{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:32:56Z","timestamp":1788993176969,"version":"build-2803163510"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2017,5,6]],"date-time":"2017-05-06T00:00:00Z","timestamp":1494028800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drugs Aging"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1007\/s40266-017-0465-7","type":"journal-article","created":{"date-parts":[[2017,5,6]],"date-time":"2017-05-06T05:54:31Z","timestamp":1494050071000},"page":"479-487","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Antiepileptic Drug Treatment in Community-Dwelling Older Patients with Epilepsy: A Retrospective Observational Study of Old- Versus New-Generation Antiepileptic Drugs"],"prefix":"10.1007","volume":"34","author":[{"given":"Jacques","family":"Theitler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Brik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dotan","family":"Shaniv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matitiahu","family":"Berkovitch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Revital","family":"Gandelman-Marton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,5,6]]},"reference":[{"key":"465_CR1","volume-title":"World population ageing: 1950\u20132050","author":"United Nations","year":"2007","unstructured":"United Nations. World population ageing: 1950\u20132050. New York: United Nations Publications; 2007."},{"key":"465_CR2","doi-asserted-by":"crossref","first-page":"576","DOI":"10.4065\/71.6.576","volume":"71","author":"WA Hauser","year":"1996","unstructured":"Hauser WA, Annegers JF, Rocca WA. Descriptive epidemiology of epilepsy: contributions of population-based studies from Rochester, Minnesota. Mayo Clin Proc. 1996;71:576\u201386.","journal-title":"Mayo Clin Proc"},{"key":"465_CR3","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0920-1211(99)00039-X","volume":"37","author":"MJ Brodie","year":"1999","unstructured":"Brodie MJ, Overstall PW, Giorgi L. Multicentre, double-blind, randomized comparison between lamotrigine and carbamazepine in elderly patients with newly diagnosed epilepsy. The UK Lamotrigine Elderly Study Group. Epilepsy Res. 1999;37:81\u20137.","journal-title":"Epilepsy Res"},{"key":"465_CR4","doi-asserted-by":"crossref","unstructured":"Rowan AJ, Ramsay RE, Collins JF, et al.; VA Cooperative Study 428 Group. New onset geriatric epilepsy: a randomized study of gabapentin, lamotrigine, and carbamazepine. Neurology 2005;64:1868\u2013187.","DOI":"10.1212\/01.WNL.0000167384.68207.3E"},{"key":"465_CR5","doi-asserted-by":"crossref","unstructured":"Saetre E, Perucca E, Isojarvi J, et al.; LAM 40089 Study Group. An international multicenter randomized double-blind controlled trial of lamotrigine and sustained release carbamazepine in the treatment of newly diagnosed epilepsy in the elderly. Epilepsia 2007;48:1292\u20131302.","DOI":"10.1111\/j.1528-1167.2007.01128.x"},{"key":"465_CR6","doi-asserted-by":"crossref","first-page":"861","DOI":"10.2165\/00002512-200623110-00002","volume":"23","author":"MJ Pugh","year":"2006","unstructured":"Pugh MJ, Foreman PJ, Berlowitz DR. Prescribing antiepileptics for the elderly: differences between guideline recommendations and clinical practice. Drug Aging. 2006;23:861\u201375.","journal-title":"Drug Aging"},{"key":"465_CR7","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/epi.12926","volume":"56","author":"KJ Werhahn","year":"2015","unstructured":"Werhahn KJ, Trinka E, Dobesberger J, et al. A randomized, double-blind comparison of antiepileptic drug treatment in the elderly with new-onset focal epilepsy. Epilepsia. 2015;56:450\u20139.","journal-title":"Epilepsia"},{"key":"465_CR8","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S1525-5050(03)00037-4","volume":"4","author":"E Kutluay","year":"2003","unstructured":"Kutluay E, McCague K, D\u2019Souza J, et al. Safety and tolerability of oxcarbazepine in elderly patients with epilepsy. Epilepsy Behav. 2003;4:175\u201380.","journal-title":"Epilepsy Behav"},{"key":"465_CR9","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/ane.12162","volume":"128","author":"E Trinka","year":"2013","unstructured":"Trinka E, Giorgi L, Patten A, et al. Safety and tolerability of zonisamide in elderly patients with epilepsy. Acta Neurol Scand. 2013;128:422\u20138.","journal-title":"Acta Neurol Scand"},{"key":"465_CR10","doi-asserted-by":"crossref","unstructured":"Pugh MJ, Van Cott AC, Cramer JA, et al.; Treatment In Geriatric Epilepsy Research (TIGER) team. Trends in antiepileptic drug prescribing for older patients with new-onset epilepsy: 2000\u20132004. Neurology 2008;70:2171\u20138.","DOI":"10.1212\/01.wnl.0000313157.15089.e6"},{"key":"465_CR11","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.seizure.2015.06.016","volume":"31","author":"E Bruun","year":"2015","unstructured":"Bruun E, Virta LJ, K\u00e4lvi\u00e4inen R, et al. Choice of the first anti-epileptic drug in elderly patients with newly diagnosed epilepsy: a Finnish retrospective study. Seizure. 2015;31:27\u201332.","journal-title":"Seizure"},{"key":"465_CR12","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.eplepsyres.2015.11.009","volume":"119","author":"CA Galimberti","year":"2016","unstructured":"Galimberti CA, Tartara E, Dispenza S, et al. Antiepileptic drug use and epileptic seizures in nursing home residents in the Province of Pavia, Italy: a reappraisal 12\u00a0years after a first survey. Epilepsy Res. 2016;119:41\u20138.","journal-title":"Epilepsy Res"},{"key":"465_CR13","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.yebeh.2016.05.004","volume":"61","author":"E Berman","year":"2016","unstructured":"Berman E, Marom E, Ekstein D, et al. Utilization of antiepileptic drugs in Israel. Epilepsy Behav. 2016;61:82\u20135.","journal-title":"Epilepsy Behav"},{"key":"465_CR14","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1590\/0004-282X20140151","volume":"72","author":"TR Assis","year":"2014","unstructured":"Assis TR, Nascimento OJ, Costa G, et al. Antiepileptic drugs patterns in elderly inpatients in a Brazilian tertiary center, Salvador, Brazil. Arq Neuropsiquiatr. 2014;72:874\u201380.","journal-title":"Arq Neuropsiquiatr"},{"key":"465_CR15","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1600-0404.2010.01464.x","volume":"124","author":"H Stefan","year":"2011","unstructured":"Stefan H. Epilepsy in the elderly: facts and challenges. Acta Neurol Scand. 2011;124:223\u201337.","journal-title":"Acta Neurol Scand"},{"key":"465_CR16","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.seizure.2013.07.011","volume":"22","author":"V Belcastro","year":"2013","unstructured":"Belcastro V, Vidale S, Pierguidi L, et al. Intravenous lacosamide as treatment option in post-stroke non convulsive status epilepticus in the elderly: a proof-of-concept, observational study. Seizure. 2013;22:905\u20137.","journal-title":"Seizure"},{"key":"465_CR17","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.eplepsyres.2014.11.015","volume":"110","author":"IE Leppik","year":"2015","unstructured":"Leppik IE, Wechsler RT, Williams B, et al. Efficacy and safety of perampanel in the subgroup of elderly patients included in the phase III epilepsy clinical trials. Epilepsy Res. 2015;110:216\u201320.","journal-title":"Epilepsy Res"},{"key":"465_CR18","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1111\/j.1528-1167.2010.02522.x","volume":"51","author":"AT Berg","year":"2010","unstructured":"Berg AT, Berkovic SF, Brodie MJ, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005\u20132009. Epilepsia. 2010;51:676\u201385.","journal-title":"Epilepsia"},{"key":"465_CR19","unstructured":"Micromedex\u00ae 2.0 [electronic version]. Greenwood Village: Truven Health Analytics. http:\/\/www.micromedexsolutions.com . Accessed 27 July 2016."},{"key":"465_CR20","unstructured":"Baxter K, editor. Stockley\u2019s drug interactions [online]. London: Pharmaceutical Press. http:\/\/www.medicinescomplete.com\/ . Accessed 27 July 2016."},{"key":"465_CR21","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/ane.12218","volume":"129","author":"H Stefan","year":"2014","unstructured":"Stefan H, May TW, Pf\u00e4fflin M, et al. Epilepsy in the elderly: comparing clinical characteristics with younger patients. Acta Neurol Scand 2014;129:283\u2013293.","journal-title":"Acta Neurol Scand"},{"key":"465_CR22","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.yebeh.2012.11.041","volume":"27","author":"AG Besocke","year":"2013","unstructured":"Besocke AG, Rosso B, Cristiano E, et al. Outcome of newly-diagnosed epilepsy in older patients. Epilepsy Behav 2013;27:29\u201335.","journal-title":"Epilepsy Behav"},{"key":"465_CR23","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.eplepsyres.2006.06.018","volume":"71","author":"SA Hussain","year":"2006","unstructured":"Hussain SA, Haut SR, Lipton RB, et al. Incidence of epilepsy in a racially diverse, community-dwelling, elderly cohort: results from the Einstein aging study. Epilepsy Res 2006;71:195\u2013205.","journal-title":"Epilepsy Res"},{"key":"465_CR24","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/j.1528-1157.1996.tb00017.x","volume":"37","author":"L Forsgren","year":"1996","unstructured":"Forsgren L, Bucht G, Eriksson S, et al. Incidence and clinical characterization of unprovoked seizures in adults: a prospective population-based study. Epilepsia 1996;37:224\u2013229.","journal-title":"Epilepsia"},{"key":"465_CR25","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1528-1157.1993.tb02586.x","volume":"34","author":"WA Hauser","year":"1993","unstructured":"Hauser WA, Annegers JF, Kurland LT. Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota: 1935\u20131984. Epilepsia 1993;34:453\u2013468.","journal-title":"Epilepsia"},{"key":"465_CR26","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1111\/j.1528-1167.2009.02140.x","volume":"50","author":"K Parko","year":"2009","unstructured":"Parko K, Thurman DJ. Prevalence of epilepsy and seizures in the Navajo Nation 1998-2002. Epilepsia 2009;50:2180\u20132185.","journal-title":"Epilepsia"},{"key":"465_CR27","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1528-1157.1986.tb03503.x","volume":"27","author":"AF Haerer","year":"1986","unstructured":"Haerer AF, Anderson DW, Schoenberg BS. Prevalence and clinical features of epilepsy in a biracial United States population. Epilepsia 1986;27:66\u201375.","journal-title":"Epilepsia"},{"key":"465_CR28","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1528-1157.1986.tb03516.x","volume":"27","author":"K L\u00fchdorf","year":"1986","unstructured":"L\u00fchdorf K, Jensen LK, Plesner AM. Epilepsy in the elderly: incidence, social function, and disability. Epilepsia 1986;27:135\u2013141.","journal-title":"Epilepsia"},{"key":"465_CR29","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.seizure.2010.12.015","volume":"20","author":"KJ Werhahn","year":"2011","unstructured":"Werhahn KJ, Klimpe S, Balkaya S, et al. The safety and efficacy of add-on levetiracetam in elderly patients with focal epilepsy: a one-year observational study. Seizure 2011;20:305\u2013311.","journal-title":"Seizure"},{"key":"465_CR30","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s12883-016-0663-7","volume":"16","author":"B Pohlmann-Eden","year":"2016","unstructured":"Pohlmann-Eden B, Marson AG, Noack-Rink M, et al. Comparative effectiveness of levetiracetam, valproate and carbamazepine among elderly patients with newly diagnosed epilepsy: subgroup analysis of the randomized, unblinded KOMET study. BMC Neurol 2016;16:149.","journal-title":"BMC Neurol"},{"key":"465_CR31","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/JCP.0b013e318253a186","volume":"32","author":"CM Eddy","year":"2012","unstructured":"Eddy CM, Richards HE, Cavanna AE. Behavioral adverse effects of antiepileptic drugs in epilepsy. J Clin Psychopharmacol. 2012;32:362\u201375.","journal-title":"J Clin Psychopharmacol"},{"key":"465_CR32","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.pediatrneurol.2004.04.012","volume":"31","author":"AM Albsoul-Younes","year":"2004","unstructured":"Albsoul-Younes AM, Salem HA, Ajlouni SF, et al. Topiramate slow dose titration: improved efficacy and tolerability. Pediatr Neurol 2004;31:349\u2013352.","journal-title":"Pediatr Neurol"},{"key":"465_CR33","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1532-5415.2010.02732.x","volume":"58","author":"MJ Pugh","year":"2010","unstructured":"Pugh MJ, Vancott AC, Steinman MA, et al. Choice of initial antiepileptic drug for older veterans: possible pharmacokinetic drug interactions with existing medications. J Am Geriatr Soc 2010;58:465\u2013471.","journal-title":"J Am Geriatr Soc"},{"key":"465_CR34","first-page":"81","volume":"8","author":"SM Jankovic","year":"2012","unstructured":"Jankovic SM, Dostic M. Choice of antiepileptic drugs for the elderly: possible drug interactions and adverse effects. Expert Opin Drug Metab Toxicol 2012;8:81\u201391.","journal-title":"Epilepsia"},{"key":"465_CR35","doi-asserted-by":"crossref","first-page":"255","DOI":"10.2165\/00002512-199915040-00002","volume":"15","author":"E Faught","year":"1999","unstructured":"Faught E. Epidemiology and drug treatment of epilepsy in elderly people. Drug Aging. 1999;15:255\u201369.","journal-title":"Drug Aging"},{"key":"465_CR36","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.seizure.2013.06.005","volume":"22","author":"A Tanaka","year":"2013","unstructured":"Tanaka A, Akamatsu N, Shouzaki T, et al. Clinical characteristics and treatment responses in new-onset epilepsy in the elderly. Seizure. 2013;22:772\u20135.","journal-title":"Seizure"},{"key":"465_CR37","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.seizure.2010.11.024","volume":"20","author":"SA Massengo","year":"2011","unstructured":"Massengo SA, Ondze B, Bastard J, et al. Elderly patients with epileptic seizures: in-patient observational study of two French community hospitals. Seizure. 2011;20:231\u20139.","journal-title":"Seizure"}],"container-title":["Drugs &amp; Aging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40266-017-0465-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40266-017-0465-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40266-017-0465-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T16:02:45Z","timestamp":1569254565000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40266-017-0465-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,6]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["465"],"URL":"https:\/\/doi.org\/10.1007\/s40266-017-0465-7","relation":{},"ISSN":["1170-229X","1179-1969"],"issn-type":[{"value":"1170-229X","type":"print"},{"value":"1179-1969","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,6]]}}}