{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:21:53Z","timestamp":1740144113092,"version":"3.37.3"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drugs Aging"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1007\/s40266-018-0574-y","type":"journal-article","created":{"date-parts":[[2018,8,2]],"date-time":"2018-08-02T20:58:19Z","timestamp":1533243499000},"page":"699-705","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Management of Menopausal Symptoms in Women Following Breast Cancer: An Overview"],"prefix":"10.1007","volume":"35","author":[{"given":"Cheryl","family":"Phua","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7043-5099","authenticated-orcid":false,"given":"Rodney","family":"Baber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,8,3]]},"reference":[{"issue":"1","key":"574_CR1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21387","volume":"67","author":"R Siegel","year":"2017","unstructured":"Siegel R, Miller K, Jemal A. Cancer statistics. Cancer J Clin. 2017;67(1):7\u201330.","journal-title":"Cancer J Clin"},{"key":"574_CR2","volume-title":"Breast cancer facts & figures 2017\u20132018","author":"American Cancer Society","year":"2017","unstructured":"American Cancer Society. Breast cancer facts & figures 2017\u20132018. Atlanta: American Cancer Society, Inc; 2017."},{"issue":"10","key":"574_CR3","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1097\/GME.0000000000000219","volume":"21","author":"S Davis","year":"2014","unstructured":"Davis S, et al. Menopausal symptoms in breast cancer survivors nearly 6\u00a0years after diagnosis. Menopause. 2014;21(10):1075\u201381.","journal-title":"Menopause"},{"issue":"4","key":"574_CR4","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.maturitas.2011.09.008","volume":"70","author":"A Pinto","year":"2011","unstructured":"Pinto A, de Azambuja E. Improving quality of life after breast cancer: dealing with symptoms. Maturitas. 2011;70(4):343\u20138.","journal-title":"Maturitas"},{"issue":"10","key":"574_CR5","doi-asserted-by":"publisher","first-page":"3647","DOI":"10.1210\/jc.2017-01138","volume":"102","author":"R Santen","year":"2017","unstructured":"Santen R, et al. Managing menopausal symptoms and associated clinical issues in breast cancer survivors. J Clin Endocrinol Metab. 2017;102(10):3647\u201361.","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"574_CR6","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1093\/jnci\/djr541","volume":"104","author":"J Howard-Anderson","year":"2012","unstructured":"Howard-Anderson J, et al. Quality of life, fertility concerns, and behavioural health outcomes in younger breast cancer survivors: a systematic review. J Natl Cancer Inst. 2012;104(5):386\u2013405.","journal-title":"J Natl Cancer Inst"},{"issue":"Pt A","key":"574_CR7","first-page":"32","volume":"99","author":"J Ingle","year":"2015","unstructured":"Ingle J, et al. Estrogens and their precursors in postmenopausal women with early breast cancer receiving anastrozole. J Clin Endocrinol Metab. 2015;99(Pt A):32\u20138.","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"574_CR8","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1210\/jc.2010-1679","volume":"96","author":"R Santen","year":"2011","unstructured":"Santen R. Effect of endocrine therapy on bone in breast cancer patients. J Clin Endocrinol Metab. 2011;96(2):308\u201319.","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"574_CR9","doi-asserted-by":"publisher","first-page":"3975","DOI":"10.1210\/jc.2015-2236","volume":"100","author":"C Stuenkel","year":"2015","unstructured":"Stuenkel C, et al. Treatment of symptoms of the menopause: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2015;100(11):3975\u20134011.","journal-title":"J Clin Endocrinol Metab"},{"issue":"7 Suppl 1","key":"574_CR10","doi-asserted-by":"publisher","first-page":"s1","DOI":"10.1210\/jc.2009-2509","volume":"95","author":"R Santen","year":"2010","unstructured":"Santen R, et al. Postmenopausal hormone therapy: an Endocrine Society scientific statement. J Clin Endocrinol Metab. 2010;95(7 Suppl 1):s1\u201366.","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"574_CR11","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1080\/13697130500487224","volume":"29","author":"P Gupta","year":"2006","unstructured":"Gupta P, et al. Menopausal symptoms in women treated for breast cancer: the prevalence and severity of symptoms and their perceived effects on quality of life. Climacteric. 2006;29(1):49\u201358.","journal-title":"Climacteric"},{"issue":"3","key":"574_CR12","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1097\/GME.0b013e3182976f46","volume":"21","author":"J Marino","year":"2014","unstructured":"Marino J, et al. Nature and severity of menopausal symptoms and their impact on quality of life and sexual function in cancer survivors compared with women without a cancer history. Menopause. 2014;21(3):267\u201374.","journal-title":"Menopause"},{"issue":"4","key":"574_CR13","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1097\/01.GME.0000151655.10243.48","volume":"12","author":"D Conde","year":"2005","unstructured":"Conde D, et al. Menopause symptoms and quality of life in women aged 45 to 65\u00a0years with and without breast cancer. Menopause. 2005;12(4):436\u201343.","journal-title":"Menopause"},{"issue":"2","key":"574_CR14","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1111\/j.1365-2702.2004.01030.x","volume":"14","author":"P Schultz","year":"2005","unstructured":"Schultz P, et al. Breast cancer: relationship between menopausal symptoms, physiologic health effects of cancer treatment and physical constraints on quality of life in long-term survivors. J Clin Nurs. 2005;14(2):204\u201311.","journal-title":"J Clin Nurs"},{"issue":"1","key":"574_CR15","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S0378-5122(03)00087-2","volume":"45","author":"N Baglia","year":"2003","unstructured":"Baglia N, et al. Menopause after breast cancer: a survey on breast cancer survivors. Maturitas. 2003;45(1):29\u201338.","journal-title":"Maturitas"},{"issue":"5","key":"574_CR16","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1097\/01.GME.0000117061.40493.AB","volume":"11","author":"C Crandall","year":"2004","unstructured":"Crandall C, et al. Association of breast cancer and its therapy with menopause-related symptoms. Menopause. 2004;11(5):519\u201330.","journal-title":"Menopause"},{"issue":"6","key":"574_CR17","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/S0885-3924(02)00395-0","volume":"23","author":"P Harris","year":"2002","unstructured":"Harris P, et al. Prevalence and treatment of menopausal symptoms among breast cancer survivors. J Pain Symptom Manage. 2002;23(6):501\u20139.","journal-title":"J Pain Symptom Manage"},{"key":"574_CR18","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/S1470-2045(05)70316-8","volume":"6","author":"M Hickey","year":"2005","unstructured":"Hickey M, Saunders C, Stuckey B. Management of menopausal symptoms in patients with breast cancer: an evidence-based approach. Lancet Oncol. 2005;6:687\u201395.","journal-title":"Lancet Oncol"},{"key":"574_CR19","doi-asserted-by":"publisher","first-page":"109","DOI":"10.3109\/13697137.2015.1129166","volume":"19","author":"R Baber","year":"2016","unstructured":"Baber R, et al. 2016 IMS Recommendations on women\u2019s midlife health and MHT. Climacteric. 2016;19:109\u201350.","journal-title":"Climacteric"},{"key":"574_CR20","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1093\/jnci\/djn313","volume":"100","author":"A Elsen","year":"2008","unstructured":"Elsen A, et al. Hormone therapy and the risk of breast cancer in BRCA1 mutation carriers. J Natl Cancer Inst. 2008;100:1361\u20137.","journal-title":"J Natl Cancer Inst"},{"doi-asserted-by":"crossref","unstructured":"Kotsopoulos J et al. HRT after oophorectomy and breast cancer risk among BRCA1 mutation carriers. JAMA Oncol. 2018 (published on line April 19).","key":"574_CR21","DOI":"10.1001\/jamaoncol.2018.0211"},{"key":"574_CR22","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/GME.0000000000000956","volume":"25","author":"C Crandall","year":"2018","unstructured":"Crandall C, et al. Breast cancer, endometrial cancer, cardiovascular events in participants who used vaginal estrogens in the WHI observational study. Menopause. 2018;25:11\u201320.","journal-title":"Menopause"},{"issue":"10","key":"574_CR23","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1093\/annonc\/mdn353","volume":"19","author":"M Hickey","year":"2008","unstructured":"Hickey M, et al. Practical clinical guidelines for assessing and managing menopausal symptoms after breast cancer. Ann Oncol. 2008;19(10):1669\u201380.","journal-title":"Ann Oncol"},{"issue":"2","key":"574_CR24","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/s10549-007-9548-1","volume":"107","author":"D Cella","year":"2008","unstructured":"Cella D, Fallowfield L. Recognition and management of treatment-related side effects for breast cancer patients receiving adjuvant endocrine therapy. Breast Cancer Res Treat. 2008;107(2):167\u201380.","journal-title":"Breast Cancer Res Treat"},{"issue":"11","key":"574_CR25","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1097\/GME.0000000000000546","volume":"22","author":"Nonhormonal management of menopause-associated vasomotor symptoms","year":"2015","unstructured":"Nonhormonal management of menopause-associated vasomotor symptoms. 2015 position statement of The North American Menopause Society. Menopause. 2015;22(11):1155\u201372.","journal-title":"Menopause"},{"key":"574_CR26","first-page":"CD006108","volume":"11","author":"AH Daley","year":"2014","unstructured":"Daley AH, Stokes-Lampard H, Macarthur C. Exercise for vasomotor menopausal symptoms. Cochrane Database Syst Rev. 2014;11:CD006108.","journal-title":"Cochrane Database Syst Rev"},{"issue":"7","key":"574_CR27","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1097\/GME.0000000000000625","volume":"23","author":"T Bailey","year":"2016","unstructured":"Bailey T, et al. Exercise training reduces the frequency of menopausal hot flushes by improving thermoregulatory control. Menopause. 2016;23(7):708\u201318.","journal-title":"Menopause"},{"key":"574_CR28","doi-asserted-by":"publisher","first-page":"j5101","DOI":"10.1136\/bmj.j5101","volume":"359","author":"M Hickey","year":"2017","unstructured":"Hickey M, Szabo R, Hunter M. Non-hormonal treatments for menopausal symptoms. BMJ. 2017;359:j5101.","journal-title":"BMJ"},{"issue":"31","key":"574_CR29","doi-asserted-by":"publisher","first-page":"5022","DOI":"10.1200\/JCO.2008.16.6389","volume":"26","author":"G Elkins","year":"2008","unstructured":"Elkins G, et al. Randomized trial of a hypnosis intervention for treatment of hot flashes among breast cancer survivors. J Clin Oncol. 2008;26(31):5022\u20136.","journal-title":"J Clin Oncol"},{"key":"574_CR30","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007410.pub2","author":"S Dodin","year":"2013","unstructured":"Dodin S, et al. Acupuncture for menopausal hot flushes. Cochrane Database Syst Rev. 2013. \n                    https:\/\/doi.org\/10.1002\/14651858.CD007410.pub2\n                    \n                  .","journal-title":"Cochrane Database Syst Rev"},{"key":"574_CR31","doi-asserted-by":"publisher","first-page":"146","DOI":"10.7326\/M15-1380","volume":"164","author":"C Ee","year":"2016","unstructured":"Ee C, et al. Acupuncture for menopausal hot flushes. Ann Intern Med. 2016;164:146\u201354.","journal-title":"Ann Intern Med"},{"issue":"6","key":"574_CR32","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/S1470-2045(08)70131-1","volume":"9","author":"E Lipov","year":"2008","unstructured":"Lipov E, et al. Effects of stellate-ganglion block on hot flushes and night awakenings in survivors of breast cancer: a pilot study. Lancet Oncol. 2008;9(6):523\u201332.","journal-title":"Lancet Oncol"},{"issue":"7","key":"574_CR33","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1007\/s00520-010-0907-9","volume":"19","author":"D Pachman","year":"2011","unstructured":"Pachman D, et al. Pilot evaluation of a stellate ganglion block for the treatment of hot flashes. Support Care Cancer. 2011;19(7):941\u20137.","journal-title":"Support Care Cancer"},{"issue":"6","key":"574_CR34","doi-asserted-by":"publisher","first-page":"1449","DOI":"10.1093\/annonc\/mdr478","volume":"23","author":"K Haest","year":"2012","unstructured":"Haest K, et al. Stellate ganglion block for the management of hot flashes and sleep disturbances in breast cancer survivors: an uncontrolled experimental study with 24\u00a0weeks of follow-up. Ann Oncol. 2012;23(6):1449\u201354.","journal-title":"Ann Oncol"},{"issue":"1","key":"574_CR35","doi-asserted-by":"publisher","first-page":"41","DOI":"10.3109\/13697137.2012.709889","volume":"16","author":"P Gastel van","year":"2013","unstructured":"van Gastel P, et al. Stellate-ganglion block as a treatment for severe postmenopausal flushing. Climacteric. 2013;16(1):41\u20137.","journal-title":"Climacteric"},{"issue":"8","key":"574_CR36","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1097\/GME.0000000000000194","volume":"21","author":"D Walega","year":"2014","unstructured":"Walega D, et al. Effects of stellate ganglion block on vasomotor symptoms: findings from a randomized, controlled clinical trial in postmenopausal women. Menopause. 2014;21(8):807\u201314.","journal-title":"Menopause"},{"key":"574_CR37","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009023.pub2","author":"X Zhu","year":"2016","unstructured":"Zhu X, Liew Y, Liu Z. Chinese herbal medicines for menopausal symptoms. Cochrane Database Syst Rev. 2016. \n                    https:\/\/doi.org\/10.1002\/14651858.CD009023.pub2\n                    \n                  .","journal-title":"Cochrane Database Syst Rev."},{"issue":"12","key":"574_CR38","first-page":"CD001395","volume":"10","author":"A Lethaby","year":"2013","unstructured":"Lethaby A, et al. Phytoestrogens for menopausal vasomotor symptoms. Cochrane databases Syst Rev. 2013;10(12):CD001395.","journal-title":"Cochrane databases Syst Rev"},{"key":"574_CR39","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004923.pub2","author":"G Rada","year":"2010","unstructured":"Rada G, et al. Non-hormonal interventions for hot flushes in women with a history of breast cancer. Cochrane Database Syst Rev. 2010. \n                    https:\/\/doi.org\/10.1002\/14651858.CD004923.pub2\n                    \n                  .","journal-title":"Cochrane Database Syst Rev."},{"issue":"9407","key":"574_CR40","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/S0140-6736(04)15493-7","volume":"363","author":"L Holmberg","year":"2004","unstructured":"Holmberg L, Anderson H. HABITS (hormonal replacement therapy after breast cancer\u2014is it safe?), a randomized comparison: trial stopped. Lancet. 2004;363(9407):453\u20135.","journal-title":"Lancet"},{"issue":"7","key":"574_CR41","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1093\/jnci\/dji071","volume":"97","author":"E Schoultz von","year":"2005","unstructured":"von Schoultz E, Rutqvist L. Menopausal hormone therapy after breast cancer: the Stockholm randomized trial. J Natl Cancer Inst. 2005;97(7):533\u20135.","journal-title":"J Natl Cancer Inst"},{"issue":"606","key":"574_CR42","doi-asserted-by":"publisher","first-page":"51","DOI":"10.3399\/bjgp13X660977","volume":"63","author":"L Cusack","year":"2013","unstructured":"Cusack L, et al. Menopausal symptoms in breast cancer survivors: management update. Br J Gen Pract. 2013;63(606):51\u20132.","journal-title":"Br J Gen Pract"},{"issue":"2","key":"574_CR43","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/S1470-2045(08)70341-3","volume":"10","author":"P Kenemans","year":"2009","unstructured":"Kenemans P, et al. Safety and efficacy of tibolone in breast-cancer patients with vasomotor symptoms: a double-blind, randomised, non-inferiority trial. Lancet Oncol. 2009;10(2):135\u201346.","journal-title":"Lancet Oncol"},{"issue":"suppl1","key":"574_CR44","first-page":"7","volume":"125","author":"I Russo","year":"1991","unstructured":"Russo I, Russo J. Progestagens and mammary gland development: differentiation versus carcinogenesis. Acta Endocrinol (Copenh). 1991;125(suppl1):7\u201312.","journal-title":"Acta Endocrinol (Copenh)"},{"issue":"suppl 1","key":"574_CR45","doi-asserted-by":"publisher","first-page":"S59","DOI":"10.1016\/j.maturitas.2003.09.020","volume":"46","author":"R Druckmann","year":"2003","unstructured":"Druckmann R. Progestins and their effects on the breast. Maturitas. 2003;46(suppl 1):S59\u201369.","journal-title":"Maturitas"},{"key":"574_CR46","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/0378-5122(81)90008-6","volume":"3","author":"Y Erlik","year":"1981","unstructured":"Erlik Y, et al. Effect of megestrol acetate on flushing and bone metabolism in post-menopausal women. Maturitas. 1981;3:167\u201372.","journal-title":"Maturitas"},{"key":"574_CR47","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/0002-9378(80)90017-4","volume":"138","author":"J Morrison","year":"1980","unstructured":"Morrison J, et al. The use of medroxyprogesterone acetate for relief of climacteric symptoms. Am J Obstet Gynecol. 1980;138:99\u2013104.","journal-title":"Am J Obstet Gynecol"},{"issue":"6","key":"574_CR48","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/S0885-3924(02)00525-0","volume":"24","author":"D Barton","year":"2002","unstructured":"Barton D, et al. Depomedroxyprogesterone acetate for hot flashes. J Pain Symptom Manag. 2002;24(6):603\u20137.","journal-title":"J Pain Symptom Manag"},{"issue":"1","key":"574_CR49","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.fertnstert.2007.05.033","volume":"90","author":"X Trinh","year":"2007","unstructured":"Trinh X, et al. Use of the levonorgestrel-releasing intrauterine system in breast cancer patients. Fertil Steril. 2007;90(1):17\u201322.","journal-title":"Fertil Steril"},{"key":"574_CR50","doi-asserted-by":"publisher","first-page":"188","DOI":"10.3109\/0284186X.2015.1062538","volume":"55","author":"T Soini","year":"2016","unstructured":"Soini T, et al. Levonorgestrel IUS and the risk of breast cancer. Acta Oncol. 2016;55:188\u201392.","journal-title":"Acta Oncol"},{"issue":"8","key":"574_CR51","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1016\/j.mayocp.2016.04.009","volume":"91","author":"S Faubion","year":"2016","unstructured":"Faubion S, Loprinzi C, Ruddy K. Management of hormone deprivation symptoms after cancer. Mayo Clin Proc. 2016;91(8):1133\u201346.","journal-title":"Mayo Clin Proc"},{"key":"574_CR52","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.ctrv.2016.11.012","volume":"52","author":"R Leon-Ferre","year":"2017","unstructured":"Leon-Ferre R, Majithia N, Loprinzi C. Management of hot flashes in women with breast cancer receiving ovarian function suppression. Cancer Treat Rev. 2017;52:82\u201390.","journal-title":"Cancer Treat Rev"},{"issue":"4 Pt 1","key":"574_CR53","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1097\/gme.0b013e3181679150","volume":"15","author":"C Loprinzi","year":"2008","unstructured":"Loprinzi C, et al. Mayo Clinic and North Central Cancer Treatment Group hot flash studies: a 20-year experience. Menopause. 2008;15(4 Pt 1):655\u201360.","journal-title":"Menopause"},{"key":"574_CR54","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.maturitas.2010.08.005","volume":"67","author":"J Desmarais","year":"2010","unstructured":"Desmarais J, Looper K. Managing menopausal symptoms and depression in tamoxifen users: implications of drug and medicinal interactions. Maturitas. 2010;67:296\u2013308.","journal-title":"Maturitas"},{"issue":"2","key":"574_CR55","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1097\/PSY.0000000000000143","volume":"77","author":"E Freeman","year":"2015","unstructured":"Freeman E, et al. Placebo improvement in pharmacologic treatment of menopausal hot flashes: time course, duration, and predictors. Psychosom Med. 2015;77(2):167\u201375.","journal-title":"Psychosom Med"},{"issue":"2","key":"574_CR56","first-page":"337","volume":"101","author":"TJ Guttuso","year":"2003","unstructured":"Guttuso TJ, et al. Gabapentin\u2019s effects on hot flashes in postmenopausal women: a randomized controlled trial. Obstet Gynecol. 2003;101(2):337\u201345.","journal-title":"Obstet Gynecol"},{"key":"574_CR57","doi-asserted-by":"publisher","first-page":"3862","DOI":"10.1200\/JCO.2010.33.1298","volume":"10","author":"A Boekhout","year":"2011","unstructured":"Boekhout A, et al. Management of hot flashes in patients who have breast cancer with venlafaxine and clonidine: a randomized, double-blind, placebo-controlled trial. J Clin Oncol. 2011;10:3862\u20138.","journal-title":"J Clin Oncol"},{"key":"574_CR58","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.jsbmb.2016.03.016","volume":"159","author":"C Martel","year":"2016","unstructured":"Martel C, et al. Serum steroid concentrations remain within normal postmenopausal values in women receiving daily 6.5\u00a0mg intravaginal prasterone for 12 weeks. J Steroid Biochem Mol Biol. 2016;159:142\u201353.","journal-title":"J Steroid Biochem Mol Biol"},{"key":"574_CR59","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/s10549-016-4002-x","volume":"160","author":"J Hervik","year":"2016","unstructured":"Hervik J, Stub T. Adverse effects of non-hormonal pharmacological interventions in breast cancer survivors suffering from hot flashes: a systematic review and meta-analysis. Br Cancer Res Treat. 2016;160:223\u201336.","journal-title":"Br Cancer Res Treat"},{"key":"574_CR60","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.yfrne.2013.07.003","volume":"34","author":"N Rance","year":"2013","unstructured":"Rance N, et al. Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: a novel hypothesis on the mechanism of hot flushes. Front Neuroendocrinol. 2013;34:21.","journal-title":"Front Neuroendocrinol"},{"key":"574_CR61","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1016\/S0140-6736(17)30823-1","volume":"389","author":"J Prague","year":"2017","unstructured":"Prague J, et al. Neurokinin 3 receptor antagonism as a novel treatment for menopausal hot flushes: a phase 2, randomized, double-blind, placebo-controlled trial. Lancet. 2017;389:1809\u201320.","journal-title":"Lancet"}],"container-title":["Drugs & Aging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40266-018-0574-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40266-018-0574-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40266-018-0574-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T19:14:24Z","timestamp":1564773264000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40266-018-0574-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":61,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["574"],"URL":"https:\/\/doi.org\/10.1007\/s40266-018-0574-y","relation":{},"ISSN":["1170-229X","1179-1969"],"issn-type":[{"type":"print","value":"1170-229X"},{"type":"electronic","value":"1179-1969"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"3 August 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":":No funding was provided for the preparation of this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"Author Cheryl Phua has received speaker\u2019s honorarium from Besins Healthcare. Rodney Baber has received speaker\u2019s honoraria from Besins Healthcare and Pfizer, and has conducted research in women\u2019s health funded by Pfizer, Bayer, and Organon. He received no personal remuneration for these studies.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}