{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:38:44Z","timestamp":1792787924627,"version":"4.5.0"},"reference-count":91,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"name":"The University of Sydney","id":[{"id":"https:\/\/ror.org\/0384j8v12","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drugs"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s40265-026-02284-3","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T13:02:36Z","timestamp":1772024556000},"page":"533-550","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Harms of Opioid Analgesics for Acute Pain: Overview of Systematic Reviews and Meta-analyses"],"prefix":"10.1007","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7335-8842","authenticated-orcid":false,"given":"Stephanie","family":"Mathieson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8981-2125","authenticated-orcid":false,"given":"Joshua R.","family":"Zadro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8706-2113","authenticated-orcid":false,"given":"Sujita W.","family":"Narayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4674-0242","authenticated-orcid":false,"given":"Andrew J.","family":"McLachlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0741-9771","authenticated-orcid":false,"given":"Jane C.","family":"Ballantyne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1128-6756","authenticated-orcid":false,"given":"Fiona M.","family":"Blyth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6045-6937","authenticated-orcid":false,"given":"Richard O.","family":"Day","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1628-7857","authenticated-orcid":false,"given":"Christopher G.","family":"Maher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0895-3922","authenticated-orcid":false,"given":"Hanan","family":"McLachlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6192-7238","authenticated-orcid":false,"given":"Chung-Wei Christine","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3012-5499","authenticated-orcid":false,"given":"Steven J.","family":"Kamper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1258-5125","authenticated-orcid":false,"given":"Christina","family":"Abdel Shaheed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,25]]},"reference":[{"issue":"6","key":"2284_CR1","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1177\/15589447231160211","volume":"19","author":"MNQ Huynh","year":"2024","unstructured":"Huynh MNQ, Yuan M, Gallo L, et al. Opioid consumption after upper extremity surgery: a systematic review. HAND. 2024;19(6):1002\u201311. https:\/\/doi.org\/10.1177\/15589447231160211.","journal-title":"HAND"},{"issue":"18","key":"2284_CR2","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.5435\/jaaos-d-24-00908","volume":"33","author":"AL Rancu","year":"2024","unstructured":"Rancu AL, Gouzoulis MJ, Winter AD, et al. Opioid prescribing trends following lumbar discectomy. J Am Acad Orthop Surg. 2024;33(18):1054\u20139. https:\/\/doi.org\/10.5435\/jaaos-d-24-00908.","journal-title":"J Am Acad Orthop Surg"},{"issue":"1","key":"2284_CR3","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2024-065814","volume":"154","author":"KP Chua","year":"2024","unstructured":"Chua KP, Brummett CM, Kelley-Quon LI, et al. Pediatric surgical opioid prescribing by procedure, 2020-2021. Pediatrics. 2024;154(1):e2024065814. https:\/\/doi.org\/10.1542\/peds.2024-065814.","journal-title":"Pediatrics"},{"issue":"5","key":"2284_CR4","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1111\/scd.12709","volume":"42","author":"P Suarez-Durall","year":"2022","unstructured":"Suarez-Durall P, Osborne MS, Chan C, et al. Opioids and older adults: increasing trends in opioid usage in a dental population compared to a national database (NHANES). Spec Care Dentist. 2022;42(5):445\u201355. https:\/\/doi.org\/10.1111\/scd.12709.","journal-title":"Spec Care Dentist"},{"issue":"11","key":"2284_CR5","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1093\/aje\/kwae094","volume":"193","author":"RA Hoopsick","year":"2024","unstructured":"Hoopsick RA, Yockey RA, Campbell BM, et al. Suicide deaths involving opioid poisoning in the United States, by sex, 1999-2021. Am J Epidemiol. 2024;193(11):1511\u20138. https:\/\/doi.org\/10.1093\/aje\/kwae094.","journal-title":"Am J Epidemiol"},{"issue":"2","key":"2284_CR6","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1111\/bcp.15028","volume":"88","author":"TC Chen","year":"2022","unstructured":"Chen TC, Knaggs RD, Chen LC. Association between opioid-related deaths and persistent opioid prescribing in primary care in England: a nested case-control study. Br J Clin Pharmacol. 2022;88(2):798\u2013809. https:\/\/doi.org\/10.1111\/bcp.15028.","journal-title":"Br J Clin Pharmacol"},{"key":"2284_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2022.109402","volume":"234","author":"A Fugelstad","year":"2022","unstructured":"Fugelstad A, \u00c5gren G, Ramstedt M, et al. Oxycodone-related deaths in Sweden 2006-2018. Drug Alcohol Depend. 2022;234:109402. https:\/\/doi.org\/10.1016\/j.drugalcdep.2022.109402.","journal-title":"Drug Alcohol Depend"},{"issue":"1","key":"2284_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/09687637.2024.2306826","volume":"32","author":"KA McCormick","year":"2025","unstructured":"McCormick KA, Samora J, Claborn KR, et al. A systematic review of macro-, meso, and micro-level harm reduction interventions addressing the U.S. opioid overdose epidemic. Drugs Educ Prev Policy. 2025;32(1):1\u201314. https:\/\/doi.org\/10.1080\/09687637.2024.2306826.","journal-title":"Drugs Educ Prev Policy"},{"issue":"4","key":"2284_CR9","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1001\/jamapediatrics.2024.5920","volume":"179","author":"L Olejnik","year":"2025","unstructured":"Olejnik L, Lima JP, Sadeghirad B, et al. Pharmacologic management of acute pain in children: a systematic review and network meta-analysis. JAMA Pediatr. 2025;179(4):407\u201317. https:\/\/doi.org\/10.1001\/jamapediatrics.2024.5920. ((In eng)).","journal-title":"JAMA Pediatr"},{"issue":"1","key":"2284_CR10","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1136\/bjsports-2020-103596","volume":"56","author":"S Gianola","year":"2022","unstructured":"Gianola S, Bargeri S, Del Castillo G, et al. Effectiveness of treatments for acute and subacute mechanical non-specific low back pain: a systematic review with network meta-analysis. Br J Sports Med. 2022;56(1):41\u201350. https:\/\/doi.org\/10.1136\/bjsports-2020-103596.","journal-title":"Br J Sports Med"},{"issue":"9","key":"2284_CR11","doi-asserted-by":"publisher","first-page":"730","DOI":"10.7326\/M19-3601","volume":"173","author":"JW Busse","year":"2020","unstructured":"Busse JW, Sadeghirad B, Oparin Y, et al. Management of acute pain from non-low back, musculoskeletal injuries\u202f: a systematic review and network meta-analysis of randomized trials. Ann Intern Med. 2020;173(9):730\u20138. https:\/\/doi.org\/10.7326\/M19-3601.","journal-title":"Ann Intern Med"},{"issue":"3","key":"2284_CR12","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s40265-024-01999-5","volume":"84","author":"CMP Jones","year":"2024","unstructured":"Jones CMP, Langford A, Maher CG, et al. Opioids for acute musculoskeletal pain: a systematic review with meta-analysis. Drugs. 2024;84(3):305\u201317. https:\/\/doi.org\/10.1007\/s40265-024-01999-5.","journal-title":"Drugs"},{"issue":"11","key":"2284_CR13","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1016\/j.jpain.2023.07.001","volume":"24","author":"B Aguilar","year":"2023","unstructured":"Aguilar B, Penm J, Liu S, et al. Efficacy and safety of transdermal buprenorphine for acute postoperative pain: a systematic review and meta-analysis. J Pain. 2023;24(11):1905\u201314. https:\/\/doi.org\/10.1016\/j.jpain.2023.07.001.","journal-title":"J Pain"},{"issue":"10343","key":"2284_CR14","doi-asserted-by":"publisher","first-page":"2280","DOI":"10.1016\/s0140-6736(22)00582-7","volume":"399","author":"JF Fiore Jr","year":"2022","unstructured":"Fiore JF Jr, El-Kefraoui C, Chay MA, et al. Opioid versus opioid-free analgesia after surgical discharge: a systematic review and meta-analysis of randomised trials. Lancet. 2022;399(10343):2280\u201393. https:\/\/doi.org\/10.1016\/s0140-6736(22)00582-7.","journal-title":"Lancet"},{"issue":"10","key":"2284_CR15","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1097\/pec.0000000000003187","volume":"40","author":"M Alsabri","year":"2024","unstructured":"Alsabri M, Hafez AH, Singer E, et al. Efficacy and safety of intranasal fentanyl in pediatric emergencies: a systematic review and meta-analysis. Pediatr Emerg Care. 2024;40(10):748\u201352. https:\/\/doi.org\/10.1097\/pec.0000000000003187.","journal-title":"Pediatr Emerg Care"},{"issue":"1","key":"2284_CR16","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-023-04203-x","volume":"23","author":"MG Prescott","year":"2023","unstructured":"Prescott MG, Iakovleva E, Simpson MR, et al. Intranasal analgesia for acute moderate to severe pain in children\u2014a systematic review and meta-analysis. BMC Pediatr. 2023;23(1):405. https:\/\/doi.org\/10.1186\/s12887-023-04203-x.","journal-title":"BMC Pediatr"},{"issue":"1","key":"2284_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.15585\/mmwr.rr6501e1","volume":"65","author":"D Dowell","year":"2016","unstructured":"Dowell D, Haegerich TM, Chou R. CDC guideline for prescribing opioids for chronic pain\u2014United States, 2016. MMWR Recomm Rep. 2016;65(1):1\u201349. https:\/\/doi.org\/10.15585\/mmwr.rr6501e1.","journal-title":"MMWR Recomm Rep"},{"issue":"1","key":"2284_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/2046-4053-4-1","volume":"4","author":"DSL Moher","year":"2015","unstructured":"Moher DSL, Clarke M, Ghersi D, et al. Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) 2015 statement. Syst Rev. 2015;4(1):1. https:\/\/doi.org\/10.1186\/2046-4053-4-1.","journal-title":"Syst Rev"},{"issue":"372","key":"2284_CR19","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71","volume":"2021","author":"MJ Page","year":"2020","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, The PRISMA, et al. statement: an updated guideline for reporting systematic reviews. BMJ. 2020;2021(372):n71. https:\/\/doi.org\/10.1136\/bmj.n71.","journal-title":"BMJ"},{"key":"2284_CR20","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2022-070849","volume":"378","author":"M Gates","year":"2022","unstructured":"Gates M, Gates A, Pieper D, et al. Reporting guideline for overviews of reviews of healthcare interventions: development of the PRIOR statement. BMJ. 2022;378:e070849.","journal-title":"BMJ"},{"issue":"7650","key":"2284_CR21","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","volume":"336","author":"GH Guyatt","year":"2008","unstructured":"Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 2008;336(7650):924\u20136. https:\/\/doi.org\/10.1136\/bmj.39489.470347.AD.","journal-title":"BMJ"},{"issue":"11","key":"2284_CR22","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD015023.pub2","volume":"11","author":"P Backe","year":"2022","unstructured":"Backe P, Bruschettini M, Sibrecht G, et al. Pharmacological interventions for pain and sedation management in newborn infants undergoing therapeutic hypothermia. Cochrane Database Syst Rev. 2022;11(11):CD015023. https:\/\/doi.org\/10.1002\/14651858.CD015023.pub2.","journal-title":"Cochrane Database Syst Rev"},{"key":"2284_CR23","unstructured":"Agency for Clinical Innovation. Pain management. 2022. https:\/\/www.acihealthnswgovau\/networks\/eci\/clinical\/ed-factsheets\/pain-management. Accessed 26 May 2025."},{"key":"2284_CR24","unstructured":"Centers for Disease Control and Prevention. CDC compilation of benzodiazepines, muscle relaxants, stimulants, zolpidem, and opioid analgesics with oral morphine milligram equivalent conversion factors, 2016 Version. Atlanta, GA: Centers for Disease Control and Prevention."},{"key":"2284_CR25","unstructured":"Higgins JPT, Thomas J, Chandler J, et al. Cochrane handbook for systematic reviews of interventions version 6.5 (updated August 2024). www.training.cochrane.org\/handbook. Accessed 26 May 2025."},{"issue":"21","key":"2284_CR26","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.1097\/BRS.0000000000001061","volume":"40","author":"AD Furlan","year":"2015","unstructured":"Furlan AD, Malmivaara A, Chou R, et al. 2015 updated method guideline for systematic reviews in the Cochrane Back and Neck Group. Spine (Phila Pa 1976). 2015;40(21):1660\u201373. https:\/\/doi.org\/10.1097\/BRS.0000000000001061.","journal-title":"Spine (Phila Pa 1976)"},{"key":"2284_CR27","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j4008","volume":"358","author":"BJ Shea","year":"2017","unstructured":"Shea BJ, Reeves BC, Wells G, et al. AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both. BMJ. 2017;358:j4008. https:\/\/doi.org\/10.1136\/bmj.j4008.","journal-title":"BMJ"},{"issue":"8","key":"2284_CR28","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1007\/s40265-024-02065-w","volume":"84","author":"Z Cao","year":"2024","unstructured":"Cao Z, Han K, Lu H, et al. Paracetamol combination therapy for back pain and osteoarthritis: a systematic review and meta-analyses. Drugs. 2024;84(8):953\u201367. https:\/\/doi.org\/10.1007\/s40265-024-02065-w.","journal-title":"Drugs"},{"issue":"4","key":"2284_CR29","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1213\/ANE.0000000000003549","volume":"127","author":"C Cozowicz","year":"2018","unstructured":"Cozowicz C, Chung F, Doufas AG, et al. Opioids for acute pain management in patients with obstructive sleep apnea: a systematic review. Anesth Analg. 2018;127(4):988\u20131001. https:\/\/doi.org\/10.1213\/ANE.0000000000003549.","journal-title":"Anesth Analg"},{"issue":"8","key":"2284_CR30","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1586\/ern.11.63","volume":"11","author":"MP Davis","year":"2011","unstructured":"Davis MP. Fentanyl for breakthrough pain: a systematic review. Expert Rev Neurother. 2011;11(8):1197\u2013216. https:\/\/doi.org\/10.1586\/ern.11.63.","journal-title":"Expert Rev Neurother"},{"key":"2284_CR31","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13092560","author":"MN de Grunt","year":"2024","unstructured":"de Grunt MN, de Jong B, Hollmann MW, et al. Parenteral, non-intravenous analgesia in acute traumatic pain-a narrative review based on a systematic literature search. J Clin Med. 2024. https:\/\/doi.org\/10.3390\/jcm13092560.","journal-title":"J Clin Med"},{"issue":"9","key":"2284_CR32","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1007\/s12630-013-9989-4","volume":"60","author":"BX Du","year":"2013","unstructured":"Du BX, Song ZM, Wang K, et al. Butorphanol prevents morphine-induced pruritus without increasing pain and other side effects: a systematic review of randomized controlled trials. Can J Anaesth. 2013;60(9):907\u201317. https:\/\/doi.org\/10.1007\/s12630-013-9989-4.","journal-title":"Can J Anaesth"},{"issue":"3","key":"2284_CR33","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-025232","volume":"9","author":"GS Duarte","year":"2019","unstructured":"Duarte GS, Nunes-Ferreira A, Rodrigues FB, et al. Morphine in acute coronary syndrome: systematic review and meta-analysis. BMJ Open. 2019;9(3):e025232. https:\/\/doi.org\/10.1136\/bmjopen-2018-025232.","journal-title":"BMJ Open"},{"key":"2284_CR34","doi-asserted-by":"publisher","first-page":"157","DOI":"10.4103\/jpp.jpp_116_21","volume":"12","author":"D Elango","year":"2021","unstructured":"Elango D, Malathi D, Palanisamy PR. Oliceridine \u2011 breakthrough in the management of pain. J Pharmacol Pharmacother. 2021;12:157\u201362. https:\/\/doi.org\/10.4103\/jpp.jpp_116_21.","journal-title":"J Pharmacol Pharmacother"},{"issue":"12","key":"2284_CR35","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1016\/j.purol.2017.05.011","volume":"27","author":"HA Garcia-Perdomo","year":"2017","unstructured":"Garcia-Perdomo HA, Echeverria-Garcia F, Lopez H, et al. Pharmacologic interventions to treat renal colic pain in acute stone episodes: systematic review and meta-analysis. Prog Urol. 2017;27(12):654\u201365. https:\/\/doi.org\/10.1016\/j.purol.2017.05.011.","journal-title":"Prog Urol"},{"issue":"2","key":"2284_CR36","doi-asserted-by":"publisher","first-page":"121","DOI":"10.14740\/jocmr3690","volume":"11","author":"P Gavriilidis","year":"2019","unstructured":"Gavriilidis P, de\u2019Angelis N, Tobias A. To use or not to use opioid analgesia for acute abdominal pain before definitive surgical diagnosis? A systematic review and network meta-analysis. J Clin Med Res. 2019;11(2):121\u20136. https:\/\/doi.org\/10.14740\/jocmr3690.","journal-title":"J Clin Med Res"},{"issue":"6","key":"2284_CR37","doi-asserted-by":"publisher","DOI":"10.1111\/dth.15150","volume":"34","author":"Y Gutierrez","year":"2021","unstructured":"Gutierrez Y, Pourali SP, Kucharik AH, et al. Topical opioid use in dermatologic disease: a systematic review. Dermatol Ther. 2021;34(6):e15150. https:\/\/doi.org\/10.1111\/dth.15150.","journal-title":"Dermatol Ther"},{"issue":"3","key":"2284_CR38","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.jpain.2020.04.004","volume":"22","author":"V Hanna","year":"2021","unstructured":"Hanna V, Senderovich H. Methadone in pain management: a systematic review. J Pain. 2021;22(3):233\u201345. https:\/\/doi.org\/10.1016\/j.jpain.2020.04.004.","journal-title":"J Pain"},{"issue":"4","key":"2284_CR39","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1111\/j.1399-6576.2011.02613.x","volume":"56","author":"MS Hansen","year":"2012","unstructured":"Hansen MS, Mathiesen O, Trautner S, et al. Intranasal fentanyl in the treatment of acute pain\u2014a systematic review. Acta Anaesthesiol Scand. 2012;56(4):407\u201319. https:\/\/doi.org\/10.1111\/j.1399-6576.2011.02613.x.","journal-title":"Acta Anaesthesiol Scand"},{"issue":"1","key":"2284_CR40","doi-asserted-by":"publisher","first-page":"124","DOI":"10.2174\/13894501113149990210","volume":"15","author":"W Leppert","year":"2014","unstructured":"Leppert W. Oxycodone\/naloxone in the management of patients with pain and opioid\u2013induced bowel dysfunction. Curr Drug Targets. 2014;15(1):124\u201335. https:\/\/doi.org\/10.2174\/13894501113149990210.","journal-title":"Curr Drug Targets"},{"issue":"1","key":"2284_CR41","volume":"8","author":"B Naghipour","year":"2020","unstructured":"Naghipour B, Pouraghaei M, Tabatabaey A, et al. Comparison of ketamine and tramadol in management of acute pain; a systematic review. Arch Acad Emerg Med. 2020;8(1):e68.","journal-title":"Arch Acad Emerg Med"},{"issue":"5","key":"2284_CR42","doi-asserted-by":"publisher","DOI":"10.3390\/ph15050643","volume":"15","author":"P Piirainen","year":"2022","unstructured":"Piirainen P, Kokki H, Kokki M. Epidural oxycodone for acute pain. Pharmaceuticals (Basel). 2022;15(5):643. https:\/\/doi.org\/10.3390\/ph15050643.","journal-title":"Pharmaceuticals (Basel)"},{"issue":"11","key":"2284_CR43","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1111\/acem.12509","volume":"21","author":"N Poonai","year":"2014","unstructured":"Poonai N, Paskar D, Konrad SL, et al. Opioid analgesia for acute abdominal pain in children: a systematic review and meta-analysis. Acad Emerg Med. 2014;21(11):1183\u201392. https:\/\/doi.org\/10.1111\/acem.12509.","journal-title":"Acad Emerg Med"},{"issue":"10","key":"2284_CR44","doi-asserted-by":"publisher","first-page":"711","DOI":"10.2165\/11205830-000000000-00000","volume":"30","author":"S Dhillion","year":"2010","unstructured":"Dhillion S. Tramadol\/paracetamol fixed-dose combination: a review of its use in the management of moderate to severe pain. Clin Drug Investig. 2010;30(10):711\u201338. https:\/\/doi.org\/10.2165\/11205830-000000000-00000.","journal-title":"Clin Drug Investig"},{"issue":"3","key":"2284_CR45","first-page":"509","volume":"4","author":"S Payami","year":"2018","unstructured":"Payami S. The efficacy of fentanyl for pain management in emergency department: a review. Arch Anesth Crit Care. 2018;4(3):509\u201312.","journal-title":"Arch Anesth Crit Care"},{"issue":"7","key":"2284_CR46","doi-asserted-by":"publisher","first-page":"2609","DOI":"10.17605\/OSF.IO\/PHMC8","volume":"12","author":"S Serra","year":"2023","unstructured":"Serra S, Spampinato DM, Riccardi A, et al. Intranasal fentanyl for acute pain management in children, adults and elderly patients in the prehospital emergency service and in the emergency department: a systematic review. J Clin Med. 2023;12(7):2609. https:\/\/doi.org\/10.17605\/OSF.IO\/PHMC8.","journal-title":"J Clin Med"},{"key":"2284_CR47","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2024.101194","volume":"65","author":"P Telfer","year":"2024","unstructured":"Telfer P, Anie KA, Kotsiopoulou S, et al. The acute pain crisis in sickle cell disease: what can be done to improve outcomes? Blood Rev. 2024;65:101194. https:\/\/doi.org\/10.1016\/j.blre.2024.101194.","journal-title":"Blood Rev"},{"issue":"1","key":"2284_CR48","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1111\/pan.14324","volume":"32","author":"SM Walker","year":"2022","unstructured":"Walker SM, Selers EL, Jay MA. Intravenous opioids for chemotherapy-induced severe mucositis pain in children: systematic review and single-center case series of management with patient- or nurse-controlled analgesia (PCA\/NCA). Paediatr Anaesth. 2022;32(1):17\u201334. https:\/\/doi.org\/10.1111\/pan.14324.","journal-title":"Paediatr Anaesth"},{"issue":"9","key":"2284_CR49","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.32041","volume":"7","author":"AR Alimy","year":"2024","unstructured":"Alimy AR, Anastasilakis AD, Carey JJ, et al. Conservative treatments in the management of acute painful vertebral compression fractures: a systematic review and network meta-analysis. JAMA Netw Open. 2024;7(9):e2432041. https:\/\/doi.org\/10.1001\/jamanetworkopen.2024.32041.","journal-title":"JAMA Netw Open"},{"issue":"10","key":"2284_CR50","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1097\/AJP.0000000000000746","volume":"35","author":"C Abdel Shaheed","year":"2019","unstructured":"Abdel Shaheed C, Maher CG, McLachlan AJ. Efficacy and safety of low-dose codeine-containing combination analgesics for pain: systematic review and meta-analysis. Clin J Pain. 2019;35(10):836\u201343. https:\/\/doi.org\/10.1097\/AJP.0000000000000746.","journal-title":"Clin J Pain"},{"issue":"5","key":"2284_CR51","doi-asserted-by":"publisher","first-page":"405","DOI":"10.5055\/jom.2021.0674","volume":"17","author":"YH AbdelQadir","year":"2021","unstructured":"AbdelQadir YH, Nabhan AE, Abdelghany EA, et al. Efficacy and safety of intrathecal morphine in total knee arthroplasty: a systematic review and meta-analysis. J Opioid Manag. 2021;17(5):405\u201316. https:\/\/doi.org\/10.5055\/jom.2021.0674.","journal-title":"J Opioid Manag"},{"issue":"1","key":"2284_CR52","doi-asserted-by":"publisher","first-page":"65","DOI":"10.4103\/sja.sja_822_22","volume":"17","author":"MS Albaqami","year":"2023","unstructured":"Albaqami MS, Alqarni AA, Alabeesy MS, et al. Buprenorphine for acute post-surgical pain: a systematic review and meta-analysis. Saudi J Anaesth. 2023;17(1):65\u201371. https:\/\/doi.org\/10.4103\/sja.sja_822_22.","journal-title":"Saudi J Anaesth"},{"issue":"5","key":"2284_CR53","doi-asserted-by":"publisher","first-page":"2807","DOI":"10.1111\/odi.14773","volume":"30","author":"CM Ardila","year":"2024","unstructured":"Ardila CM, Jimenez-Arbelaez GA, Vivares-Builes AM. Perioperative analgesic efficacy and adverse events of fentanyl in dentistry: a systematic review. Oral Dis. 2024;30(5):2807\u201319. https:\/\/doi.org\/10.1111\/odi.14773.","journal-title":"Oral Dis"},{"issue":"4","key":"2284_CR54","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1007\/s40261-019-00772-x","volume":"39","author":"ED Deeks","year":"2019","unstructured":"Deeks ED. Sufentanil 30 microg sublingual tablet: a review in acute pain. Clin Drug Investig. 2019;39(4):411\u20138. https:\/\/doi.org\/10.1007\/s40261-019-00772-x.","journal-title":"Clin Drug Investig"},{"key":"2284_CR55","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000007352","author":"X Deng","year":"2024","unstructured":"Deng X, Zhao S, Guo W, et al. Comparative effectiveness of analgesia for early pain management after pediatric tonsillectomy: a systematic review and network meta-analysis. Anesth Analg. 2024. https:\/\/doi.org\/10.1213\/ANE.0000000000007352.","journal-title":"Anesth Analg"},{"key":"2284_CR56","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010107.pub3","author":"S Derry","year":"2015","unstructured":"Derry S, Karlin SM, Moore RA. Single dose oral ibuprofen plus codeine for acute postoperative pain in adults. Cochrane Database Syst Rev. 2015. https:\/\/doi.org\/10.1002\/14651858.CD010107.pub3.","journal-title":"Cochrane Database Syst Rev"},{"issue":"10","key":"2284_CR57","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004908.pub3","volume":"10","author":"AR Deussen","year":"2020","unstructured":"Deussen AR, Ashwood P, Martis R, et al. Relief of pain due to uterine cramping\/involution after birth. Cochrane Database Syst Rev. 2020;10(10):CD004908. https:\/\/doi.org\/10.1002\/14651858.CD004908.pub3.","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"2284_CR58","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1007\/s10006-023-01179-x","volume":"28","author":"MM Gounari","year":"2024","unstructured":"Gounari MM, Tsaousi G, Zouloumis L, et al. Efficacy and safety of parenteral and local application of tramadol in mandibular third molar extraction: a qualitative systematic review of current evidence. Oral Maxillofac Surg. 2024;28(2):499\u2013513. https:\/\/doi.org\/10.1007\/s10006-023-01179-x.","journal-title":"Oral Maxillofac Surg"},{"key":"2284_CR59","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/4741141","volume":"2022","author":"H Huang","year":"2022","unstructured":"Huang H, Wang S, Lin R, et al. Sufentanil for spinal analgesia during cesarean section delivery: a systematic review and meta-analysis of randomized controlled trials. Int J Clin Pract. 2022;2022:4741141. https:\/\/doi.org\/10.1155\/2022\/4741141.","journal-title":"Int J Clin Pract"},{"issue":"10","key":"2284_CR60","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1111\/aas.14527","volume":"68","author":"PK Hyldmo","year":"2024","unstructured":"Hyldmo PK, Rehn M, Dahl Friesgaard K, et al. Inhaled analgesics for the treatment of prehospital acute pain\u2014a systematic review. Acta Anaesthesiol Scand. 2024;68(10):1306\u201318. https:\/\/doi.org\/10.1111\/aas.14527.","journal-title":"Acta Anaesthesiol Scand"},{"key":"2284_CR61","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-015-0137-2","volume":"15","author":"GP Joshi","year":"2015","unstructured":"Joshi GP, Jaschinski T, Bonnet F, et al. Optimal pain management for radical prostatectomy surgery: what is the evidence? BMC Anesthesiol. 2015;15:159. https:\/\/doi.org\/10.1186\/s12871-015-0137-2.","journal-title":"BMC Anesthesiol"},{"key":"2284_CR62","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD014876.pub2","author":"M Kinoshita","year":"2023","unstructured":"Kinoshita M, Stempel KS, Borges do Nascimento IJ, et al. Systemic opioids versus other analgesics and sedatives for postoperative pain in neonates. Cochrane Database Syst Rev. 2023. https:\/\/doi.org\/10.1002\/14651858.CD014876.pub2.","journal-title":"Cochrane Database Syst Rev"},{"key":"2284_CR63","doi-asserted-by":"publisher","DOI":"10.1136\/rapm-2024-105478","author":"X Luxey","year":"2024","unstructured":"Luxey X, Lemoine A, Dewinter G, et al. Acute pain management after vaginal delivery with perineal tears or episiotomy. Reg Anesth Pain Med. 2024. https:\/\/doi.org\/10.1136\/rapm-2024-105478.","journal-title":"Reg Anesth Pain Med"},{"issue":"10","key":"2284_CR64","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1097\/EJA.0000000000001881","volume":"40","author":"T Mae\u00dfen","year":"2023","unstructured":"Mae\u00dfen T, Korir N, Van de Velde M, et al. Pain management after cardiac surgery via median sternotomy: a systematic review with procedure-specific postoperative pain management (PROSPECT) recommendations. Eur J Anaesthesiol. 2023;40(10):758\u201368. https:\/\/doi.org\/10.1097\/EJA.0000000000001881.","journal-title":"Eur J Anaesthesiol"},{"issue":"3","key":"2284_CR65","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1093\/bja\/aeu414","volume":"114","author":"V Martinez","year":"2015","unstructured":"Martinez V, Guichard L, Fletcher D. Effect of combining tramadol and morphine in adult surgical patients: a systematic review and meta-analysis of randomized trials. Br J Anaesth. 2015;114(3):384\u201395. https:\/\/doi.org\/10.1093\/bja\/aeu414.","journal-title":"Br J Anaesth"},{"issue":"10","key":"2284_CR66","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1097\/EJA.0000000000001877","volume":"40","author":"FP Mestdagh","year":"2023","unstructured":"Mestdagh FP, Lavand\u2019homme PM, Pirard G, et al. Pain management after elective craniotomy: a systematic review with procedure-specific postoperative pain management (PROSPECT) recommendations. Eur J Anaesthesiol. 2023;40(10):747\u201357. https:\/\/doi.org\/10.1097\/EJA.0000000000001877.","journal-title":"Eur J Anaesthesiol"},{"issue":"4","key":"2284_CR67","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1177\/00220345221139230","volume":"102","author":"A Miroshnychenko","year":"2023","unstructured":"Miroshnychenko A, Ibrahim S, Azab M, et al. Acute postoperative pain due to dental extraction in the adult population: a systematic review and network meta-analysis. J Dent Res. 2023;102(4):391\u2013401. https:\/\/doi.org\/10.1177\/00220345221139230.","journal-title":"J Dent Res"},{"issue":"9","key":"2284_CR68","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008659.pub3","volume":"2015","author":"RA Moore","year":"2015","unstructured":"Moore RA, Derry S, Aldington D, Wiffen PJ. Single dose oral analgesics for acute postoperative pain in adults\u2014an overview of Cochrane reviews. Cochrane Database Syst Rev. 2015;2015(9):CD008659. https:\/\/doi.org\/10.1002\/14651858.CD008659.pub3.","journal-title":"Cochrane Database Syst Rev"},{"issue":"10","key":"2284_CR69","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011407.pub2","volume":"2015","author":"RA Moore","year":"2015","unstructured":"Moore RA, Derry S, Aldington D, et al. Adverse events associated with single dose oral analgesics for acute postoperative pain in adults\u2014an overview of Cochrane reviews. Cochrane Database Syst Rev. 2015;2015(10):CD011407. https:\/\/doi.org\/10.1002\/14651858.CD011407.pub2.","journal-title":"Cochrane Database Syst Rev"},{"issue":"5","key":"2284_CR70","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.contraception.2009.12.008","volume":"81","author":"RM Renner","year":"2010","unstructured":"Renner RM, Jensen JT, Nichols MD, et al. Pain control in first-trimester surgical abortion: a systematic review of randomized controlled trials. Contraception. 2010;81(5):372\u201388. https:\/\/doi.org\/10.1016\/j.contraception.2009.12.008.","journal-title":"Contraception"},{"issue":"7","key":"2284_CR71","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009583.pub2","volume":"2014","author":"A Schnabel","year":"2014","unstructured":"Schnabel A, Reichl SU, Zahn PK, et al. Nalbuphine for postoperative pain treatment in children. Cochrane Database Syst Rev. 2014;2014(7):CD009583. https:\/\/doi.org\/10.1002\/14651858.CD009583.pub2.","journal-title":"Cochrane Database Syst Rev"},{"issue":"6","key":"2284_CR72","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007396.pub3","volume":"6","author":"LA Smith","year":"2018","unstructured":"Smith LA, Burns E, Cuthbert A. Parenteral opioids for maternal pain management in labour. Cochrane Database Syst Rev. 2018;6(6):CD007396. https:\/\/doi.org\/10.1002\/14651858.CD007396.pub3.","journal-title":"Cochrane Database Syst Rev"},{"issue":"3","key":"2284_CR73","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.ajog.2017.03.013","volume":"217","author":"AC Steinberg","year":"2017","unstructured":"Steinberg AC, Schimpf MO, White AB, et al. Preemptive analgesia for postoperative hysterectomy pain control: systematic review and clinical practice guidelines. Am J Obstet Gynecol. 2017;217(3):303-313 e6. https:\/\/doi.org\/10.1016\/j.ajog.2017.03.013.","journal-title":"Am J Obstet Gynecol"},{"issue":"12","key":"2284_CR74","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1007\/s40266-016-0409-7","volume":"33","author":"ER Viscusi","year":"2016","unstructured":"Viscusi ER, Ding L, Itri LM. The efficacy and safety of the fentanyl iontophoretic transdermal system (IONSYS((R))) in the geriatric population: results of a meta-analysis of Phase III and IIIb trials. Drugs Aging. 2016;33(12):901\u201312. https:\/\/doi.org\/10.1007\/s40266-016-0409-7.","journal-title":"Drugs Aging"},{"issue":"6","key":"2284_CR75","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1007\/s40122-024-00645-y","volume":"13","author":"ER Viscusi","year":"2024","unstructured":"Viscusi ER, Epelde F, Roca Ruiz LJ, et al. Present and future of pharmacological management for acute moderate-to-severe postoperative, traumatic, or musculoskeletal pain in Europe: a narrative review. Pain Ther. 2024;13(6):1351\u201376. https:\/\/doi.org\/10.1007\/s40122-024-00645-y.","journal-title":"Pain Ther"},{"issue":"1","key":"2284_CR76","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1093\/pm\/pnw154","volume":"18","author":"JP Xiao","year":"2017","unstructured":"Xiao JP, Li AL, Feng BM, et al. Efficacy and safety of tapentadol immediate release assessment in treatment of moderate to severe pain: a systematic review and meta-analysis. Pain Med. 2017;18(1):14\u201324. https:\/\/doi.org\/10.1093\/pm\/pnw154.","journal-title":"Pain Med"},{"issue":"8","key":"2284_CR77","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1016\/j.arthro.2013.04.005","volume":"29","author":"C Zeng","year":"2013","unstructured":"Zeng C, Gao SG, Cheng L, et al. Single-dose intra-articular morphine after arthroscopic knee surgery: a meta-analysis of randomized placebo-controlled studies. Arthroscopy. 2013;29(8):1450\u20138. https:\/\/doi.org\/10.1016\/j.arthro.2013.04.005.","journal-title":"Arthroscopy"},{"issue":"5","key":"2284_CR78","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008918.pub2","volume":"2016","author":"Z Zou","year":"2016","unstructured":"Zou Z, An MM, Xie Q, et al. Single dose intra-articular morphine for pain control after knee arthroscopy. Cochrane Database Syst Rev. 2016;2016(5):CD008918. https:\/\/doi.org\/10.1002\/14651858.CD008918.pub2.","journal-title":"Cochrane Database Syst Rev"},{"issue":"7","key":"2284_CR79","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1080\/17512433.2021.1919084","volume":"14","author":"E Bakhtiari","year":"2021","unstructured":"Bakhtiari E, Mousavi SH, Gharavi Fard M. Pharmacological control of pain during propofol injection: a systematic review and meta-analysis. Expert Rev Clin Pharmacol. 2021;14(7):889\u201399. https:\/\/doi.org\/10.1080\/17512433.2021.1919084.","journal-title":"Expert Rev Clin Pharmacol"},{"issue":"3","key":"2284_CR80","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD013732.pub2","volume":"3","author":"R Bellu","year":"2021","unstructured":"Bellu R, Romantsik O, Nava C, et al. Opioids for newborn infants receiving mechanical ventilation. Cochrane Database Syst Rev. 2021;3(3):CD013732. https:\/\/doi.org\/10.1002\/14651858.CD013732.pub2.","journal-title":"Cochrane Database Syst Rev"},{"issue":"5","key":"2284_CR81","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1016\/j.jmig.2020.01.008","volume":"27","author":"PM De Silva","year":"2020","unstructured":"De Silva PM, Mahmud A, Smith PP, et al. Analgesia for office hysteroscopy: a systematic review and meta-analysis. J Minim Invasive Gynecol. 2020;27(5):1034\u201347. https:\/\/doi.org\/10.1016\/j.jmig.2020.01.008.","journal-title":"J Minim Invasive Gynecol"},{"issue":"2","key":"2284_CR82","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.contraception.2010.07.014","volume":"83","author":"E Jackson","year":"2011","unstructured":"Jackson E, Kapp N. Pain control in first-trimester and second-trimester medical termination of pregnancy: a systematic review. Contraception. 2011;83(2):116\u201326. https:\/\/doi.org\/10.1016\/j.contraception.2010.07.014.","journal-title":"Contraception"},{"issue":"5","key":"2284_CR83","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1007\/s40272-023-00583-w","volume":"25","author":"A Maroni","year":"2023","unstructured":"Maroni A, Aubelle MS, Chollat C. Fetal, preterm, and term neonate exposure to remifentanil: a systematic review of efficacy and safety. Paediatr Drugs. 2023;25(5):537\u201355. https:\/\/doi.org\/10.1007\/s40272-023-00583-w.","journal-title":"Paediatr Drugs"},{"issue":"7","key":"2284_CR84","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1111\/papr.13138","volume":"22","author":"AJ Thirunavukarasu","year":"2022","unstructured":"Thirunavukarasu AJ, Hassan R, Savant SV, et al. Analgesia for retinopathy of prematurity screening: a systematic review. Pain Pract. 2022;22(7):642\u201351. https:\/\/doi.org\/10.1111\/papr.13138.","journal-title":"Pain Pract"},{"issue":"12","key":"2284_CR85","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1111\/acem.14790","volume":"30","author":"R Daoust","year":"2023","unstructured":"Daoust R, Paquet J, Marquis M, et al. Efficacy of prescribed opioids for acute pain after being discharged from the emergency department: a systematic review and meta-analysis. Acad Emerg Med. 2023;30(12):1253\u201363. https:\/\/doi.org\/10.1111\/acem.14790.","journal-title":"Acad Emerg Med"},{"issue":"7","key":"2284_CR86","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pmed.1000097","volume":"6","author":"D Moher","year":"2009","unstructured":"Moher D, Liberati A, Tetziaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6(7):1\u20136. https:\/\/doi.org\/10.1371\/journal.pmed.1000097.","journal-title":"PLoS Med"},{"key":"2284_CR87","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2022-072415","volume":"380","author":"GE Ferreira","year":"2023","unstructured":"Ferreira GE, Abdel-Shaheed C, Underwood M, et al. Efficacy, safety, and tolerability of antidepressants for pain in adults: overview of systematic reviews. BMJ. 2023;380:e072415. https:\/\/doi.org\/10.1136\/bmj-2022-072415.","journal-title":"BMJ"},{"key":"2284_CR88","unstructured":"Australian Commission on Safety and Quality in Health Care (ACSQHC). Opioid analgesic stewardship in acute pain clinical care standard\u2014acute care edition. 2022. ACSQHC, Sydney. https:\/\/www.safetyandquality.gov.au\/sites\/default\/files\/2022-04\/opioid-analgesic-stewardship-in-acute-pain-clinical-care-standard.pdf. Accessed 28 Oct 2025."},{"key":"2284_CR89","unstructured":"NICE. Chronic pain (primary and secondary) in over 16s: assessment of all chronic pain and management of chronic primary pain. 2021. www.nice.org.uk\/guidance\/ng193. Accessed 25 May 2025."},{"key":"2284_CR90","unstructured":"World Health Organization. WHO guideline for non-surgical management of chronic primary low back pain in adults in primary and community care settings. Geneva: World Health Organization; 2023. Licence: CC BY-NC-SA 3.0 IGO."},{"issue":"10489","key":"2284_CR91","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1016\/S0140-6736(25)00672-5","volume":"405","author":"S Hopewell","year":"2025","unstructured":"Hopewell S, Chan AW, Collins GS, et al. CONSORT 2025 statement: updated guideline for reporting randomised trials. Lancet. 2025;405(10489):1633\u201340. https:\/\/doi.org\/10.1016\/S0140-6736(25)00672-5.","journal-title":"Lancet"}],"updated-by":[{"DOI":"10.1007\/s40265-026-02406-x","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:00:00Z","timestamp":1792713600000}}],"container-title":["Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40265-026-02284-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40265-026-02284-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40265-026-02284-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:01:27Z","timestamp":1792785687000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40265-026-02284-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,25]]},"references-count":91,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["2284"],"URL":"https:\/\/doi.org\/10.1007\/s40265-026-02284-3","relation":{},"ISSN":["0012-6667","1179-1950"],"issn-type":[{"value":"0012-6667","type":"print"},{"value":"1179-1950","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,25]]},"assertion":[{"value":"31 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 October 2026","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s40265-026-02406-x","URL":"https:\/\/doi.org\/10.1007\/s40265-026-02406-x","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"SM, SWN, AJM, JCB, ROD and SJK have no conflicts to declare. JZ is funded by a National Health and Medical Research Council (NHMRC) Investigator Grant (APP1194105). The funder had no influence on the work done on this paper. FB has received funding support for travel and attending meetings from professional societies for invited talks at international conferences and is an executive of a research collaborative network funded by NHMRC Centre for Research Excellence funding: Australia and New Zealand Low Back Pain Research Network. She is an executive of an educational training program in development (Online Pain Education Network) funded by the Department of Health and Aged Care, Canberra, and serves as a Councillor for the International Association for the Study of Pain. CM holds hold a research fellowship from the NHMRC that includes a research support package that could be used to pay for article processing charges for the present manuscript, holds several research grants and a research fellowship from the NHMRC and several grants from the Medical Research Future Fund (MRFF). Both the NHMRC and MRFF are Australian Government medical research funding agencies. CM has also received research grants from New South Wales Health, Ramsay Hospital Research Foundation, Hospitals Contribution Fund of Australia (HCF) Research Foundation, Arthritis Australia, Australian Rheumatology Association and Royal Prince Alfred Hospital; he also received the 2023 Royal Prince Alfred Hospital Research Medal and prize. The prize was paid into a hospital account and was used to fund research at Royal Prince Alfred Hospital. CM received a research grant from the Sao Paulo Research Foundation for the period 2019\u20132023. Travel expenses have been covered when he was an invited speaker at a scientific conference; he is also an executive of three research collaborative networks funded by NHMRC Centre for Research Excellence funding: Wiser Healthcare, Australia and New Zealand Musculoskeletal Clinical Trials Network, Australia and New Zealand Low Back Pain Research Network. HM has received support in the form of registration and travel costs for attending conferences as a PhD student from Australia and New Zealand Low Back Pain Research Network. CWL holds several research grants and a research fellowship from the NHMRC; and several grants from MRFF. Both the NHMRC and MRFF are Australian Government medical research funding agencies. CAS is funded by an NHMRC Investigator Grant (APP2026038) and holds other NHMRC (APP2000989) and MRRF grants (APP2030414). She has received support to attend conferences and presentations (Consultant Pharmacist Conference for keynote presentations), developed educational modules for Pharmaceutical Society of Australia and is a Data Safety Monitoring Board member (RESHAPED trial).","order":1,"name":"Ethics","label":"Conflict of Interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Ethical Approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Consent\u00a0for Participation \/ Publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":4,"name":"Ethics","label":"Code Availability","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No data was collected from participants. Outcome data are presented in ESM\u00a08.","order":5,"name":"Ethics","label":"Data Sharing","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"CAS conceived the review and drafted the protocol. All authors agreed on the protocol. CAS conducted the search. SM, JZ, SN and CAS extracted data. SM and JZ conducted the analyses. SM and JZ verified the data. All authors had access to the data. All authors contributed to the interpretation of the results. SM drafted the manuscript. All authors contributed, edited and approved the final manuscript.","order":6,"name":"Ethics","label":"Author Contributions","group":{"name":"EthicsHeading","label":"Declarations"}}]}}