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WH is supported by the National Natural Science Foundation of China (no. 81973632). GB is supported by German Research Council (DFG BE 6395-1\/1) and the TransBioLine Consortium. RS is supported by an NIHR Senior Investigator Award, an EME Award (15\/20\/01), an MRC Award (MR\/T002220\/1) and the TransBioLine Consortium. The TransBioLine project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (Grant agreement no. 821283). This Joint Undertaking receives support from the European Union\u2019s Horizon 2020 research and innovation programme and EFPIA. This communication reflects the authors\u2019 view and neither IMI nor the European Union or EFPIA are responsible for any use that may be made of the information contained therein.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"TG has consulted for Albireo (ongoing). WH has received research funding from Cypralis, Farsight, and Corvidia, with all funds paid to West China Hospital of Sichuan University. RS has consulted for AbbVie CalciMedica, GlaxoSmithKline (GSK), Novartis and Takeda, and has received research funding from CalciMedica, EA Pharma, GSK, Lilly, Merck\/MSD, Pfizer as well as multiple public sources in the last three years. RS is collaborating in the IMI2 TransBioLine Consortium with Janssen, Lilly, Merck\/MSD, Novartis, Pfizer, Roche, and Sanofi-Aventis. All funds received have been paid to the University of Liverpool and\/or Liverpool University Hospitals NHS Foundation Trust.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest\/competing interests"}},{"value":"This article was written by RS, PS and TG with critical intellectual input from WC, WH, CH and GB. All authors meet the International Committee of Medical Journal Editors criteria for authorship of this paper, take full responsibility for the integrity of the work, and have given their approval for this final version to be published.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author contributions"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All authors have contributed to review and enhancement of the quality of this paper and have reviewed and approved the final version of the manuscript.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate and consent for publication"}},{"value":"Not applicable.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data and material"}},{"value":"Not applicable.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}}]}}