{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T22:01:48Z","timestamp":1783980108344,"version":"3.55.0"},"reference-count":79,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T00:00:00Z","timestamp":1574726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T00:00:00Z","timestamp":1574726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drugs Aging"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1007\/s40266-019-00727-z","type":"journal-article","created":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T06:02:52Z","timestamp":1574748172000},"page":"11-18","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Interstitial Lung Disease in Elderly Rheumatoid Arthritis Patients"],"prefix":"10.1007","volume":"37","author":[{"given":"Riccardo","family":"Messina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliana","family":"Guggino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alida","family":"Benfante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6400-6573","authenticated-orcid":false,"given":"Nicola","family":"Scichilone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,11,26]]},"reference":[{"key":"727_CR1","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1136\/ard.56.10.596","volume":"56","author":"B Cortet","year":"1997","unstructured":"Cortet B, Perez T, Roux N, Flipo RM, Duquesnoy B, Delcambre B, et al. Pulmonary function tests and high resolution computed tomography of the lungs in patients with rheumatoid arthritis. Ann Rheum Dis. 1997;56:596\u2013600.","journal-title":"Ann Rheum Dis"},{"key":"727_CR2","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.semarthrit.2006.03.002","volume":"35","author":"A Balbir-Gurman","year":"2006","unstructured":"Balbir-Gurman A, Yigla M, Nahir AM, et al. Rheumatoid pleural effusion. Semin Arthritis Rheum. 2006;35:368\u201378.","journal-title":"Semin Arthritis Rheum"},{"key":"727_CR3","doi-asserted-by":"crossref","first-page":"55","DOI":"10.4187\/respcare.02597","volume":"59","author":"JP Corcoran","year":"2014","unstructured":"Corcoran JP, Ahmad M, Mukherjee R, et al. Pleuro-pulmonary complications of rheumatoid arthritis. Respir Care. 2014;59:55\u20139.","journal-title":"Respir Care"},{"issue":"2","key":"727_CR4","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.rdc.2014.12.004","volume":"41","author":"ZX Yunt","year":"2015","unstructured":"Yunt ZX, Solomon JJ. Lung disease in rheumatoid arthritis. Rheum Dis Clin N Am. 2015;41(2):225\u201336.","journal-title":"Rheum Dis Clin N Am"},{"issue":"10","key":"727_CR5","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1002\/art.40574","volume":"70","author":"Paolo Spagnolo","year":"2018","unstructured":"Spagnolo Paolo, Lee Joyce S, Sverzellati Nicola, Rossi Giulio, Cottin Vincent. The lung in rheumatoid arthritis: focus on interstitial lung disease. Arthritis Rheumatol. 2018;70(10):1544\u201354.","journal-title":"Arthritis Rheumatol"},{"key":"727_CR6","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.autrev.2013.05.001","volume":"12","author":"B Marigliano","year":"2013","unstructured":"Marigliano B, Soriano A, Margiotta D, Vadacca M, Afeltra A. Lung involvement in connective tissue diseases: a comprehensive review and a focus on rheumatoid arthritis. Autoimmun Rev. 2013;12:1076\u201384.","journal-title":"Autoimmun Rev"},{"key":"727_CR7","first-page":"344","volume":"56","author":"JA Zamora-Legoff","year":"2017","unstructured":"Zamora-Legoff JA, Krause ML, Crowson CS, Ryu JH, Matteson EL. Patterns of interstitial lung disease and mortality in rheumatoid arthritis. Rheumatology (Oxford). 2017;56:344\u201350.","journal-title":"Rheumatology (Oxford)"},{"key":"727_CR8","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.ejim.2013.07.004","volume":"24","author":"DN O\u2019Dwyer","year":"2013","unstructured":"O\u2019Dwyer DN, Armstrong ME, Cooke G, et al. Rheumatoid arthritis (RA) associated interstitial lung disease (ILD). Eur J Intern Med. 2013;24:597\u2013603.","journal-title":"Eur J Intern Med"},{"key":"727_CR9","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1378\/chest.127.6.2019","volume":"127","author":"HK Lee","year":"2005","unstructured":"Lee HK, Kim DS, Yoo B, Seo JB, Rho JY, Colby TV, et al. Histopathologic pattern and clinical features of rheumatoid arthritis-associated interstitial lung disease. Chest. 2005;127:2019\u201327.","journal-title":"Chest"},{"issue":"2","key":"727_CR10","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1183\/13993003.00398-2016","volume":"48","author":"M Selman","year":"2016","unstructured":"Selman M, L\u00f3pez-Ot\u00edn C, Pardo A. Age-driven developmental drift in the pathogenesis of idiopathic pulmonary fibrosis. Eur Respir J. 2016;48(2):538\u201352.","journal-title":"Eur Respir J"},{"issue":"5","key":"727_CR11","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1055\/s-0030-1265893","volume":"31","author":"MR Miller","year":"2010","unstructured":"Miller MR. Structural and physiological age-associated changes in aging lungs. Semin Respir Crit Care Med. 2010;31(5):521\u20137.","journal-title":"Semin Respir Crit Care Med."},{"key":"727_CR12","doi-asserted-by":"crossref","first-page":"389","DOI":"10.2147\/COPD.S31630","volume":"7","author":"C Sorino","year":"2012","unstructured":"Sorino C, Battaglia S, Scichilone N, Pedone C, Antonelli-Incalzi R, Sherrill D, Bellia V. Diagnosis of airway obstruction in the elderly: contribution of the SARA study. Int J Chronic Obstr Pulm Dis. 2012;7:389\u201395.","journal-title":"Int J Chronic Obstr Pulm Dis"},{"key":"727_CR13","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S0140-6736(10)61087-2","volume":"376","author":"PG Gibson","year":"2010","unstructured":"Gibson PG, McDonald VM, Marks GB. Asthma in older adults. Lancet. 2010;376:803\u201313.","journal-title":"Lancet"},{"key":"727_CR14","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/j.1365-2567.2007.02555.x","volume":"120","author":"D Aw","year":"2007","unstructured":"Aw D, Silva AB, Palmer DB. Immunosenescence: emerging challenges for an ageing population. Immunology. 2007;120:435\u201346.","journal-title":"Immunology"},{"issue":"2","key":"727_CR15","doi-asserted-by":"crossref","first-page":"419","DOI":"10.14336\/AD.2018.0601","volume":"10","author":"LA Murtha","year":"2019","unstructured":"Murtha LA, Morten M, Schuliga MJ, Mabotuwana NS, Hardy SA, Waters DW. The role of pathological aging in cardiac and pulmonary fibrosis. Aging Dis. 2019;10(2):419\u201328.","journal-title":"Aging Dis."},{"issue":"2","key":"727_CR16","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1172\/JCI74942","volume":"125","author":"M Bueno","year":"2015","unstructured":"Bueno M, Lai YC, Romero Y, Brands J, St Croix CM, Kamga C, et al. PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis. J Clin Investig. 2015;125(2):521\u201338.","journal-title":"J Clin Investig"},{"issue":"1","key":"727_CR17","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/MAJ.0b013e318234c132","volume":"344","author":"V Sueblinvong","year":"2012","unstructured":"Sueblinvong V, Neujahr DC, Mills ST, Roser-Page S, Ritzenthaler JD, Guidot D, et al. Predisposition for disrepair in the aged lung. Am J Med Sci. 2012;344(1):41\u201351.","journal-title":"Am J Med Sci"},{"key":"727_CR18","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1080\/03009740410005845","volume":"33","author":"S Sihvonen","year":"2004","unstructured":"Sihvonen S. Mortality and causes of death in patients with rheumatoid arthritis. Scand J Reumatol. 2004;33:221\u20137.","journal-title":"Scand J Reumatol"},{"issue":"2","key":"727_CR19","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1093\/rheumatology\/kel253","volume":"46","author":"A Young","year":"2007","unstructured":"Young A, Koduri G, Batley M, Kulinskaya E, Gough A, Norton S, Dixey J, Early Rheumatoid Arthritis Study (ERAS) group. Mortality in rheumatoid arthritis. Increased in the early course of disease, in ischaemic heart disease and in pulmonary fibrosis. Rheumatology (Oxford). 2007;46(2):350\u20137.","journal-title":"Rheumatology (Oxford)"},{"issue":"6","key":"727_CR20","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1002\/art.27405","volume":"62","author":"T Bongartz","year":"2010","unstructured":"Bongartz T, Nannini C, Medina-Velasquez YF, Achenbach SJ, Crowson CS, Ryu JH, Vassallo R, et al. Incidence and mortality of interstitial lung disease in rheumatoid arthritis: a population-based study. Arthritis Rheum. 2010;62(6):1583\u201391.","journal-title":"Arthritis Rheum"},{"key":"727_CR21","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1164\/rccm.201004-0622OC","volume":"183","author":"AL Olson","year":"2011","unstructured":"Olson AL, Swigris JJ, Sprunger DB, Fischer A, Fernandez-Perez ER, Solomon JJ, et al. Rheumatoid arthritis-interstitial lung disease-associated mortality. Am J Respir Crit Care Med. 2011;183:372\u20138.","journal-title":"Am J Respir Crit Care Med"},{"key":"727_CR22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1183\/09059180.00008014","volume":"24","author":"M Shaw","year":"2015","unstructured":"Shaw M, Collins BF, Ho LA, Raghu G. Rheumatoid arthritis-related interstitial lung disease. Eur Respir Rev. 2015;24:1\u201316.","journal-title":"Eur Respir Rev"},{"issue":"9","key":"727_CR23","first-page":"1285","volume":"18","author":"DM van der Heijde","year":"1991","unstructured":"van der Heijde DM, van Riel PL, van Leeuwen MA, van\u2019t Hof MA, van Rijswijk MH, van de Putte LB. Older versus younger onset rheumatoid arthritis: results at onset and after 2\u00a0years of a prospective followup study of early rheumatoid arthritis. J Rheumatol. 1991;18(9):1285\u20139.","journal-title":"J Rheumatol"},{"issue":"9","key":"727_CR24","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1002\/art.1780280905","volume":"28","author":"CL Deal","year":"1985","unstructured":"Deal CL, Meenan RF, Goldenberg DL, Anderson JJ, Sack B, Pastan RS, Cohen AS. The clinical features of elderly-onset rheumatoid arthritis. A comparison with younger-onset disease of similar duration. Arthritis Rheum. 1985;28(9):987\u201394.","journal-title":"Arthritis Rheum"},{"issue":"3","key":"727_CR25","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1093\/rheumatology\/38.3.228","volume":"38","author":"CT Pease","year":"1999","unstructured":"Pease CT, Bhakta BB, Devlin J, Emery P. Does the age of onset of rheumatoid arthritis influence phenotype? A prospective study of outcome and prognostic factors. Rheumatology (Oxford). 1999;38(3):228\u201334.","journal-title":"Rheumatology (Oxford)"},{"issue":"4","key":"727_CR26","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1093\/rheumatology\/ket399","volume":"53","author":"RB Mueller","year":"2013","unstructured":"Mueller RB, Kaegi T, Finckh A, Haile SR, Schulze-Koops H, von Kempis J. Is radiographic progression of late-onset rheumatoid arthritis different from young-onset rheumatoid arthritis? Results from the Swiss prospective observational cohort. Rheumatology (Oxford). 2013;53(4):671\u20137.","journal-title":"Rheumatology (Oxford)"},{"key":"727_CR27","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1183\/09031936.00092309","volume":"35","author":"EJ Kim","year":"2010","unstructured":"Kim EJ, Elicker BM, Maldonado F, Webb WR, Ryu JH, Van Uden JH, et al. Usual interstitial pneumonia in rheumatoid arthritis-associated interstitial lung disease. Eur Respir J. 2010;35:1322\u20138.","journal-title":"Eur Respir J"},{"key":"727_CR28","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1164\/ajrccm.156.2.9609016","volume":"156","author":"E Gabbay","year":"1997","unstructured":"Gabbay E, Tarala R, Will R, Carroll G, Adler B, Cameron D, et al. Interstitial lung disease in recent onset rheumatoid arthritis. Am J Respir Crit Care Med. 1997;156:528\u201335.","journal-title":"Am J Respir Crit Care Med"},{"key":"727_CR29","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s10067-010-1492-5","volume":"30","author":"HM Habib","year":"2011","unstructured":"Habib HM, Eisa AA, Arafat WR, Marie MA. Pulmonary involvement in early rheumatoid arthritis patients. Clin Rheumatol. 2011;30:217\u201321.","journal-title":"Clin Rheumatol"},{"key":"727_CR30","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1002\/art.1780391014","volume":"39","author":"KG Saag","year":"1996","unstructured":"Saag KG, Kolluri S, Koehnke RK, Georgou TA, Rachow JW, Hunninghake GW, et al. Rheumatoid arthritis lung disease: determinants of radiographic and physiologic abnormalities. Arthritis Rheum. 1996;39:1711\u20139.","journal-title":"Arthritis Rheum"},{"key":"727_CR31","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1177\/1479972310393758","volume":"8","author":"A De Lauretis","year":"2011","unstructured":"De Lauretis A, Veeraraghavan S, Renzoni E. Review series: aspects of interstitial lung disease: connective tissue disease-associated interstitial lung disease: how does it differ from IPF? How should the clinical approach differ? Chronic Respir Dis. 2011;8:53\u201382.","journal-title":"Chronic Respir Dis."},{"key":"727_CR32","doi-asserted-by":"crossref","first-page":"983","DOI":"10.3899\/jrheum.101133","volume":"38","author":"E Myasoedova","year":"2011","unstructured":"Myasoedova E, Crowson CS, Turesson C, Gabriel SE, Matteson EL. Incidence of extraarticular rheumatoid arthritis in Olmsted County, Minnesota, in 1995\u20132007 versus 1985\u20131994: a population-based study. J Rheumatol. 2011;38:983\u20139.","journal-title":"J Rheumatol"},{"key":"727_CR33","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.rmed.2012.07.006","volume":"106","author":"S Mori","year":"2012","unstructured":"Mori S, Koga Y, Sugimoto M. Different risk factors between interstitial lung disease and airway disease in rheumatoid arthritis. Respir Med. 2012;106:1591\u20139.","journal-title":"Respir Med"},{"key":"727_CR34","doi-asserted-by":"crossref","first-page":"e003132","DOI":"10.1136\/bmjopen-2013-003132","volume":"3","author":"H Hozumi","year":"2013","unstructured":"Hozumi H, Nakamura Y, Johkoh T, Sumikawa H, Colby TV, Kono M, et al. Acute exacerbation in rheumatoid arthritis-associated interstitial lung disease: a retrospective case control study. BMJ Open. 2013;3:e003132.","journal-title":"BMJ Open"},{"key":"727_CR35","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1093\/rheumatology\/40.9.1022","volume":"40","author":"BA Rajasekaran","year":"2001","unstructured":"Rajasekaran BA, Shovlin D, Lord P, Kelly CA. Interstitial lung disease in patients with rheumatoid arthritis: a comparison with cryptogenic fibrosing alveolitis over 5 years. Rheumatology (Oxford). 2001;40:1022\u20135.","journal-title":"Rheumatology (Oxford)"},{"issue":"3","key":"727_CR36","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.ijcard.2007.04.084","volume":"127","author":"N Udayakumar","year":"2008","unstructured":"Udayakumar N, Venkatesan S, Rajendiran C. Pulmonary hypertension in rheumatoid arthritis\u2014relation with the duration of the disease. Int J Cardiol. 2008;127(3):410\u20132.","journal-title":"Int J Cardiol"},{"key":"727_CR37","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/j.rmed.2013.05.002","volume":"107","author":"JJ Solomon","year":"2013","unstructured":"Solomon JJ, Ryu JH, Tazelaar HD, Myers JL, Tuder R, Cool CD, et al. Fibrosing interstitial pneumonia predicts survival in patients with rheumatoid arthritis-associated interstitial lung disease (RAILD). Respir Med. 2013;107:1247\u201352.","journal-title":"Respir Med"},{"key":"727_CR38","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s40248-019-0179-2","volume":"14","author":"N Ciancio","year":"2019","unstructured":"Ciancio N, Pavone M, Torrisi SE, Vancheri A, Sambataro D, Palmucci S, et al. Contribution of pulmonary function tests (PFTs) to the diagnosis and follow up of connective tissue diseases. Multidiscip Respir Med. 2019;14:17.","journal-title":"Multidiscip Respir Med"},{"key":"727_CR39","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1164\/rccm.200210-1245OC","volume":"168","author":"PI Latsi","year":"2003","unstructured":"Latsi PI, du Bois RM, Nicholson AG, Colby TV, Bisirtzoglou D, Nikolakopoulou A, et al. Fibrotic idiopathic interstitial pneumonia: the prognostic value of longitudinal functional trends. Am J Respir Crit Care Med. 2003;168:531\u20137.","journal-title":"Am J Respir Crit Care Med"},{"key":"727_CR40","first-page":"58","volume":"63","author":"B Bradley","year":"2008","unstructured":"Bradley B, Branley HM, Egan JJ, Greaves MS, Hansell DM, Harrison NK, et al. Interstitial lung disease guideline: the British Thoracic Society in collaboration with the Thoracic Society of Australia and New Zealand and the Irish Thoracic Society. Thorax. 2008;63:58.","journal-title":"Thorax"},{"key":"727_CR41","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1378\/chest.09-0444","volume":"136","author":"EJ Kim","year":"2009","unstructured":"Kim EJ, Collard HR, King TE Jr. Rheumatoid arthritis-associated interstitial lung disease: the relevance of histopathologic and radiographic pattern. Chest. 2009;136:1397\u2013405.","journal-title":"Chest"},{"key":"727_CR42","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1164\/rccm.2106012","volume":"165","author":"D Bouros","year":"2002","unstructured":"Bouros D, Wells AU, Nicholson AG, Colby TV, Polychronopoulos V, Pantelidis P, et al. Histopathologic subsets of fibrosing alveolitis in patients with systemic sclerosis and their relationship to outcome. Am J Respir Crit Care Med. 2002;165:1581\u20136.","journal-title":"Am J Respir Crit Care Med"},{"key":"727_CR43","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/j.rmed.2007.02.017","volume":"101","author":"JW Huh","year":"2007","unstructured":"Huh JW, Kim DS, Lee CK, Yoo B, Bum Seo J, Kitaichi M, et al. Two distinct clinical types of interstitial lung disease associated with polymyositis-dermatomyositis. Respir Med. 2007;101:1761\u20139.","journal-title":"Respir Med"},{"key":"727_CR44","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s12890-016-0269-2","volume":"16","author":"HM Nurmi","year":"2016","unstructured":"Nurmi HM, Purokivi MK, Karkkainen MS, Kettunen HP, Selander TA, Kaarteenaho RL. Variable course of disease of rheumatoid arthritis-associated usual interstitial pneumonia compared with other subtypes. BMC Pulm Med. 2016;16:107.","journal-title":"BMC Pulm Med"},{"key":"727_CR45","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1093\/rheumatology\/keq035","volume":"49","author":"G Koduri","year":"2010","unstructured":"Koduri G, Norton S, Young A, Cox N, Davies P, Devlin J, et al. Interstitial lung disease has a poor prognosis in rheumatoid arthritis: results from an inception cohort. Rheumatology (Oxford). 2010;49:1483\u20139.","journal-title":"Rheumatology (Oxford)"},{"key":"727_CR46","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1183\/13993003.00357-2015","volume":"47","author":"JJ Solomon","year":"2016","unstructured":"Solomon JJ, Chung JH, Cosgrove GP, Demoruelle MK, Fernandez-Perez ER, Fischer A, et al. Predictors of mortality in rheumatoid arthritis-associated interstitial lung disease. Eur Respir J. 2016;47:588\u201396.","journal-title":"Eur Respir J"},{"key":"727_CR47","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1136\/thoraxjnl-2013-203843","volume":"69","author":"SL Walsh","year":"2014","unstructured":"Walsh SL, Sverzellati N, Devaraj A, Keir GJ, Wells AU, Hansell DM. Connective tissue disease related fibrotic lung disease: high resolution computed tomographic and pulmonary function indices as prognostic determinants. Thorax. 2014;69:216\u201322.","journal-title":"Thorax"},{"key":"727_CR48","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1097\/MCP.0b013e328356803b","volume":"18","author":"V Cottin","year":"2012","unstructured":"Cottin V, Cordier JF. Combined pulmonary fibrosis and emphysema in connective tissue disease. Curr Opin Pulm Med. 2012;18:418\u201327.","journal-title":"Curr Opin Pulm Med"},{"key":"727_CR49","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1164\/rccm.201308-1483ST","volume":"188","author":"WD Travis","year":"2013","unstructured":"Travis WD, Costabel U, Hansell DM, King TE Jr, Lynch DA, Nicholson AG, et al. An official American Thoracic Society\/European Respiratory statement: update of the international multidisciplinary classification of the idiopathic pneumonias. Am J Respir Crit Care Med. 2013;188:733\u201348.","journal-title":"Am J Respir Crit Care Med"},{"key":"727_CR50","doi-asserted-by":"crossref","first-page":"h6819","DOI":"10.1136\/bmj.h6819","volume":"352","author":"S Mathai","year":"2016","unstructured":"Mathai S, Danoff SK. Management of interstitial lung disease associated with connective tissue disease. BMJ. 2016;352:h6819.","journal-title":"BMJ"},{"issue":"4","key":"727_CR51","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1183\/13993003.00150-2015","volume":"46","author":"A Fischer","year":"2015","unstructured":"Fischer A, Antoniou KM, Brown KK, Cadranel J, Corte TJ, du Bois RM, et al. An official European Respiratory Society\/American Thoracic Society research statement: interstitial pneumonia with autoimmune features. Eur Respir J. 2015;46(4):976\u201387.","journal-title":"Eur Respir J"},{"issue":"11","key":"727_CR52","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.3899\/jrheum.171314","volume":"45","author":"Y Levi","year":"2018","unstructured":"Levi Y, Israeli-Shani L, Kuchuk M, Epstein Shochet G, Matthew Koslow M, David Shitrit D. Rheumatological assessment is important for interstitial lung disease diagnosis. J Rheumatol. 2018;45(11):1509\u201314.","journal-title":"J Rheumatol"},{"issue":"144","key":"727_CR53","doi-asserted-by":"crossref","first-page":"170002","DOI":"10.1183\/16000617.0002-2017","volume":"26","author":"SLF Walsh","year":"2017","unstructured":"Walsh SLF. Multidisciplinary evaluation of interstitial lung diseases: current insights. Eur Respir Rev. 2017;26(144):170002.","journal-title":"Eur Respir Rev"},{"issue":"2","key":"727_CR54","doi-asserted-by":"crossref","first-page":"R94","DOI":"10.1186\/ar4540","volume":"16","author":"L Innala","year":"2014","unstructured":"Innala L, Berglin E, M\u00f6ller B, Ljung L, Smedby T, S\u00f6dergren A, et al. Age at onset determines severity and choice of treatment in early rheumatoid arthritis: a prospective study. Arthritis Res Ther. 2014;16(2):R94.","journal-title":"Arthritis Res Ther"},{"key":"727_CR55","doi-asserted-by":"crossref","first-page":"739","DOI":"10.2165\/11316740-000000000-00000","volume":"26","author":"JI Villa-Blanco","year":"2009","unstructured":"Villa-Blanco JI, Calvo-Al\u00e9n J. Elderly onset rheumatoid arthritis: differential diagnosis and choice of first-line and subsequent therapy. Drugs Aging. 2009;26:739\u201350.","journal-title":"Drugs Aging"},{"key":"727_CR56","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.rdc.2006.12.006","volume":"33","author":"Z Tutuncu","year":"2007","unstructured":"Tutuncu Z, Kavanaugh A. Rheumatic disease in the elderly: rheumatoid arthritis. Rheum Dis Clin N Am. 2007;33:57\u201370.","journal-title":"Rheum Dis Clin N Am"},{"key":"727_CR57","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1136\/ard.2005.051144","volume":"65","author":"Z Tutuncu","year":"2006","unstructured":"Tutuncu Z, Reed G, Kremer J, Kavanaugh A. Do patients with older-onset rheumatoid arthritis receive less aggressive treatment? Ann Rheum Dis. 2006;65:1226\u20139.","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"727_CR58","first-page":"691","volume":"30","author":"RM Fleischmann","year":"2003","unstructured":"Fleischmann RM, Baumgartner SW, Tindall EA, Weaver AL, Moreland LW, Schiff MH, et al. Response to etanercept (Enbrel) in elderly patients with rheumatoid arthritis: a retrospective analysis of clinical trial results. J Rheumatol. 2003;30(4):691\u20136.","journal-title":"J Rheumatol"},{"issue":"6","key":"727_CR59","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1002\/art.22600","volume":"56","author":"S Schneeweiss","year":"2007","unstructured":"Schneeweiss S, Setoguchi S, Weinblatt ME, Katz JN, Avorn J, Sax PE, et al. Anti\u2013tumor necrosis factor \u03b1 therapy and the risk of serious bacterial infections in elderly patients with rheumatoid arthritis. Arthritis Rheum. 2007;56(6):1754\u201364.","journal-title":"Arthritis Rheum"},{"key":"727_CR60","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1056\/NEJMoa1113354","volume":"366","author":"G Raghu","year":"2012","unstructured":"Idiopathic Pulmonary Fibrosis Clinical Research Network, Raghu G, Anstrom KJ, King TE Jr, Lasky JA, Martinez FJ. Prednisone, azathioprine, and N-acetylcysteine for pulmonary fibrosis. N Engl J Med. 2012;366:1968\u201377.","journal-title":"N Engl J Med"},{"key":"727_CR61","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.rmed.2012.04.004","volume":"106","author":"Y Nakamura","year":"2012","unstructured":"Nakamura Y, Suda T, Kaida Y, Kono M, Hozumi H, Hashimoto D, et al. Rheumatoid lung disease: prognostic analysis of 54 biopsy-proven cases. Respir Med. 2012;106:1164\u20139.","journal-title":"Respir Med"},{"key":"727_CR62","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/art.20765","volume":"52","author":"C Turesson","year":"2005","unstructured":"Turesson C, Matteson EL, Colby TV, Vuk-Pavlovic Z, Vassallo R, Weyand CM, et al. Increased CD4+ T cell infiltrates in rheumatoid arthritis\u2013associated interstitial pneumonitis compared with idiopathic interstitial pneumonitis. Arthritis Rheum. 2005;52:73\u20139.","journal-title":"Arthritis Rheum"},{"key":"727_CR63","doi-asserted-by":"crossref","first-page":"640","DOI":"10.3899\/jrheum.121043","volume":"40","author":"A Fischer","year":"2013","unstructured":"Fischer A, Brown KK, Du Bois RM, Frankel SK, Cosgrove GP, Fernandez-Perez ER, et al. Mycophenolate mofetil improves lung function in connective tissue disease-associated interstitial lung disease. J Rheumatol. 2013;40:640\u20136.","journal-title":"J Rheumatol"},{"issue":"6","key":"727_CR64","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1002\/art.23721","volume":"59","author":"KG Saag","year":"2008","unstructured":"Saag KG, Teng GG, Patkar NM, Anuntiyo J, Finney C, Curtis JR, et al. American College of Rheumatology 2008 recommendations for the use of nonbiologic and biologic disease-modifying antirheumatic drugs in rheumatoid arthritis. Arthritis Rheum. 2008;59(6):762\u201384.","journal-title":"Arthritis Rheum"},{"issue":"2","key":"727_CR65","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1002\/art.37723","volume":"65","author":"MC Wasko","year":"2013","unstructured":"Wasko MC, Dasgupta A, Hubert H, Fries JF, Ward MM. Propensity-adjusted association of methotrexate with overall survival in rheumatoid arthritis. Arthrits Rheum. 2013;65(2):334\u201342.","journal-title":"Arthrits Rheum"},{"issue":"7","key":"727_CR66","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1136\/ard.53.7.434","volume":"53","author":"P Barrera","year":"1994","unstructured":"Barrera P, Laan RF, van Riel PL, Dekhuijzen PN, Boerbooms AM, van de Putte LB. Methotrexate-related pulmonary complications in rheumatoid arthritis. Ann Rheum Dis. 1994;53(7):434\u20139.","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"727_CR67","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1002\/art.38322","volume":"66","author":"R Conway","year":"2014","unstructured":"Conway R, Low C, Coughlan RJ, O\u2019Donnell MJ, Carey JJ. Methotrexate and lung disease in rheumatoid arthritis: a meta-analysis of randomized controlled trials. Arthritis Rheumatol. 2014;66(4):803\u201312.","journal-title":"Arthritis Rheumatol"},{"issue":"6","key":"727_CR68","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1093\/qjmed\/94.6.309","volume":"94","author":"ML Grove","year":"2001","unstructured":"Grove ML, Hassell AB, Hay EM, Shadforth MF. Adverse reactions to disease-modifying antirheumatic drugs in clinical practice. QJM. 2001;94(6):309\u201319.","journal-title":"QJM"},{"issue":"1","key":"727_CR69","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s10067-011-1758-6","volume":"31","author":"N Sathi","year":"2012","unstructured":"Sathi N, Chikura B, Kaushik VV, Wiswell R, Dawson JK. How common is methotrexate pneumonitis? A large prospective study investigates. Clin Rheumatol. 2012;31(1):79\u201383.","journal-title":"Clin Rheumatol"},{"issue":"5","key":"727_CR70","doi-asserted-by":"crossref","first-page":"356","DOI":"10.7326\/0003-4819-127-5-199709010-00003","volume":"127","author":"GS Alarcon","year":"1997","unstructured":"Alarcon GS, Kremer JM, Macaluso M, Weinblatt ME, Cannon GW, Palmer WR, et al. Risk factors for methotrexate-induced lung injury in patients with rheumatoid arthritis. A multicenter, case\u2013control study. Methotrexate-Lung Study Group. Ann Intern Med. 1997;127(5):356\u201364.","journal-title":"Ann Intern Med"},{"issue":"1","key":"727_CR71","first-page":"2","volume":"32","author":"A Fischer","year":"2015","unstructured":"Fischer A, Chartrand S. Assessment and management of connective tissue disease-associated interstitial lung disease. Sarcoidosis Vasc Diffuse Lung Dis. 2015;32(1):2\u201321.","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"727_CR72","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1183\/09031936.00080209","volume":"35","author":"H Liote","year":"2010","unstructured":"Liote H, Liote F, Seroussi B, Mayaud C, Cadranel J. Rituximab-induced lung disease: a systematic literature review. Eur Respir J. 2010;35:681\u20137.","journal-title":"Eur Respir J"},{"issue":"8","key":"727_CR73","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1093\/rheumatology\/kex072","volume":"56","author":"MY Md Yusof","year":"2017","unstructured":"Md Yusof MY, Kabia A, Darby M, Lettieri G, Beirne P, Vital EM, et al. Effect of rituximab on the progression of rheumatoid arthritis-related interstitial lung disease: 10\u00a0years\u2019 experience at a single centre. Rheumatology (Oxford). 2017;56(8):1348\u201357.","journal-title":"Rheumatology (Oxford)"},{"key":"727_CR74","doi-asserted-by":"publisher","DOI":"10.1111\/imj.14306","author":"A Fui","year":"2019","unstructured":"Fui A, Bergantini L, Selvi E, Mazzei MA, Bennett D, Pieroni MG, et al. Rituximab therapy in interstitial lung disease associated with rheumatoid arthritis. Intern Med J. 2019. https:\/\/doi.org\/10.1111\/imj.14306.","journal-title":"Intern Med J"},{"issue":"4","key":"727_CR75","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1136\/ard.2009.123919","volume":"69","author":"JS Smolen","year":"2010","unstructured":"Smolen JS, Aletaha D, Bijlsma JW, Breedveld FC, Boumpas D, Burmester G, et al. Treating rheumatoid arthritis to target: recommendations of an international task force. Ann Rheum Dis. 2010;69(4):631\u20137.","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"727_CR76","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.semarthrit.2010.11.002","volume":"41","author":"R Perez-Alvarez","year":"2011","unstructured":"Perez-Alvarez R, Perez-de-Lis M, Diaz-Lagares C, Pego-Reigosa JM, Retamozo S, Bove A, et al. Interstitial lung disease induced or exacerbated by TNF-targeted therapies: analysis of 122 cases. Semin Arthritis Rheum. 2011;41(2):256\u201364.","journal-title":"Semin Arthritis Rheum"},{"issue":"12","key":"727_CR77","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.2169\/internalmedicine.2226-18","volume":"58","author":"I Kurata","year":"2019","unstructured":"Kurata I, Tsuboi H, Terasaki M, Shimizu M, Toko H, Honda F, et al. Effect of biological disease-modifying anti-rheumatic drugs on airway and interstitial lung disease in patients with rheumatoid arthritis. Intern Med. 2019;58(12):1703\u201312.","journal-title":"Intern Med"},{"issue":"18","key":"727_CR78","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1056\/NEJMoa1908681","volume":"381","author":"KR Flaherty","year":"2019","unstructured":"Flaherty KR, Wells AU, Cottin V, Devaraj A, Walsh SLF, Inoue Y, et al. Nintedanib in progressive fibrosing interstitial lung diseases. N Engl J Med. 2019;381(18):1718\u201327.","journal-title":"N Engl J Med"},{"issue":"11","key":"727_CR79","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.1007\/s12325-019-01086-2","volume":"36","author":"JJ Solomon","year":"2019","unstructured":"Solomon JJ, Danoff SK, Goldberg HJ, Woodhead F, Kolb M, Chambers DC, et al. The design and rationale of the Trail1 trial: a randomized double-blind phase 2 clinical trial of pirfenidone in rheumatoid arthritis-associated interstitial lung disease. Adv Ther. 2019;36(11):3279\u201387.","journal-title":"Adv Ther"}],"container-title":["Drugs & Aging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40266-019-00727-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40266-019-00727-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40266-019-00727-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T00:32:04Z","timestamp":1606264324000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40266-019-00727-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,26]]},"references-count":79,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["727"],"URL":"https:\/\/doi.org\/10.1007\/s40266-019-00727-z","relation":{},"ISSN":["1170-229X","1179-1969"],"issn-type":[{"value":"1170-229X","type":"print"},{"value":"1179-1969","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,26]]},"assertion":[{"value":"26 November 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"RM, GG, AB, and NS have no conflicts of interest to declare.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}