{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T09:38:45Z","timestamp":1793093925721,"version":"4.5.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:00:00Z","timestamp":1740182400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2025,2,22]],"date-time":"2025-02-22T00:00:00Z","timestamp":1740182400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drugs"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1007\/s40265-025-02154-4","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T23:53:58Z","timestamp":1740182038000},"page":"557-570","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Safety and Longevity of Intraocular Pressure Control After Bimatoprost Implant Administration: Interim Analysis of a Phase 3b Clinical Trial (TRITON)"],"prefix":"10.1007","volume":"85","clinical-trial-number":[{"clinical-trial-number":"nct03850782","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8243-2485","authenticated-orcid":false,"given":"Steven M.","family":"Silverstein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2504-0004","authenticated-orcid":false,"given":"Francesco","family":"Oddone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8697-0734","authenticated-orcid":false,"given":"Miriam","family":"Kolko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian K.","family":"Brinkmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C.","family":"Christie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6147-3504","authenticated-orcid":false,"given":"Amanda K.","family":"Bicket","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petrus N. J.","family":"Gous","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3946-5759","authenticated-orcid":false,"given":"Jan","family":"Luebke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8727-0692","authenticated-orcid":false,"given":"Jyotsna","family":"Maram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5362-0708","authenticated-orcid":false,"given":"Ashley","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2077-659X","authenticated-orcid":false,"given":"E. Randy","family":"Craven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjia","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Bejanian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the TRITON Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Bercovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Gentile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon Fabian","family":"Lerner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anahi","family":"Lupinacci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Ignacio","family":"Zeolite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Kerr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Botio","family":"Anguelov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veselin","family":"Daskalov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitar","family":"Dzhelebov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Grupcheva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin","family":"Hristozov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislava","family":"Ivanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneta","family":"Misheva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milen","family":"Penkov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malina","family":"Topchiyska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petar","family":"Yanev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Fichtl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Brinkmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Lubke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Schargus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"van Oterendorp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasna","family":"Pavicic-Astalos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Cagini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Milano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Scorcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enzo M.","family":"Vingolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Wells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Slawomir","family":"Cisiecki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorota","family":"Raczynska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Slawomir","family":"Teper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Zalewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petrus","family":"Gous","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolaas van","family":"Helsdingen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pouya","family":"Alaghband","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupert","family":"Bourne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Cheeseman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Dubois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Hopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerassimos","family":"Lascaratos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Levin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Husam","family":"Ansari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdi","family":"Basha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Berdahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Bettis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Bicket","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Blasberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delmar","family":"Caldwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Cantor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Christie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eran","family":"Duzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Elfervig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailesh","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Gutmark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Hendrix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Jerkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Jorgensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Kammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Khaimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aarup","family":"Kubal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Lind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dwayne","family":"Logan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayoko","family":"Moroi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlene","family":"Moster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Moyes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Nolan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Paauw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemang","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Steven","family":"Sarkisian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Segal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjool","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Silverstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Sims","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Slabaugh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Walman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Walters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Wirta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,22]]},"reference":[{"key":"2154_CR1","doi-asserted-by":"publisher","first-page":"13762","DOI":"10.1038\/s41598-021-92971-w","volume":"11","author":"N Zhang","year":"2021","unstructured":"Zhang N, Wang J, Li Y, Jiang B. Prevalence of primary open angle glaucoma in the last 20 years: a meta-analysis and systematic review. Sci Rep. 2021;11:13762. https:\/\/doi.org\/10.1038\/s41598-021-92971-w.","journal-title":"Sci Rep"},{"key":"2154_CR2","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","volume":"121","author":"YC Tham","year":"2014","unstructured":"Tham YC, Li X, Wong TY, Quigley HA, Aung T, Cheng CY. Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis. Ophthalmology. 2014;121:2081\u201390. https:\/\/doi.org\/10.1016\/j.ophtha.2014.05.013.","journal-title":"Ophthalmology"},{"key":"2154_CR3","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1001\/archopht.121.1.48","volume":"121","author":"MC Leske","year":"2003","unstructured":"Leske MC, Heijl A, Hussein M, Bengtsson B, Hyman L, Komaroff E. Factors for glaucoma progression and the effect of treatment: the Early Manifest Glaucoma Trial. Arch Ophthalmol. 2003;121:48\u201356. https:\/\/doi.org\/10.1001\/archopht.121.1.48.","journal-title":"Arch Ophthalmol"},{"key":"2154_CR4","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1016\/s0140-6736(14)62111-5","volume":"385","author":"DF Garway-Heath","year":"2015","unstructured":"Garway-Heath DF, Crabb DP, Bunce C, Lascaratos G, Amalfitano F, Anand N, et al. Latanoprost for open-angle glaucoma (UKGTS): a randomised, multicentre, placebo-controlled trial. Lancet. 2015;385:1295\u2013304. https:\/\/doi.org\/10.1016\/s0140-6736(14)62111-5.","journal-title":"Lancet"},{"key":"2154_CR5","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1001\/archopht.120.6.701","volume":"120","author":"MA Kass","year":"2002","unstructured":"Kass MA, Heuer DK, Higginbotham EJ, Johnson CA, Keltner JL, Miller JP, et al. The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma. Arch Ophthalmol. 2002;120:701\u201313. (discussion 829-30). https:\/\/doi.org\/10.1001\/archopht.120.6.701.","journal-title":"Arch Ophthalmol"},{"key":"2154_CR6","doi-asserted-by":"publisher","first-page":"P71","DOI":"10.1016\/j.ophtha.2020.10.022","volume":"128","author":"SJ Gedde","year":"2021","unstructured":"Gedde SJ, Vinod K, Wright MM, Muir KW, Lind JT, Chen PP, et al. Primary open-angle glaucoma Preferred Practice Pattern\u00ae. Ophthalmology. 2021;128:P71\u2013150. https:\/\/doi.org\/10.1016\/j.ophtha.2020.10.022","journal-title":"Ophthalmology"},{"key":"2154_CR7","doi-asserted-by":"publisher","first-page":"P151","DOI":"10.1016\/j.ophtha.2020.10.023","volume":"128","author":"SJ Gedde","year":"2021","unstructured":"Gedde SJ, Lind JT, Wright MM, Chen PP, Muir KW, Vinod K, et al. Primary open-angle glaucoma suspect Preferred Practice Pattern\u00ae. Ophthalmology. 2021;128:P151\u201392. https:\/\/doi.org\/10.1016\/j.ophtha.2020.10.023.","journal-title":"Ophthalmology"},{"key":"2154_CR8","doi-asserted-by":"publisher","first-page":"441","DOI":"10.2147\/ppa.S23780","volume":"5","author":"G Reardon","year":"2011","unstructured":"Reardon G, Kotak S, Schwartz GF. Objective assessment of compliance and persistence among patients treated for glaucoma and ocular hypertension: a systematic review. Patient Prefer Adherence. 2011;5:441\u201363. https:\/\/doi.org\/10.2147\/ppa.S23780.","journal-title":"Patient Prefer Adherence"},{"key":"2154_CR9","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1080\/17469899.2019.1635456","volume":"14","author":"AL Robin","year":"2019","unstructured":"Robin AL, Muir KW. Medication adherence in patients with ocular hypertension or glaucoma. Expert Rev Ophthalmol. 2019;14:199\u2013210. https:\/\/doi.org\/10.1080\/17469899.2019.1635456.","journal-title":"Expert Rev Ophthalmol."},{"key":"2154_CR10","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1016\/j.ophtha.2004.12.035","volume":"112","author":"CM Olthoff","year":"2005","unstructured":"Olthoff CM, Schouten JS, van de Borne BW, Webers CA. Noncompliance with ocular hypotensive treatment in patients with glaucoma or ocular hypertension an evidence-based review. Ophthalmology. 2005;112:953\u201361. https:\/\/doi.org\/10.1016\/j.ophtha.2004.12.035.","journal-title":"Ophthalmology"},{"issue":"Suppl 1","key":"2154_CR11","doi-asserted-by":"publisher","first-page":"S57","DOI":"10.1016\/j.survophthal.2008.08.002","volume":"53","author":"GF Schwartz","year":"2008","unstructured":"Schwartz GF, Quigley HA. Adherence and persistence with glaucoma therapy. Surv Ophthalmol. 2008;53(Suppl 1):S57-68. https:\/\/doi.org\/10.1016\/j.survophthal.2008.08.002.","journal-title":"Surv Ophthalmol"},{"key":"2154_CR12","doi-asserted-by":"publisher","first-page":"2010","DOI":"10.1016\/j.ophtha.2015.06.039","volume":"122","author":"PA Newman-Casey","year":"2015","unstructured":"Newman-Casey PA, Blachley T, Lee PP, Heisler M, Farris KB, Stein JD. Patterns of glaucoma medication adherence over four years of follow-up. Ophthalmology. 2015;122:2010\u201321. https:\/\/doi.org\/10.1016\/j.ophtha.2015.06.039.","journal-title":"Ophthalmology"},{"key":"2154_CR13","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1097\/opx.0000000000000009","volume":"90","author":"LE Dreer","year":"2013","unstructured":"Dreer LE, Girkin CA, Campbell L, Wood A, Gao L, Owsley C. Glaucoma medication adherence among African Americans: program development. Optom Vis Sci. 2013;90:883\u201397. https:\/\/doi.org\/10.1097\/opx.0000000000000009.","journal-title":"Optom Vis Sci"},{"key":"2154_CR14","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1016\/j.ophtha.2015.03.026","volume":"122","author":"PA Newman-Casey","year":"2015","unstructured":"Newman-Casey PA, Robin AL, Blachley T, Farris K, Heisler M, Resnicow K, et al. The most common barriers to glaucoma medication adherence: a cross-sectional survey. Ophthalmology. 2015;122:1308\u201316. https:\/\/doi.org\/10.1016\/j.ophtha.2015.03.026.","journal-title":"Ophthalmology"},{"key":"2154_CR15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0251699","volume":"16","author":"K Kashiwagi","year":"2021","unstructured":"Kashiwagi K, Matsuda Y, Ito Y, Kawate H, Sakamoto M, Obi S, et al. Investigation of visual and physical factors associated with inadequate instillation of eyedrops among patients with glaucoma. PLoS\u00a0One. 2021;16: e0251699. https:\/\/doi.org\/10.1371\/journal.pone.0251699.","journal-title":"PLoS\u00a0One"},{"key":"2154_CR16","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1097\/ijg.0000000000001965","volume":"31","author":"J Gatwood","year":"2022","unstructured":"Gatwood J, Brooks C, Meacham R, Abou-Rahma J, Cernasev A, Brown E, et al. Facilitators and barriers to glaucoma medication adherence. J Glaucoma. 2022;31:31\u20136. https:\/\/doi.org\/10.1097\/ijg.0000000000001965.","journal-title":"J Glaucoma"},{"key":"2154_CR17","doi-asserted-by":"publisher","first-page":"2863","DOI":"10.1007\/s40123-023-00797-8","volume":"12","author":"SG Moore","year":"2023","unstructured":"Moore SG, Richter G, Modjtahedi BS. Factors affecting glaucoma medication adherence and interventions to improve adherence: a narrative review. Ophthalmol Ther. 2023;12:2863\u201380. https:\/\/doi.org\/10.1007\/s40123-023-00797-8.","journal-title":"Ophthalmol Ther"},{"key":"2154_CR18","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.ophtha.2019.10.022","volume":"127","author":"PA Newman-Casey","year":"2020","unstructured":"Newman-Casey PA, Niziol LM, Gillespie BW, Janz NK, Lichter PR, Musch DC. The association between medication adherence and visual field progression in the Collaborative Initial Glaucoma Treatment Study. Ophthalmology. 2020;127:477\u201383. https:\/\/doi.org\/10.1016\/j.ophtha.2019.10.022.","journal-title":"Ophthalmology"},{"key":"2154_CR19","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1097\/ijg.0000000000001943","volume":"30","author":"YH Shu","year":"2021","unstructured":"Shu YH, Wu J, Luong T, Mattox C, Fang EN, Lee BL, et al. Topical medication adherence and visual field progression in open-angle glaucoma: analysis of a large US health care system. J Glaucoma. 2021;30:1047\u201355. https:\/\/doi.org\/10.1097\/ijg.0000000000001943.","journal-title":"J Glaucoma"},{"key":"2154_CR20","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.ajo.2016.11.020","volume":"175","author":"RA Lewis","year":"2017","unstructured":"Lewis RA, Christie WC, Day DG, Craven ER, Walters T, Bejanian M, et al. Bimatoprost sustained-release implants for glaucoma therapy: 6-month results from a phase I\/II clinical trial. Am J Ophthalmol. 2017;175:137\u201347. https:\/\/doi.org\/10.1016\/j.ajo.2016.11.020.","journal-title":"Am J Ophthalmol"},{"key":"2154_CR21","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1016\/j.ophtha.2020.06.018","volume":"127","author":"FA Medeiros","year":"2020","unstructured":"Medeiros FA, Walters TR, Kolko M, Coote M, Bejanian M, Goodkin ML, et al. Phase 3, randomized, 20-month study of bimatoprost implant in open-angle glaucoma and ocular hypertension (ARTEMIS 1). Ophthalmology. 2020;127:1627\u201341. https:\/\/doi.org\/10.1016\/j.ophtha.2020.06.018.","journal-title":"Ophthalmology"},{"key":"2154_CR22","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.1007\/s11095-010-0159-x","volume":"27","author":"SS Lee","year":"2010","unstructured":"Lee SS, Hughes P, Ross AD, Robinson MR. Biodegradable implants for sustained drug release in the eye. Pharm Res. 2010;27:2043\u201353. https:\/\/doi.org\/10.1007\/s11095-010-0159-x.","journal-title":"Pharm Res"},{"key":"2154_CR23","doi-asserted-by":"publisher","first-page":"2017","DOI":"10.1007\/s40265-021-01624-9","volume":"81","author":"J Bacharach","year":"2021","unstructured":"Bacharach J, Tatham A, Ferguson G, Belalc\u00e1zar S, Thieme H, Goodkin ML, et al. Phase 3, randomized, 20-month study of the efficacy and safety of bimatoprost implant in patients with open-angle glaucoma and ocular hypertension (ARTEMIS 2). Drugs. 2021;81:2017\u201333. https:\/\/doi.org\/10.1007\/s40265-021-01624-9.","journal-title":"Drugs"},{"key":"2154_CR24","doi-asserted-by":"publisher","first-page":"3023","DOI":"10.2147\/opth.S427976","volume":"17","author":"WC Christie","year":"2023","unstructured":"Christie WC, Basha MM, Ho Q, Kim K, Craven ER, Kolko M. Phase 3, randomized study comparing intracameral bimatoprost implant 15 \u00b5g and selective laser trabeculectomy in patients with open-angle glaucoma or ocular hypertension. Clin Ophthalmol. 2023;17:3023\u201336. https:\/\/doi.org\/10.2147\/opth.S427976.","journal-title":"Clin Ophthalmol"},{"key":"2154_CR25","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/s40265-019-01248-0","volume":"80","author":"ER Craven","year":"2020","unstructured":"Craven ER, Walters T, Christie WC, Day DG, Lewis RA, Goodkin ML, et al. 24-Month phase I\/II clinical trial of bimatoprost sustained-release implant (Bimatoprost SR) in glaucoma patients. Drugs. 2020;80:167\u201379. https:\/\/doi.org\/10.1007\/s40265-019-01248-0.","journal-title":"Drugs"},{"key":"2154_CR26","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1136\/bjophthalmol-2013-304064","volume":"98","author":"I Goldberg","year":"2014","unstructured":"Goldberg I, Gil Pina R, Lanzagorta-Aresti A, Schiffman RM, Liu C, Bejanian M. Bimatoprost 0.03%\/timolol 0.5% preservative-free ophthalmic solution versus bimatoprost 0.03%\/timolol 0.5% ophthalmic solution (Ganfort) for glaucoma or ocular hypertension: a 12-week randomised controlled trial. Br J Ophthalmol. 2014;98:926\u201331. https:\/\/doi.org\/10.1136\/bjophthalmol-2013-304064.","journal-title":"Br J Ophthalmol"},{"key":"2154_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/ICO.0b013e31815892da","volume":"27","author":"BE McCarey","year":"2008","unstructured":"McCarey BE, Edelhauser HF, Lynn MJ. Review of corneal endothelial specular microscopy for FDA clinical trials of refractive procedures, surgical devices, and new intraocular drugs and solutions. Cornea. 2008;27:1\u201316. https:\/\/doi.org\/10.1097\/ICO.0b013e31815892da.","journal-title":"Cornea"},{"key":"2154_CR28","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1097\/j.jcrs.0000000000001365","volume":"50","author":"IIK Ahmed","year":"2024","unstructured":"Ahmed IIK, Sheybani A, De Francesco T, Samuelson TW. Corneal endothelial safety profile in minimally invasive glaucoma surgery. J Cataract Refract Surg. 2024;50:369\u201377. https:\/\/doi.org\/10.1097\/j.jcrs.0000000000001365.","journal-title":"J Cataract Refract Surg"},{"key":"2154_CR29","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1007\/s40123-022-00527-6","volume":"11","author":"FA Medeiros","year":"2022","unstructured":"Medeiros FA, Sheybani A, Shah MM, Rivas M, Bai Z, Werts E, et al. Single administration of intracameral bimatoprost implant 10 \u00b5g in patients with open-angle glaucoma or ocular hypertension. Ophthalmol Ther. 2022;11:1517\u201337. https:\/\/doi.org\/10.1007\/s40123-022-00527-6.","journal-title":"Ophthalmol Ther"},{"key":"2154_CR30","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.ogla.2023.06.007","volume":"6","author":"RN Weinreb","year":"2023","unstructured":"Weinreb RN, Christie WC, Medeiros FA, Craven ER, Kim K, Nguyen A, et al. Single administration of bimatoprost implant: effects on 24-hour intraocular pressure and 1-year outcomes. Ophthalmol Glaucoma. 2023;6:599\u2013608. https:\/\/doi.org\/10.1016\/j.ogla.2023.06.007.","journal-title":"Ophthalmol Glaucoma"},{"key":"2154_CR31","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1089\/jop.2023.0013","volume":"39","author":"W Xu","year":"2023","unstructured":"Xu W, Zhou P, Kansara ND, Frankfort BJ, Blieden LS, Chang PT. Intraocular pressure and eyedrop usage reduction with intracameral bimatoprost implant. J Ocul Pharmacol Ther. 2023;39:398\u2013403. https:\/\/doi.org\/10.1089\/jop.2023.0013.","journal-title":"J Ocul Pharmacol Ther"},{"key":"2154_CR32","doi-asserted-by":"publisher","first-page":"187","DOI":"10.2147\/opth.S445005","volume":"18","author":"S Teymoorian","year":"2024","unstructured":"Teymoorian S, Craven ER, Nguyen L, Werts E. Real-world study of the effectiveness and safety of intracameral bimatoprost implant in a clinical setting in the United States. Clin Ophthalmol. 2024;18:187\u201399. https:\/\/doi.org\/10.2147\/opth.S445005.","journal-title":"Clin Ophthalmol"},{"key":"2154_CR33","doi-asserted-by":"publisher","first-page":"917","DOI":"10.2147\/opth.S452159","volume":"18","author":"SR Sarkisian Jr","year":"2024","unstructured":"Sarkisian SR Jr, Mitchell EC. Real-world analysis of the efficacy of bimatoprost sustained-release glaucoma implant where American Indians comprise the largest minority population. Clin Ophthalmol. 2024;18:917\u201327. https:\/\/doi.org\/10.2147\/opth.S452159.","journal-title":"Clin Ophthalmol"},{"key":"2154_CR34","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.2147\/opth.S450220","volume":"18","author":"AA Ali","year":"2024","unstructured":"Ali AA, Avil\u00e9s Elescano D, Grover DS. Bimatoprost SR for glaucoma therapy implanted at the slit-lamp in a real-world setting. Clin Ophthalmol. 2024;18:1371\u20137. https:\/\/doi.org\/10.2147\/opth.S450220.","journal-title":"Clin Ophthalmol"},{"key":"2154_CR35","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1089\/jop.2022.0137","volume":"39","author":"RN Weinreb","year":"2023","unstructured":"Weinreb RN, Bacharach J, Brubaker JW, Medeiros FA, Bejanian M, Bernstein P, et al. Bimatoprost implant biodegradation in the phase 3, randomized, 20-month ARTEMIS studies. J Ocul Pharmacol Ther. 2023;39:55\u201362. https:\/\/doi.org\/10.1089\/jop.2022.0137.","journal-title":"J Ocul Pharmacol Ther"},{"key":"2154_CR36","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1089\/jop.2018.0067","volume":"35","author":"JR Seal","year":"2019","unstructured":"Seal JR, Robinson MR, Burke J, Bejanian M, Coote M, Attar M. Intracameral sustained-release bimatoprost implant delivers bimatoprost to target tissues with reduced drug exposure to off-target tissues. J Ocul Pharmacol Ther. 2019;35:50\u20137. https:\/\/doi.org\/10.1089\/jop.2018.0067.","journal-title":"J Ocul Pharmacol Ther"},{"key":"2154_CR37","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1089\/jop.2019.0146","volume":"36","author":"RN Weinreb","year":"2020","unstructured":"Weinreb RN, Robinson MR, Dibas M, Stamer WD. Matrix metalloproteinases and glaucoma treatment. J Ocul Pharmacol Ther. 2020;36:208\u201328. https:\/\/doi.org\/10.1089\/jop.2019.0146.","journal-title":"J Ocul Pharmacol Ther"},{"key":"2154_CR38","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1089\/jop.2018.0095","volume":"35","author":"SS Lee","year":"2019","unstructured":"Lee SS, Dibas M, Almazan A, Robinson MR. Dose-response of intracameral bimatoprost sustained-release implant and topical bimatoprost in lowering intraocular pressure. J Ocul Pharmacol Ther. 2019;35:138\u201344. https:\/\/doi.org\/10.1089\/jop.2018.0095.","journal-title":"J Ocul Pharmacol Ther"},{"key":"2154_CR39","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1167\/iovs.64.3.15","volume":"64","author":"WD Stamer","year":"2023","unstructured":"Stamer WD, Perkumas KM, Kang MH, Dibas M, Robinson MR, Rhee DJ. Proposed mechanism of long-term intraocular pressure lowering with the bimatoprost implant. Invest Ophthalmol Vis Sci. 2023;64:15. https:\/\/doi.org\/10.1167\/iovs.64.3.15.","journal-title":"Investig Ophthalmol Vis Sci"}],"container-title":["Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40265-025-02154-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40265-025-02154-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40265-025-02154-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T22:54:12Z","timestamp":1743288852000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40265-025-02154-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,22]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["2154"],"URL":"https:\/\/doi.org\/10.1007\/s40265-025-02154-4","relation":{},"ISSN":["0012-6667","1179-1950"],"issn-type":[{"value":"0012-6667","type":"print"},{"value":"1179-1950","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,22]]},"assertion":[{"value":"27 January 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 February 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Allergan (prior to its acquisition by AbbVie) and\/or AbbVie funded this study and participated in the study design, research, analysis, data collection, interpretation of data, reviewing, and approval of the publication.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"Amanda K. Bicket is a consultant for W.L. Gore and Associates, Inc. Christian Brinkmann has received financial compensation from AbbVie, Afidera, Appelis, Bayer, Heidelberg Engineering, Novartis, Santen, Teleon Surgical, and Th\u00e9a Laboratories. William C. Christie is a consultant for Allergan (an AbbVie company). Petrus N.J. Gous has no financial interests to disclose. Miriam Kolko is a speaker for AbbVie, Santen, Th\u00e9a Laboratories, and Topcon; and sits on advisory boards for AbbVie, Santen, and Th\u00e9a Laboratories. Jan Luebke is a speaker for AbbVie, Alcon, Glaukos, iStar Medical, Santen, and Th\u00e9a Laboratories and sits on advisory boards for AbbVie and Santen. Francesco Oddone is a speaker for AbbVie, Omikron Italia, Santen, Sifi, and The\u00e0; sits on advisory boards for AbbVie, Domp\u00e8, and Santen; and has received research grants from AbbVie, Santen, and Omikron Italia. Steven M. Silverstein has no disclosures beyond participation in this clinical study. Marina Bejanian, E. Randy Craven, Jenny Jiao, Jyotsna Maram, Ashley Nguyen, Yongjia Pu, and Michael R. Robinson are employees of AbbVie and may hold AbbVie stock.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Institutional review board or independent ethics committee approval was obtained at each site before the study began, and the study was performed in compliance with Good Clinical Practice, the principles of the Declaration of Helsinki, and applicable laws and regulations (ClinicalTrials.gov registration number NCT03850782).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All patients in this study provided written informed consent before undergoing any study-related procedure.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent\u00a0for participation"}},{"value":"AbbVie is committed to responsible data sharing regarding the clinical trials we sponsor. This includes access to anonymized, individual, and trial-level data (analysis data sets), as well as other information (e.g., protocols, clinical study reports, or analysis plans), as long as the trials are not part of an ongoing or planned regulatory submission. This includes requests for clinical trial data for unlicensed products and indications. These clinical trial data can be requested by any qualified researchers who engage in rigorous, independent, scientific research and will be provided following review and approval of a research proposal, statistical analysis plan (SAP), and execution of a data sharing agreement (DSA). Data requests can be submitted at any time after approval in the USA and Europe and after acceptance of this manuscript for publication. The data will be accessible for 12 months, with possible extensions considered. For more information on the process or to submit a request, visit the following link:\n                      \n                      .","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data availability"}},{"value":"Not applicable.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}},{"value":"Study design: M.B. and A.N.; data collection: A.K.B., C.K.B., W.C.C., P.N.J.G., J.L., M.K., F.O., and S.M.S.; statistical analysis: J.J. and Y.P.; data interpretation: M.B., A.K.B., C.K.B., W.C.C., P.N.J.G., J.J., J.L., M.K., J.M., A.N., F.O., Y.P., and S.M.S.; drafting, revision, and approval of the manuscript: M.B., A.K.B., C.K.B., W.C.C., P.N.J.G., J.J., J.L., M.K., J.M., A.N., F.O., Y.P., and S.M.S.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author contributions"}}]}}