{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T02:38:47Z","timestamp":1788057527512,"version":"build-2784847793"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T00:00:00Z","timestamp":1625702400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T00:00:00Z","timestamp":1625702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100010857","name":"Texas A and M University-Central Texas","doi-asserted-by":"crossref","award":["500"],"award-info":[{"award-number":["500"]}],"id":[{"id":"10.13039\/100010857","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Drugs Aging"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1007\/s40266-021-00870-6","type":"journal-article","created":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T22:02:38Z","timestamp":1625695358000},"page":"713-723","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Impact of Fall Risk and Direct Oral Anticoagulant Treatment on Quality-Adjusted Life-Years in Older Adults with Atrial Fibrillation: A Markov Decision Analysis"],"prefix":"10.1007","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3518-0171","authenticated-orcid":false,"given":"Wenfei","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafia S.","family":"Rasu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2553-3159","authenticated-orcid":false,"given":"Jos\u00e9 J.","family":"Hern\u00e1ndez-Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renee J.","family":"Flores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahid J.","family":"Rianon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genesis A.","family":"Hern\u00e1ndez-Vizcarrondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam T.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,8]]},"reference":[{"issue":"18","key":"870_CR1","doi-asserted-by":"publisher","first-page":"2370","DOI":"10.1001\/jama.285.18.2370","volume":"285","author":"AS Go","year":"2001","unstructured":"Go AS, Hylek EM, Phillips KA, Chang Y, Henault LE, Selby JV, et al. Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) study. JAMA. 2001;285(18):2370\u20135. https:\/\/doi.org\/10.1001\/jama.285.18.2370.","journal-title":"JAMA"},{"issue":"8","key":"870_CR2","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1016\/j.amjcard.2013.05.063","volume":"112","author":"S Colilla","year":"2013","unstructured":"Colilla S, Crow A, Petkun W, Singer DE, Simon T, Liu X. Estimates of current and future incidence and prevalence of atrial fibrillation in the US adult population. Am J Cardiol. 2013;112(8):1142\u20137. https:\/\/doi.org\/10.1016\/j.amjcard.2013.05.063.","journal-title":"Am J Cardiol"},{"issue":"3","key":"870_CR3","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1161\/CIRCOUTCOMES.110.958165","volume":"4","author":"MH Kim","year":"2011","unstructured":"Kim MH, Johnston SS, Chu BC, Dalal MR, Schulman KL. Estimation of total incremental health care costs in patients with atrial fibrillation in the United States. Circ Cardiovasc Qual Outcomes. 2011;4(3):313\u201320. https:\/\/doi.org\/10.1161\/CIRCOUTCOMES.110.958165.","journal-title":"Circ Cardiovasc Qual Outcomes"},{"issue":"8","key":"870_CR4","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1111\/imj.14236","volume":"49","author":"PM Thein","year":"2019","unstructured":"Thein PM, Ong J, Crozier TM, Nasis A, Mirzaee S, Tan SX, et al. Predictors of acute hospital mortality and length of stay in patients with new-onset atrial fibrillation: a first-hand experience from a medical emergency team response provider. Intern Med J. 2019;49(8):969\u201377. https:\/\/doi.org\/10.1111\/imj.14236.","journal-title":"Intern Med J"},{"issue":"12","key":"870_CR5","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1001\/archinte.160.12.1749","volume":"160","author":"B Luderitz","year":"2000","unstructured":"Luderitz B, Jung W. Quality of life in patients with atrial fibrillation. Arch Intern Med. 2000;160(12):1749\u201357. https:\/\/doi.org\/10.1001\/archinte.160.12.1749.","journal-title":"Arch Intern Med"},{"issue":"2","key":"870_CR6","doi-asserted-by":"publisher","first-page":"e125","DOI":"10.1161\/CIR.0000000000000665","volume":"140","author":"CT January","year":"2019","unstructured":"January CT, Wann LS, Calkins H, Chen LY, Cigarroa JE, Cleveland JC Jr, et al. 2019 AHA\/ACC\/HRS focused update of the 2014 AHA\/ACC\/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology\/American Heart Association Task Force on clinical practice guidelines and the Heart Rhythm Society in collaboration with the Society of Thoracic Surgeons. Circulation. 2019;140(2):e125\u201351. https:\/\/doi.org\/10.1161\/CIR.0000000000000665.","journal-title":"Circulation"},{"issue":"4","key":"870_CR7","doi-asserted-by":"publisher","first-page":"226","DOI":"10.3109\/02813432.2014.984952","volume":"32","author":"C Johansson","year":"2014","unstructured":"Johansson C, Hagg L, Johansson L, Jansson JH. Characterization of patients with atrial fibrillation not treated with oral anticoagulants. Scand J Prim Health Care. 2014;32(4):226\u201331. https:\/\/doi.org\/10.3109\/02813432.2014.984952.","journal-title":"Scand J Prim Health Care"},{"key":"870_CR8","doi-asserted-by":"publisher","first-page":"749","DOI":"10.2147\/CIA.S159373","volume":"13","author":"N Ekerstad","year":"2018","unstructured":"Ekerstad N, Karlsson T, Soderqvist S, Karlson BW. Hospitalized frail elderly patients: atrial fibrillation, anticoagulation and 12 months\u2019 outcomes. Clin Interv Aging. 2018;13:749\u201356. https:\/\/doi.org\/10.2147\/CIA.S159373.","journal-title":"Clin Interv Aging"},{"key":"870_CR9","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s12959-020-00218-x","volume":"18","author":"J Seelig","year":"2020","unstructured":"Seelig J, Verheugt FWA, Hemels MEW, Illingworth L, Lucassen A, Adriaansen H, et al. Changes in anticoagulant prescription in Dutch patients with recent-onset atrial fibrillation: observations from the GARFIELD-AF registry. Thromb J. 2020;18:5. https:\/\/doi.org\/10.1186\/s12959-020-00218-x.","journal-title":"Thromb J"},{"issue":"6","key":"870_CR10","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1093\/ageing\/afr097","volume":"40","author":"D Pugh","year":"2011","unstructured":"Pugh D, Pugh J, Mead GE. Attitudes of physicians regarding anticoagulation for atrial fibrillation: a systematic review. Age Ageing. 2011;40(6):675\u201383. https:\/\/doi.org\/10.1093\/ageing\/afr097.","journal-title":"Age Ageing"},{"issue":"1","key":"870_CR11","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1111\/jgs.13200","volume":"63","author":"O Bahri","year":"2015","unstructured":"Bahri O, Roca F, Lechani T, Druesne L, Jouanny P, Serot JM, et al. Underuse of oral anticoagulation for individuals with atrial fibrillation in a nursing home setting in France: comparisons of resident characteristics and physician attitude. J Am Geriatr Soc. 2015;63(1):71\u20136. https:\/\/doi.org\/10.1111\/jgs.13200.","journal-title":"J Am Geriatr Soc"},{"issue":"3","key":"870_CR12","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.amjmed.2017.10.036","volume":"131","author":"MP Rao","year":"2018","unstructured":"Rao MP, Vinereanu D, Wojdyla DM, Alexander JH, Atar D, Hylek EM, et al. Clinical outcomes and history of fall in patients with atrial fibrillation treated with oral anticoagulation: insights from the ARISTOTLE trial. Am J Med. 2018;131(3):269\u201377. https:\/\/doi.org\/10.1016\/j.amjmed.2017.10.036 (e2).","journal-title":"Am J Med"},{"issue":"7","key":"870_CR13","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1001\/archinte.159.7.677","volume":"159","author":"M Man-Son-Hing","year":"1999","unstructured":"Man-Son-Hing M, Nichol G, Lau A, Laupacis A. Choosing antithrombotic therapy for elderly patients with atrial fibrillation who are at risk for falls. Arch Intern Med. 1999;159(7):677\u201385. https:\/\/doi.org\/10.1001\/archinte.159.7.677.","journal-title":"Arch Intern Med"},{"issue":"6","key":"870_CR14","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/S1474-4422(12)70092-3","volume":"11","author":"JD Easton","year":"2012","unstructured":"Easton JD, Lopes RD, Bahit MC, Wojdyla DM, Granger CB, Wallentin L, et al. Apixaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of the ARISTOTLE trial. Lancet Neurol. 2012;11(6):503\u201311. https:\/\/doi.org\/10.1016\/S1474-4422(12)70092-3.","journal-title":"Lancet Neurol"},{"issue":"2","key":"870_CR15","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1161\/CIRCULATIONAHA.113.005008","volume":"130","author":"JL Halperin","year":"2014","unstructured":"Halperin JL, Hankey GJ, Wojdyla DM, Piccini JP, Lokhnygina Y, Patel MR, et al. Efficacy and safety of rivaroxaban compared with warfarin among elderly patients with nonvalvular atrial fibrillation in the Rivaroxaban Once Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF). Circulation. 2014;130(2):138\u201346. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.113.005008.","journal-title":"Circulation"},{"issue":"1","key":"870_CR16","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1080\/03007995.2017.1375470","volume":"34","author":"S Peng","year":"2018","unstructured":"Peng S, Deger KA, Ustyugova A, Gandhi P, Qiao N, Wang C, et al. Cost-effectiveness analysis of dabigatran versus rivaroxaban for stroke prevention in patients with non-valvular atrial fibrillation using real-world evidence in elderly US Medicare beneficiaries. Curr Med Res Opin. 2018;34(1):55\u201363. https:\/\/doi.org\/10.1080\/03007995.2017.1375470.","journal-title":"Curr Med Res Opin"},{"issue":"28","key":"870_CR17","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.1093\/eurheartj\/ehu046","volume":"35","author":"S Halvorsen","year":"2014","unstructured":"Halvorsen S, Atar D, Yang H, De Caterina R, Erol C, Garcia D, et al. Efficacy and safety of apixaban compared with warfarin according to age for stroke prevention in atrial fibrillation: observations from the ARISTOTLE trial. Eur Heart J. 2014;35(28):1864\u201372. https:\/\/doi.org\/10.1093\/eurheartj\/ehu046.","journal-title":"Eur Heart J"},{"issue":"10","key":"870_CR18","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1056\/NEJMoa1009638","volume":"365","author":"MR Patel","year":"2011","unstructured":"Patel MR, Mahaffey KW, Garg J, Pan G, Singer DE, Hacke W, et al. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med. 2011;365(10):883\u201391. https:\/\/doi.org\/10.1056\/NEJMoa1009638.","journal-title":"N Engl J Med"},{"issue":"12","key":"870_CR19","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1093\/eurheartj\/ehr488","volume":"33","author":"L Friberg","year":"2012","unstructured":"Friberg L, Rosenqvist M, Lip GY. Evaluation of risk stratification schemes for ischaemic stroke and bleeding in 182,678 patients with atrial fibrillation: the Swedish Atrial Fibrillation cohort study. Eur Heart J. 2012;33(12):1500\u201310. https:\/\/doi.org\/10.1093\/eurheartj\/ehr488.","journal-title":"Eur Heart J"},{"issue":"9586","key":"870_CR20","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/S0140-6736(07)61233-1","volume":"370","author":"J Mant","year":"2007","unstructured":"Mant J, Hobbs FD, Fletcher K, Roalfe A, Fitzmaurice D, Lip GY, et al. Warfarin versus aspirin for stroke prevention in an elderly community population with atrial fibrillation (the Birmingham Atrial Fibrillation Treatment of the Aged Study, BAFTA): a randomised controlled trial. Lancet. 2007;370(9586):493\u2013503. https:\/\/doi.org\/10.1016\/S0140-6736(07)61233-1.","journal-title":"Lancet"},{"key":"870_CR21","doi-asserted-by":"crossref","unstructured":"Atrial Fibrillation Investigators. Risk factors for stroke and efficacy of antithrombotic therapy in atrial fibrillation: analysis of pooled data from five randomized controlled trials. Arch Intern Med. 1994;154(13):1449\u201357.","DOI":"10.1001\/archinte.1994.00420130036007"},{"issue":"1","key":"870_CR22","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1093\/ageing\/afv156","volume":"45","author":"KH Ng","year":"2016","unstructured":"Ng KH, Shestakovska O, Connolly SJ, Eikelboom JW, Avezum A, Diaz R, et al. Efficacy and safety of apixaban compared with aspirin in the elderly: a subgroup analysis from the AVERROES trial. Age Ageing. 2016;45(1):77\u201383. https:\/\/doi.org\/10.1093\/ageing\/afv156.","journal-title":"Age Ageing"},{"issue":"10","key":"870_CR23","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1161\/CIRCULATIONAHA.114.009107","volume":"130","author":"KK Sogaard","year":"2014","unstructured":"Sogaard KK, Schmidt M, Pedersen L, Horvath-Puho E, Sorensen HT. 30-year mortality after venous thromboembolism: a population-based cohort study. Circulation. 2014;130(10):829\u201336. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.114.009107.","journal-title":"Circulation"},{"issue":"21","key":"870_CR24","doi-asserted-by":"publisher","first-page":"2271","DOI":"10.1016\/j.jacc.2015.09.024","volume":"66","author":"MW Sherwood","year":"2015","unstructured":"Sherwood MW, Nessel CC, Hellkamp AS, Mahaffey KW, Piccini JP, Suh EY, et al. Gastrointestinal bleeding in patients with atrial fibrillation treated with rivaroxaban or warfarin: ROCKET AF trial. J Am Coll Cardiol. 2015;66(21):2271\u201381. https:\/\/doi.org\/10.1016\/j.jacc.2015.09.024.","journal-title":"J Am Coll Cardiol"},{"issue":"9","key":"870_CR25","doi-asserted-by":"publisher","first-page":"e0221875","DOI":"10.1371\/journal.pone.0221875","volume":"14","author":"B Janakiraman","year":"2019","unstructured":"Janakiraman B, Temesgen MH, Jember G, Gelaw AY, Gebremeskel BF, Ravichandran H, et al. Falls among community-dwelling older adults in Ethiopia; a preliminary cross-sectional study. PLoS One. 2019;14(9):e0221875. https:\/\/doi.org\/10.1371\/journal.pone.0221875.","journal-title":"PLoS One"},{"key":"870_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.apnr.2019.151190","author":"LK Anderson","year":"2019","unstructured":"Anderson LK, Lane K. Characteristics of falls and recurrent falls in residents of an aging in place community: a case-control study. Appl Nurs Res. 2019. https:\/\/doi.org\/10.1016\/j.apnr.2019.151190.","journal-title":"Appl Nurs Res"},{"issue":"8","key":"870_CR27","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/j.amjmed.2012.01.033","volume":"125","author":"J Donze","year":"2012","unstructured":"Donze J, Clair C, Hug B, Rodondi N, Waeber G, Cornuz J, et al. Risk of falls and major bleeds in patients on oral anticoagulation therapy. Am J Med. 2012;125(8):773\u20138. https:\/\/doi.org\/10.1016\/j.amjmed.2012.01.033.","journal-title":"Am J Med"},{"issue":"1","key":"870_CR28","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1186\/s12913-019-4634-8","volume":"19","author":"S Stephen","year":"2019","unstructured":"Stephen S, Wong EWW, Idris AM, Lim AKH. Intracranial haemorrhage detected by cerebral computed tomography after falls in hospital acute medical wards. BMC Health Serv Res. 2019;19(1):792. https:\/\/doi.org\/10.1186\/s12913-019-4634-8.","journal-title":"BMC Health Serv Res"},{"issue":"1","key":"870_CR29","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s12873-018-0179-0","volume":"18","author":"N Mann","year":"2018","unstructured":"Mann N, Welch K, Martin A, Subichin M, Wietecha K, Birmingham LE, et al. Delayed intracranial hemorrhage in elderly anticoagulated patients sustaining a minor fall. BMC Emerg Med. 2018;18(1):27. https:\/\/doi.org\/10.1186\/s12873-018-0179-0.","journal-title":"BMC Emerg Med"},{"issue":"6","key":"870_CR30","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.amjmed.2005.02.022","volume":"118","author":"BF Gage","year":"2005","unstructured":"Gage BF, Birman-Deych E, Kerzner R, Radford MJ, Nilasena DS, Rich MW. Incidence of intracranial hemorrhage in patients with atrial fibrillation who are prone to fall. Am J Med. 2005;118(6):612\u20137. https:\/\/doi.org\/10.1016\/j.amjmed.2005.02.022.","journal-title":"Am J Med"},{"issue":"5","key":"870_CR31","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1111\/jgs.16338","volume":"68","author":"K de Wit","year":"2020","unstructured":"de Wit K, Parpia S, Varner C, Worster A, McLeod S, Clayton N, et al. Clinical predictors of intracranial bleeding in older adults who have fallen: a cohort study. J Am Geriatr Soc. 2020;68(5):970\u20136. https:\/\/doi.org\/10.1111\/jgs.16338.","journal-title":"J Am Geriatr Soc"},{"issue":"11","key":"870_CR32","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1056\/NEJMoa1107039","volume":"365","author":"CB Granger","year":"2011","unstructured":"Granger CB, Alexander JH, McMurray JJ, Lopes RD, Hylek EM, Hanna M, et al. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 2011;365(11):981\u201392. https:\/\/doi.org\/10.1056\/NEJMoa1107039.","journal-title":"N Engl J Med"},{"issue":"2","key":"870_CR33","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.jacc.2010.09.024","volume":"57","author":"GY Lip","year":"2011","unstructured":"Lip GY, Frison L, Halperin JL, Lane DA. Comparative validation of a novel risk score for predicting bleeding risk in anticoagulated patients with atrial fibrillation: the HAS-BLED (Hypertension, Abnormal Renal\/Liver Function, Stroke, Bleeding History or Predisposition, Labile INR, Elderly, Drugs\/Alcohol Concomitantly) score. J Am Coll Cardiol. 2011;57(2):173\u201380. https:\/\/doi.org\/10.1016\/j.jacc.2010.09.024.","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"870_CR34","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1093\/ageing\/afz125","volume":"49","author":"M Franklin","year":"2019","unstructured":"Franklin M, Hunter RM. A modelling-based economic evaluation of primary-care-based fall-risk screening followed by fall-prevention intervention: a cohort-based Markov model stratified by older age groups. Age Ageing. 2019;49(1):57\u201366. https:\/\/doi.org\/10.1093\/ageing\/afz125.","journal-title":"Age Ageing"},{"key":"870_CR35","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007146.pub3","author":"LD Gillespie","year":"2012","unstructured":"Gillespie LD, Robertson MC, Gillespie WJ, Sherrington C, Gates S, Clemson LM, et al. Interventions for preventing falls in older people living in the community. Cochrane Database Syst Rev. 2012. https:\/\/doi.org\/10.1002\/14651858.CD007146.pub3.","journal-title":"Cochrane Database Syst Rev"},{"issue":"9","key":"870_CR36","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1136\/jech.57.9.740","volume":"57","author":"P Scuffham","year":"2003","unstructured":"Scuffham P, Chaplin S, Legood R. Incidence and costs of unintentional falls in older people in the United Kingdom. J Epidemiol Community Health. 2003;57(9):740\u20134. https:\/\/doi.org\/10.1136\/jech.57.9.740.","journal-title":"J Epidemiol Community Health"},{"issue":"2","key":"870_CR37","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.ahj.2010.11.002","volume":"161","author":"MB Sellers","year":"2011","unstructured":"Sellers MB, Newby LK. Atrial fibrillation, anticoagulation, fall risk, and outcomes in elderly patients. Am Heart J. 2011;161(2):241\u20136. https:\/\/doi.org\/10.1016\/j.ahj.2010.11.002.","journal-title":"Am Heart J"},{"issue":"4","key":"870_CR38","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1345\/aph.1K498","volume":"42","author":"CL Garwood","year":"2008","unstructured":"Garwood CL, Corbett TL. Use of anticoagulation in elderly patients with atrial fibrillation who are at risk for falls. Ann Pharmacother. 2008;42(4):523\u201332. https:\/\/doi.org\/10.1345\/aph.1K498.","journal-title":"Ann Pharmacother"},{"issue":"5","key":"870_CR39","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1136\/emj.20.5.421","volume":"20","author":"JC Close","year":"2003","unstructured":"Close JC, Hooper R, Glucksman E, Jackson SH, Swift CG. Predictors of falls in a high risk population: results from the prevention of falls in the elderly trial (PROFET). Emerg Med J. 2003;20(5):421\u20135. https:\/\/doi.org\/10.1136\/emj.20.5.421.","journal-title":"Emerg Med J"},{"key":"870_CR40","doi-asserted-by":"publisher","first-page":"e2754","DOI":"10.1590\/1518-8345.0671.2754","volume":"25","author":"AA Smith","year":"2017","unstructured":"Smith AA, Silva AO, Rodrigues RA, Moreira MA, Nogueira JA, Tura LF. Assessment of risk of falls in elderly living at home. Rev Lat Am Enfermagem. 2017;25:e2754. https:\/\/doi.org\/10.1590\/1518-8345.0671.2754.","journal-title":"Rev Lat Am Enfermagem"},{"key":"870_CR41","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s12877-016-0212-7","volume":"16","author":"SZ Kalula","year":"2016","unstructured":"Kalula SZ, Ferreira M, Swingler GH, Badri M. Risk factors for falls in older adults in a South African Urban Community. BMC Geriatr. 2016;16:51. https:\/\/doi.org\/10.1186\/s12877-016-0212-7.","journal-title":"BMC Geriatr"},{"issue":"11","key":"870_CR42","doi-asserted-by":"publisher","first-page":"e006212","DOI":"10.1161\/CIRCOUTCOMES.119.006212","volume":"12","author":"SJ Shah","year":"2019","unstructured":"Shah SJ, Singer DE, Fang MC, Reynolds K, Go AS, Eckman MH. Net clinical benefit of oral anticoagulation among older adults with atrial fibrillation. Circ Cardiovasc Qual Outcomes. 2019;12(11):e006212. https:\/\/doi.org\/10.1161\/CIRCOUTCOMES.119.006212.","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"870_CR43","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1016\/j.ijcard.2016.06.087","volume":"220","author":"YJ Zhao","year":"2016","unstructured":"Zhao YJ, Lin L, Zhou HJ, Tan KT, Chew AP, Foo CG, et al. Cost-effectiveness modelling of novel oral anticoagulants incorporating real-world elderly patients with atrial fibrillation. Int J Cardiol. 2016;220:794\u2013801. https:\/\/doi.org\/10.1016\/j.ijcard.2016.06.087.","journal-title":"Int J Cardiol"},{"issue":"6","key":"870_CR44","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.1016\/s0149-2918(03)80167-4","volume":"25","author":"CP Gross","year":"2003","unstructured":"Gross CP, Vogel EW, Dhond AJ, Marple CB, Edwards RA, Hauch O, et al. Factors influencing physicians\u2019 reported use of anticoagulation therapy in nonvalvular atrial fibrillation: a cross-sectional survey. Clin Ther. 2003;25(6):1750\u201364. https:\/\/doi.org\/10.1016\/s0149-2918(03)80167-4.","journal-title":"Clin Ther"},{"issue":"22","key":"870_CR45","doi-asserted-by":"publisher","first-page":"2980","DOI":"10.1182\/blood-2016-08-731638","volume":"129","author":"RD Lopes","year":"2017","unstructured":"Lopes RD, Guimaraes PO, Kolls BJ, Wojdyla DM, Bushnell CD, Hanna M, et al. Intracranial hemorrhage in patients with atrial fibrillation receiving anticoagulation therapy. Blood. 2017;129(22):2980\u20137. https:\/\/doi.org\/10.1182\/blood-2016-08-731638.","journal-title":"Blood"},{"issue":"1","key":"870_CR46","doi-asserted-by":"publisher","first-page":"8","DOI":"10.18043\/ncm.75.1.8","volume":"75","author":"ZY Kerr","year":"2014","unstructured":"Kerr ZY, Harmon KJ, Marshall SW, Proescholdbell SK, Waller AE. The epidemiology of traumatic brain injuries treated in emergency departments in North Carolina, 2010\u20132011. N C Med J. 2014;75(1):8\u201314. https:\/\/doi.org\/10.18043\/ncm.75.1.8.","journal-title":"N C Med J"},{"issue":"5","key":"870_CR47","doi-asserted-by":"publisher","first-page":"E1","DOI":"10.1097\/HTR.0000000000000190","volume":"31","author":"JS Albrecht","year":"2016","unstructured":"Albrecht JS, Hirshon JM, McCunn M, Bechtold KT, Rao V, Simoni-Wastila L, et al. Increased rates of mild traumatic brain injury among older adults in US emergency departments, 2009\u20132010. J Head Trauma Rehabil. 2016;31(5):E1-7. https:\/\/doi.org\/10.1097\/HTR.0000000000000190.","journal-title":"J Head Trauma Rehabil"},{"issue":"4","key":"870_CR48","doi-asserted-by":"publisher","first-page":"e0175868","DOI":"10.1371\/journal.pone.0175868","volume":"12","author":"WW Fu","year":"2017","unstructured":"Fu WW, Fu TS, Jing R, McFaull SR, Cusimano MD. Predictors of falls and mortality among elderly adults with traumatic brain injury: a nationwide, population-based study. PLoS One. 2017;12(4):e0175868. https:\/\/doi.org\/10.1371\/journal.pone.0175868.","journal-title":"PLoS One"},{"issue":"10","key":"870_CR49","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1007\/s00701-015-2512-7","volume":"157","author":"W Peeters","year":"2015","unstructured":"Peeters W, van den Brande R, Polinder S, Brazinova A, Steyerberg EW, Lingsma HF, et al. Epidemiology of traumatic brain injury in Europe. Acta Neurochir (Wien). 2015;157(10):1683\u201396. https:\/\/doi.org\/10.1007\/s00701-015-2512-7.","journal-title":"Acta Neurochir (Wien)"},{"issue":"1\u20132","key":"870_CR50","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1159\/000452634","volume":"6","author":"S Rangaraju","year":"2017","unstructured":"Rangaraju S, Haussen D, Nogueira RG, Nahab F, Frankel M. Comparison of 3-month stroke disability and quality of life across Modified Rankin Scale categories. Interv Neurol. 2017;6(1\u20132):36\u201341. https:\/\/doi.org\/10.1159\/000452634.","journal-title":"Interv Neurol"},{"issue":"10","key":"870_CR51","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.2165\/00019053-200624100-00009","volume":"24","author":"PW Sullivan","year":"2006","unstructured":"Sullivan PW, Arant TW, Ellis SL, Ulrich H. The cost effectiveness of anticoagulation management services for patients with atrial fibrillation and at high risk of stroke in the US. Pharmacoeconomics. 2006;24(10):1021\u201333. https:\/\/doi.org\/10.2165\/00019053-200624100-00009.","journal-title":"Pharmacoeconomics"},{"issue":"16","key":"870_CR52","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1001\/archinte.1996.00440150083009","volume":"156","author":"BF Gage","year":"1996","unstructured":"Gage BF, Cardinalli AB, Owens DK. The effect of stroke and stroke prophylaxis with aspirin or warfarin on quality of life. Arch Intern Med. 1996;156(16):1829\u201336.","journal-title":"Arch Intern Med"},{"issue":"6","key":"870_CR53","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1001\/jama.293.6.699","volume":"293","author":"CL O'Brien","year":"2005","unstructured":"O\u2019Brien CL, Gage BF. Costs and effectiveness of ximelagatran for stroke prophylaxis in chronic atrial fibrillation. JAMA. 2005;293(6):699\u2013706. https:\/\/doi.org\/10.1001\/jama.293.6.699.","journal-title":"JAMA"},{"issue":"7","key":"870_CR54","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1161\/STROKEAHA.111.630731","volume":"43","author":"MC Fang","year":"2012","unstructured":"Fang MC, Go AS, Chang Y, Borowsky LH, Pomernacki NK, Udaltsova N, et al. Thirty-day mortality after ischemic stroke and intracranial hemorrhage in patients with atrial fibrillation on and off anticoagulants. Stroke. 2012;43(7):1795\u20139. https:\/\/doi.org\/10.1161\/STROKEAHA.111.630731.","journal-title":"Stroke"},{"issue":"8","key":"870_CR55","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1016\/j.amjmed.2006.07.034","volume":"120","author":"MC Fang","year":"2007","unstructured":"Fang MC, Go AS, Chang Y, Hylek EM, Henault LE, Jensvold NG, et al. Death and disability from warfarin-associated intracranial and extracranial hemorrhages. Am J Med. 2007;120(8):700\u20135. https:\/\/doi.org\/10.1016\/j.amjmed.2006.07.034.","journal-title":"Am J Med"},{"issue":"5","key":"870_CR56","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1161\/STROKEAHA.113.004506","volume":"45","author":"GJ Hankey","year":"2014","unstructured":"Hankey GJ, Stevens SR, Piccini JP, Lokhnygina Y, Mahaffey KW, Halperin JL, et al. Intracranial hemorrhage among patients with atrial fibrillation anticoagulated with warfarin or rivaroxaban: the rivaroxaban once daily, oral, direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and embolism trial in atrial fibrillation. Stroke. 2014;45(5):1304\u201312. https:\/\/doi.org\/10.1161\/STROKEAHA.113.004506.","journal-title":"Stroke"},{"issue":"9118","key":"870_CR57","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1016\/s0140-6736(98)04311-6","volume":"351","author":"L Hansson","year":"1998","unstructured":"Hansson L, Zanchetti A, Carruthers SG, Dahlof B, Elmfeldt D, Julius S, et al. Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial. HOT Study Group. Lancet. 1998;351(9118):1755\u201362. https:\/\/doi.org\/10.1016\/s0140-6736(98)04311-6.","journal-title":"Lancet"},{"issue":"23","key":"870_CR58","doi-asserted-by":"publisher","first-page":"2510","DOI":"10.1001\/jama.2014.15690","volume":"312","author":"Y Ikeda","year":"2014","unstructured":"Ikeda Y, Shimada K, Teramoto T, Uchiyama S, Yamazaki T, Oikawa S, et al. Low-dose aspirin for primary prevention of cardiovascular events in Japanese patients 60 years or older with atherosclerotic risk factors: a randomized clinical trial. JAMA. 2014;312(23):2510\u201320. https:\/\/doi.org\/10.1001\/jama.2014.15690.","journal-title":"JAMA"},{"issue":"3","key":"870_CR59","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.chest.2019.04.108","volume":"156","author":"YH Chan","year":"2019","unstructured":"Chan YH, Lee HF, See LC, Tu HT, Chao TF, Yeh YH, et al. Effectiveness and safety of four direct oral anticoagulants in Asian Patients with nonvalvular atrial fibrillation. Chest. 2019;156(3):529\u201343. https:\/\/doi.org\/10.1016\/j.chest.2019.04.108.","journal-title":"Chest"},{"issue":"11","key":"870_CR60","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1016\/j.lpm.2013.04.010","volume":"42","author":"E Puymirat","year":"2013","unstructured":"Puymirat E, Aissaoui N, Simon T, Bataille V, Drouet E, Mulak G, et al. Acute myocardial infarction in the elderly. The FAST-MI registry. Presse Med. 2013;42(11):1432\u201341. https:\/\/doi.org\/10.1016\/j.lpm.2013.04.010.","journal-title":"Presse Med"}],"container-title":["Drugs & Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40266-021-00870-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40266-021-00870-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40266-021-00870-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T22:27:04Z","timestamp":1628202424000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40266-021-00870-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,8]]},"references-count":60,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["870"],"URL":"https:\/\/doi.org\/10.1007\/s40266-021-00870-6","relation":{},"ISSN":["1170-229X","1179-1969"],"issn-type":[{"value":"1170-229X","type":"print"},{"value":"1179-1969","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,8]]},"assertion":[{"value":"22 May 2021","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Texas A&M University College of Pharmacy provided the analytic software (500). No sources of funding were received for the conduct of this study or the preparation of this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"Wenfei Wei, Rafia S. Rasu, Jos\u00e9 J. Hern\u00e1ndez-Mu\u00f1oz, Renee J. Flores, Nahid J. Rianon, Genesis A. Hern\u00e1ndez-Vizcarrondo, and Adam T. Brown have no conflicts of interest that are directly relevant to the content of this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All data generated or analyzed during this study are included in this published article.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data and material"}},{"value":"Available upon request.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}},{"value":"All authors made substantial contributions to the conception or design of the work; or the acquisition, analysis, or interpretation of data; drafted the work or revised it critically for important intellectual content; approved the version to be published; and agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.","order":9,"name":"Ethics","group":{"name":"EthicsHeading","label":"Authors\u2019 contributions"}}]}}