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M.R. and S.K. performed investigator-initiated research with support from Boehringer Ingelheim, Novo Nordisk, and Sanofi to the German Diabetes Center (DDZ). GIS serves on the scientific advisory boards of Orsobio, Novo Nordisk, Equator Therapeutics, Esperion, and MitoRx. No conflicts of interest, financial or otherwise, have been declared by the other authors.","order":1,"name":"Ethics","label":"Conflict of Interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All data reported in this article will be shared by the lead contact upon reasonable request. This article does not report the original code. Any additional information required to reanalyze the data reported in this paper is available from the lead contact upon reasonable request.","order":2,"name":"Ethics","label":"Availability of Data","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Consent to Publish","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":4,"name":"Ethics","label":"Code Availability","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the institutional ethics committee (ethics board of the Medical Faculty of Heinrich Heine University D\u00fcsseldorf, Germany, no. 2018-77-KFogU, date of approval: 26\/OCT\/2018). The study was conducted between 2019 and 2023 and was performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments.","order":5,"name":"Ethics","label":"Ethical Approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All participants were informed about the procedures and risks and provided their written consent to the protocol.","order":6,"name":"Ethics","label":"Consent to Participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"M.R., K.F.P., and G.I.S. designed the study. S.K. analysed the results and drafted the manuscript. S.K., K.F.P., T.L., G.H., B.D., K.P., T.S., S.F., M.J., and V.S-H. acquired and analyzed the data. P.B. provided statistical support. All authors contributed to and approved the final manuscript. M.R. is the guarantor of this work, with full access to all data and analyses related to the content of this article.","order":7,"name":"Ethics","label":"Author Contributions","group":{"name":"EthicsHeading","label":"Declarations"}}]}}