{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T20:34:05Z","timestamp":1776371645356,"version":"3.51.2"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drugs Aging"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1007\/s40266-018-0529-3","type":"journal-article","created":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T03:15:57Z","timestamp":1519874157000},"page":"249-259","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Safety of Injectable HP\u03b2CD-Diclofenac in Older Patients with Acute Moderate-to-Severe Postoperative Pain: A Pooled Analysis of Three Phase III Trials"],"prefix":"10.1007","volume":"35","clinical-trial-number":[{"clinical-trial-number":"nct00448110","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct00507026","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct00726388","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Jacques E.","family":"Chelly","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter G.","family":"Lacouture","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian Russel D.","family":"Reyes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,3,1]]},"reference":[{"issue":"12","key":"529_CR1","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1007\/s40265-016-0619-7","volume":"76","author":"SM Hoy","year":"2016","unstructured":"Hoy SM. Diclofenac sodium bolus injection (Dyloject(TM)): a review in acute pain management. Drugs. 2016;76(12):1213\u201320.","journal-title":"Drugs."},{"issue":"8","key":"529_CR2","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1007\/s40265-015-0392-z","volume":"75","author":"R Altman","year":"2015","unstructured":"Altman R, Bosch B, Brune K, Patrignani P, Young C. Advances in NSAID development: evolution of diclofenac products using pharmaceutical technology. Drugs. 2015;75(8):859\u201377.","journal-title":"Drugs."},{"issue":"1\u20132","key":"529_CR3","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.ijpharm.2005.05.042","volume":"302","author":"T Loftsson","year":"2005","unstructured":"Loftsson T, Hreinsd\u00f3ttir D, M\u00e1sson M. Evaluation of cyclodextrin solubilization of drugs. Int J Pharm. 2005;302(1\u20132):18\u201328.","journal-title":"Int J Pharm."},{"issue":"5","key":"529_CR4","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1213\/ANE.0b013e3182691bf9","volume":"115","author":"TJ Gan","year":"2012","unstructured":"Gan TJ, Daniels SE, Singla N, Hamilton DA, Carr DB. A novel injectable formulation of diclofenac compared with intravenous ketorolac or placebo for acute moderate-to-severe pain after abdominal or pelvic surgery: a multicenter, double-blind, randomized, multiple-dose study. Anesth Analg. 2012;115(5):1212\u201320.","journal-title":"Anesth Analg."},{"issue":"8","key":"529_CR5","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1097\/AJP.0b013e318270f957","volume":"29","author":"S Daniels","year":"2013","unstructured":"Daniels S, Melson T, Hamilton DA, Lang E, Carr DB. Analgesic efficacy and safety of a novel injectable formulation of diclofenac compared with intravenous ketorolac and placebo after orthopedic surgery: a multicenter, randomized, double-blinded, multiple-dose trial. Clin J Pain. 2013;29(8):655\u201363.","journal-title":"Clin J Pain."},{"issue":"5","key":"529_CR6","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1111\/pme.12076","volume":"14","author":"JE Chelly","year":"2013","unstructured":"Chelly JE, Singla SK, Melson TI, Lacouture PG, Paadre S, Carr DB. Safety of a novel parenteral formulation of diclofenac after major orthopedic or abdominal\/pelvic surgery in a population including anticoagulated, elderly or renally insufficient patients: an open-label, multiday, repeated dose clinical trial. Pain Med. 2013;14(5):749\u201361.","journal-title":"Pain Med."},{"issue":"6","key":"529_CR7","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1213\/00000539-199412000-00025","volume":"79","author":"AJ Souter","year":"1994","unstructured":"Souter AJ, Fredman B, White PF. Controversies in the perioperative use of nonsterodial antiinflammatory drugs. Anesth Analg. 1994;79(6):1178\u201390.","journal-title":"Anesth Analg."},{"issue":"1","key":"529_CR8","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.bpa.2006.12.005","volume":"21","author":"F Aubrun","year":"2007","unstructured":"Aubrun F, Marmion F. The elderly patient and postoperative pain treatment. Best Pract Res Clin Anaesthesiol. 2007;21(1):109\u201327.","journal-title":"Best Pract Res Clin Anaesthesiol."},{"key":"529_CR9","doi-asserted-by":"publisher","first-page":"d2495","DOI":"10.1136\/bmj.d2495","volume":"343","author":"JH Gurwitz","year":"2011","unstructured":"Gurwitz JH. NSAIDs and atrial fibrillation. BMJ. 2011;343:d2495.","journal-title":"BMJ."},{"issue":"7","key":"529_CR10","first-page":"538","volume":"6","author":"TJ Gan","year":"2015","unstructured":"Gan TJ, Singla N, Daniels SE, et al. Clinical and laboratory hematologic findings in patients receiving repeated-dose injectable Hp\u03b2cd-diclofenac for acute postoperative pain: pooled analysis of two randomized controlled phase III clinical trials. J Anesth Clin Res. 2015;6(7):538.","journal-title":"J Anesth Clin Res."},{"issue":"12","key":"529_CR11","doi-asserted-by":"publisher","first-page":"2378","DOI":"10.1093\/pm\/pnw146","volume":"17","author":"SE Daniels","year":"2016","unstructured":"Daniels SE, Gan TJ, Hamilton DA, et al. A pooled analysis evaluating renal safety in placebo- and active comparator-controlled phase III trials of multiple-dose injectable HP\u03b2CD-diclofenac in subjects with acute postoperative pain. Pain Med. 2016;17(12):2378\u201388.","journal-title":"Pain Med."},{"key":"529_CR12","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.jclinane.2016.01.020","volume":"31","author":"TJ Gan","year":"2016","unstructured":"Gan TJ, Singla N, Daniels SE, et al. Cardiovascular safety of hydroxypropyl-\u03b2-cyclodextrin-diclofenac in the management of acute postsurgical pain: a pooled analysis of 2 randomized, double-blind, placebo- and active comparator-controlled phase III clinical trials. J Clin Anesth. 2016;31:249\u201358.","journal-title":"J Clin Anesth."},{"issue":"2","key":"529_CR13","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1124\/pr.56.2.4","volume":"56","author":"AJ McLean","year":"2004","unstructured":"McLean AJ, Le Couteur DG. Aging biology and geriatric clinical pharmacology. Pharmacol Rev. 2004;56(2):163\u201384.","journal-title":"Pharmacol Rev."},{"issue":"3","key":"529_CR14","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1111\/j.1472-8206.2007.00473.x","volume":"21","author":"SN Hilmer","year":"2007","unstructured":"Hilmer SN, McLachlan AJ, Le Couteur DG. Clinical pharmacology in the geriatric patient. Fundam Clin Pharmacol. 2007;21(3):217\u201330.","journal-title":"Fundam Clin Pharmacol."},{"issue":"5","key":"529_CR15","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.jamda.2010.04.009","volume":"12","author":"JG Chester","year":"2011","unstructured":"Chester JG, Rudolph JL. Vital signs in older patients: age-related changes. J Am Med Dir Assoc. 2011;12(5):337\u201343.","journal-title":"J Am Med Dir Assoc."},{"issue":"3","key":"529_CR16","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.anclin.2015.05.003","volume":"33","author":"BD Alvis","year":"2015","unstructured":"Alvis BD, Hughes CG. Physiology considerations in geriatric patients. Anesthesiol Clin. 2015;33(3):447\u201356.","journal-title":"Anesthesiol Clin."},{"issue":"3","key":"529_CR17","doi-asserted-by":"publisher","first-page":"185","DOI":"10.2165\/00002512-200522030-00001","volume":"22","author":"R Savage","year":"2005","unstructured":"Savage R. Cyclo-oxygenase-2 inhibitors: when should they be used in the elderly? Drugs Aging. 2005;22(3):185\u2013200.","journal-title":"Drugs Aging."},{"issue":"10","key":"529_CR18","doi-asserted-by":"publisher","first-page":"775","DOI":"10.2165\/11539430-000000000-00000","volume":"27","author":"RL Barkin","year":"2010","unstructured":"Barkin RL, Beckerman M, Blum SL, Clark FM, Koh EK, Wu DS. Should nonsteroidal anti-inflammatory drugs (NSAIDs) be prescribed to the older adult? Drugs Aging. 2010;27(10):775\u201389.","journal-title":"Drugs Aging."},{"issue":"Suppl 1","key":"529_CR19","doi-asserted-by":"publisher","first-page":"i1","DOI":"10.1093\/ageing\/afs200","volume":"42","author":"A Abdulla","year":"2013","unstructured":"Abdulla A, Adams N, Bone M, et al. Guidance on the management of pain in older people. Age Ageing. 2013;42(Suppl 1):i1\u201357.","journal-title":"Age Ageing."},{"issue":"3","key":"529_CR20","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.anclin.2015.05.010","volume":"33","author":"JL McKeown","year":"2015","unstructured":"McKeown JL. Pain management issues for the geriatric surgical patient. Anesthesiol Clin. 2015;33(3):563\u201376.","journal-title":"Anesthesiol Clin."},{"issue":"2","key":"529_CR21","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1093\/bja\/88.2.227","volume":"88","author":"JB Forrest","year":"2002","unstructured":"Forrest JB, Camu F, Greer IA, et al. Ketorolac, diclofenac, and ketoprofen are equally safe for pain relief after major surgery. Br J Anaesth. 2002;88(2):227\u201333.","journal-title":"Br J Anaesth."},{"issue":"6","key":"529_CR22","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1001\/jamainternmed.2014.946","volume":"174","author":"BL Davidson","year":"2014","unstructured":"Davidson BL, Verheijen S, Lensing AW, et al. Bleeding risk of patients with acute venous thromboembolism taking nonsteroidal anti-inflammatory drugs or aspirin. JAMA Intern Med. 2014;174(6):947\u201353.","journal-title":"JAMA Intern Med."},{"issue":"6","key":"529_CR23","doi-asserted-by":"publisher","first-page":"1884","DOI":"10.1213\/01.ANE.0000219597.16143.4D","volume":"102","author":"TJ Gan","year":"2006","unstructured":"Gan TJ. Risk factors for postoperative nausea and vomiting. Anesth Analg. 2006;102(6):1884\u201398.","journal-title":"Anesth Analg."},{"issue":"1","key":"529_CR24","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/ajg.2011.349","volume":"107","author":"JF Gallegos-Orozco","year":"2012","unstructured":"Gallegos-Orozco JF, Foxx-Orenstein AE, Sterler SM, Stoa JM. Chronic constipation in the elderly. Am J Gastroenterol. 2012;107(1):18\u201325.","journal-title":"Am J Gastroenterol."},{"issue":"1","key":"529_CR25","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1681\/ASN.2010090934","volume":"22","author":"S Anderson","year":"2011","unstructured":"Anderson S, Eldadah B, Halter JB, et al. Acute kidney injury in older adults. J Am Soc Nephrol. 2011;22(1):28\u201338.","journal-title":"J Am Soc Nephrol."},{"issue":"6","key":"529_CR26","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1097\/01.anes.0000290588.29668.38","volume":"107","author":"S Kheterpal","year":"2007","unstructured":"Kheterpal S, Tremper KK, Englesbe MJ, et al. Predictors of postoperative acute renal failure after noncardiac surgery in patients with previously normal renal function. Anesthesiology. 2007;107(6):892\u2013902.","journal-title":"Anesthesiology."},{"issue":"3","key":"529_CR27","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1097\/ALN.0b013e3181979440","volume":"110","author":"S Kheterpal","year":"2009","unstructured":"Kheterpal S, Tremper KK, Heung M, et al. Development and validation of an acute kidney injury risk index for patients undergoing general surgery: results from a national data set. Anesthesiology. 2009;110(3):505\u201315.","journal-title":"Anesthesiology."}],"container-title":["Drugs & Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40266-018-0529-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40266-018-0529-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40266-018-0529-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T17:20:34Z","timestamp":1628616034000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40266-018-0529-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["529"],"URL":"https:\/\/doi.org\/10.1007\/s40266-018-0529-3","relation":{},"ISSN":["1170-229X","1179-1969"],"issn-type":[{"value":"1170-229X","type":"print"},{"value":"1179-1969","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"1 March 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"Jacques E. Chelly reports no conflict of interest. Peter G. Lacouture is a former employee of Hospira. Christian Russel D. Reyes is an employee of Pfizer and holds stock options with Pfizer.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was sponsored by Hospira, Inc., which was acquired by Pfizer in September 2015. The three clinical trials included in the analysis were sponsored by Javelin Pharmaceuticals, Inc., which was acquired by Hospira, Inc. in 2010.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"All three trials included in this analysis adhered to the International Ethical Guidelines for Biomedical Research Involving Human Subjects, the International Conference on Harmonisation Good Clinical Practice guidelines, and the Helsinki Declaration. Each of the three trials was approved by the appropriate institutional review board and all patients provided written informed consent.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and informed consent"}}]}}