{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T16:17:11Z","timestamp":1784823431056,"version":"3.55.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2017,4,12]],"date-time":"2017-04-12T00:00:00Z","timestamp":1491955200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drugs Aging"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1007\/s40266-017-0455-9","type":"journal-article","created":{"date-parts":[[2017,4,12]],"date-time":"2017-04-12T11:09:05Z","timestamp":1491995345000},"page":"437-443","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":158,"title":["The Comparative Risk of Delirium with Different Opioids: A Systematic Review"],"prefix":"10.1007","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0434-1203","authenticated-orcid":false,"given":"Lieke M.","family":"Swart","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"van der Zanden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra E.","family":"Spies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia E.","family":"de Rooij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara C.","family":"van Munster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,4,12]]},"reference":[{"key":"455_CR1","first-page":"CD009537","volume":"1","author":"A Clegg","year":"2014","unstructured":"Clegg A, Siddiqi N, Heaven A, et al. Interventions for preventing delirium in older people in institutional longterm care. Cochrane Database Syst Rev. 2014;1:CD009537.","journal-title":"Cochrane Database Syst Rev."},{"issue":"2","key":"455_CR2","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1017\/S1041610291000625","volume":"3","author":"S Levkoff","year":"1991","unstructured":"Levkoff S, Cleary P, Liptzin B, Evans DA. Epidemiology of delirium: an overview of research issues and findings. Int Psychogeriatr. 1991;3(2):149\u201367.","journal-title":"Int Psychogeriatr."},{"issue":"6","key":"455_CR3","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1111\/j.1532-5415.2000.tb04718.x","volume":"48","author":"ER Marcantonio","year":"2000","unstructured":"Marcantonio ER, Flacker JM, Michaels M, Resnick NM. Delirium is independently associated with poor functional recovery after hip fracture. J Am Geriatr Soc. 2000;48(6):618\u201324.","journal-title":"J Am Geriatr Soc."},{"issue":"8","key":"455_CR4","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1007\/s001340101017","volume":"27","author":"MJ Dubois","year":"2001","unstructured":"Dubois MJ, Bergeron N, Dumont M, et al. Delirium in an intensive care unit: a study of risk factors. Intensive Care Med. 2001;27(8):1297\u2013304.","journal-title":"Intensive Care Med."},{"issue":"1","key":"455_CR5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1001\/archinternmed.2007.4","volume":"168","author":"DL Leslie","year":"2008","unstructured":"Leslie DL, Marcantonio ER, Zhang Y, et al. One-year health care costs associated with delirium in the elderly population. Arch Intern Med. 2008;168(1):27\u201332.","journal-title":"Arch Intern Med."},{"issue":"3","key":"455_CR6","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jpsychores.2008.05.026","volume":"65","author":"JV Laurila","year":"2008","unstructured":"Laurila JV, Laakkonen ML, Tilvis RS, Pitkala KH. Predisposing and precipitating factors for delirium in a frail geriatric population. J Psychosom Res. 2008;65(3):249\u201354.","journal-title":"J Psychosom Res."},{"issue":"19","key":"455_CR7","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1001\/jama.1994.03520190064036","volume":"272","author":"ER Marcantonio","year":"1994","unstructured":"Marcantonio ER, Juarez G, Goldman L, et al. The relationship of postoperative delirium with psychoactive medications. JAMA. 1994;272(19):1518\u201322.","journal-title":"JAMA."},{"issue":"1","key":"455_CR8","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1093\/ageing\/afq140","volume":"40","author":"A Clegg","year":"2011","unstructured":"Clegg A, Young JB. Which medications to avoid in people at risk of delirium: a systematic review. Age Ageing. 2011;40(1):23\u20139.","journal-title":"Age Ageing."},{"issue":"1","key":"455_CR9","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1093\/gerona\/58.1.M76","volume":"58","author":"RS Morrison","year":"2003","unstructured":"Morrison RS, Magaziner J, Gilbert M, et al. Relationship between pain and opioid analgesics on the development of delirium following hip fracture. J Gerontol A Biol Sci Med Sci. 2003;58(1):76\u201381.","journal-title":"J Gerontol A Biol Sci Med Sci."},{"issue":"3","key":"455_CR10","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jpsychores.2008.05.019","volume":"65","author":"AMJ MacLullich","year":"2008","unstructured":"MacLullich AMJ, Ferguson KJ, Miller T, et al. Unravelling the pathophysiology of delirium: a focus on the role of aberrant stress responses. J Psychosom Res. 2008;65(3):229\u201338.","journal-title":"J Psychosom Res."},{"issue":"9716","key":"455_CR11","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0140-6736(09)61158-2","volume":"375","author":"WA Gool Van","year":"2010","unstructured":"Van Gool WA, Van de Beek D, Eikelenboom P. Systemic infection and delirium: when cytokines and acetylcholine collide. Lancet. 2010;375(9716):773\u20135.","journal-title":"Lancet."},{"issue":"4","key":"455_CR12","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1213\/01.ane.0000198602.29716.53","volume":"102","author":"HK Fong","year":"2006","unstructured":"Fong HK, Sands LP, Leung JM. The role of postoperative analgesia in delirium and cognitive decline in elderly patients: a systematic review. Anesth Analg. 2006;102(4):1255\u201366.","journal-title":"Anesth Analg."},{"key":"455_CR13","first-page":"492685","volume":"2013","author":"S Ghosh","year":"2013","unstructured":"Ghosh S, Mondal SK, Bhattacharya A, Saddichha S. Acute delirium due to parenteral tramadol. Case Rep Emerg Med. 2013;2013:492685.","journal-title":"Case Rep Emerg Med."},{"issue":"8","key":"455_CR14","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1176\/ajp.144.8.1062","volume":"144","author":"SJ Eisendrath","year":"1987","unstructured":"Eisendrath SJ, Goldman B, Douglas J, et al. Meperidine-induced delirium. Am J Psychiatry. 1987;144(8):1062\u20135.","journal-title":"Am J Psychiatry."},{"issue":"7","key":"455_CR15","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1046\/j.1440-1681.2000.03290.x","volume":"27","author":"M Smith","year":"2000","unstructured":"Smith M. Neuroexcitatory effects of morphine and hydromorphone: evidence implicating the 3-glucuronide metabolites. Clin Exp Pharmacol Physiol. 2000;27(7):524\u20138.","journal-title":"Clin Exp Pharmacol Physiol."},{"key":"455_CR16","first-page":"79","volume":"7","author":"X Basurto Ona","year":"2013","unstructured":"Basurto Ona X, Comas DR, Urr\u00fatia G. Opioids for acute pancreatitis pain. Cochrane Database Syst Rev. 2013;7:79.","journal-title":"Cochrane Database Syst Rev."},{"issue":"6","key":"455_CR17","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.amjopharm.2012.09.004","volume":"10","author":"CK O\u2019Neil","year":"2012","unstructured":"O\u2019Neil CK, Hanlon JT, Marcum ZA. Adverse effects of analgesics commonly used by older adults with osteoarthritis: focus on non-opioid and opioid analgesics. Am J Geriatr Pharmacother. 2012;10(6):331\u201342.","journal-title":"Am J Geriatr Pharmacother."},{"issue":"3","key":"455_CR18","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1136\/amiajnl-2011-000319","volume":"19","author":"EM Glind Van de","year":"2012","unstructured":"Van de Glind EM, Van Munster BC, Spijker R, et al. Search filters to identify geriatric medicine in Medline. J Am Med Inform Assoc. 2012;19(3):468\u201372.","journal-title":"J Am Med Inform Assoc."},{"key":"455_CR19","doi-asserted-by":"crossref","unstructured":"Scholten RJPM, Offringa M, Assendelft WJJ. Inleiding in evidence-based medicine. Klinisch handelen gebaseerd op bewijsmateriaal. Vierde herziene druk. Houten: Bohn, Stafleu, Van Loghum; 2013.","DOI":"10.1007\/978-90-313-9904-8"},{"issue":"4","key":"455_CR20","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1097\/SLA.0b013e3181c1cfc9","volume":"251","author":"A Brouquet","year":"2010","unstructured":"Brouquet A, Cudennec T, Benoist S, et al. Impaired mobility, ASA status and administration of tramadol are risk factors for postoperative delirium in patients aged 75 years or more after major abdominal surgery. Ann Surg. 2010;251(4):759\u201365.","journal-title":"Ann Surg."},{"issue":"2","key":"455_CR21","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.arth.2013.06.004","volume":"29","author":"S Nandi","year":"2014","unstructured":"Nandi S, Harvey WF, Saillant J, et al. Pharmacologic risk factors for post-operative delirium in total joint arthroplasty patients: a case-control study. J Arthroplasy. 2014;29(2):268\u201371.","journal-title":"J Arthroplasy."},{"issue":"6","key":"455_CR22","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.ijom.2009.01.011","volume":"38","author":"M Shiiba","year":"2009","unstructured":"Shiiba M, Takei M, Nakatsuru M, et al. Clinical observations of postoperative delirium after surgery for oral carcinoma. Int J Oral Maxillofac Surg. 2009;38(6):661\u20135.","journal-title":"Int J Oral Maxillofac Surg."},{"issue":"3","key":"455_CR23","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0167-4943(02)00045-6","volume":"35","author":"A Adunsky","year":"2002","unstructured":"Adunsky A, Levy R, Heim M, et al. Meperidine analgesia and delirium in aged hip fracture patients. Arch Gerontol Geriatr. 2002;35(3):253\u20139.","journal-title":"Arch Gerontol Geriatr."},{"issue":"5","key":"455_CR24","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1111\/anae.13090","volume":"70","author":"N Rughooputh","year":"2015","unstructured":"Rughooputh N, Griffiths R. Tramadol and delirium. Anaesthesia. 2015;70(5):632\u20133.","journal-title":"Anaesthesia."},{"key":"455_CR25","unstructured":"GIP\/Zorginstituut Nederland. Aantal gebruikers naar leeftijd en geslacht voor ATC-subgroep N02: analgetica in 2015. Available from: https:\/\/www.gipdatabank.nl\/databank.asp?tabel=03-lftgesl&geg=gebr&item=N02A . Accessed 7 Feb 2017."},{"issue":"2","key":"455_CR26","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1177\/0267659111425621","volume":"27","author":"J Andrejaitiene","year":"2012","unstructured":"Andrejaitiene J, Sirvinskas E. Early post-cardiac surgery delirium risk factors. Perfusion. 2012;27(2):105\u201312.","journal-title":"Perfusion."},{"issue":"4","key":"455_CR27","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1053\/j.jvca.2010.01.003","volume":"24","author":"CS Burkhart","year":"2010","unstructured":"Burkhart CS, Dell-Kuster S, Gamberini M, et al. Modifiable and nonmodifiable risk factors for postoperative delirium after cardiac surgery with cardiopulmonary bypass. J Cardiothorac Vasc Anesth. 2010;24(4):555\u20139.","journal-title":"J Cardiothorac Vasc Anesth."},{"issue":"4","key":"455_CR28","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1213\/01.ane.0000199156.59226.af","volume":"102","author":"LE Vaurio","year":"2006","unstructured":"Vaurio LE, Sands LP, Wang Y, et al. Postoperative delirium: the importance of pain and pain management. Anesth Analg. 2006;102(4):1267\u201373.","journal-title":"Anesth Analg."},{"issue":"6","key":"455_CR29","doi-asserted-by":"crossref","first-page":"738","DOI":"10.7326\/0003-4819-86-6-738","volume":"86","author":"HH Szeto","year":"1977","unstructured":"Szeto HH, Inturrisi CE, Houde R, et al. Accumulation of normeperidine, an active metabolite of meperidine, in patients with renal failure of cancer. Ann Intern Med. 1977;86(6):738\u201341.","journal-title":"Ann Intern Med."},{"issue":"1","key":"455_CR30","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/nn.4189","volume":"19","author":"Z Guan","year":"2016","unstructured":"Guan Z, Kuhn JA, Wang X, et al. Injured sensory neuron-derived CSF1 induces microglial proliferation and DAP12-dependent pain. Nat Neurosci. 2016;19(1):94\u2013101.","journal-title":"Nat Neurosci."}],"container-title":["Drugs &amp; Aging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40266-017-0455-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40266-017-0455-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40266-017-0455-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T03:20:38Z","timestamp":1692760838000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40266-017-0455-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,12]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["455"],"URL":"https:\/\/doi.org\/10.1007\/s40266-017-0455-9","relation":{},"ISSN":["1170-229X","1179-1969"],"issn-type":[{"value":"1170-229X","type":"print"},{"value":"1179-1969","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,12]]}}}