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This study was supported by an unrestricted grand from Pfizer to the Scientific Direction of Ca\u2019 Granda Maggiore Policlinico Hospital Foundation.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"PMM: Honoraria for lectures as speaker or chair symposia organized by Bayer, Grifols, Kedrion, LFB, Novo Nordisk, and Pfizer; scientific consultant for Bayer, Baxalta, and Kedrion, outside of the submitted work. The other authors have no conflicts to disclose.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study protocol was first approved by the Ethics Committee of the promoting center and then by each enrolling site and the local Committees.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All patients provided written informed consent to participate in the study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All relevant data regarding this paper are available within the article.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data"}},{"value":"Not Applicable.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}},{"value":"AG conceived the study, interpreted results, drafted the first version, and extensively revised the manuscript; MP conceived the study, analyzed data, interpreted results, drafted the first version, and extensively revised the manuscript; EP conceived the study, interpreted results, and revised the manuscript; PMM coordinated data collection and provided extensive revision of the manuscript for relevant intellectual content; AN coordinated data collection and provided extensive revision of the manuscript for relevant intellectual content; MM conceived the study, interpreted results, drafted the first version, and extensively revised the manuscript. All authors approved the final version of the manuscript.","order":9,"name":"Ethics","group":{"name":"EthicsHeading","label":"Authors\u2019 contribution"}}]}}