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Maria Heinrich, Anika M\u00fcller, Andela Cvijan, Rudolf M\u00f6rgeli, Jochen Kruppa, Georg Winterer, Arjen J. C. Slooter and Claudia D. Spies have no conflicts of interest that are directly relevant to the content of this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This was a prospective multicenter observational study conducted at the clinical study centers Charit\u00e9-Universit\u00e4tsmedizin Berlin, Department of Anesthesiology and Operative Intensive Care Medicine, Berlin, Germany, and the University Medical Center Utrecht, Department of Intensive Care Medicine, Utrecht, Netherlands. The study was approved by the local Ethics Committees (ref.: EA2\/092\/14 and 14-469) and conducted in accordance with the declaration of Helsinki (ClinicalTrials.gov: NCT02265263).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent was obtained from each patient, and all local data privacy regulations were followed.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Written informed consent was obtained from each patient.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The datasets generated and analyzed during the current study are not publicly available as no consent for this was obtained from participants but are available from the corresponding author on reasonable request.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data and material"}},{"value":"Not applicable.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}},{"value":"Maria Heinrich, Anika M\u00fcller, and Rudolf M\u00f6rgeli were involved in data collection and plausibility checks. Maria Heinrich, Anika M\u00fcller, and Claudia Spies developed the research question. Maria Heinrich and Jochen Kruppa carried out the analyses. The first draft of the manuscript was written by Maria Heinrich, and all authors commented on subsequent versions and read and approved the final manuscript. Georg Winterer, Arjen Slooter, and Claudia Spies designed and directed the BioCog project.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author contributions"}}]}}