},{"key":"1551_CR10","unstructured":"Viscusi E, Minkowitz H, Onel E, et al. Synergistic effect of the active components in HTX-011, a novel fixed-ratio formulation of bupivacaine and meloxicam, across multiple doses and surgical models [abstract no. 5605 plus poster]. In: Regional Anesthesia & Pain Management. 2018."},{"issue":"4 Suppl. 2","key":"1551_CR11","doi-asserted-by":"publisher","first-page":"e147","DOI":"10.1016\/j.jamcollsurg.2017.07.924","volume":"225","author":"D Leiman","year":"2017","unstructured":"Leiman D, Minkowitz HS, Patel SS, et al. Reduced pain intensity and opioid consumption for 96 hours after abdominoplasty after administration of HTX-011, a proprietary, extended-release combination of bupivacaine and meloxicam. J Am Coll Surg. 2017;225(4 Suppl. 2):e147.","journal-title":"J Am Coll Surg"},{"key":"1551_CR12","doi-asserted-by":"publisher","first-page":"e37","DOI":"10.1016\/j.jamcollsurg.2017.07.617","volume":"225","author":"E Viscusi","year":"2017","unstructured":"Viscusi E, DeLeon-Casasola O, Gan T, et al. HTX-011, a proprietary, extended-release synergistic combination of bupivacaine and meloxicam for the relief of acute postoperative pain. J Am Coll Surg. 2017;225:e37.","journal-title":"J Am Coll Surg"},{"issue":"1","key":"1551_CR13","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1136\/rapm-2019-100531","volume":"44","author":"E Viscusi","year":"2019","unstructured":"Viscusi E, Gimbel JS, Pollack RA, et al. HTX-011 reduced pain intensity and opioid consumption versus bupivacaine HCl in bunionectomy: phase III results from the randomized EPOCH 1 study. Reg Anesth Pain Med. 2019;44(1):700\u20136.","journal-title":"Reg Anesth Pain Med"},{"issue":"6","key":"1551_CR14","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1007\/s10029-019-02023-6","volume":"23","author":"E Viscusi","year":"2019","unstructured":"Viscusi E, Minkowitz H, Winkle P, et al. HTX-011 reduced pain intensity and opioid consumption versus bupivacaine HCl in herniorrhaphy: results from the phase 3 EPOCH 2 study. Hernia. 2019;23(6):1071\u201380.","journal-title":"Hernia"},{"key":"1551_CR15","doi-asserted-by":"publisher","DOI":"10.7547\/20-204","author":"R Pollak","year":"2021","unstructured":"Pollak R, Cai D, Gan TJ. Opioid-free recovery from bunionectomy with HTX-011, a dual-acting local anesthetic combining bupivacaine and meloxicam, as the foundation of non-opioid multimodal analgesia. J Am Podiatr Med Assoc. 2021. https:\/\/doi.org\/10.7547\/20-204.","journal-title":"J Am Podiatr Med Assoc"},{"issue":"5","key":"1551_CR16","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1016\/j.surg.2020.06.036","volume":"168","author":"N Singla","year":"2020","unstructured":"Singla N, Winkle P, Bertoch T, et al. Opioid-free recovery after herniorrhaphy with HTX-011 as the foundation of a multimodal analgesic regimen. Surgery. 2020;168(5):915\u201320.","journal-title":"Surgery"},{"issue":"10","key":"1551_CR17","doi-asserted-by":"publisher","first-page":"2843","DOI":"10.1016\/j.arth.2020.05.044","volume":"35","author":"PF Lachiewicz","year":"2020","unstructured":"Lachiewicz PF, Lee GC, Pollak RA, et al. HTX-011 reduced pain and opioid use after primary total knee arthroplasty: results of a randomized phase 2b trial. J Arthroplasty. 2020;35(10):2843\u201351.","journal-title":"J Arthroplasty"},{"key":"1551_CR18","unstructured":"Hacker S. Postoperative pain management of total knee arthroplasty using HTX-011 with multimodal analgesia: results from a phase 3b open-label study [poster]. In: Orthopedics Today Hawaii. 2020."},{"key":"1551_CR19","unstructured":"Fanikos J, Minkowitz H, Reinhorn M, et al. HTX-011 as the foundation of a non-opioid, multimodal analgesic regimen reduces the need for opioids following herniorrhaphy in a real-world study [abstract no. 4-144 plus poster]. In: American Society of Health-System Pharmacists (ASHP) Midyear Congress. 2019."},{"key":"1551_CR20","unstructured":"Singla N, Hu J, Minkowitz H, et al. HTX-011 with alternating or concurrently administered ibuprofen and acetaminophen after herniorrhaphy in a real-world setting: effective pain management, reduction in opioid prescriptions, and high patient satisfaction [abstract no. P042 plus poster]. In: Americas Hernia Society (AHS) Annual Meeting. 2020."},{"key":"1551_CR21","unstructured":"Viscusi E, Minkowitz H, Hu J. HTX-011: no evidence of local anesthetic systemic toxicity [abstract no. A4279 plus poster]. In: American Society of Anesthesiology (ASA) Annual Meeting. 2020."},{"key":"1551_CR22","unstructured":"International Association for the Study of Pain. Management of postsurgical pain in adults: pharmacotherapy and regional anesthesia. 2017. https:\/\/www.iasp-pain.org\/GlobalYear\/AfterSurgery. Accessed 9 Jun 2021."}],"container-title":["Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40265-021-01551-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40265-021-01551-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40265-021-01551-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T12:26:36Z","timestamp":1626351996000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40265-021-01551-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":22,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["1551"],"URL":"https:\/\/doi.org\/10.1007\/s40265-021-01551-9","relation":{},"ISSN":["0012-6667","1179-1950"],"issn-type":[{"value":"0012-6667","type":"print"},{"value":"1179-1950","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"9 June 2021","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The preparation of this review was not supported by any external funding.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"Hannah Blair is a salaried employee of Adis International Ltd\/Springer Nature, and declares no relevant conflicts of interest. All authors contributed to the review and are responsible for the article content.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Authorship and Conflict of interest"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval, Consent to participate, Consent to publish, Availability of data and material, Code availability"}}]}}