{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:59:15Z","timestamp":1792198755942,"version":"4.4.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"S1","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drugs Aging"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1007\/s40266-019-00660-1","type":"journal-article","created":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T10:27:30Z","timestamp":1557397650000},"page":"15-24","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":217,"title":["Safety of Oral Non-Selective Non-Steroidal Anti-Inflammatory Drugs in Osteoarthritis: What Does the Literature Say?"],"prefix":"10.1007","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3510-0709","authenticated-orcid":false,"given":"Cyrus","family":"Cooper","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Chapurlat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasser","family":"Al-Daghri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Herrero-Beaumont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4269-9393","authenticated-orcid":false,"given":"Olivier","family":"Bruy\u00e8re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Rannou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Roth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Uebelhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6290-752X","authenticated-orcid":false,"given":"Jean-Yves","family":"Reginster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,5,9]]},"reference":[{"issue":"3","key":"660_CR1","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.semarthrit.2014.05.014","volume":"44","author":"O Bruyere","year":"2014","unstructured":"Bruyere O, Cooper C, Pelletier JP, Branco J, Brandi ML, Guillemin F, et al. An algorithm recommendation for the management of knee osteoarthritis in Europe and internationally: a report from a task force of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Semin Arthritis Rheum. 2014;44(3):253\u201363. \n                    https:\/\/doi.org\/10.1016\/j.semarthrit.2014.05.014\n                    \n                  .","journal-title":"Semin Arthritis Rheum"},{"issue":"3","key":"660_CR2","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.joca.2014.01.003","volume":"22","author":"TE McAlindon","year":"2014","unstructured":"McAlindon TE, Bannuru RR, Sullivan MC, Arden NK, Berenbaum F, Bierma-Zeinstra SM, et al. OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthr Cartil. 2014;22(3):363\u201388. \n                    https:\/\/doi.org\/10.1016\/j.joca.2014.01.003\n                    \n                  .","journal-title":"Osteoarthr Cartil"},{"issue":"4","key":"660_CR3","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1002\/acr.21596","volume":"64","author":"MC Hochberg","year":"2012","unstructured":"Hochberg MC, Altman RD, April KT, Benkhalti M, Guyatt G, McGowan J, et al. American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. Arthritis Care Res. 2012;64(4):465\u201374. \n                    https:\/\/doi.org\/10.1002\/acr.21596\n                    \n                  .","journal-title":"Arthritis Care Res."},{"key":"660_CR4","unstructured":"National Institute for Health and Care Excellence. Osteoarthritis care and management in adults: Methods, evidence and recommendations. National Clinical Guideline Centre. London: National Institute for Health and Care Excellence; 2014: Report no. CG177."},{"issue":"12","key":"660_CR5","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1136\/ard.2003.011742","volume":"62","author":"KM Jordan","year":"2003","unstructured":"Jordan KM, Arden NK, Doherty M, Bannwarth B, Bijlsma JWJ, Dieppe P, et al. EULAR recommendations 2003: an evidence based approach to the management of knee osteoarthritis: report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). Ann Rheum Dis. 2003;62(12):1145\u201355. \n                    https:\/\/doi.org\/10.1136\/ard.2003.011742\n                    \n                  .","journal-title":"Ann Rheum Dis"},{"issue":"7","key":"660_CR6","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1111\/j.1533-2500.2012.00532.x","volume":"12","author":"M Gore","year":"2012","unstructured":"Gore M, Tai KS, Sadosky A, Leslie D, Stacey BR. Use and costs of prescription medications and alternative treatments in patients with osteoarthritis and chronic low back pain in community-based settings. Pain Pract. 2012;12(7):550\u201360. \n                    https:\/\/doi.org\/10.1111\/j.1533-2500.2012.00532.x\n                    \n                  .","journal-title":"Pain Pract."},{"issue":"5","key":"660_CR7","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1093\/rheumatology\/ket463","volume":"53","author":"SR Kingsbury","year":"2014","unstructured":"Kingsbury SR, Gross HJ, Isherwood G, Conaghan PG. Osteoarthritis in Europe: impact on health status, work productivity and use of pharmacotherapies in five European countries. Rheumatology (Oxford). 2014;53(5):937\u201347. \n                    https:\/\/doi.org\/10.1093\/rheumatology\/ket463\n                    \n                  .","journal-title":"Rheumatology (Oxford)"},{"issue":"5","key":"660_CR8","doi-asserted-by":"publisher","first-page":"R106","DOI":"10.1186\/ar4286","volume":"15","author":"SR Kingsbury","year":"2013","unstructured":"Kingsbury SR, Hensor EM, Walsh CA, Hochberg MC, Conaghan PG. How do people with knee osteoarthritis use osteoarthritis pain medications and does this change over time? Data from the Osteoarthritis Initiative. Arthritis Res Ther. 2013;15(5):R106. \n                    https:\/\/doi.org\/10.1186\/ar4286\n                    \n                  .","journal-title":"Arthritis Res Ther."},{"key":"660_CR9","doi-asserted-by":"publisher","unstructured":"American Geriatrics Society Panel on the Pharmacological Management of Persistent Pain in Older Persons. Pharmacological management of persistent pain in older persons. Pain Med. 2009;10(6):1062\u201383. \n                    https:\/\/doi.org\/10.1111\/j.1526-4637.2009.00699.x\n                    \n                  .","DOI":"10.1111\/j.1526-4637.2009.00699.x"},{"issue":"4","key":"660_CR10","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1002\/art.21328","volume":"53","author":"C Lee","year":"2005","unstructured":"Lee C, Hunsche E, Balshaw R, Kong SX, Schnitzer TJ. Need for common internal controls when assessing the relative efficacy of pharmacologic agents using a meta-analytic approach: case study of cyclooxygenase 2-selective inhibitors for the treatment of osteoarthritis. Arthritis Rheum. 2005;53(4):510\u20138. \n                    https:\/\/doi.org\/10.1002\/art.21328\n                    \n                  .","journal-title":"Arthritis Rheum"},{"key":"660_CR11","unstructured":"Chou R, McDonagh MS, Nakamoto E, Griffin J. Analgesics for osteoarthritis: an update of the 2006 Comparative Effectiveness Review. Comparative Effectiveness Review No. 38. October 2011. AHRQ Publication No. 11(12)-EHC076-EF. Rockville (MD): Agency for Healthcare Research and Quality. Available from: \n                    https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK65646\/pdf\/Bookshelf_NBK65646.pdf\n                    \n                  . Accessed 27 Apr 2018."},{"issue":"10","key":"660_CR12","doi-asserted-by":"publisher","first-page":"775","DOI":"10.2165\/11539430-000000000-00000","volume":"27","author":"RL Barkin","year":"2010","unstructured":"Barkin RL, Beckerman M, Blum SL, Clark FM, Koh EK, Wu DS. Should nonsteroidal anti-inflammatory drugs (NSAIDs) be prescribed to the older adult? Drugs Aging. 2010;27(10):775\u201389. \n                    https:\/\/doi.org\/10.2165\/11539430-000000000-00000\n                    \n                  .","journal-title":"Drugs Aging"},{"issue":"Suppl. 4S","key":"660_CR13","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1016\/j.semarthrit.2015.11.010","volume":"45","author":"O Bruyere","year":"2016","unstructured":"Bruyere O, Cooper C, Pelletier J-P, Maheu E, Rannou F, Branco J, et al. A consensus statement on the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) algorithm for the management of knee osteoarthritis: from evidence-based medicine to the real-life setting. Semin Arthritis Rheum. 2016;45(Suppl. 4S):S3\u201311.","journal-title":"Semin Arthritis Rheum"},{"key":"660_CR14","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-019-00664-x","author":"E Curtis","year":"2019","unstructured":"Curtis E, Fuggle N, Shaw S, Spooner L, Ntani G, Parsons C, et al. Safety of cyclo-oxygenase-2 inhibitors in osteoarthritis: outcomes of a systematic review and meta-analysis. Drugs Aging. 2019;36(Suppl. 1). \n                    https:\/\/doi.org\/10.1007\/s40266-019-00664-x\n                    \n                  .","journal-title":"Drugs Aging."},{"issue":"5 Suppl. 51","key":"660_CR15","first-page":"S120","volume":"26","author":"MC Hochberg","year":"2008","unstructured":"Hochberg MC. Mortality in osteoarthritis. Clin Exp Rheumatol. 2008;26(5 Suppl. 51):S120\u20134.","journal-title":"Clin Exp Rheumatol"},{"issue":"7553","key":"660_CR16","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1136\/bmj.332.7553.1302","volume":"332","author":"PM Kearney","year":"2006","unstructured":"Kearney PM, Baigent C, Godwin J, Halls H, Emberson JR, Patrono C. Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials. BMJ. 2006;332(7553):1302\u20138. \n                    https:\/\/doi.org\/10.1136\/bmj.332.7553.1302\n                    \n                  .","journal-title":"BMJ."},{"issue":"13","key":"660_CR17","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1001\/jama.296.13.jrv60011","volume":"296","author":"P McGettigan","year":"2006","unstructured":"McGettigan P, Henry D. Cardiovascular risk and inhibition of cyclooxygenase: a systematic review of the observational studies of selective and nonselective inhibitors of cyclooxygenase 2. JAMA. 2006;296(13):1633\u201344. \n                    https:\/\/doi.org\/10.1001\/jama.296.13.jrv60011\n                    \n                  .","journal-title":"JAMA"},{"issue":"3","key":"660_CR18","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1111\/j.1742-7843.2006.pto_302.x","volume":"98","author":"S Hernandez-Diaz","year":"2006","unstructured":"Hernandez-Diaz S, Varas-Lorenzo C, Garcia Rodriguez LA. Non-steroidal antiinflammatory drugs and the risk of acute myocardial infarction. Basic Clin Pharmacol Toxicol. 2006;98(3):266\u201374. \n                    https:\/\/doi.org\/10.1111\/j.1742-7843.2006.pto_302.x\n                    \n                  .","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"660_CR19","doi-asserted-by":"publisher","unstructured":"Rostom A, Muir K, Dube C, Jolicoeur E, Boucher M, Joyce J, et al. Gastrointestinal safety of cyclooxygenase-2 inhibitors: a Cochrane Collaboration systematic review. Clin Gastroenterol Hepatol. 2007;5(7):818\u201328, 828.e1\u20135. \n                    https:\/\/doi.org\/10.1016\/j.cgh.2007.03.011\n                    \n                  \n                           (quiz 768).","DOI":"10.1016\/j.cgh.2007.03.011"},{"issue":"3","key":"660_CR20","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.semarthrit.2007.10.004","volume":"38","author":"L Laine","year":"2008","unstructured":"Laine L, White WB, Rostom A, Hochberg M. COX-2 selective inhibitors in the treatment of osteoarthritis. Semin Arthritis Rheum. 2008;38(3):165\u201387. \n                    https:\/\/doi.org\/10.1016\/j.semarthrit.2007.10.004\n                    \n                  .","journal-title":"Semin Arthritis Rheum"},{"key":"660_CR21","doi-asserted-by":"publisher","first-page":"d1165","DOI":"10.1136\/bmj.d1165","volume":"342","author":"E Nuesch","year":"2011","unstructured":"Nuesch E, Dieppe P, Reichenbach S, Williams S, Iff S, Juni P. All cause and disease specific mortality in patients with knee or hip osteoarthritis: population based cohort study. BMJ. 2011;342:d1165. \n                    https:\/\/doi.org\/10.1136\/bmj.d1165\n                    \n                  .","journal-title":"BMJ"},{"key":"660_CR22","doi-asserted-by":"publisher","first-page":"d1407","DOI":"10.1136\/bmj.d1407","volume":"342","author":"C Cooper","year":"2011","unstructured":"Cooper C, Arden NK. Excess mortality in osteoarthritis. BMJ. 2011;342:d1407. \n                    https:\/\/doi.org\/10.1136\/bmj.d1407\n                    \n                  .","journal-title":"BMJ"},{"issue":"3","key":"660_CR23","doi-asserted-by":"publisher","first-page":"e91286","DOI":"10.1371\/journal.pone.0091286","volume":"9","author":"GA Hawker","year":"2014","unstructured":"Hawker GA, Croxford R, Bierman AS, Harvey PJ, Ravi B, Stanaitis I, et al. All-cause mortality and serious cardiovascular events in people with hip and knee osteoarthritis: a population based cohort study. PLoS One. 2014;9(3):e91286. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0091286\n                    \n                  .","journal-title":"PLoS One"},{"key":"660_CR24","unstructured":"Leyland KM, Gates LS, Sanchez-Santos MT, Prieto-Alhambra D, Judge A, Collins G, et al. The association of knee osteoarthritis and premature mortality in the community: an international individual patient level meta-analysis in six prospective cohorts. Osteoporos Int. 2017;28(Suppl. 1):abstract no. OC10."},{"issue":"2","key":"660_CR25","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.semarthrit.2016.04.002","volume":"46","author":"N Veronese","year":"2016","unstructured":"Veronese N, Cereda E, Maggi S, Luchini C, Solmi M, Smith T, et al. Osteoarthritis and mortality: a prospective cohort study and systematic review with meta-analysis. Semin Arthritis Rheum. 2016;46(2):160\u20137. \n                    https:\/\/doi.org\/10.1016\/j.semarthrit.2016.04.002\n                    \n                  .","journal-title":"Semin Arthritis Rheum"},{"issue":"10","key":"660_CR26","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1136\/annrheumdis-2015-208056","volume":"75","author":"S Kluzek","year":"2016","unstructured":"Kluzek S, Sanchez-Santos MT, Leyland KM, Judge A, Spector TD, Hart D, et al. Painful knee but not hand osteoarthritis is an independent predictor of mortality over 23\u00a0years follow-up of a population-based cohort of middle-aged women. Ann Rheum Dis. 2016;75(10):1749\u201356. \n                    https:\/\/doi.org\/10.1136\/annrheumdis-2015-208056\n                    \n                  .","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"660_CR27","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1136\/annrheumdis-2013-203789","volume":"74","author":"IK Haugen","year":"2015","unstructured":"Haugen IK, Ramachandran VS, Misra D, Neogi T, Niu J, Yang T, et al. Hand osteoarthritis in relation to mortality and incidence of cardiovascular disease: data from the Framingham Heart Study. Ann Rheum Dis. 2015;74(1):74\u201381. \n                    https:\/\/doi.org\/10.1136\/annrheumdis-2013-203789\n                    \n                  .","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"660_CR28","doi-asserted-by":"publisher","first-page":"e000344","DOI":"10.1136\/rmdopen-2016-000344","volume":"3","author":"A Courties","year":"2017","unstructured":"Courties A, Sellam J, Maheu E, Cadet C, Barthe Y, Carrat F, et al. Coronary heart disease is associated with a worse clinical outcome of hand osteoarthritis: a cross-sectional and longitudinal study. RMD Open. 2017;3(1):e000344. \n                    https:\/\/doi.org\/10.1136\/rmdopen-2016-000344\n                    \n                  .","journal-title":"RMD Open."},{"issue":"5","key":"660_CR29","doi-asserted-by":"publisher","first-page":"821","DOI":"10.18433\/J3VW2F","volume":"16","author":"S Harirforoosh","year":"2013","unstructured":"Harirforoosh S, Asghar W, Jamali F. Adverse effects of nonsteroidal antiinflammatory drugs: an update of gastrointestinal, cardiovascular and renal complications. J Pharm Pharm Sci. 2013;16(5):821\u201347.","journal-title":"J Pharm Pharm Sci."},{"key":"660_CR30","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.yjmcc.2016.03.016","volume":"94","author":"R Ghosh","year":"2016","unstructured":"Ghosh R, Hwang SM, Cui Z, Gilda JE, Gomes AV. Different effects of the nonsteroidal anti-inflammatory drugs meclofenamate sodium and naproxen sodium on proteasome activity in cardiac cells. J Mol Cell Cardiol. 2016;94:131\u201344. \n                    https:\/\/doi.org\/10.1016\/j.yjmcc.2016.03.016\n                    \n                  .","journal-title":"J Mol Cell Cardiol"},{"issue":"11","key":"660_CR31","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1056\/NEJMoa050493","volume":"352","author":"RS Bresalier","year":"2005","unstructured":"Bresalier RS, Sandler RS, Quan H, Bolognese JA, Oxenius B, Horgan K, et al. Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial. N Engl J Med. 2005;352(11):1092\u2013102. \n                    https:\/\/doi.org\/10.1056\/NEJMoa050493\n                    \n                  .","journal-title":"N Engl J Med"},{"key":"660_CR32","doi-asserted-by":"publisher","unstructured":"Coxib and traditional NSAID Trialists\u2019 (CNT) Collaboration, Bhala N, Emberson J, Merhi A, Abramson S, Arber N, et al. Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials. Lancet. 2013;382(9894):769\u201379. \n                    https:\/\/doi.org\/10.1016\/s0140-6736(13)60900-9\n                    \n                  .","DOI":"10.1016\/s0140-6736(13)60900-9"},{"issue":"10","key":"660_CR33","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1097\/MEG.0b013e328349de81","volume":"23","author":"X Wang","year":"2011","unstructured":"Wang X, Tian HJ, Yang HK, Wanyan P, Peng YJ. Meta-analysis: cyclooxygenase-2 inhibitors are no better than nonselective nonsteroidal anti-inflammatory drugs with proton pump inhibitors in regard to gastrointestinal adverse events in osteoarthritis and rheumatoid arthritis. Eur J Gastroenterol Hepatol. 2011;23(10):876\u201380. \n                    https:\/\/doi.org\/10.1097\/MEG.0b013e328349de81\n                    \n                  .","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"7","key":"660_CR34","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1185\/03007995.2011.581274","volume":"27","author":"SR Mallen","year":"2011","unstructured":"Mallen SR, Essex MN, Zhang R. Gastrointestinal tolerability of NSAIDs in elderly patients: a pooled analysis of 21 randomized clinical trials with celecoxib and nonselective NSAIDs. Curr Med Res Opin. 2011;27(7):1359\u201366. \n                    https:\/\/doi.org\/10.1185\/03007995.2011.581274\n                    \n                  .","journal-title":"Curr Med Res Opin"},{"issue":"1","key":"660_CR35","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/jcpt.12484","volume":"42","author":"BR Gunter","year":"2017","unstructured":"Gunter BR, Butler KA, Wallace RL, Smith SM, Harirforoosh S. Non-steroidal anti-inflammatory drug-induced cardiovascular adverse events: a meta-analysis. J Clin Pharm Ther. 2017;42(1):27\u201338. \n                    https:\/\/doi.org\/10.1111\/jcpt.12484\n                    \n                  .","journal-title":"J Clin Pharm Ther"},{"issue":"26","key":"660_CR36","doi-asserted-by":"publisher","first-page":"2519","DOI":"10.1056\/NEJMoa1611593","volume":"375","author":"SE Nissen","year":"2016","unstructured":"Nissen SE, Yeomans ND, Solomon DH, Luscher TF, Libby P, Husni ME, et al. Cardiovascular safety of celecoxib, naproxen, or ibuprofen for arthritis. N Engl J Med. 2016;375(26):2519\u201329. \n                    https:\/\/doi.org\/10.1056\/NEJMoa1611593\n                    \n                  .","journal-title":"N Engl J Med"},{"key":"660_CR37","doi-asserted-by":"publisher","first-page":"j1909","DOI":"10.1136\/bmj.j1909","volume":"357","author":"M Bally","year":"2017","unstructured":"Bally M, Dendukuri N, Rich B, Nadeau L, Helin-Salmivaara A, Garbe E, et al. Risk of acute myocardial infarction with NSAIDs in real world use: Bayesian meta-analysis of individual patient data. BMJ. 2017;357:j1909. \n                    https:\/\/doi.org\/10.1136\/bmj.j1909\n                    \n                  .","journal-title":"BMJ"},{"issue":"2","key":"660_CR38","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1002\/clc.22502","volume":"39","author":"P Ungprasert","year":"2016","unstructured":"Ungprasert P, Srivali N, Thongprayoon C. Nonsteroidal anti-inflammatory drugs and risk of incident heart failure: a systematic review and meta-analysis of observational studies. Clin Cardiol. 2016;39(2):111\u20138. \n                    https:\/\/doi.org\/10.1002\/clc.22502\n                    \n                  .","journal-title":"Clin Cardiol"},{"issue":"2","key":"660_CR39","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1161\/STROKEAHA.115.011678","volume":"47","author":"P Ungprasert","year":"2016","unstructured":"Ungprasert P, Matteson EL, Thongprayoon C. Nonaspirin nonsteroidal anti-inflammatory drugs and risk of hemorrhagic stroke: a systematic review and meta-analysis of observational studies. Stroke. 2016;47(2):356\u201364. \n                    https:\/\/doi.org\/10.1161\/STROKEAHA.115.011678\n                    \n                  .","journal-title":"Stroke"},{"issue":"5","key":"660_CR40","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1161\/CIRCULATIONAHA.105.568451","volume":"112","author":"EM Antman","year":"2005","unstructured":"Antman EM, DeMets D, Loscalzo J. Cyclooxygenase inhibition and cardiovascular risk. Circulation. 2005;112(5):759\u201370. \n                    https:\/\/doi.org\/10.1161\/circulationaha.105.568451\n                    \n                  .","journal-title":"Circulation"},{"issue":"11","key":"660_CR41","doi-asserted-by":"publisher","first-page":"E437","DOI":"10.1111\/j.1464-410X.2012.11679_4.x","volume":"110","author":"J Fairweather","year":"2012","unstructured":"Fairweather J, Jawad AS. Cardiovascular risk with nonsteroidal anti-inflammatory drugs (NSAIDs): the urological perspective. BJU Int. 2012;110(11):E437. \n                    https:\/\/doi.org\/10.1111\/j.1464-410X.2012.11679_4.x\n                    \n                  .","journal-title":"BJU Int."},{"issue":"4","key":"660_CR42","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.ejim.2015.03.008","volume":"26","author":"P Ungprasert","year":"2015","unstructured":"Ungprasert P, Cheungpasitporn W, Crowson CS, Matteson EL. Individual non-steroidal anti-inflammatory drugs and risk of acute kidney injury: a systematic review and meta-analysis of observational studies. Eur J Intern Med. 2015;26(4):285\u201391. \n                    https:\/\/doi.org\/10.1016\/j.ejim.2015.03.008\n                    \n                  .","journal-title":"Eur J Intern Med."},{"issue":"3","key":"660_CR43","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1111\/jgs.12148","volume":"61","author":"L Rolita","year":"2013","unstructured":"Rolita L, Spegman A, Tang X, Cronstein BN. Greater number of narcotic analgesic prescriptions for osteoarthritis is associated with falls and fractures in elderly adults. J Am Geriatr Soc. 2013;61(3):335\u201340. \n                    https:\/\/doi.org\/10.1111\/jgs.12148\n                    \n                  .","journal-title":"J Am Geriatr Soc"},{"issue":"6","key":"660_CR44","doi-asserted-by":"publisher","first-page":"571","DOI":"10.2174\/092986710790416326","volume":"17","author":"A Corsonello","year":"2010","unstructured":"Corsonello A, Pedone C, Incalzi RA. Age-related pharmacokinetic and pharmacodynamic changes and related risk of adverse drug reactions. Curr Med Chem. 2010;17(6):571\u201384.","journal-title":"Curr Med Chem"},{"issue":"5","key":"660_CR45","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.jpainsymman.2006.05.015","volume":"32","author":"S Mercadante","year":"2006","unstructured":"Mercadante S, Ferrera P, Villari P, Casuccio A. Opioid escalation in patients with cancer pain: the effect of age. J Pain Symptom Manag. 2006;32(5):413\u20139. \n                    https:\/\/doi.org\/10.1016\/j.jpainsymman.2006.05.015\n                    \n                  .","journal-title":"J Pain Symptom Manag"},{"issue":"22","key":"660_CR46","doi-asserted-by":"publisher","first-page":"1968","DOI":"10.1001\/archinternmed.2010.391","volume":"170","author":"DH Solomon","year":"2010","unstructured":"Solomon DH, Rassen JA, Glynn RJ, Lee J, Levin R, Schneeweiss S. The comparative safety of analgesics in older adults with arthritis. Arch Intern Med. 2010;170(22):1968\u201376. \n                    https:\/\/doi.org\/10.1001\/archinternmed.2010.391\n                    \n                  .","journal-title":"Arch Intern Med"},{"issue":"2","key":"660_CR47","doi-asserted-by":"publisher","first-page":"229.e15","DOI":"10.1016\/j.amjmed.2016.09.006","volume":"130","author":"D Misra","year":"2017","unstructured":"Misra D, Peloquin C, Kiel DP, Neogi T, Lu N, Zhang Y. Intermittent nitrate use and risk of hip fracture. Am J Med. 2017;130(2):229.e15\u201320. \n                    https:\/\/doi.org\/10.1016\/j.amjmed.2016.09.006\n                    \n                  .","journal-title":"Am J Med"}],"container-title":["Drugs & Aging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40266-019-00660-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40266-019-00660-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40266-019-00660-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T23:08:43Z","timestamp":1588892923000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40266-019-00660-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":47,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["660"],"URL":"https:\/\/doi.org\/10.1007\/s40266-019-00660-1","relation":{},"ISSN":["1170-229X","1179-1969"],"issn-type":[{"value":"1170-229X","type":"print"},{"value":"1179-1969","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"9 May 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The Working Group was entirely funded by ESCEO, a Belgian not-for-profit organization. ESCEO receives unrestricted educational grants, to support its educational and scientific activities, from non-governmental organizations, not-for-profit organizations, and non-commercial and corporate partners. The choice of topics, participants, content, and agenda of the working groups as well as the writing, editing, submission, and reviewing of the manuscript is under the sole responsibility of ESCEO, without any influence from third parties.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"Olivier Bruy\u00e8re reports grants from Biophytis, IBSA, MEDA, Servier, SMB, and Theramex, outside of the submitted work. Cyrus Cooper reports personal fees from Alliance for Better Bone Health, Amgen, Eli Lilly, GlaxoSmithKline, Medtronic, Merck, Novartis, Pfizer, Roche, Servier, Takeda, and UCB, outside of the submitted work. Jean-Yves Reginster reports grants from IBSA-Genevrier, Mylan, CNIEL, and Radius Health (through institution), consulting fees from IBSA-Genevrier, Mylan, CNIEL, Radius Health, and Pierre Fabre, fees for participation in review activities from IBSA-Genevrier, MYLAN, CNIEL, Radius Health, and Teva, payment for lectures from AgNovos, CERIN, CNIEL, Dairy Research Council, Echolight, IBSA-Genevrier, Mylan, Pfizer Consumer Health, Teva, and Theramex, outside of the submitted work. Fran\u00e7ois Rannou reports grants from APHP, INSERM, University Paris Descartes, and Arthritis (Road Network), and consulting fees from Pierre Fabre, Expanscience, Thuasne, Servier, Genevrier, Sanofi Aventis, and Genzyme, outside of the submitted work. Roland Chapurlat, Nasser Al-Daghri, Gabriel Herrero-Beaumont, Roland Roth, and Daniel Uebelhart have not conflicts of interest that are directly relevant to the content of this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}